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40 条记录 (耗时 0.049 秒)

    Use of a polypeptide for detecting, preventing or treating a pathological condition associated with a degenerative, neurological or autoimmune disease
    2.
    发明授权
    Use of a polypeptide for detecting, preventing or treating a pathological condition associated with a degenerative, neurological or autoimmune disease 失效
    使用多肽来检测，预防或治疗与退行性，神经性或自身免疫疾病相关的病理状况

    公开(公告)号：US07510843B2

    公开(公告)日：2009-03-31

    申请号：US11450360

    申请日：2006-06-12

    申请人： Dominique Roecklin ,  Hanno Kolbe ,  Marie-Helene Charles ,  Carine Malcus ,  Lyse Santoro ,  Herve Perron

    发明人： Dominique Roecklin ,  Hanno Kolbe ,  Marie-Helene Charles ,  Carine Malcus ,  Lyse Santoro ,  Herve Perron

    IPC分类号： G01N33/53 ,  C07K16/18

    CPC分类号： G01N33/564 ,  A61K38/1709 ,  C07K14/47 ,  G01N33/6896 ,  G01N2800/52

    摘要： The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28, and SEQ ID No 29, and the peptide sequences having at least 70% identity, preferably at least 80% identity and advantageously at least 98% identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 10 to SEQ ID No 29, and the peptide sequences or fragments of said sequences belonging to a common family of proteins selected among perlecan, the precursor of the retinol-binding plasmatic protein, of the GM2 activator protein, of calgranulin B and of saponin B.

    摘要翻译： 本发明涉及使用包含蛋白质片段的至少一种多肽以获得用于检测，预防或治疗与退行性和/或神经和/或自身免疫疾病相关的病理状况的诊断，预后，预防或治疗组合物，所述蛋白质 选自天然状态的肽序列的蛋白质对应于SEQ ID No 1，SEQ ID No 2，SEQ ID No 3，SEQ ID No 4，SEQ ID No 5，SEQ ID No 6，SEQ ID No 7，SEQ ID No 8，SEQ ID No 9，SEQ ID No 10，SEQ ID No 11，SEQ ID No 12，SEQ ID No 13，SEQ ID No 14，SEQ ID No 15，SEQ ID No 16，SEQ ID No 17，SEQ ID No 18，SEQ ID No 19，SEQ ID No 20，SEQ ID No 21，SEQ ID No 22，SEQ ID No 23，SEQ ID No 24，SEQ ID No 25，SEQ ID No 26，SEQ ID No 27，SEQ ID No 28和SEQ ID No 29，以及肽序列与肽序列SEQ ID No.1至SEQ ID NO：1至SEQ ID NO：1中的任何一个具有至少70％同一性，优选至少80％同一性，有利地至少98％的同一性 ID No 8和SEQ ID No 10至SEQ ID No 29，并且属于共同家族蛋白质的所述序列的肽序列或片段，其选自Perlecan，视黄醇结合性血浆蛋白的前体，GM2激活蛋白， 的钙粒蛋白B和皂角苷B.

    Method for detecting and/or quantifying a gliotoxic factor
    3.
    发明授权
    Method for detecting and/or quantifying a gliotoxic factor 失效
    用于检测和/或定量胶质毒性因子的方法

    公开(公告)号：US06270953B1

    公开(公告)日：2001-08-07

    申请号：US09202118

    申请日：1999-03-29

    申请人： Carine Malcus-Vocanson ,  Herve Perron ,  Bernard Mandrand

    发明人： Carine Malcus-Vocanson ,  Herve Perron ,  Bernard Mandrand

    IPC分类号： C12Q100

    CPC分类号： G01N33/564 ,  G01N33/5014 ,  G01N33/6896

    摘要： The invention proposes a method for detecting and/or quantifying, in a biological sample, a cytotoxic factor, in particular a gliotoxic factor, with respect to adherent target cells, in particular macroglial cells, the toxicity of which causes the death by apoptosis of said cells. The method comprises providing an initial fraction of the sample, optionally enriched with the toxic factor by previous treatment, incubating the initial toxic factor with a reference culture medium comprising adherent target cells, and detecting and/or quantifying in the adherent target cells killed by apoptosis, by flow cytometry, at least one direct or indirect characteristic associated with the apoptotic adherent cells of the whole or part of the incubated medium, which, if it is present and/or is quantified, qualifies the sample as positive, i.e. as containing said toxic factor. The initial biological sample is preferably a urine specimen.

    摘要翻译： 本发明提出了一种用于在生物样品中检测和/或定量细胞毒性因子，特别是胶质毒性因子的方法，所述细胞毒性因子涉及粘附的靶细胞，特别是大胶质细胞，其毒性导致所述 细胞。 该方法包括提供样品的初始级分，任选地通过先前的处理富集毒性因子，将初始毒性因子与包含贴壁靶细胞的参照培养基孵育，并在凋亡死亡的贴壁靶细胞中检测和/或定量 通过流式细胞术，与整个或部分培养的培养基的凋亡贴壁细胞相关联的至少一个直接或间接特征，如果存在和/或定量，则将样品鉴定为阳性，即含有所述 毒性因素。 初始生物样品优选为尿样。