-
公开(公告)号：US20080166730A1
公开(公告)日：2008-07-10
申请号：US11977132
申请日：2007-10-23
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： C12Q1/68
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
-
公开(公告)号：US06414128B1
公开(公告)日：2002-07-02
申请号：US09043816
申请日：1998-09-17
申请人： Douglas James Hilton , Tracy Willson , Timothy Gainsford , Warren S Alexander , Donald Metcalf , Ashley Ng , Nicos A Nicola
发明人： Douglas James Hilton , Tracy Willson , Timothy Gainsford , Warren S Alexander , Donald Metcalf , Ashley Ng , Nicos A Nicola
IPC分类号： C12N1512
CPC分类号： C07K14/72 , C07K14/715
摘要： The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.
摘要翻译： 本发明涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。 受体分子及其衍生物和本发明编码相同基因的序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。 本发明特别涉及瘦素受体。
-
公开(公告)号：US06261548B1
公开(公告)日：2001-07-17
申请号：US08839909
申请日：1997-04-21
申请人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
发明人： David Paul Gearing , Nicholas Martin Gough , Douglas James Hilton , Julie Ann King , Donald Metcalf , Edouard Collins Nice , Nicos Anthony Nicola , Richard John Simpson , Tracy Ann Willson
IPC分类号： C07K1452
CPC分类号： C12N15/86 , A61K38/00 , C07K14/5415 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N15/81 , C12N2740/13043 , C12P21/02 , C12P21/06
摘要： The present invention provides isolated DNA molecules encoding human and murine LIF and methods of producing LIF by the expression of the isolated DNA and suitable host cells. The invention further provides human and murine LIF polypeptides, pharmaceutical compositions containing LIF, and methods of use thereof.
摘要翻译： 本发明提供编码人和鼠LIF的分离的DNA分子和通过分离的DNA和合适的宿主细胞的表达产生LIF的方法。 本发明还提供人和鼠LIF多肽，含有LIF的药物组合物及其使用方法。
-
公开(公告)号：US07049418B2
公开(公告)日：2006-05-23
申请号：US09908805
申请日：2001-07-19
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： C07H17/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
-
公开(公告)号：US06911530B1
公开(公告)日：2005-06-28
申请号：US09688286
申请日：2000-10-13
IPC分类号： A61K38/00 , C07K14/715 , C07K16/00 , A61K39/395 , C07K14/00 , C07N15/11
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention relates generally to a novel haemopoietin receptor or components or part thereof and to genetic sequences encoding same. The receptor molecules and their components and/or parts and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
摘要翻译： 本发明一般涉及一种新型促血细胞生成素受体或其组分或部分，以及编码该基因的遗传序列。 受体分子及其组分和/或部分以及编码本发明的基因序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。
-
公开(公告)号：US06905842B1
公开(公告)日：2005-06-14
申请号：US08962560
申请日：1997-10-31
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68 , C21P21/06 , C14P14/00
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
-
公开(公告)号：US20050004015A1
公开(公告)日：2005-01-06
申请号：US10014156
申请日：2001-12-07
申请人： Douglas Hilton , Tracy Willson , Timothy Gainsford , Warren Alexander , Donald Metcalf , Ashley Ng , Nicos Nicola
发明人： Douglas Hilton , Tracy Willson , Timothy Gainsford , Warren Alexander , Donald Metcalf , Ashley Ng , Nicos Nicola
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/16 , C07K14/575 , C07K14/715 , C07K14/72 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/17
CPC分类号： C07K14/72 , C07K14/715
摘要： The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.
摘要翻译： 本发明涉及一种新型促血细胞生成素受体或其衍生物和编码该基因的遗传序列。 受体分子及其衍生物和本发明编码相同基因的序列可用于开发基于配体与其受体相互作用的广泛范围的激动剂，拮抗剂，治疗剂和诊断试剂。 本发明特别涉及瘦素受体。
-
8.发明授权Monoclonal antibody to human granulocyte macrophage colony stimulating factor 失效人粒细胞巨噬细胞集落刺激因子的单克隆抗体
公开(公告)号：US5747032A
公开(公告)日：1998-05-05
申请号：US411812
申请日：1995-06-02
申请人： Donald Metcalf , Nicos Antony Nicola , Andrew Wallace Boyd , Judith Eleanor Layton , Kaye Wycherley
发明人： Donald Metcalf , Nicos Antony Nicola , Andrew Wallace Boyd , Judith Eleanor Layton , Kaye Wycherley
IPC分类号： A61K38/00 , C07K16/28 , C12N5/18 , C12P21/08 , A61K39/395 , A61K39/40 , A61K39/42 , C07K16/00
CPC分类号： C07K16/2866 , A61K38/00
摘要： The invention relates to monoclonal antibodies specific for the receptor for human granulocyte-macrophage colony stimulating factor (hGM-CSF). The antibodies inhibit the biological activity of hGM-CSF. Methods and compositions for treatment of GM-CSF dependent condition, and methods for screening of selective antagonists to GM-CSF, are also disclosed and claimed.
摘要翻译： PCT No.PCT / AU93 / 00516 Sec。 371日期：1995年6月2日 102（e）日期1995年6月2日PCT提交1993年10月8日PCT公布。 出版物WO94 / 09149 日本1994年4月28日本发明涉及对于粒细胞 - 巨噬细胞集落刺激因子（hGM-CSF）受体特异性的单克隆抗体。 抗体抑制hGM-CSF的生物活性。 用于治疗GM-CSF依赖性病症的方法和组合物以及筛选GM-CSF选择性拮抗剂的方法也被公开并要求保护。
-
公开(公告)号：US5427925A
公开(公告)日：1995-06-27
申请号：US58979
申请日：1993-05-06
申请人： David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
发明人： David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
IPC分类号： A61K38/00 , A61K49/00 , A61P35/02 , C07K1/18 , C07K1/20 , C07K1/22 , C07K4/12 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C12N1/16 , C12N1/19 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/14 , C12N15/19 , C12N15/81 , C12N15/867 , C12P21/02 , C12P21/06 , C12Q1/68 , C12R1/865 , C12R1/91 , G01N33/53 , C12N1/21 , C12N15/85
CPC分类号： C12N15/86 , C07K14/5415 , C12N15/81 , C12P21/02 , C12P21/06 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N2740/13043
摘要： The present invention provides a method for producing recombinant leukemia inhibitory factor (LIF) by the expression, in suitable host cells, of recombinant DNA molecules encoding LIF.
摘要翻译： 本发明提供了通过在合适的宿主细胞中表达编码LIF的重组DNA分子来产生重组白血病抑制因子（LIF）的方法。
-
公开(公告)号：US20060003377A1
公开(公告)日：2006-01-05
申请号：US11214199
申请日：2005-08-29
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
-
-
-
-
-
-
-
-
-
搜索结果
30 条记录 (耗时 0.033 秒)
