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公开(公告)号：US09339224B2
公开(公告)日：2016-05-17
申请号：US13371183
申请日：2012-02-10
CPC分类号： A61B5/4064 , A61B5/1112 , A61B5/165 , A61B5/6803 , A61B5/7275 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , F41H1/02 , F41H1/04 , F42D5/00 , G06F19/00 , Y10T29/49002
摘要： A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.
摘要翻译： 剂量测定装置包括壳体中的至少一个传感器和具有存储器的剂量测定处理装置。 剂量测定处理装置耦合到壳体中的至少一个传感器。 剂量测定处理装置被配置为执行存储在存储器中的编程指令，包括：从传感器获得读数; 存储读数; 对存储的读数进行分析以确定伤害风险评估; 并且输出所确定的伤害风险评估或存储的读数的进行分析中的至少一个。
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公开(公告)号：US09668689B2
公开(公告)日：2017-06-06
申请号：US15130074
申请日：2016-04-15
CPC分类号： A61B5/4064 , A61B5/1112 , A61B5/165 , A61B5/6803 , A61B5/7275 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , F41H1/02 , F41H1/04 , F42D5/00 , G06F19/00 , Y10T29/49002
摘要： A method including a dosimetry device having at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.
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公开(公告)号：US6051422A
公开(公告)日：2000-04-18
申请号：US113015
申请日：1998-07-09
IPC分类号： C12M1/34 , G01N33/487 , C12M3/00
CPC分类号： G01N33/48728 , C12M41/46
摘要： The invention relates to an apparatus and method for monitoring cells and to a method for monitoring changes in cells upon addition of an analyte to the cell's environment, comprising a device which includes an array of microelectrodes disposed in a cell culture chamber, upon which array a portion of cells adhere to the surfaces of the microelectrodes. The diameter of the cells are larger than the diameters of the microelectrodes. A voltage signal is applied across each of the microelectrodes and a reference electrode. Detection and monitoring of the signals resulting from the application of the voltage signal provides information regarding the electrical characteristics of the individual cells, including impedance (combined cell membrane capacitance and conductance), action potential parameters, cell membrane capacitance, cell membrane conductance, and cell/substrate seal resistance. Such an invention is useful in detecting or screening a variety of biological and chemical agents.
摘要翻译： 本发明涉及一种用于监测细胞的装置和方法，以及一种用于监测细胞在向细胞环境中加入分析物时细胞变化的方法，包括一种装置，该装置包括设置在细胞培养室中的微电极阵列，阵列a 细胞的一部分粘附在微电极的表面上。 电池的直径大于微电极的直径。 电压信号施加在每个微电极和参考电极上。 检测和监测由施加电压信号产生的信号，提供有关各个细胞的电气特性的信息，包括阻抗（组合细胞膜电容和电导），动作电位参数，细胞膜电容，细胞膜电导和细胞 /基片密封电阻。 这种发明可用于检测或筛选各种生物和化学试剂。
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公开(公告)号：US5981268A
公开(公告)日：1999-11-09
申请号：US866063
申请日：1997-05-30
IPC分类号： C12M1/34 , G01N33/487 , C12M3/00
CPC分类号： G01N33/48728 , C12M41/46
摘要： The invention relates to an apparatus and method for monitoring cells and to a method for monitoring changes in cells upon addition of an analyte to the cell's environment, comprising a device which includes an array of microelectrodes disposed in a cell culture chamber, upon which array a portion of cells adhere to the surfaces of the microelectrodes. The diameter of the cells are larger than the diameters of the microelectrodes. A voltage signal is applied across each of the microelectrodes and a reference electrode. Detection and monitoring of the signals resulting from the application of the voltage signal provides information regarding the electrical characteristics of the individual cells, including impedance (combined cell membrane capacitance and conductance), action potential parameters, cell membrane capacitance, cell membrane conductance, and cell/substrate seal resistance. Such an invention is useful in detecting or screening a variety of biological and chemical agents.
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公开(公告)号：US20160228045A1
公开(公告)日：2016-08-11
申请号：US15130074
申请日：2016-04-15
CPC分类号： A61B5/4064 , A61B5/1112 , A61B5/165 , A61B5/6803 , A61B5/7275 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , F41H1/02 , F41H1/04 , F42D5/00 , G06F19/00 , Y10T29/49002
摘要： A method including a dosimetry device having at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.
