公开(公告)号：US20050009083A1

公开(公告)日：2005-01-13

申请号：US10914529

申请日：2004-08-09

申请人： David Anderson ,  Lin Liu ,  Sergey Podkovyrov ,  Baomin Wang

发明人： David Anderson ,  Lin Liu ,  Sergey Podkovyrov ,  Baomin Wang

IPC分类号： C12N15/09 ,  C12N1/16 ,  C12N1/19 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/78 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12P19/38 ,  C12R1/19 ,  C12R1/86 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/22

CPC分类号： C12N9/0036 ,  C12N9/0093 ,  C12N9/1007 ,  C12N9/1205 ,  C12N9/78 ,  C12N15/52 ,  C12P19/385

摘要： Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin or a uridine kinase gene and/or a dCTP deaminase gene. In preferred embodiments the constructs comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin further comprise DNA sequences encoding for thymidylate synthase and/or transcription units comprising sequences encoding for uridine kinase preferably together with dCTP deaminase. In particularly preferred embodiments, the host cells comprise constructs having all of the above characteristics wherein the host cell displays repressed or no uracil DNA glycosylase activity. This may be achieved by removal of the host cell ung gene. Use of host cells in the manufacture of pyrimidine deoxyribonucleotides e.g. thymidine is also disclosed.

摘要翻译： 公开了新的DNA构建体和包含其的宿主细胞。 DNA构建体包含包含编码核糖核苷酸还原酶和硫氧还蛋白或尿苷激酶基因和/或dCTP脱氨酶基因的DNA序列的转录单位（例如操纵子）。 在优选实施方案中，包含编码核糖核苷酸还原酶和硫氧还蛋白的DNA序列的构建体还包含编码胸苷酸合酶的DNA序列和/或包含编码尿苷激酶的序列的转录单元，优选与dCTP脱氨酶一起。 在特别优选的实施方案中，宿主细胞包含具有所有上述特征的构建体，其中宿主细胞显示被抑制或没有尿嘧啶DNA糖基化酶活性。 这可以通过去除宿主细胞ung基因来实现。 宿主细胞在制造嘧啶脱氧核糖核苷酸中的用途，例如 还公开了胸苷。

公开(公告)号：US11027382B1

公开(公告)日：2021-06-08

申请号：US16188242

申请日：2018-11-12

申请人： David Anderson

发明人： David Anderson

IPC分类号： B23Q3/10 ,  B23Q1/42 ,  B23Q3/18

摘要： The instant-mount aspect of the present invention allows a user to rapidly accurately dismount a mounted CNC calibration device from a CNC work table, and rapidly replace the CNC calibration device to its previously mounted position within 0.0001, in seconds. The alignment aspect of the present invention allows faster and more robust high-accuracy alignment of a CNC calibration device once it is mounted on a CNC work table. The remote nest aspect of the present invention allows rapid re-positioning of a CNC calibration device within a CNC milling machine cabinet in a way that does not disrupt the data connection between the CNC control computer and the CNC calibration device, and allows for utilization of more of the worktable surface during milling operations.

公开(公告)号：US20200235513A1

公开(公告)日：2020-07-23

申请号：US16745701

申请日：2020-01-17

申请人： David Anderson ,  Myles Keefer ,  Larry Le

发明人： David Anderson ,  Myles Keefer ,  Larry Le

IPC分类号： H01R13/207 ,  H01R13/58 ,  E21B43/12

摘要： A power pin alignment and crimping fixture having a fixture body. The fixture body includes a plurality of channels each having a first open end and a second open end. The plurality of channels are disposed at an angle diverging away from one another in a direction from the first open end to the second open end such that each of the plurality of channels are disposed along a corresponding side edge of a symmetrical shape.

公开(公告)号：US20170361813A1

公开(公告)日：2017-12-21

申请号：US15626772

申请日：2017-06-19

申请人： David Anderson

发明人： David Anderson

IPC分类号： B60S9/04 ,  F16M11/16 ,  B60S9/02

CPC分类号： B60S9/04 ,  B60D1/58 ,  B60S9/02 ,  F16M11/16

摘要： A hitch receiver stand comprises a hitch receiver assembly having a hitch receiver than can removably mount a device having a standard hitch and is removably attached to a framework. The framework may include a number of releasably coupled components.

