公开(公告)号：US20130193223A1

公开(公告)日：2013-08-01

申请号：US13820493

申请日：2011-09-02

申请人： Dongsheng Mei ,  Ming Zou ,  Zhenyu Han ,  Quan Xu ,  Hua Guo ,  Yong Deng ,  Dadong Li ,  Li Tang ,  Yun Zhao ,  Jianhua Liu

发明人： Dongsheng Mei ,  Ming Zou ,  Zhenyu Han ,  Quan Xu ,  Hua Guo ,  Yong Deng ,  Dadong Li ,  Li Tang ,  Yun Zhao ,  Jianhua Liu

IPC分类号： E01B5/02

CPC分类号： E01B5/02 ,  C21D9/04 ,  C21D2211/005 ,  C21D2211/009 ,  C22C38/005 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/24 ,  C22C38/28 ,  Y10T29/49991

摘要： The present discloses a steel rail for high speed and quasi-high speed railways and a manufacturing method thereof. The steel rail having a superior rolling contact fatigue property can be obtained by reducing content of carbon in conjunction with controlled cooling after rolling. The steel rail includes 0.40-0.64% by weight of C, 0.10-1.00% by weight of Si, 0.30-1.50% by weight of Mn, less than or equal to 0.025% by weight of P, less than or equal to 0.025% by weight of S, less than or equal to 0.005% by weight of Al, more than 0 and less than or equal to 0.05% by weight of a rare earth element, more than 0 and less than or equal to 0.20% by weight of at least one of V, Cr, and Ti, and a remainder of Fe and inevitable impurities. The steel rail manufactured according to the method of the present invention maintains the strength and hardness of the existing steel rail for the high speed railways, while enhancing the toughness, plasticity and yield strength, and an energy value required for initiating and expanding microcracks formed at the surface of the steel rail due to fatigue is increased, and thus under the same conditions, the rolling contact fatigue property of the steel rail can be improved, thereby finally improving the service lifetime and the transportation safety of the steel rail.

摘要翻译： 本发明公开了一种用于高速和准高速铁路的钢轨及其制造方法。 具有优异的滚动疲劳性能的钢轨可以通过在轧制后与可控制的冷却相结合地减少碳含量来获得。 钢轨包含0.40-0.64重量％的C，0.10-1.00重量％的Si，0.30-1.50重量％的Mn，小于或等于0.025重量％的P，小于或等于0.025重量％ 的S，小于或等于0.005重量％的Al，大于0和小于或等于0.05重量％的稀土元素，大于0重量％且小于等于0.20重量％ V，Cr和Ti中的至少一种，剩余的Fe和不可避免的杂质。 根据本发明的方法制造的钢轨在提高韧性，塑性和屈服强度的同时保持现有的高速铁路钢轨的强度和硬度，以及形成的微裂纹所需的能量值 钢轨的疲劳表面增加，因此在相同条件下，能够提高钢轨的滚动疲劳特性，从而最终提高钢轨的使用寿命和运输安全性。

公开(公告)号：US09157131B2

公开(公告)日：2015-10-13

申请号：US12953382

申请日：2010-11-23

申请人： Ming Zou ,  Dongsheng Mei ,  Quan Xu ,  Yong Deng ,  Hua Guo ,  Ming Liu ,  Li Tang ,  Yun Zhao ,  Gongming Tao

发明人： Ming Zou ,  Dongsheng Mei ,  Quan Xu ,  Yong Deng ,  Hua Guo ,  Ming Liu ,  Li Tang ,  Yun Zhao ,  Gongming Tao

IPC分类号： C21D9/04 ,  C22C38/18 ,  C21D1/667 ,  C22C38/00 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/24 ,  C22C38/28 ,  B21B1/085

CPC分类号： C21D9/04 ,  B21B1/085 ,  C21D1/667 ,  C21D2211/004 ,  C21D2211/009 ,  C21D2221/00 ,  C21D2221/02 ,  C22C38/001 ,  C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/24 ,  C22C38/28

摘要： A high carbon content and high strength heat-treated steel rail including by weight 0.80-1.20% carbon, 0.20-1.20% silicon, 0.20-1.60% manganese, 0.15-1.20% chromium, 0.01-0.20% vanadium, 0.002-0.050% titanium, less than or equal to 0.030% phosphorus, less than or equal to 0.030% sulfur, less than or equal to 0.010% aluminum, less than or equal to 0.0100% nitrogen, and iron. The steel rail has excellent wear resistance and plasticity and can satisfy the requirement for overloading. A method for producing the steal rail by heating a slab to a heating temperature, multi-pass rolling, and accelerated cooling, wherein a maximum heating temperature (° C.) of said slab is equal to 1,400 minus 100[% C], [% C] representing the carbon content (wt. %) of said slab multiplied by 100.

