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公开(公告)号：US20050242162A1
公开(公告)日：2005-11-03
申请号：US11146571
申请日：2005-06-07
申请人： Dana Medlin , Steven Charlebois , William Clarke , Dirk Pletcher , Joel Scrafton , H. Shetty , Dale Swarts
发明人： Dana Medlin , Steven Charlebois , William Clarke , Dirk Pletcher , Joel Scrafton , H. Shetty , Dale Swarts
IPC分类号： A61L27/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/34 , A61F2/38 , A61L27/04 , A61L27/30 , A61L27/56 , B22F7/00 , B22F7/06 , B22F7/08 , C23C26/00 , B23K20/00
CPC分类号： C23C26/00 , A61F2/30767 , A61F2/30907 , A61F2/3094 , A61F2/3859 , A61F2002/30787 , A61F2002/30967 , A61F2002/30968 , A61F2002/30978 , A61F2002/3401 , A61F2310/00023 , A61F2310/00029 , A61F2310/00407 , A61F2310/00544 , A61L27/04 , A61L27/30 , A61L27/56 , B22F7/004 , B22F7/064
摘要： A method for attaching a porous metal layer to a dense metal substrate, wherein the method is particularly useful in forming orthopedic implants such as femoral knee components or acetabular cups. The method, in one embodiment thereof, comprises providing a structured porous layer; providing a dense metal substrate; providing a binding mixture; applying the binding mixture to the exterior of the substrate; placing the porous layer against the substrate such that the binding mixture is disposed there between forming an assembly; and heat treating the assembly to metallurgically bond the porous layer to the substrate.
摘要翻译： 一种将多孔金属层附着到致密金属基底上的方法，其中该方法特别可用于形成诸如股骨膝盖部件或髋臼杯之类的矫形植入物。 该方法在其一个实施方案中包括提供结构化的多孔层; 提供致密的金属基底; 提供结合混合物; 将结合混合物施加到基底的外部; 将所述多孔层放置在所述基底上，使得所述粘合混合物在其之间形成组件; 并且对所述组件进行热处理以将所述多孔层冶金结合到所述基底。
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2.发明授权Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications 有权用于医疗器械应用的抗氧化稳定的交联超高分子量聚乙烯公开(公告)号：US08664290B2
公开(公告)日：2014-03-04
申请号：US12847741
申请日：2010-07-30
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
CPC分类号： C08J3/247 , A61B17/8085 , A61L27/16 , A61L27/505 , C08J3/28 , C08J2323/26 , C08K5/005 , C08K5/1545 , C08K9/10 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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![Polymer [[s]] compositions including an antioxidant](/abs-image/US/2013/03/19/US08399535B2/abs.jpg.150x150.jpg)
公开(公告)号：US08399535B2
公开(公告)日：2013-03-19
申请号：US12813401
申请日：2010-06-10
申请人： Dirk Pletcher
发明人： Dirk Pletcher
CPC分类号： C08K5/1545 , C08K5/005 , C08K5/524 , C08L23/06
摘要： Certain embodiments described herein are directed to polymer compositions including a protected antioxidant. In some examples, the compositions can also include a deprotected antioxidant, an unprotected antioxidant or both. Methods of producing compositions including a protected antioxidant and articles including a protected antioxidant are also described.
摘要翻译： 本文所述的某些实施方案涉及包含受保护的抗氧化剂的聚合物组合物。 在一些实例中，组合物还可以包括去保护的抗氧化剂，未保护的抗氧化剂或两者。 还描述了制备包含受保护的抗氧化剂的组合物和包含受保护的抗氧化剂的制品的方法。
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4.发明申请ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 审中-公开用于医疗器械应用的抗氧化稳定交联超高分子量聚乙烯公开(公告)号：US20080319137A1
公开(公告)日：2008-12-25
申请号：US12100894
申请日：2008-04-10
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
IPC分类号： C08F110/02 , C08F2/46 , B29C35/08 , A61L2/14 , A61L2/02
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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公开(公告)号：US20160158976A1
公开(公告)日：2016-06-09
申请号：US14957790
申请日：2015-12-03
申请人： Dirk Pletcher
发明人： Dirk Pletcher
CPC分类号： B29C43/02 , A61F2/30 , A61F2002/30685 , A61L27/16 , A61L27/56 , A61L2300/428 , B29C67/0029 , B29C69/02 , B29C70/00 , B29C71/04 , B29K2023/0683 , B29K2105/0058 , B29K2995/0088 , B29L2031/7532 , C08J3/128 , C08L23/06
摘要： Various embodiments disclosed relate to antioxidant-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of adding antioxidant to UHMWPE. The method includes obtaining or providing a porous solid material including UHMWPE. The method includes coating the porous solid material with a liquid composition including at least one antioxidant such that at least some of the liquid composition enters void space of the porous solid material, to provide an antioxidant-infused solid material. The method also includes melt-consolidating the antioxidant-infused solid material, to provide a melt-consolidated material.
