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公开(公告)号：US08486621B2
公开(公告)日：2013-07-16
申请号：US11464184
申请日：2006-08-11
申请人： Dan Luo , Soong Ho Um
发明人： Dan Luo , Soong Ho Um
摘要： Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.
摘要翻译： 提供各种基于核酸的基质，其包含核酸单体作为结构单元，以及编码蛋白质的核酸，以便产生新的生物材料。 使用这种生物材料的方法包括无细胞蛋白质合成。
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公开(公告)号：US20100324124A1
公开(公告)日：2010-12-23
申请号：US12456587
申请日：2009-06-17
申请人： Darrell J. Irvine , Soong Ho Um , Dan Luo
发明人： Darrell J. Irvine , Soong Ho Um , Dan Luo
CPC分类号： C12N15/87 , A61K48/0091 , C07H21/00 , C12P19/34 , Y10T428/2982
摘要： The invention provides compositions and methods relating to delivery of agents in vivo or in vitro. More specifically, the invention provides nanoparticles synthesized from crosslinked nucleic acids, optionally having a lipid shell or coating, and may further comprise for example small molecule or high molecular weight compounds as therapeutic or diagnostic agents.
摘要翻译： 本发明提供了与体内或体外递送试剂有关的组合物和方法。 更具体地，本发明提供了由交联的核酸合成的纳米颗粒，任选地具有脂壳或涂层，并且还可以包含例如作为治疗剂或诊断剂的小分子或高分子量化合物。
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公开(公告)号：US07223544B2
公开(公告)日：2007-05-29
申请号：US10877697
申请日：2004-06-25
CPC分类号： C07H21/04 , C12N15/10 , Y10S977/924
摘要： The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further relates to the use of DNA as a bulding block for DNA-materials that are of high yield and purity and that can be incorporated into larger structures.
摘要翻译： 本发明涉及核酸分子的设计和使用以产生新的材料。 本发明还涉及DNA作为具有高产率和纯度并可并入更大结构的DNA材料的结晶块的用途。
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公开(公告)号：US20050130180A1
公开(公告)日：2005-06-16
申请号：US10877697
申请日：2004-06-25
CPC分类号： C07H21/04 , C12N15/10 , Y10S977/924
摘要： The present invention relates to the design and use of nucleic acid molecules to create novel materials.
摘要翻译： 本发明涉及核酸分子的设计和使用以产生新的材料。
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公开(公告)号：US09255002B2
公开(公告)日：2016-02-09
申请号：US12888146
申请日：2010-09-22
申请人： Dan Luo , Wenlong Cheng
发明人： Dan Luo , Wenlong Cheng
CPC分类号： B82Y40/00 , B81C99/0025 , B81C2201/0149 , B81C2201/0187 , B82Y30/00 , C07H21/00 , Y10S977/773 , Y10S977/774
摘要： Apparatus and methods for forming self-assembly arrays of substances, such as nanoparticles, on a substrate are disclosed. The apparatus may include a substrate supporting a liquid composition including the substance and a solvent, and a removable micro-mold placed over the substrate and the liquid composition. To form the self assembly arrays of the substance, the solvent may be evaporated through at least one evaporation channel formed between the micro-mold and the substrate. The evaporation channel may be adjustable by subjecting the micro-mold to a positive pressure.
摘要翻译： 公开了用于在衬底上形成诸如纳米颗粒的物质自组装阵列的装置和方法。 该装置可以包括支撑包括物质和溶剂的液体组合物的基底和放置在基底和液体组合物上的可移除微型模具。 为了形成物质的自组装阵列，溶剂可以通过形成在微模和基底之间的至少一个蒸发通道蒸发。 可以通过使微型模具经受正压力来调节蒸发通道。
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公开(公告)号：US20120045430A1
公开(公告)日：2012-02-23
申请号：US13210095
申请日：2011-08-15
IPC分类号： A61K31/7052 , A61K38/14 , A61K38/36 , A61K39/395 , A61K38/54 , A61K38/27 , A61K38/25 , A61K38/31 , A61K38/09 , A61K38/24 , A61K38/23 , A61K38/29 , A61K38/26 , A61K38/11 , A61K38/22 , A61K38/28 , A61K39/165 , A61K39/112 , A61K39/29 , A61K39/245 , A61K39/02 , A61K39/145 , A61K39/10 , A61K39/275 , A61K39/13 , A61K39/002 , A61K39/07 , A61K39/108 , A61K39/21 , A61K35/76 , A61P35/00 , A61P29/00 , A61P31/18 , A61P37/06 , A61P25/08 , A61P31/12 , A61P25/20 , A61P25/16 , A61P21/02 , A61P33/00 , A61P33/02 , A61P31/10 , A61P9/12 , A61P7/02 , A61K39/00
CPC分类号： C12P21/02 , C08G83/003 , C12N11/18 , C12N15/111 , C12N2310/52 , C12N2320/32
摘要： Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. The nucleic acids are used to form dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds in biomedical and biotechnological applications. In particular, the macromolecules may be used for the delivery of drugs, genetic material, imaging components or other functional molecule to which they can be conjugated. An additional feature of the macromolecules is their ability to be targeted for certain organs, tumors, or types of tissues. Methods of utilizing such biomaterials include delivery of functional molecules to cells.