摘要翻译： 高碳含量和高强度热处理钢轨，包括重量为0.80-1.20％碳，0.20-1.20％硅，0.20-1.60％锰，0.15-1.20％铬，0.01-0.20％钒，0.002-0.050％钛 ，小于或等于0.030％的磷，小于或等于0.030％的硫，小于或等于0.010％的铝，小于或等于0.0100的氮和铁。 钢轨具有优异的耐磨性和可塑性，可以满足超载要求。 一种通过将板坯加热至加热温度，多次轧制和加速冷却来制造所述钢轨的方法，其中所述板坯的最大加热温度（℃）等于1,400减去100 [℃]，[ ％C]表示所述板的碳含量（重量％）乘以100。

公开(公告)号：US09486434B2

公开(公告)日：2016-11-08

申请号：US13609531

申请日：2012-09-11

申请人： Yuesheng Zhang ,  Arup Bhattacharya ,  Li Tang ,  Yun Li ,  Joseph D. Paonessa ,  Feng Geng ,  Yi Ding

发明人： Yuesheng Zhang ,  Arup Bhattacharya ,  Li Tang ,  Yun Li ,  Joseph D. Paonessa ,  Feng Geng ,  Yi Ding

IPC分类号： A61K36/31 ,  A61K31/26

CPC分类号： A61K31/26 ,  A61K36/31 ,  A61K2236/10

摘要： Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual. The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) or a derivative thereof such that the administration inhibits the growth and/or recurrence of bladder cancer. Nutraceutical compositions are also provided.

摘要翻译： 本发明提供一种含有西兰花籽和芥菜籽混合物的组合物。 在将西兰花种子与芥菜种子混合之前，将花椰菜种子进行烘烤和加压热处理。 将青花菜种子在至少200华氏度的温度下烘烤至少60分钟，并在至少10磅/平方英寸的压力下进行至少200华氏度的加压热处理至少5分钟 。 还提供了治疗和/或预防个体中膀胱癌的方法。 该方法需要向个体口服含有异硫氰酸酯（ITC）或其衍生物的组合物，使得该给药抑制膀胱癌的生长和/或复发。 还提供营养组合物。

公开(公告)号：US20130052485A1

公开(公告)日：2013-02-28

申请号：US13217531

申请日：2011-08-25

申请人： Zhong Wu ,  Li Tang ,  Shoutao Wang ,  Abebe Hailu

发明人： Zhong Wu ,  Li Tang ,  Shoutao Wang ,  Abebe Hailu

IPC分类号： G11B5/66 ,  G11B5/84

CPC分类号： G11B5/66

摘要： A perpendicular magnetic recording stack with a dual continuous layer and a method of manufacturing the same. The perpendicular magnetic recording stack includes a substrate, one or more magnetic granular recording layers, and a dual continuous layer having first and second continuous layers. The first continuous layer, disposed between the second continuous layer and the magnetic granular recording layers, has an intermediate lateral exchange coupling, which is higher than the lateral exchange coupling of the magnetic granular layers. The second continuous layer has a higher lateral exchange coupling than the first continuous layer.

摘要翻译： 具有双连续层的垂直磁记录堆叠及其制造方法。 垂直磁记录堆叠包括基板，一个或多个磁性粒状记录层，以及具有第一和第二连续层的双连续层。 设置在第二连续层和磁性粒状记录层之间的第一连续层具有比磁性颗粒层的横向交换耦合高的中间横向交换耦合。 第二连续层具有比第一连续层更高的横向交换耦合。

公开(公告)号：US20120065171A1

公开(公告)日：2012-03-15

申请号：US12896144

申请日：2010-10-01

申请人： Li Tang ,  Rongguo Qiu

发明人： Li Tang ,  Rongguo Qiu

IPC分类号： A61K31/366 ,  C07D309/32 ,  A61P9/10 ,  A61K31/665 ,  A61P35/00 ,  C07F9/655 ,  C12N5/071

CPC分类号： C07F9/6552 ,  C07D309/32

摘要： Novel Fostriecin (or FST) derivatives represented by formula (I), the pharmaceutical compositions and preparation methods thereof. The pharmaceutical uses of these compounds, especially the use for the preparation of pharmaceutical compositions for treating tumor, inhibiting cell over growth, or lowering myocardial infarction and the injury to cells.

