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    Rhodamine derivatives and the use thereof
    8.
    发明授权
    Rhodamine derivatives and the use thereof 有权
    罗丹明衍生物及其用途

    公开(公告)号：US06184379B2

    公开(公告)日：2001-02-06

    申请号：US09324265

    申请日：1999-06-02

    申请人： Hans-Peter Josel ,  Rupert Herrmann ,  Dieter Heindl ,  Klaus Muhlegger ,  Gregor Sagner ,  Karl Heinz Drexhage ,  Jorg Frantzeskos ,  Jutta Arden-Jacob

    发明人： Hans-Peter Josel ,  Rupert Herrmann ,  Dieter Heindl ,  Klaus Muhlegger ,  Gregor Sagner ,  Karl Heinz Drexhage ,  Jorg Frantzeskos ,  Jutta Arden-Jacob

    IPC分类号： C07D49147

    CPC分类号： C09B11/24 ,  Y10S436/80

    摘要： The invention concerns rhodamine derivatives of the general formulae in which Ca-Cd each denote a C atom, and Ca and Cb as well as Cc and Cd are either linked together by a single bond or by a double bond; X1 to X16 denote independently of one another halogen, sulfonic acid, hydrogen or an alkyl residue with 1-20 C atoms in which the alkyl residue can be substituted with one or several halogen or sulfonic acid residues; R1 and R2 are either identical or different and denote either hydrogen, alkyl with 1-20 C atoms, polyoxyhydrocarbyl units, phenyl or phenylalkyl with 1-3 carbon atoms in the alkyl chain in which the alkyl and/or phenyl residues can be substituted by one or several hydroxy, halogen, sulfonic acid, amino, carboxy or alkoxycarbonyl groups where alkoxy can have 1-4 carbon atoms, R1 contains at least one activatable group, R2 and X4 can be optionally linked together via a bridge composed of 0-2 C atoms. In contrast to the prior art, these compounds are characterized in that A1, A2 and A3 can independently of one another denote hydrogen, cyano, halogen and sulfonic acid; B1 denotes either halogen, cyano or hydrogen; B2 denotes hydrogen, amide, halogen and an alkyl residue with 1-20 C atoms. In addition the invention concerns activated rhodamine derivatives, correspondingly conjugated biomolecules and their use in diagnostic systems.

    摘要翻译： 本发明涉及一般式的罗丹明衍生物，其中Ca-Cd各自表示C原子，Ca和Cb以及C c和Cd通过单键或双键连接在一起; X1至X16彼此独立地表示卤素，磺酸，氢或具有1-20个C原子的烷基残基，其中烷基残基可被一个或几个卤素或磺酸残基取代; R 1和R 2可以相同或不同，表示氢，具有1-20个C原子的烷基，聚氧烃基单元，烷基链中具有1-3个碳原子的苯基或苯基烷基，其中烷基和/或苯基残基可被 一个或几个羟基，卤素，磺酸，氨基，羧基或烷氧基羰基，其中烷氧基可以具有1-4个碳原子，R 1包含至少一个可活化基团，R 2和X 4可以任选地通过由0-2 C原子。 与现有技术相反，这些化合物的特征在于，A1，A2和A3可以彼此独立地表示氢，氰基，卤素和磺酸; B1表示卤素，氰基或氢; B2表示氢，酰胺，卤素和具有1-20个C原子的烷基。 此外，本发明涉及活化的罗丹明衍生物，相应的共轭生物分子及其在诊断系统中的用途。