公开(公告)号：US20050032677A1

公开(公告)日：2005-02-10

申请号：US10486327

申请日：2002-08-09

申请人： Eiichi Kitakuni ,  Tadashi Yoneda ,  Toshi Tsuzuki ,  Eiji Ogata

发明人： Eiichi Kitakuni ,  Tadashi Yoneda ,  Toshi Tsuzuki ,  Eiji Ogata

IPC分类号： A01N43/713 ,  A01N43/72 ,  A01N63/00 ,  A01N63/02

CPC分类号： A01N43/72 ,  A01N63/00 ,  A01N63/02 ,  A01N2300/00 ,  A01N25/28 ,  A01N25/02

摘要： The present invention relates to a fungicidal and/or bactericidal composition comprising a combination of iturin and surfactin which are a cyclic peptide produced by a mircoorganism, preferably a microorganism belonging to the genus Bacillus, with an amphipathic organic material having a hydrocarbon chain, its production process and sterilization method using the same. The fungicidal and/or bactericidal composition of the present invention is highly safe to human body or environment, is free of generation of resistant bacteria even on repeated use and has a wide sterilization spectrum.

摘要翻译： 本发明涉及杀真菌和/或杀菌组合物，其包含由微生物产生的环状肽，优选属于芽孢杆菌属的微生物和具有烃链的两亲性有机材料产生的环肽的组合，其生产 过程和灭菌方法使用相同。 本发明的杀真菌剂和/或杀菌剂组合物对人体或环境高度安全，甚至在重复使用时也不会产生耐药性细菌，并具有广泛的杀菌谱。

公开(公告)号：US20050266521A1

公开(公告)日：2005-12-01

申请号：US10528773

申请日：2003-09-22

申请人： Tadashi Yoneda ,  Eiichi Kitakuni ,  Kazuo Furuya

发明人： Tadashi Yoneda ,  Eiichi Kitakuni ,  Kazuo Furuya

IPC分类号： A01N63/02 ,  C07H21/04 ,  C07K7/56 ,  C07K7/64 ,  C12N1/20 ,  C12N1/21 ,  C12P21/02 ,  C12P21/06

CPC分类号： C07K7/56 ,  A01N63/02 ,  C12N1/20 ,  C12P21/02

摘要： (1) A method for producing iturin A and its homologues by cultivating a Bacillus microbe that produces iturin A and its homologue in a medium containing 2 mass % or more of soybean pulverisate or its extract as a nitrogen source to allow the microbe to accumulate iturin A and its homologue in the medium at a concentration of 1.5 g/L or more, (2) a culture containing iturin A and its homologue accumulated by the method, (3) a solid obtained from the culture and (4) a method of using the culture or the solid, are provided.

摘要翻译： （1）通过培养在含有2质量％以上的大豆粉状物质或其提取物作为氮源的培养基中培养产生神经蛋白A的芽孢杆菌微生物及其同系物的方法，以使微生物积累神经元 A和其在1.5g / L以上浓度的培养基中的同系物，（2）含有神经蛋白A的培养物及其通过该方法积累的同源物，（3）从培养物获得的固体，（4） 使用文化或固体。

公开(公告)号：US07011969B2

公开(公告)日：2006-03-14

申请号：US10381698

申请日：2001-09-28

申请人： Tadashi Yoneda ,  Yoshiaki Miyota ,  Kazuo Furuya ,  Toshi Tsuzuki

发明人： Tadashi Yoneda ,  Yoshiaki Miyota ,  Kazuo Furuya ,  Toshi Tsuzuki

IPC分类号： C12N1/20

CPC分类号： C12R1/125 ,  C07K14/32 ,  C12N1/20 ,  C12P17/08

摘要： A process for producing Surfactin, comprising culturing a microorganism of the genus Bacillus in a liquid culture medium containing flour of beans such as soybean or an extract thereof as a nitrogen source and accumulating Surfactin in the culture broth, and a microorganism of the genus Bacillus which have an activity to produce a crude Surfactin in a concentration of from 8 to 50 g/L on culturing for 20 to 90 hours.

摘要翻译： 一种生产枯草芽孢杆菌素的方法，包括在含有诸如大豆或其提取物的豆的面粉的液体培养基中培养芽孢杆菌属的微生物作为氮源并在培养肉汤中积累枯草芽孢杆菌素和芽孢杆菌属的微生物 具有在培养20〜90小时时产生浓度为8〜50g / L的粗的枯草菌素的活性。

公开(公告)号：US20070140998A1

公开(公告)日：2007-06-21

申请号：US10575624

申请日：2004-10-13

申请人： Eiko Kato ,  Tadashi Yoneda ,  Eiji Ogata

发明人： Eiko Kato ,  Tadashi Yoneda ,  Eiji Ogata

IPC分类号： A61K8/55

CPC分类号： A61K8/345 ,  A61K8/602 ,  A61K8/676 ,  A61K2800/52 ,  A61Q19/00 ,  C07D307/62 ,  C07F9/65515

摘要： An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.