摘要翻译： 所公开的各种实施方案涉及抗氧化稳定材料，包括超高分子量聚乙烯（UHMWPE），其制备方法和包括其的医用植入物。 在各种实施方案中，本发明提供了一种向UHMWPE中加入抗氧化剂的方法。 该方法包括获得或提供包含UHMWPE的多孔固体材料。 该方法包括用包括至少一种抗氧化剂的液体组合物涂覆多孔固体材料，使得至少一些液体组合物进入多孔固体材料的空隙，以提供抗氧化剂输注的固体材料。 该方法还包括熔融固化抗氧化剂注入的固体材料，以提供熔融融合的材料。
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公开(公告)号：US09107755B2
公开(公告)日：2015-08-18
申请号：US12889910
申请日：2010-09-24
CPC分类号： A61F2/38 , A61F2/3094 , A61F2/3859 , A61F2/389 , A61F2002/30014 , A61F2002/30934 , A61F2002/30937 , A61F2250/0018 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00203 , A61F2310/00239 , A61F2310/00281 , A61F2310/00317 , A61F2310/0058 , A61F2310/0088 , A61F2310/00886
摘要： A femoral prosthesis may be formed as a femoral component incorporating a base material and an articulating material. In one exemplary embodiment, the base material is a metal and the articulating material is a polymer. Specifically, the base material provides strength and rigidity to the femoral component, while the articulating material contacts a tibial prosthesis or natural tibia during joint articulation. In one exemplary embodiment, the articulating material forms the articulating surface of one or more condyle portions of the femoral component.
摘要翻译： 股骨假体可以形成为并入基材和关节材料的股骨部件。 在一个示例性实施例中，基底材料是金属，并且铰接材料是聚合物。 具体地说，基体材料为股骨部件提供强度和刚性，而在关节铰接过程中，铰接材料接触胫骨假体或天然胫骨。 在一个示例性实施例中，关节运动材料形成股骨部件的一个或多个髁部分的关节表面。
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7.发明申请ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 有权用于医疗设备应用的抗氧化稳定交联超高分子量聚乙烯公开(公告)号：US20110028600A1
公开(公告)日：2011-02-03
申请号：US12847741
申请日：2010-07-30
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
CPC分类号： C08J3/247 , A61B17/8085 , A61L27/16 , A61L27/505 , C08J3/28 , C08J2323/26 , C08K5/005 , C08K5/1545 , C08K9/10 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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8.发明申请POLYMER ARTICLES HAVING CHEMICALLY BONDED AGENTS AND METHODS OF MAKING THE SAME 审中-公开具有化学键合剂的聚合物及其制备方法公开(公告)号：US20140024736A1
公开(公告)日：2014-01-23
申请号：US13883041
申请日：2011-11-02
IPC分类号： A61L31/04
CPC分类号： A61L31/048 , A61L27/16 , C08L23/06 , C08L23/12
摘要： Modified polymeric articles having modifying agents dispersed within and bonded to an interior region of the article. Methods of modifying polymer materials used to form polymeric articles, and methods of making polymeric articles from polymer particles having modifying agents bonded thereto.
摘要翻译： 具有分散在制品的内部区域内并结合到制品的内部区域的改性剂的改性聚合物制品。 改性用于形成聚合物制品的聚合物材料的方法，以及由具有与其结合的改性剂的聚合物颗粒制备聚合物制品的方法。
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公开(公告)号：US20110306698A1
公开(公告)日：2011-12-15
申请号：US12813401
申请日：2010-06-10
申请人： Dirk Pletcher
发明人： Dirk Pletcher
IPC分类号： C08J3/28 , C08K5/1545 , C08L23/06
CPC分类号： C08K5/1545 , C08K5/005 , C08K5/524 , C08L23/06
摘要： Certain embodiments described herein are directed to polymer compositions including a protected antioxidant. In some examples, the compositions can also include a deprotected antioxidant, an unprotected antioxidant or both. Methods of producing compositions including a protected antioxidant and articles including a protected antioxidant are also described.
摘要翻译： 本文所述的某些实施方案涉及包含受保护的抗氧化剂的聚合物组合物。 在一些实例中，组合物还可以包括去保护的抗氧化剂，未保护的抗氧化剂或两者。 还描述了制备包含受保护的抗氧化剂的组合物和包含受保护的抗氧化剂的制品的方法。
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10.发明申请公开(公告)号：US20100022678A1
公开(公告)日：2010-01-28
申请号：US12408913
申请日：2009-03-23
申请人： Donald Yakimicki , Brian H. Thomas , Alicia Rufner , Dirk Pletcher , Hallie E. Brinkerhuff , Michael E. Hawkins
发明人： Donald Yakimicki , Brian H. Thomas , Alicia Rufner , Dirk Pletcher , Hallie E. Brinkerhuff , Michael E. Hawkins
CPC分类号： B29C71/04 , A61L27/16 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29C2791/005 , B29K2023/0683 , B29L2031/7532 , C08J3/247 , C08J3/28 , C08J7/08 , C08J2323/06 , C08L23/06
摘要： UHMWPE is exposed to crosslinking radiation and than heated utilizing infrared radiation in an inert environment. In one exemplary embodiment, the infrared radiation is provided by an infrared heater having a tungsten heating element with a quartz tube. In this embodiment, the infrared radiation may have the wavelength from about 1.0 micron to about 1.5 microns. In another exemplary embodiment, the UHMWPE is compression molded into bars prior to exposure to the crosslinking radiation.
摘要翻译： UHMWPE暴露于交联辐射，并且在惰性环境中使用红外辐射加热。 在一个示例性实施例中，红外辐射由具有带有石英管的钨加热元件的红外加热器提供。 在该实施例中，红外辐射可以具有约1.0微米至约1.5微米的波长。 在另一示例性实施例中，UHMWPE在暴露于交联辐射之前被压缩成型。
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