摘要翻译： 由式（I）表示的新型福斯特灵（或FST）衍生物，其药物组合物及其制备方法。 这些化合物的药物用途，特别是用于制备用于治疗肿瘤的药物组合物，抑制细胞超过生长或降低心肌梗塞和细胞损伤的用途。

公开(公告)号：US20110112149A1

公开(公告)日：2011-05-12

申请号：US12919487

申请日：2009-03-02

申请人： Li Tang ,  Rongguo Qiu

发明人： Li Tang ,  Rongguo Qiu

IPC分类号： A61K31/427 ,  C07D417/06 ,  C07D493/04 ,  C07D401/06 ,  A61K31/4427 ,  A61P35/00 ,  A61P25/00 ,  A61P19/02 ,  A61P9/10

CPC分类号： C07D417/14 ,  C07C63/04 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel 15-membered thiazole lactone or lactam polyketide compounds, their pharmaceutical compositions, their use and their preparations. The disclosed compounds relate to those of general formula I, their preparations and their use for preparing therapeutical compositions used as cell inhibitors.

摘要翻译： 本发明涉及新的15-元噻唑内酯或内酰胺聚酮化合物，其药物组合物及其用途及其制备方法。 所公开的化合物涉及通式I，其制备方法及其用于制备用作细胞抑制剂的治疗组合物的化合物。

公开(公告)号：US07897835B2

公开(公告)日：2011-03-01

申请号：US11718661

申请日：2005-01-28

申请人： Sang-Soo Kwak ,  Suk-Yoon Kwon ,  Haeng-Soon Lee ,  Li Tang ,  Soon Lim ,  Byung-Hyun Lee

发明人： Sang-Soo Kwak ,  Suk-Yoon Kwon ,  Haeng-Soon Lee ,  Li Tang ,  Soon Lim ,  Byung-Hyun Lee

IPC分类号： C12N15/82 ,  A01H5/00 ,  C07H21/04

CPC分类号： C12N9/0065 ,  C12N9/0089 ,  C12N15/8271 ,  C12N15/8273 ,  C12N15/895

摘要： The present invention relates to a recombinant expression vector, pSSA-K or pSSA-H, containing oxidative stress inducible promoter, such as sweetpotato peroxidase anionic 2 (SWEPA2), a nucleotide encoding superoxide dismutase (SOD) and a nucleotide sequence encoding ascorbate peroxidase (APX) linked to the promoter, antibiotics resistant gene, tobacco etch virus leader sequence, a polynucleotide encloding a transit peptide for chloroplast targeted expression, CaMV 35S transcription terminator, and T-DNA boarder sequence, and a method for preparing multiple stress tolerant transgenic plants using the recombinant expression vector.

摘要翻译： 本发明涉及含有氧化应激诱导型启动子的重组表达载体pSSA-K或pSSA-H，如甘薯过氧化物酶阴离子2（SWEPA2），编码超氧化物歧化酶（SOD）的核苷酸序列和编码抗坏血酸过氧化物酶 APX），抗生素抗性基因，烟草蚀刻病毒前导序列，包围用于叶绿体靶向表达的转运肽的多核苷酸，CaMV 35S转录终止子和T-DNA边界序列，以及制备多种耐应力转基因植物的方法 使用重组表达载体。

公开(公告)号：US20080244792A1

公开(公告)日：2008-10-02

申请号：US11718661

申请日：2005-01-28

申请人： Sang-Soo Kwak ,  Suk-Yoon Kwon ,  Haeng-Soon Lee ,  Li Tang ,  Soon Lim ,  Byung-Hyun Lee

发明人： Sang-Soo Kwak ,  Suk-Yoon Kwon ,  Haeng-Soon Lee ,  Li Tang ,  Soon Lim ,  Byung-Hyun Lee