摘要翻译： 本发明的皮肤外用剂含有抗坏血酸-2-磷酸酯和多元醇的高级脂肪酸酯的盐。 根据本发明，即使使用抗坏血酸-2-磷酸酯的高级脂肪酸酯的特定盐制备皮肤外用剂，也可以防止浊度或时间的沉淀发生，从而提高稳定性。 因此，本发明对于皮肤外用的所有试剂，特别是化妆品是有用的。

公开(公告)号：US08278350B2

公开(公告)日：2012-10-02

申请号：US10575624

申请日：2004-10-13

申请人： Eiko Kato ,  Tadashi Yoneda ,  Eiji Ogata

发明人： Eiko Kato ,  Tadashi Yoneda ,  Eiji Ogata

IPC分类号： A61K31/375 ,  C07D307/62

CPC分类号： A61K8/345 ,  A61K8/602 ,  A61K8/676 ,  A61K2800/52 ,  A61Q19/00 ,  C07D307/62 ,  C07F9/65515

摘要： An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.

摘要翻译： 本发明的皮肤外用剂含有抗坏血酸-2-磷酸酯和多元醇的高级脂肪酸酯的盐。 根据本发明，即使使用抗坏血酸-2-磷酸酯的高级脂肪酸酯的特定盐制备皮肤外用剂，也可以防止浊度或时间的沉淀发生，从而提高稳定性。 因此，本发明对于皮肤外用的所有试剂，特别是化妆品是有用的。

公开(公告)号：US20050208002A1

公开(公告)日：2005-09-22

申请号：US10506335

申请日：2003-03-06

申请人： Eiko Kato ,  Eiji Ogata ,  Tadashi Yoneda ,  Jiro Takata

发明人： Eiko Kato ,  Eiji Ogata ,  Tadashi Yoneda ,  Jiro Takata

IPC分类号： A61K8/67 ,  A61K31/355 ,  A61Q19/02 ,  A61K7/135

CPC分类号： A61K31/355 ,  A61K8/678 ,  A61Q19/02

摘要： A preparation for external use on skin which comprises an active ingredient exhibiting superior effects of preventing pigmentation or eliminating pigments formed in the skin, and has a high level of safety, and in particular, a cosmetic composition exhibiting superior so-called whitening effects, are provided. The whitening cosmetic composition comprises a tocopherol alkylglycine ester and/or a salt thereof.

摘要翻译： 皮肤外用的制剂，其特征在于，具有表现出优异的防止色素沉着的作用的活性成分或消除皮肤中形成的颜料，并且具有高水平的安全性，特别是具有优异的所谓的美白效果的化妆品组合物。 提供。 美白化妆品组合物包含生育酚烷基甘氨酸酯和/或其盐。

公开(公告)号：US06379935B1

公开(公告)日：2002-04-30

申请号：US09369144

申请日：1999-08-05

申请人： Harumi Kamachi ,  Tadashi Yoneda ,  Motoaki Kamachi ,  Nobuyoshi Esaki

发明人： Harumi Kamachi ,  Tadashi Yoneda ,  Motoaki Kamachi ,  Nobuyoshi Esaki

IPC分类号： C12P1710

CPC分类号： C12P7/24 ,  C12P7/40 ,  C12P7/52

摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an a-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond.

摘要翻译： 一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于 醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属 ，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。 假单胞菌属 伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。

公开(公告)号：US20080311234A1

公开(公告)日：2008-12-18

申请号：US10593692

申请日：2005-03-22

申请人： Tadashi Yoneda ,  Naoko Ito ,  Kazuo Furuya

发明人： Tadashi Yoneda ,  Naoko Ito ,  Kazuo Furuya

IPC分类号： A61K35/66 ,  A61Q19/00

CPC分类号： A61K8/06 ,  A61K8/062 ,  A61K8/64 ,  A61K8/731 ,  A61Q19/00

摘要： An oil-in-water emulsified composition suitable for external preparation for skin and cosmetic product, which comprised 0.1 to 5% by mass of (A) lipopeptide compound derived from a microorganism such as surfactin and its analogous compound, 0.05 to 1.5% by mass of (B) xanthan gum, 25 to 70% by mass of (C) oil component and (D) water, free from non-ionic surfactants and acrylic water-soluble polymers, and is excellent in feeling upon use, moisture retention, emollient property and stability as well as environmental suitability and safety for living organisms, and external preparation for skin and cosmetic product using the composition.

