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1.发明授权公开(公告)号：US09398955B2
公开(公告)日：2016-07-26
申请号：US14285968
申请日：2014-05-23
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Clarence T. Tegreene
CPC分类号： A61F2/30 , A61F2/30742 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2002/30079 , A61F2002/30087 , A61F2002/30558 , A61F2002/30673 , A61F2002/30682 , A61F2002/30683 , A61F2002/3082 , A61F2002/3092 , A61F2002/3429 , A61F2002/3631 , A61F2002/482
摘要： Prosthetic artificial joints are described, including hip, knee and shoulder joints. In some embodiments, an artificial joint prosthesis includes: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis, the non-contact surface adjacent to the bone-facing surface of the artificial joint prosthesis; at least one fluid deflection structure positioned adjacent to the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo; a mechanism attached to the fluid deflection structure, the mechanism operable to move the fluid deflection structure to direct synovial fluid away from the bone-prosthesis interface in vivo; and at least one particle retaining structure positioned to contact the directed flow of synovial fluid and configured to retain non-physiological particles present within the synovial fluid.
摘要翻译： 描述了假肢人工关节，包括髋关节，膝关节和肩关节。 在一些实施例中，人造关节假体包括：人造关节假体的面向骨的表面，所述面向骨的表面构造成在体内面向骨假体界面; 人造关节假体的非接触表面，与人造关节假体的面向骨的表面相邻的非接触表面; 定位成邻近非接触表面定位的至少一个流体偏转结构，所述流体偏转结构被定位成使滑液在体内远离骨假体界面偏转; 附接到所述流体偏转结构的机构，所述机构可操作以移动所述流体偏转结构以将滑液体在体内远离所述骨假体界面引导; 以及至少一个颗粒保持结构，定位成接触滑液的定向流并被配置为保留存在于滑液内的非生理性颗粒。
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2.发明申请公开(公告)号：US20150238691A1
公开(公告)日：2015-08-27
申请号：US14189255
申请日：2014-02-25
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Philip A. Eckhoff , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Gary L. McKnight , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Clarence T. Tegreene
CPC分类号： A61F2/30 , A61B5/1036 , A61B5/11 , A61F2/30742 , A61F2002/3067 , A61F2002/3068 , A61F2002/4666 , A61F2002/482 , A61F2250/0068 , A61F2250/0096 , A61M31/002 , A61M2205/3306 , A61M2205/3317 , A61M2205/332 , A61M2205/3523 , A61M2210/02 , A61M2230/63
摘要： In some embodiments, a system for responsive release of a medicament in an artificial joint region includes: an implantable sensor unit including at least one sensor, the implantable sensor unit configured to be implanted in an artificial joint region; a responsive release control unit including an electronic controller and memory, the responsive release control unit configured to receive signals from the implantable sensor unit and to send signals to an implantable medicament release unit; and the implantable medicament release unit, including a reservoir and a controllable release unit attached to the reservoir, the controllable release unit configured to provide access to the reservoir in response to signals from the responsive release control unit, the implantable medicament release unit configured to be implanted in the artificial joint region.
摘要翻译： 在一些实施例中，用于药物在人造关节区域中的响应释放的系统包括：可植入传感器单元，其包括至少一个传感器，所述可植入传感器单元被配置为植入人造关节区域; 响应释放控制单元，包括电子控制器和存储器，所述响应释放控制单元被配置为从所述可植入传感器单元接收信号并将信号发送到可植入药物释放单元; 以及可植入药物释放单元，其包括附接到储存器的储存器和可控释放单元，所述可释放单元被配置为响应于来自所述响应释放控制单元的信号而提供对所述储存器的通路，所述可植入药物释放单元被配置为 植入人工关节区域。
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3.发明授权公开(公告)号：US08845740B2
公开(公告)日：2014-09-30
申请号：US13659020
申请日：2012-10-24
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Clarence T. Tegreene
CPC分类号： A61F2/30 , A61F2/30742 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2002/30079 , A61F2002/30087 , A61F2002/30558 , A61F2002/30673 , A61F2002/30682 , A61F2002/30683 , A61F2002/3082 , A61F2002/3092 , A61F2002/3429 , A61F2002/3631 , A61F2002/482
摘要： Prosthetic artificial joints are described, including hip, knee and shoulder joints. In some embodiments, an artificial joint prosthesis includes: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis, the non-contact surface adjacent to the bone-facing surface of the artificial joint prosthesis; at least one fluid deflection structure positioned adjacent to the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo; a mechanism attached to the fluid deflection structure, the mechanism operable to move the fluid deflection structure to direct synovial fluid away from the bone-prosthesis interface in vivo; and at least one particle retaining structure positioned to contact the directed flow of synovial fluid and configured to retain non-physiological particles present within the synovial fluid.
