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    Bioemulsifiers
    1.
    发明授权
    Bioemulsifiers 失效
    生物乳化剂

    公开(公告)号：US5840547A

    公开(公告)日：1998-11-24

    申请号：US702711

    申请日：1996-09-30

    申请人： Eugene Rosenberg ,  Eliora Z. Ron

    发明人： Eugene Rosenberg ,  Eliora Z. Ron

    IPC分类号： A23L29/10 ,  A61K8/06 ,  A61K8/60 ,  A61K9/107 ,  A61Q5/02 ,  A61Q19/00 ,  B01F17/30 ,  C07K14/22 ,  C12P19/26 ,  A23L1/05

    CPC分类号： C12P19/26 ,  A23L29/10 ,  A61K8/06 ,  A61K8/062 ,  A61K8/60 ,  A61Q19/00 ,  A61Q5/02 ,  Y10S514/938 ,  Y10S516/915 ,  Y10S530/825

    摘要： A bioemulsifier designated Alasan or E-KA53 is produced from Acinetobacter radioresistens strain KA53. In its essentially pure form it has the characteristics of a molecular weight of from about 100,000 to 2,000,000 Daltons; emulsifying activity which increases with preheating at increasing temperatures--60.degree.-90.degree. C.; resistance to strong alkali while retaining increased emulsifying activity; reduced viscosity that varies as a function of temperature treatment; and emulsifying activity that varies as a function of pH and magnesium ions.

    摘要翻译： PCT No.PCT / US96 / 00168 Sec。 371日期1996年9月30日 102（e）1996年9月30日PCT PCT 1996年1月5日PCT公布。 出版物WO96 / 20611 PCT 日期：1996年7月11日由不动杆菌不育杆菌菌株KA53生产名为Alasan或E-KA53的生物乳化剂。 在其基本上纯的形式中，其具有约100,000至2,000,000道尔顿的分子量的特征; 乳化活性随温度的升高而升高 - 60°-90°C。 耐强碱，同时保持乳化活性的增加; 作为温度处理的函数变化的粘度降低; 和作为pH和镁离子的函数而变化的乳化活性。

    Bacterial process for the production of dispersants
    3.
    发明授权
    Bacterial process for the production of dispersants 失效
    生产分散剂的细菌过程

    公开(公告)号：US4921793A

    公开(公告)日：1990-05-01

    申请号：US927716

    申请日：1986-11-07

    申请人： Eugene Rosenberg ,  Eliora Z. Ron

    发明人： Eugene Rosenberg ,  Eliora Z. Ron

    IPC分类号： B01F17/00 ,  B01F17/52 ,  B01F17/56 ,  C12P19/26

    CPC分类号： C12R1/01 ,  B01F17/0028 ,  C12P19/26

    摘要： The present invention relates to polymeric dispersing agents for finely divided materials, particularly minerals, which are fermentation products of bacteria. The invention relates to bacterial strains producing such dispersants and to a process for the production of the dispersants by fermentation of such bacteria.The invention further relates to compositions containing effective quantities of such polymeric fermentation products in order to be effective dispersants for minerals.

    摘要翻译： 本发明涉及作为细菌发酵产物的细碎材料，特别是矿物质的聚合物分散剂。 本发明涉及生产这种分散剂的细菌菌株和通过这种细菌的发酵生产分散剂的方法。 本发明还涉及含有有效量的这种聚合发酵产物以便成为矿物质的有效分散剂的组合物。

    Targeted drug-carrying bacteriophages
    4.
    发明授权
    Targeted drug-carrying bacteriophages 失效
    靶向药物携带噬菌体

    公开(公告)号：US07985573B2

    公开(公告)日：2011-07-26

    申请号：US11850942

    申请日：2007-09-06

    申请人： Iftach Yacoby ,  Eliora Z. Ron ,  Doron Shabat ,  Marina Shamis ,  Itai Benhar

    发明人： Iftach Yacoby ,  Eliora Z. Ron ,  Doron Shabat ,  Marina Shamis ,  Itai Benhar

    IPC分类号： C12N7/00 ,  A01N63/00

    CPC分类号： A61K47/62

    摘要： The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.