摘要翻译： 一种适用于皮肤和化妆品外用剂的水包油乳化组合物，其含有0.1〜5质量％的（A）衍生自微生物如表面活性素及其类似化合物的脂肽化合物，0.05〜1.5质量％ 的（B）黄原胶，25〜70质量％的（C）油成分和（D）水，不含非离子表面活性剂和丙烯酸类水溶性聚合物，使用感好，保湿性，润肤性 性质和稳定性以及生物体的环境适应性和安全性，以及使用该组合物的皮肤和化妆品的外用制剂。

公开(公告)号：US06645752B2

公开(公告)日：2003-11-11

申请号：US09962252

申请日：2001-09-26

申请人： Harumi Kamachi ,  Tadashi Yoneda ,  Motoaki Kamachi ,  Nobuyoshi Esaki

发明人： Harumi Kamachi ,  Tadashi Yoneda ,  Motoaki Kamachi ,  Nobuyoshi Esaki

IPC分类号： C12N112

CPC分类号： C12P7/24 ,  C12P7/40 ,  C12P7/52

摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;,&bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an &agr;-halocarbonyl compound having an &agr;,&bgr;-carbon-carbon double bond.

摘要翻译： 一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于 醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属 ，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。 假单胞菌属 伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。

公开(公告)号：US09144785B2

公开(公告)日：2015-09-29

申请号：US13498285

申请日：2010-08-05

申请人： Atsushi Fukuoka ,  Hirokazu Kobayashi ,  Tasuku Komanoya ,  Tadashi Yoneda ,  Ichiro Fujita

发明人： Atsushi Fukuoka ,  Hirokazu Kobayashi ,  Tasuku Komanoya ,  Tadashi Yoneda ,  Ichiro Fujita

IPC分类号： B01J31/02 ,  C13K1/02 ,  B01J21/18 ,  B01J23/40 ,  B01J23/46 ,  B01J35/00 ,  B01J35/02 ,  B01J35/10 ,  B01J37/00 ,  B01J37/08 ,  B01J21/06 ,  B01J29/03 ,  B01J29/04

CPC分类号： B01J21/18 ,  A23V2002/00 ,  B01J21/063 ,  B01J21/066 ,  B01J23/40 ,  B01J23/462 ,  B01J29/0325 ,  B01J29/043 ,  B01J35/002 ,  B01J35/023 ,  B01J35/1023 ,  B01J35/1028 ,  B01J35/1047 ,  B01J35/1061 ,  B01J37/0018 ,  B01J37/084 ,  C13K1/02 ,  A23V2250/5108

摘要： Disclosed are: a novel catalyst for the hydrolysis of cellulose, which does not require the use of a large quantity of sulfuric acid for the preparation thereof and from which sulfuric acid cannot be eluted; a novel catalyst for the hydrolysis of cellulose, which is not changed in structure even in hot water and therefore does not undergo the deterioration in activity; and a process for producing a cellulose hydrolysate, mainly including glucose, using any one of the aforementioned catalysts. Specifically disclosed are: a catalyst for the hydrolysis of cellulose, which comprises a porous carbon material having a specific surface area of 800 to 2500 m2/g inclusive and a phenolic hydroxy group content of 100 to 700 mmol/kg inclusive, such as a porous carbon material having such a structure that carbon is filled in pores of mesoporous silica that is used as a template; and a catalyst for the hydrolysis of cellulose or hemicellulose, which comprises the aforementioned porous carbon material and a transition metal belonging to Group 8 to Group 11 and supported on the porous carbon material.

摘要翻译： 公开了一种用于纤维素水解的新型催化剂，其不需要使用大量的硫酸来制备，硫酸不能被洗脱; 用于水解纤维素的新型催化剂，即使在热水中结构也不改变，因此不会发生活性降低; 以及使用上述任一种催化剂生产主要包括葡萄糖的纤维素水解产物的方法。 具体公开的是：纤维素水解用催化剂，其含有比表面积为800〜2500m2 / g，含有酚类羟基含量为100〜700mmol / kg的多孔碳材料，例如多孔碳 具有碳被填充在作为模板的介孔二氧化硅的孔中的结构的碳材料; 以及用于水解纤维素或半纤维素的催化剂，其包含上述多孔碳材料和属于第8族至第11族的过渡金属并负载在多孔碳材料上。