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公开(公告)号：US07842819B2
公开(公告)日：2010-11-30
申请号：US11584961
申请日：2006-10-23
申请人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Zimmermann , Corey Don Gutierrez
发明人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Zimmermann , Corey Don Gutierrez
IPC分类号： C07D209/02 , A61K31/40
CPC分类号： C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要： Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
摘要翻译： 磺酰胺衍生物作为离子通道拮抗剂。 该组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US20110077269A1
公开(公告)日：2011-03-31
申请号：US12879237
申请日：2010-09-10
申请人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Corey Anderson
发明人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Corey Anderson
IPC分类号： A61K31/4709 , C12N5/00 , A61K31/454 , A61P29/00 , A61P25/06 , A61P19/02 , A61P25/22 , A61P25/24 , A61K31/445 , A61K31/404
CPC分类号： C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要： Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
摘要翻译： 磺酰胺衍生物作为离子通道拮抗剂。 该组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US07713983B2
公开(公告)日：2010-05-11
申请号：US10935008
申请日：2004-09-02
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D239/94 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120178713A1
公开(公告)日：2012-07-12
申请号：US13419936
申请日：2012-03-14
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/496 , C07D403/12 , A61K31/506 , C07D417/14 , A61K31/501 , A61K31/454 , C07D471/04 , A61K31/437 , A61K31/427 , C07F7/02 , A61K31/695 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61P13/02 , C07D417/12
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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公开(公告)号：US20120040935A1
公开(公告)日：2012-02-16
申请号：US13110173
申请日：2011-05-18
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/675 , A61K31/517 , C12N5/071 , A61P29/00 , A61P25/04 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P25/28 , A61P1/00 , A61P21/00 , A61K31/5377
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07968545B2
公开(公告)日：2011-06-28
申请号：US10912912
申请日：2004-08-05
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D413/04 , C07D403/04 , C07D401/04 , A61K31/5355 , A61K31/517 , A61K31/497 , A61K31/519 , A61P21/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P9/10
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110082117A1
公开(公告)日：2011-04-07
申请号：US12844047
申请日：2010-07-27
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/635 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P25/00 , A61P13/00 , A61P17/00
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110059965A1
公开(公告)日：2011-03-10
申请号：US12830743
申请日：2010-07-06
申请人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
发明人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
IPC分类号： A61K31/5377 , A61K31/427 , A61K31/433 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/506 , A61K31/501 , A61K31/454 , A61P29/00 , A61P19/02 , A61P25/06 , A61P3/10 , A61P35/00
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
摘要翻译： 具有式（I）的双环衍生物及其组合物可用作离子通道拮抗剂：
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公开(公告)号：US08362032B2
公开(公告)日：2013-01-29
申请号：US12830743
申请日：2010-07-06
申请人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
发明人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
IPC分类号： C07D417/12 , A61K31/47
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
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公开(公告)号：US08163720B2
公开(公告)日：2012-04-24
申请号：US12844047
申请日：2010-07-27
申请人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A01N51/00 , A61N31/655
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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