    摘要翻译： 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。

    Vaccines obtained from bacterial mutant strains
    5.
    发明授权
    Vaccines obtained from bacterial mutant strains 失效
    从细菌突变菌株获得的疫苗

    公开(公告)号：US4404186A

    公开(公告)日：1983-09-13

    申请号：US245954

    申请日：1981-03-20

    申请人： Eliora Z. Ron

    发明人： Eliora Z. Ron

    IPC分类号： A61K39/02 ,  A61K39/108 ,  C12N15/01 ,  C12R1/19 ,  C12N1/20 ,  C12N15/00 ,  C12N13/00

    CPC分类号： C12R1/19 ,  A61K39/0258 ,  C12N15/01 ,  A61K2039/522

    摘要： The present invention relates to a live vaccine for the vaccination of poultry and mammals against a variety of gram negative pathogens belonging to Enterobacteriaceae, comprising a bacterial deletion mutant derived from a non-pathogenic strain of E. coli; to a process for obtaining bacterial mutant strain for use in a live vaccine according to claim 1, which comprises exposing a non-pathogenic strain of E. coli to a mutation inducing agent and selecting strains devoid of O-antigens, and cultivating same to obtain the bacteria for use in such live vaccine; to the novel mutant strain E. coli LR-2, and to a process for immunizing poultry and mammals against Enterobacteriaceae which comprises applying to the avian or to the mammal an effective dose of such a vaccine by oral route or as aerosol.

    摘要翻译： 本发明涉及用于针对属于肠杆菌科的各种革兰氏阴性病原体接种家禽和哺乳动物的活疫苗，其包含衍生自大肠杆菌非致病菌株的细菌缺失突变体; 涉及一种用于获得用于根据权利要求1的活疫苗的细菌突变菌株的方法，其包括将大肠杆菌的非致病菌株暴露于突变诱导剂并选择缺乏O-抗原的菌株，并培养以获得 用于这种活疫苗的细菌; 涉及新型突变菌株大肠杆菌LR-2，以及针对肠杆菌科免疫家禽和哺乳动物的方法，其包括通过口服途径或气雾剂向禽类或哺乳动物施用有效剂量的这种疫苗。

    TARGETED DRUG-CARRYING BACTERIOPHAGES
    6.
    发明申请
    TARGETED DRUG-CARRYING BACTERIOPHAGES 审中-公开
    有针对性的药物携带细菌

    公开(公告)号：US20110286971A1

    公开(公告)日：2011-11-24

    申请号：US13159171

    申请日：2011-06-13

    申请人： Iftach YACOBY ,  Eliora Z. Ron ,  Doron Shabat ,  Marina Shamis ,  Itai Benhar

    发明人： Iftach YACOBY ,  Eliora Z. Ron ,  Doron Shabat ,  Marina Shamis ,  Itai Benhar

    IPC分类号： A61K35/76 ,  C12N7/01 ,  A61P31/10 ,  A61P37/06 ,  A61P31/12 ,  A61P33/00 ,  A61P9/10 ,  A61P35/00 ,  C12N7/00 ,  A61P31/04

    CPC分类号： A61K47/62

    摘要： The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the drug molecules are conjugated to the outer surface of the bacteriophage. The bacteriophage optionally displays on its coat a ligand that endows it with specificity towards target cells. Thus, there is provided a targeted, high-capacity drug delivery system useful for the treatment of various pathological conditions.

    摘要翻译： 本发明涉及药物递送领域。 更具体地，本发明涉及通过不稳定/非不稳定接头缀合的或直接与至少1,000种治疗性药物分子结合的噬菌体的制备和用途，使得药物分子与噬菌体的外表面缀合。 噬菌体任选地在其外壳上显示赋予其对靶细胞特异性的配体。 因此，提供了可用于治疗各种病理状况的靶向高容量药物递送系统。

    Monitoring gene expression
    7.
    发明授权
    Monitoring gene expression 有权
    监测基因表达

    公开(公告)号：US06391549B1

    公开(公告)日：2002-05-21

    申请号：US09283916

    申请日：1999-04-01

    申请人： Eliora Z. Ron ,  Judith Rishpon ,  Israel Biran ,  Reuven Babai

    发明人： Eliora Z. Ron ,  Judith Rishpon ,  Israel Biran ,  Reuven Babai

    IPC分类号： G01N3353

    CPC分类号： C12Q1/04 ,  C12Q1/02

    摘要： A method and system for detecting a parameter of a host cell, a cell culture or medium is provided. A host cell is transfected with an expressible DNA sequence which is under expression control of an inducible promoter sequence. The promoter sequence is inducible in correlation with the parameter, the expressible sequence encoding an enzymatically active product which can catalyze a reaction giving rise to an electrical signal which is detectable in an electrochemical measurement. An electrical signal determined in an electrochemical system then serves as an indication for the parameter.

    摘要翻译： 提供了用于检测宿主细胞，细胞培养物或培养基的参数的方法和系统。 用可诱导的启动子序列的表达控制下的可表达的DNA序列转染宿主细胞。 启动子序列可以与参数相关，可编码酶活性产物的可表达序列可以催化产生可在电化学测量中检测到的电信号的反应。 然后在电化学系统中确定的电信号用作参数的指示。