IPC分类号： C12N15/63 ,  A01H5/00 ,  C12N15/87

CPC分类号： C12N9/0065 ,  C12N9/0089 ,  C12N15/8271 ,  C12N15/8273 ,  C12N15/895

摘要： The present invention relates to a recombinant expression vector for production of multiple stress tolerant plants, which is prepared by attaching multiple stress tolerant genes to oxidative stress inducible promoter, multiple stress tolerant plants transformed with the expression vector and a preparation method for the plants, more precisely, a recombinant expression vector for production of multiple stress tolerant plants that is prepared by combining oxidative stress inducible peroxidase promoter (SWPA2) originated from sweetpotato with multiple stress tolerant genes (SOD (superoxide dismutase) and APX (ascobate peroxidase)) to express the multiple stress tolerant genes in chloroplasts, multiple stress tolerant plants transformed with the expression vector above and a preparation method for the plants. The recombinant expression vector of the present invention is very useful for the production of transformed plants having very strong resistance against multiple stresses caused by oxidative stress inducible herbicides, cold injury, high temperature, salt damage, or various environmental pollutions generating active oxygen, so that the vector can be a great contribution to the increase of productivity of agricultural crops or mass-production of useful components.

摘要翻译： 本发明涉及用于产生多种胁迫耐受植物的重组表达载体，其通过将多个胁迫耐受基因连接到氧化应激诱导型启动子，用表达载体转化的多种胁迫耐受植物和植物的制备方法 准确地说，通过将源自甘薯的氧化应激诱导型过氧化物酶启动子（SWPA2）与多重胁迫耐受基因（SOD（超氧化物歧化酶）和APX（ascobate过氧化物酶））组合来制备多重胁迫耐受植物的重组表达载体，以表达 叶绿体中的多重胁迫耐受基因，用上述表达载体转化的多种胁迫耐受植物和植物的制备方法。 本发明的重组表达载体对于生产对由氧化应激诱导型除草剂，冷伤害，高温，盐损害或产生活性氧的各种环境污染引起的多重胁迫具有非常强的抗性的转化植物的生产非常有用，使得 该载体可以为提高农作物生产力或大量生产有用成分做出重大贡献。

公开(公告)号：US07271967B2

公开(公告)日：2007-09-18

申请号：US10975259

申请日：2004-10-28

申请人： Zhupei Shi ,  Li Tang ,  Jane Jie Zhang ,  Shanlin Duan

发明人： Zhupei Shi ,  Li Tang ,  Jane Jie Zhang ,  Shanlin Duan

IPC分类号： G11B27/36 ,  G11B5/02

CPC分类号： G11B19/04 ,  G11B5/4555 ,  G11B20/1816

摘要： A method for determining whether a spike in a read back signal from a read head positioned over a perpendicular recording disk having a magnetically soft underlayer (SUL) is caused by a defect in the SUL or by a thermal asperity (TA). A first read back signal with the spike is obtained in the absence of a local magnetic field near the read head. Then, a permanent magnet or electromagnet is used to induce a small local magnetic field by the read head, and a second signal is obtained. If the signals are substantially similar, a thermal asperity is indicated. Otherwise a defect in the 13 magnetically soft underlayer of the disk is indicated.

摘要翻译： 一种用于确定来自位于具有磁软底层（SUL）的垂直记录盘上的读头的回读信号中的尖峰是否由SUL中的缺陷或由热凹凸（TA）引起的方法。 在读磁头附近没有局部磁场的情况下获得具有尖峰的第一回读信号。 然后，使用永磁体或电磁体通过读取头来引起小的局部磁场，并获得第二信号。 如果信号基本相似，则表示热不均匀性。 否则表示磁盘的13个软磁性底层的缺陷。

公开(公告)号：US20050148045A1

公开(公告)日：2005-07-07

申请号：US10922282

申请日：2004-08-18

申请人： Ralph Reid ,  Zhihao Hu ,  Li Tang

发明人： Ralph Reid ,  Zhihao Hu ,  Li Tang

IPC分类号： C07H21/04 ,  C12N20060101 ,  C12N1/21 ,  C12N9/10 ,  C12N15/52 ,  C12N15/74 ,  C12P17/06 ,  C12P19/62 ,  C12P23/00 ,  C12Q1/68

CPC分类号： C12N15/52 ,  C12P17/06

摘要： Domains of fostriecin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare fostriecin in pharmaceutically useful quantities are described, as are methods to prepare fostriecin analogs and other polyketides using the polynucleotides encoding fostriecin polyketide synthase domains or modifying enzymes.

摘要翻译： 提供了福斯特蛋白聚酮化合物合酶的结构域和修饰酶以及编码它们的多核苷酸。 描述了以药学上有用量制备福斯特菌素的方法，以及使用编码福斯特肽聚酮合成酶结构域或修饰酶的多核苷酸制备福斯特菌素类似物和其它聚酮化合物的方法。