摘要翻译： 一种包括在壳体中具有至少一个传感器的剂量测定装置和具有存储器的剂量测定处理装置的方法。 所述剂量调节处理装置联接到所述壳体中的所述至少一个传感器。 剂量测定处理装置被配置为执行存储在存储器中的编程指令，包括：从传感器获得读数; 存储读数; 对存储的读数进行分析以确定伤害风险评估; 并且输出所确定的伤害风险评估或存储的读数的进行分析中的至少一个。
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公开(公告)号：US10292658B2
公开(公告)日：2019-05-21
申请号：US15190534
申请日：2016-06-23
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/11 , A61B5/0205 , A61B5/02 , A47K13/24 , A61B5/024 , A61B5/053 , A61B5/01
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
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公开(公告)号：US20190231271A1
公开(公告)日：2019-08-01
申请号：US16377938
申请日：2019-04-08
IPC分类号： A61B5/00 , A61B5/11 , A61B5/0402 , A61B5/02 , A47K13/24 , A61B5/0205
CPC分类号： A61B5/6891 , A47K13/24 , A61B5/01 , A61B5/02028 , A61B5/02055 , A61B5/02416 , A61B5/0402 , A61B5/053 , A61B5/1102 , A61B5/14551 , A61B5/4561 , A61B5/7246
摘要： Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.
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公开(公告)号：US20170354331A1
公开(公告)日：2017-12-14
申请号：US15527467
申请日：2015-11-17
IPC分类号： A61B5/021 , G09B23/28 , A61B5/02 , G09B23/30 , A61B5/0285 , A61B5/0295 , A61B5/0456
CPC分类号： A61B5/7278 , A61B5/02007 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0456 , G09B23/28 , G09B23/288 , G09B23/30
摘要： A noninvasive method for monitoring the blood pressure and arterial compliance of a patient based on measurements of a flow velocity and a pulse wave velocity is described. An embodiment uses a photoplethysmograph and includes a method to monitor the dynamic behavior of the arterial blood flow, coupled with a hemodynamic mathematical model of the arterial blood flow motion in a fully nonlinear vessel. A derived mathematical model creates the patient specific dependence of a blood pressure versus PWV and blood velocity, which allows continuous monitoring of arterial blood pressure.
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公开(公告)号：US20120076736A1
公开(公告)日：2012-03-29
申请号：US13234992
申请日：2011-09-16
申请人： David A. Borkholder
发明人： David A. Borkholder
IPC分类号： A61K49/00
CPC分类号： G01N33/542 , C07K2319/00 , C07K2319/20 , G01N33/66
摘要： The present invention relates to an in vivo method of monitoring an analyte in a subject. This method involves providing an expression vector that encodes a biosensor molecule, the biosensor molecule comprising an analyte binding domain and a signal domain. The biosensor molecule produces a signal from the signal domain upon binding of the analyte by the analyte binding domain. The signal is detectable by a non-invasive means. The expression vector is introduced locally into in vivo cells of a subject under conditions effective to express the biosensor molecule in the cells. The signal from the expressed biosensor molecule is detected by a non-invasive means, thereby monitoring the analyte in the subject in vivo.
摘要翻译： 本发明涉及一种监测受试者中分析物的体内方法。 该方法包括提供编码生物传感器分子的表达载体，生物传感器分子包含分析物结合域和信号结构域。 当分析物结合分析物结合域时，生物传感器分子从信号域产生信号。 该信号可通过非侵入性手段检测。 在有效表达细胞内的生物传感器分子的条件下，将表达载体局部引入受试者的体内细胞。 通过非侵入性手段检测来自表达的生物传感器分子的信号，从而在体内监测受试者中的分析物。
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公开(公告)号：US20210219924A1
公开(公告)日：2021-07-22
申请号：US17150920
申请日：2021-01-15
摘要： An integrated bioinstrumentation system, combining an accurate and robust quasi 1D computational model with experimental peripheral measurements, is designed to extract information on other quantities of interest, for which the direct measurements are not feasible. The system is able to quantify and visualize the distributions of a cardiac output (CO), aortic blood pressure (BP), flow, velocity, and aortic arterial compliance, based on a peripheral analysis of a pulse transit time (PTT) measured at the available peripheral sites. A preliminary calibration stage extracts the arterial properties from simultaneous measurements of a pulse transit time, and an upper arm blood pressure. Obtained transfer functions, linking noninvasive peripheral measurements to the aortic pressure, cardiac output, aortic compliance and others serve to quantify the indicators of cardiac morbidity and mortality.
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