摘要翻译： 描述了假肢人工关节，包括髋关节，膝关节和肩关节。 在一些实施例中，人造关节假体包括：人造关节假体的面向骨的表面，所述面向骨的表面构造成在体内面向骨假体界面; 人造关节假体的非接触表面，与人造关节假体的面向骨的表面相邻的非接触表面; 定位成邻近非接触表面定位的至少一个流体偏转结构，所述流体偏转结构被定位成使滑液在体内远离骨假体界面偏转; 附接到所述流体偏转结构的机构，所述机构可操作以移动所述流体偏转结构以将滑液体在体内远离所述骨假体界面引导; 以及至少一个颗粒保持结构，定位成接触滑液的定向流并被配置为保留存在于滑液内的非生理性颗粒。
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4.发明申请BREAST IMPLANT WITH REGIONALIZED ANALYTE SENSORS RESPONSIVE TO EXTERNAL POWER SOURCE 有权具有对外部电源响应的区域化分析仪传感器的乳腺植入公开(公告)号：US20140288647A1
公开(公告)日：2014-09-25
申请号：US14302814
申请日：2014-06-12
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
CPC分类号： A61F2/12 , A61B5/0031 , A61B5/14503 , A61B5/1451 , A61B5/14546 , A61B5/14735 , A61B5/4312 , A61B5/686 , A61B5/6867 , A61B2562/046 , A61F2250/0001 , A61F2250/0002
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.
摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 从所述壳体的外表面延伸的多个突起，所述突起形成与所述壳体的外表面相邻的多个隔室; 至少一个液体可渗透的盖附接到突起，所述盖完全包围壳体和多个突起; 并且多个传感器模块附接到壳体并且彼此间隔一定距离，每个传感器模块被定向成检测多个隔室中的一个内的流体中的一种或多种分析物，其中多个传感器模块 包括唯一的标识符并被配置为利用从外部源发送的能量。
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5.发明申请公开(公告)号：US20140277519A1
公开(公告)日：2014-09-18
申请号：US14282811
申请日：2014-05-20
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Clarence T. Tegreene
CPC分类号： A61F2/30 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2002/30673
摘要： Artificial joint prosthetic components including synovial fluid deflection structures are described. Embodiments of artificial joint prosthesis include those with: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis; and at least one fluid deflection structure positioned on the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo.
摘要翻译： 描述了包括滑液偏转结构在内的人造关节假体部件。 人造关节假体的实施例包括具有：人造关节假体的面向骨的表面的面向骨体的表面，所述骨对面表面构造成在体内面向骨假体界面; 人造关节假体的非接触表面; 以及定位在所述非接触表面上的至少一个流体偏转结构，所述流体偏转结构被定位成使滑液在体内远离骨假体界面偏转。
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公开(公告)号：US20140121637A1
公开(公告)日：2014-05-01
申请号：US13664273
申请日：2012-10-30
申请人： ELWHA LLC
发明人： Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
IPC分类号： A61M5/42
CPC分类号： A61M5/427 , A61B90/11 , A61B90/13 , A61B2090/364 , A61F7/00 , A61M2205/18 , A61M2205/50 , A61M2205/587 , G16H10/60 , Y02A90/26
摘要： System and methods are described herein for generating an injection guide, which include receiving one or more digital images of a body region of an individual, the body region including one or more physical registration landmarks, generating at least one digital representation of the body region using the one or more digital images, the at least one digital representation including one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region, adding one or more digitally registered injection sites to the at least one digital representation of the body region in an injection-treatment pattern, the one or more digitally registered injection sites registered relative to the one or more digital registration landmarks, and generating one or more output signals having information for controlling one or more controllable light-emitting elements to illuminate a location on a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.