公开(公告)号：US09435749B2

公开(公告)日：2016-09-06

申请号：US14208990

申请日：2014-03-13

申请人： Wade A. Winchip ,  David Anderson ,  Kelly Pepper ,  Neville Whittle

发明人： Wade A. Winchip ,  David Anderson ,  Kelly Pepper ,  Neville Whittle

IPC分类号： H04N5/235 ,  G01N21/952

CPC分类号： B21B28/04 ,  B24B5/37 ,  B24B49/12 ,  B24B55/02 ,  G01N21/8851 ,  G01N21/952

摘要： A system and method that includes, in an embodiment, a prism, a camera, a light source, and a plate. The system, in an embodiment, is configured for scanning a roll and generating an image of the roll surface. The prism, in an embodiment, is positioned below the camera and above the plate. In an embodiment, the plate is positioned below the prism and above the roll surface. In an embodiment, the light source is positioned above the prism. In an embodiment, the light source and the prism are positioned to provide light to the roll surface at an angle of at least 75 degrees measured from a line normal to the roll surface. In an embodiment, the prism is configured to refract light from the light source, the camera is a line scan camera that includes a row of pixel sensors, and the light source includes light emitting diodes.

摘要翻译： 在一个实施例中包括棱镜，照相机，光源和板的系统和方法。 在一个实施例中，该系统被配置用于扫描辊并产生辊表面的图像。 在一个实施例中，棱镜位于照相机下方和板的上方。 在一个实施例中，板位于棱镜下方并在辊表面上方。 在一个实施例中，光源位于棱镜上方。 在一个实施例中，光源和棱镜被定位成以与垂直于辊表面的线测量的至少75度的角度向辊表面提供光。 在一个实施例中，棱镜被配置为折射来自光源的光，照相机是包括一排像素传感器的行扫描照相机，并且光源包括发光二极管。

公开(公告)号：US08954144B2

公开(公告)日：2015-02-10

申请号：US13524989

申请日：2012-06-15

申请人： David Anderson ,  Daryl R. Kipke ,  Jamille Hetke ,  Rio J. Vetter ,  Kc Kong ,  John Seymour

发明人： David Anderson ,  Daryl R. Kipke ,  Jamille Hetke ,  Rio J. Vetter ,  Kc Kong ,  John Seymour

IPC分类号： A61N1/00 ,  A61N1/05

CPC分类号： A61N1/0531 ,  Y10T29/49147

摘要： An apparatus comprises a flexible substrate. The flexible substrate includes a first substrate surface, a surface electrode array that includes a plurality of electrodes disposed on the first substrate surface, one or more flexible neural probes substantially orthogonal to the first substrate surface and insertable into biological tissue, and a penetrating electrode array that includes a plurality of electrodes formed on the one or more flexible neural probes, wherein electrodes of the surface electrode array and the penetrating electrode array are configured to one or both of receive a neural signal from a neural signal source and provide electrical stimulation energy to a neural stimulation target.

摘要翻译： 一种装置包括柔性基板。 柔性基板包括第一基板表面，包括设置在第一基板表面上的多个电极的表面电极阵列，基本上与第一基板表面正交并可插入到生物组织中的一个或多个柔性神经探针，以及穿透电极阵列 其包括形成在所述一个或多个柔性神经探针上的多个电极，其中所述表面电极阵列和所述穿透电极阵列的电极被配置为接收来自神经信号源的神经信号中的一个或两个，并将电刺激能量提供给 神经刺激目标。

公开(公告)号：US08700649B2

公开(公告)日：2014-04-15

申请号：US13073573

申请日：2011-03-28

申请人： Jean Rawlings ,  David Anderson ,  Carl Kraus ,  Andrew Paris

发明人： Jean Rawlings ,  David Anderson ,  Carl Kraus ,  Andrew Paris

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： G06F19/36 ,  G06F19/00 ,  G06Q40/08 ,  G06Q50/22 ,  G16H10/20 ,  G16H15/00 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S707/941

摘要： Techniques suitable for identifying potential subjects for a clinical trial and other applications are disclosed. One or more exclusion or inclusion criteria are defined for the clinical trial. One or more specialized searching tables are pre-generated using administrative healthcare claims data and the one or more exclusion or inclusion criteria. The specialized searching tables are searched. Through the searching step, subjects are identified within the administrative healthcare claims data who match the one or more exclusion or inclusion criteria. Through the searching step, a geographical area is identified corresponding to the subjects who match the one or more exclusion or inclusion criteria. A customized report is generated using the identified subjects and geographical area.

