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    DIAMINO ALCOHOL AND STRONG BASE NEUTRALIZERS FOR LOW VOC COATING COMPOSITIONS
    1.
    发明申请
    DIAMINO ALCOHOL AND STRONG BASE NEUTRALIZERS FOR LOW VOC COATING COMPOSITIONS 审中-公开
    用于低VOC涂料组合物的DIAMINO酒精和强碱性中和剂

    公开(公告)号：US20140031470A1

    公开(公告)日：2014-01-30

    申请号：US13978962

    申请日：2010-12-22

    申请人： Esin Busche ,  Asghar Peera ,  John Quinn ,  Raymond Swedo ,  Anurima Singh ,  Ian A. Tomlinson

    发明人： Esin Busche ,  Asghar Peera ,  John Quinn ,  Raymond Swedo ,  Anurima Singh ,  Ian A. Tomlinson

    IPC分类号： C09D7/12

    CPC分类号： C09D7/63 ,  C07C215/14 ,  C08K5/17 ,  C09D5/024

    摘要： A coating composition comprising a binder, a carrier, a pigment, cations selected from the group consisting of alkali metal cations, ammonium cations, and mixtures thereof, and at least one diamino alcohol selected from the group consisting of compounds of Formula I and compounds of Formula II. The present invention also provides a method for reducing the volatile organic compound (VOC) content of a coating composition having a binder, a carrier, and a pigment, which comprises including in the coating composition the aforesaid A) cations and B) at least one diamino alcohol.The diamino alcohol may be of Formula I: wherein R1 and R2 are independently C1-C10 alkyl, or R1 and R2, together with the carbon to which they are attached, form a C3-C12 cycloalkyl ring optionally substituted with C1-C6 alkyl. For example, the compound of Formula I may be 2-(2-amino-2-methylpropylamino)-2-(hydroxymethyl)propane-1,3-diol.Alternatively, the diamino alcohol may be of Formula II: or salt thereof, wherein R1 and R2 are independently at each occurrence C1-C6 alkyl; and R3 is independently at each occurrence H or C1-C6 alkyl. For example, the compound of Formula II may be 2,2′-((2-hydroxytrimethylene)diimino)bis(2-methyl-1-propanol).

    摘要翻译： 一种涂料组合物，其包含粘合剂，载体，颜料，选自碱金属阳离子，铵阳离子及其混合物的阳离子，以及选自式I化合物和式I化合物的至少一种二氨基醇， 二级方程式 本发明还提供一种降低具有粘合剂，载体和颜料的涂料组合物的挥发性有机化合物（VOC）含量的方法，其包括在涂料组合物中包含前述A）阳离子和B）至少一种 二氨基醇。 二氨基醇可以是式I化合物：其中R 1和R 2独立地是C 1 -C 10烷基，或者R 1和R 2与它们所连接的碳一起形成任选被C 1 -C 6烷基取代的C 3 -C 12环烷基环。 例如，式I化合物可以是2-（2-氨基-2-甲基丙基氨基）-2-（羟甲基）丙烷-1,3-二醇。 或者，二氨基醇可以是式II或其盐，其中R 1和R 2在每次出现时独立地为C 1 -C 6烷基; 在每次出现时，R 3独立地为H或C 1 -C 6烷基。 例如，式II化合物可以是2,2' - （（2-羟基三亚甲基）二亚氨基）双（2-甲基-1-丙醇）。

    Low-cost production of peptides
    3.
    发明授权
    Low-cost production of peptides 有权
    低成本生产肽

    公开(公告)号：US07595173B2

    公开(公告)日：2009-09-29

    申请号：US10971444

    申请日：2004-10-22

    申请人： Joseph F. Krebs ,  Paul S. Zorner ,  Ian A. Tomlinson

    发明人： Joseph F. Krebs ,  Paul S. Zorner ,  Ian A. Tomlinson

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K5/06

    CPC分类号： C07K14/4723 ,  C07K2319/35 ,  C07K2319/50

    摘要： The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the peptide/AMP as compared to those heretofore known in the art. The subject methods also surprisingly enable the use of Pseudomonas fluorescens to produce AMPs and other peptides. There are several components of the subject invention, which can be used alone or in combination. The subject invention provides for the production of peptides/AMPs in concatemeric precursors. The subject invention also provides novel methods of assembling monomers into multimers, and of cleaving the multimers to yield active monomers. The subject invention also relates to the use of these multimers fused to carrier peptides to produce fusion proteins. Preferably, both the multimers and the fusion proteins (multimers with the carrier polypeptides) lack charge balancing. It has been surprisingly determined that it is not necessary to offset the positive charges of multiple copies of AMPs in multimeric constructs. Thus, the subject invention enables the use of a wider range of multimers and carrier peptides.

    摘要翻译： 本发明涉及通过使用微生物生产肽（包括抗微生物肽（AMP））的低成本方法。 与本领域已知的方法相比，本发明方法能够大大提高肽/ AMP的产率。 本发明的方法也令人惊奇地使得能够使用荧光假单胞菌来产生AMP和其他肽。 本发明的几个组分可单独使用或组合使用。 本发明提供了在并联前体中生产肽/ AMP。 本发明还提供了将单体组装成多聚体的新方法，以及裂解多聚体以产生活性单体。 本发明还涉及这些与载体肽融合的多聚体产生融合蛋白的用途。 优选地，多聚体和融合蛋白（携带多肽的多聚体）都缺乏电荷平衡。 已经令人惊讶地确定，不需要在多聚体构建体中抵消多个拷贝的AMP的正电荷。 因此，本发明使得能够使用更宽范围的多聚体和载体肽。