摘要翻译： 本文描述了用于产生注射引导件的系统和方法，其包括接收个体身体区域的一个或多个数字图像，身体区域包括一个或多个物理注册地标，使用以下方式生成身体区域的至少一个数字表示 所述一个或多个数字图像，所述至少一个数字表示包括对应于所述身体区域上的所述一个或多个物理注册地标的一个或多个数字注册地标，将一个或多个数字注册的注射位点添加到所述至少一个数字表示 以注射处理模式的身体区域，相对于一个或多个数字登记地标登记的一个或多个数字注册的注入地点，以及生成具有用于控制一个或多个可控发光元件的信息的一个或多个输出信号以照亮 在个体correspo的身体区域的表面上的位置 将位置填入至少一个数字注册的注册站点中的至少一个。
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公开(公告)号：US09629963B2
公开(公告)日：2017-04-25
申请号：US13664273
申请日：2012-10-30
申请人： Elwha LLC
发明人： Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
CPC分类号： A61M5/427 , A61B90/11 , A61B90/13 , A61B2090/364 , A61F7/00 , A61M2205/18 , A61M2205/50 , A61M2205/587 , G16H10/60 , Y02A90/26
摘要： System and methods are described herein for generating an injection guide, which include receiving one or more digital images of a body region of an individual, the body region including one or more physical registration landmarks, generating at least one digital representation of the body region using the one or more digital images, the at least one digital representation including one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region, adding one or more digitally registered injection sites to the at least one digital representation of the body region in an injection-treatment pattern, the one or more digitally registered injection sites registered relative to the one or more digital registration landmarks, and generating one or more output signals having information for controlling one or more controllable light-emitting elements to illuminate a location on a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.
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8.发明授权Breast implant with regionalized analyte sensors and internal power source 有权具有区域化分析物传感器和内部电源的乳房植入物公开(公告)号：US09333071B2
公开(公告)日：2016-05-10
申请号：US14301607
申请日：2014-06-11
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
IPC分类号： A61F2/12 , G01N33/574 , G01N33/52 , A61B5/00 , A61B5/145 , A61B5/07 , A61B5/1473
CPC分类号： A61F2/12 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14507 , A61B5/14546 , A61B5/14735 , A61B5/4312 , A61B5/686 , A61B5/6867 , A61B2560/0214 , A61B2560/0219 , A61B2560/0443 , A61B2562/028 , A61B2562/06 , A61B2562/162 , A61B2562/168 , G01N33/528 , G01N33/57415
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; a plurality of sensor modules attached to the shell, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier; and at least one power source operably attached to the plurality of sensor modules.
摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 从所述壳体的外表面延伸的多个突起，所述突起形成与所述壳体的外表面相邻的多个隔室; 至少一个液体可渗透的盖附接到突起，所述盖完全包围壳体和多个突起; 多个传感器模块，其附接到所述壳体，所述传感器模块中的每一个被定向以检测所述多个隔室中的一个内的流体中的一种或多种分析物，其中所述多个传感器模块中的每一个包括唯一标识符; 以及可操作地附接到所述多个传感器模块的至少一个电源。
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9.发明申请BREAST IMPLANT WITH COVERING AND ANALYTE SENSORS RESPONSIVE TO EXTERNAL POWER SOURCE 有权具有覆盖和分析传感器的外部植入物对外部电源的响应公开(公告)号：US20140296663A1
公开(公告)日：2014-10-02
申请号：US14301077
申请日：2014-06-10
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
CPC分类号： A61B5/686 , A61B5/076 , A61B5/4312 , A61B5/4848 , A61B5/4851 , A61F2/12
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; at least one fluid-permeable cover, the cover completely enveloping the shell; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid between the shell and the cover, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.
摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 至少一个流体可透过的盖，所述盖完全包围所述壳; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，每个传感器模块被定向成检测壳体和盖子之间的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括 唯一的标识符并被配置为利用从外部源发送的能量。
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10.发明授权公开(公告)号：US08828081B2
公开(公告)日：2014-09-09
申请号：US13628442
申请日：2012-09-27
申请人： Elwha LLC
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Clarence T. Tegreene
IPC分类号： A61F2/28
CPC分类号： A61F2/30 , A61F2/30742 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2002/30079 , A61F2002/30087 , A61F2002/30558 , A61F2002/30673 , A61F2002/30682 , A61F2002/30683 , A61F2002/3082 , A61F2002/3092 , A61F2002/3429 , A61F2002/3631 , A61F2002/482
摘要： Artificial joint prosthetic components including synovial fluid deflection structures are described. Embodiments of artificial joint prosthesis include those with: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis; and at least one fluid deflection structure positioned on the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo.
摘要翻译： 描述了包括滑液偏转结构在内的人造关节假体部件。 人造关节假体的实施例包括具有：人造关节假体的面向骨的表面的面向骨体的表面，所述骨对面表面构造成在体内面向骨假体界面; 人造关节假体的非接触表面; 以及定位在所述非接触表面上的至少一个流体偏转结构，所述流体偏转结构被定位成使滑液在体内远离骨假体界面偏转。
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