摘要翻译： 提供各种基于核酸的基质，其包含核酸单体作为结构单元，以及编码蛋白质的核酸，以便产生新的生物材料。 核酸用于形成可用作生物医学和生物技术应用中各种化合物的载体，载体，载体或递送载体的树枝状大分子。 特别地，大分子可以用于递送药物，遗传物质，成像组分或它们可以共轭的其它功能性分子。 大分子的另一个特征是其能够针对某些器官，肿瘤或组织类型。 利用这种生物材料的方法包括将功能分子递送至细胞。
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公开(公告)号：US20120040397A1
公开(公告)日：2012-02-16
申请号：US13057356
申请日：2009-08-05
申请人： Dan Luo , Young Hoon Roh
发明人： Dan Luo , Young Hoon Roh
摘要： Methods and compositions are provided for producing hydrogel nucleic acid structures using photo-crosslinking. Methods of using the photo-crosslinked hydrogels for cell-free protein production, and for encapsulating and delivering compounds, are also provided.
摘要翻译： 提供了使用光交联制备水凝胶核酸结构的方法和组合物。 还提供了将光交联水凝胶用于无细胞蛋白质生产以及用于封装和递送化合物的方法。
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公开(公告)号：US20110177978A1
公开(公告)日：2011-07-21
申请号：US12888146
申请日：2010-09-22
申请人： Dan Luo , Wenlong Cheng
发明人： Dan Luo , Wenlong Cheng
CPC分类号： B82Y40/00 , B81C99/0025 , B81C2201/0149 , B81C2201/0187 , B82Y30/00 , C07H21/00 , Y10S977/773 , Y10S977/774
摘要： Apparatus and methods for forming self-assembly arrays of substances, such as nanoparticles, on a substrate are disclosed. The apparatus may include a substrate supporting a liquid composition including the substance and a solvent, and a removable micro-mold placed over the substrate and the liquid composition. To form the self assembly arrays of the substance, the solvent may be evaporated through at least one evaporation channel formed between the micro-mold and the substrate. The evaporation channel may be adjustable by subjecting the micro-mold to a positive pressure.
摘要翻译： 公开了用于在衬底上形成诸如纳米颗粒的物质自组装阵列的装置和方法。 该装置可以包括支撑包括物质和溶剂的液体组合物的基底和放置在基底和液体组合物上的可移除微型模具。 为了形成物质的自组装阵列，溶剂可以通过形成在微模和基底之间的至少一个蒸发通道蒸发。 可以通过使微型模具经受正压力来调节蒸发通道。
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公开(公告)号：US20110172404A1
公开(公告)日：2011-07-14
申请号：US12993231
申请日：2009-05-19
申请人： Dan Luo , Wenlong Cheng
发明人： Dan Luo , Wenlong Cheng
摘要： A self-assembly nanodevice formed through nucleic acid engineering is disclosed. The nanodevice may include an array of nanoparticles. The nanodevice may further include a substrate that supports the array of nanoparticles. Each of the nanoparticles may be coordinated with a plurality of nucleic acids that are substantially free of Watson-Crick base-paring with nucleic acids coordinated with other nanoparticles. Methods of forming the nanodevice, as well as the microscopic organization of the nanoparticles are also disclosed. By manipulating the nucleic acids as capping ligands, the inter-particle distance may be extended to a greater range than nanotechnology based on alkyl ligands or nucleic acids base-pairing.
摘要翻译： 公开了通过核酸工程形成的自组装纳米器件。 纳米器件可以包括纳米颗粒阵列。 纳米器件可以进一步包括支撑纳米颗粒阵列的衬底。 每个纳米颗粒可以与基本上不含与与其他纳米颗粒配位的核酸的Watson-Crick碱基配对的多个核酸配位。 还公开了形成纳米器件的方法以及纳米颗粒的微观结构。 通过操纵核酸作为封端配体，颗粒间距离可以延伸到比基于烷基配体或核酸碱基配对的纳米技术更大的范围。
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公开(公告)号：US20100189794A1
公开(公告)日：2010-07-29
申请号：US12652707
申请日：2010-01-05
申请人： Dan Luo , Jong Bum Lee , Hisakage Funabashi
发明人： Dan Luo , Jong Bum Lee , Hisakage Funabashi
CPC分类号： C12P21/02 , A61K9/0019 , A61K9/06 , C12N15/87 , C12P19/34
摘要： Methods and compositions are provided for producing nucleic acid-based compositions. Methods include enzyme catalyzed or nucleic acid polymer conjugation. Compositions include nucleic acid-containing hydrogels which can be elongated via rolling circle amplification. The hydrogels can encapsulate bioactive agents for drug delivery.
摘要翻译： 提供了用于生产基于核酸的组合物的方法和组合物。 方法包括酶催化或核酸聚合物缀合。 组合物包括可通过滚环扩增而延伸的含核酸的水凝胶。 水凝胶可以包封用于药物递送的生物活性剂。
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