摘要翻译： 公开了适用于鉴定临床试验和其他应用的潜在受试者的技术。 为临床试验定义了一个或多个排除或纳入标准。 使用管理医疗保健索赔数据和一个或多个排除或纳入标准预先生成一个或多个专门的搜索表。 搜索专门的搜索表。 通过搜索步骤，在与一个或多个排除或纳入标准相匹配的行政医疗保健索赔数据内确定受试者。 通过搜索步骤，识别与匹配一个或多个排除或包含标准的受试者相对应的地理区域。 使用识别的主题和地理区域生成定制报告。

公开(公告)号：US08643772B2

公开(公告)日：2014-02-04

申请号：US13289849

申请日：2011-11-04

申请人： David Anderson

发明人： David Anderson

IPC分类号： H04N5/225

CPC分类号： H04N5/2252

摘要： Camera arrangements that can include electromagnetic protection, such as from EMP/IEMI events, is disclosed. One example camera arrangement includes a camera including a viewfinder having a lens, and an electromagnetically shielded enclosure defining an interior volume containing the camera and configured to include at least one opening aligned with the lens. The camera arrangement includes a waveguide beyond cutoff disposed across the at least one opening, the waveguide beyond cutoff including a plurality of cells sized and oriented to shield the interior volume of the enclosure from electromagnetic signals while exposing an optical path between the lens and objects external to the enclosure.

摘要翻译： 公开了可以包括诸如来自EMP / IEMI事件的电磁保护的照相机布置。 一个示例性相机布置包括包括具有透镜的取景器的照相机和限定包含照相机的内部空间的电磁屏蔽外壳，并且被配置为包括与透镜对准的至少一个开口。 照相机装置包括跨越至少一个开口的超越截止的波导，超越切除的波导包括多个单元，其大小和取向以将外壳的内部空间屏蔽电磁信号，同时暴露在透镜和对象外部之间的光路 到外壳。

公开(公告)号：US20130144365A1

公开(公告)日：2013-06-06

申请号：US13556715

申请日：2012-07-24

申请人： Daryl R. Kipke ,  Rio J. Vetter ,  Kc Kong ,  Jamille Hetke ,  David Anderson

发明人： Daryl R. Kipke ,  Rio J. Vetter ,  Kc Kong ,  Jamille Hetke ,  David Anderson

IPC分类号： A61N1/04 ,  A61N1/05 ,  A61N5/06

CPC分类号： A61N1/0476 ,  A61B5/0059 ,  A61B5/04001 ,  A61B5/0478 ,  A61B5/4064 ,  A61B5/4094 ,  A61B2562/0209 ,  A61B2562/046 ,  A61N1/0502 ,  A61N1/0531 ,  A61N1/36064 ,  A61N5/06 ,  A61N5/0622 ,  Y10T29/49117

摘要： An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.

摘要翻译： 一种装置包括柔性基板，其包括设置在柔性基板上的模块化电极阵列。 模块化电极阵列包括多个电极模块，其中电极模块包括多个电极。 柔性基板还包括模块化电极阵列的电极模块与耦合到多个电极的电极的导电互连之间的空间间隔。

公开(公告)号：US20120317288A1

公开(公告)日：2012-12-13

申请号：US13579706

申请日：2010-12-08

申请人： David Anthony Campana ,  Shemimon Manlikudy Anthru ,  Ishan Mandrekar ,  Jens Cahnbley ,  Saurabh Mathur ,  David Anderson

发明人： David Anthony Campana ,  Shemimon Manlikudy Anthru ,  Ishan Mandrekar ,  Jens Cahnbley ,  Saurabh Mathur ,  David Anderson

IPC分类号： G06F15/173

CPC分类号： H04N21/6581 ,  G06F16/40 ,  G06Q10/10 ,  H04L63/102 ,  H04N7/17318 ,  H04N21/25875 ,  H04N21/2743

摘要： A method and system enables sharing content between a plurality of users over a communications network. A link to content that has been shared by a user is selected, the link includes at least one access characteristic defining a set of users able to access the content. A request signal including the at least one access characteristic associated with the content and at least one user characteristic associated with a requesting user over the communications network is transmitted for receipt by an authorization processor. A level of access available is determined for the content by comparing the at least one access characteristic and the at least one user characteristic in the request signal with a source of content specific authentication information including data representing content-specific access levels. Access to the requested content is provided via an internet interface to an output device in accordance with the determined level of access.

摘要翻译： 一种方法和系统使得能够通过通信网络在多个用户之间共享内容。 选择已经被用户共享的内容的链接，该链接包括定义能够访问内容的一组用户的至少一个访问特征。 发送包括与内容相关联的至少一个访问特性的请求信号和通过通信网络与请求用户相关联的至少一个用户特征，以供授权处理器接收。 通过将请求信号中的至少一个访问特征和至少一个用户特征与包含表示内容特定访问级别的数据的内容特定认证信息的源进行比较来确定内容的可用访问级别。 根据确定的访问级别，通过因特网接口向输出设备提供对所请求内容的访问。