Integrated micro array system and methods therefor
    4.
    发明申请
    Integrated micro array system and methods therefor 失效
    集成微阵列系统及其方法

    公开(公告)号:US20050233325A1

    公开(公告)日:2005-10-20

    申请号:US10513485

    申请日:2002-05-29

    摘要: Various methods are provided for an integrated micro array system (100) that allows fully automated sample processing and detection/quantification of nucleic acid and protein samples in a single analytical device, which may be configured to communicate data to a person other than the person operating the device. The integrated micro array system has a housing (110) in which robotics assembly (120) controls motion of automatic pipette (124) and second actuator (122) that control motion of the automatic actuator (123). Fluidics station (130) includes a plurality of multi-reagent packs (132). Sample station (140) comprises a plurality of sample vessels (142). Pipette tip storage area (150) and magazine holder (160) that includes a plurality of magazine (162). The system also comprise of a sample processing platform (170), a stringency station (181), and optical detector (180), and a data transfer device (190).

    摘要翻译: 提供了用于集成微阵列系统(100)的各种方法,其允许在单个分析装置中完全自动化样品处理和核酸和蛋白质样品的检测/定量,其可以被配置为将数据传达给除了操作者以外的人 装置。 集成微阵列系统具有壳体(110),其中机器人组件(120)控制自动移液管(124)的运动和控制自动致动器(123)的运动的第二致动器(122)。 流化台(130)包括多个多试剂包(132)。 样品台(140)包括多个样品容器(142)。 移液器吸头存储区域(150)和包括多个盒体(162)的杂志夹保持器(160)。 该系统还包括样本处理平台(170),紧急站(181)和光学检测器(180),以及数据传送装置(190)。

    Microarray detector and methods
    6.
    发明授权
    Microarray detector and methods 失效
    微阵列检测器和方法

    公开(公告)号:US07354389B2

    公开(公告)日:2008-04-08

    申请号:US10509985

    申请日:2003-05-28

    IPC分类号: C40B60/08

    摘要: A detector for optical analysis of a biochip determines the focal position of a plurality of analytes on the biochip using one or more registration markers on the biochip, wherein the analytes and the registration marker are illuminated by different light sources. Therefore, contemplated configurations will significantly reduce overall focusing time and automate proper positioning of the biochip, while allowing to determine a focal position without photobleaching or other undesirable effects on optically labile compounds. Thus, automated analyses can be performed without manual user intervention.

    摘要翻译: 用于生物芯片的光学分析的检测器使用生物芯片上的一个或多个配准标记来确定生物芯片上的多个分析物的焦点位置,其中分析物和对准标记物被不同的光源照射。 因此,预期的配置将显着减少整体聚焦时间并自动化生物芯片的适当定位,同时允许确定焦点位置而不进行光漂白或其它对光学不稳定化合物的不期望的影响。 因此,可以执行自动化分析,而无需手动用户干预。

    Biochip
    7.
    发明申请
    Biochip 审中-公开
    生物芯片

    公开(公告)号:US20050221283A1

    公开(公告)日:2005-10-06

    申请号:US10433766

    申请日:2001-12-11

    摘要: Improved biochips comprise a matrix layer coupled to a substrate, wherein the matrix layer includes a plurality of ligands in a plurality of predetermined positions and wherein ligands bind to an anti-ligand disposed in a sample fluid. Preferred matrix layers are multi-functional matrix layers that reduce autofluorescence, incident-light-absorption, charge-effects, and/or surface unevenness of the substrate, and contemplated biochips may comprise additional matrix layers. Contemplated biochips may be useful in detection and/or quantification of various anti-ligands, including polypeptides, polynucleotides, carbohydrates, pharmacologically active molecules, bacterial or eukaryotic cells, and/or viruses.

    摘要翻译: 改进的生物芯片包括耦合到基底的基质层,其中基质层包括多个预定位置中的多个配体,并且其中配体结合设置在样品流体中的抗配体。 优选的基质层是减少底物的自发荧光,入射光吸收,电荷效应和/或表面不均匀性的多功能基质层,并且预期的生物芯片可以包含另外的基质层。 考虑的生物芯片可用于检测和/或定量各种抗配体,包括多肽,多核苷酸,碳水化合物,药理活性分子,细菌或真核细胞和/或病毒。

    Biochip
    8.
    发明申请
    Biochip 审中-公开
    生物芯片

    公开(公告)号:US20110086771A1

    公开(公告)日:2011-04-14

    申请号:US12870337

    申请日:2010-08-27

    IPC分类号: C40B30/04 C40B40/04 C40B50/18

    摘要: Improved biochips comprise a matrix layer coupled to a substrate, wherein the matrix layer includes a plurality of ligands in a plurality of predetermined positions and wherein ligands bind to an anti-ligand disposed in a sample fluid. Preferred matrix layers are multi-functional matrix layers that reduce autofluorescence, incident-light-absorption, charge-effects, and/or surface unevenness of the substrate, and contemplated biochips may comprise additional matrix layers. Contemplated biochips may be useful in detection and/or quantification of various anti-ligands, including polypeptides, polynucleotides, carbohydrates, pharmacologically active molecules, bacterial or eukaryotic cells, and/or viruses.

    摘要翻译: 改进的生物芯片包括耦合到基底的基质层,其中基质层包括多个预定位置中的多个配体,并且其中配体结合设置在样品流体中的抗配体。 优选的基质层是减少底物的自发荧光,入射光吸收,电荷效应和/或表面不均匀性的多功能基质层,并且预期的生物芯片可以包含另外的基质层。 考虑的生物芯片可用于检测和/或定量各种抗配体,包括多肽,多核苷酸,碳水化合物,药理活性分子,细菌或真核细胞和/或病毒。

    Fluid dispensing system with optical locator
    9.
    发明授权
    Fluid dispensing system with optical locator 失效
    具有光学定位器的流体分配系统

    公开(公告)号:US5141871A

    公开(公告)日:1992-08-25

    申请号:US521364

    申请日:1990-05-10

    IPC分类号: G01N35/02 G01N35/04 G01N35/10

    摘要: There is described an analytical isntrument for the analysis of fluids such as biological fluids. The instrument includes a fluid dispensing system having a pipette for dispensing fluid test samples and test reagents to assay cartridges. An optical detection system provides a light beam which intercepts a downward travel path of the pipette prior to its reaching the dispense position. Measurement of the intensity of the light beam in conjunction with the position of the pipette enables a controller to indicate the presence or absence of a pipette tip. In addition, interception of the light beam by the pipette initiates a final approach sequence for the pipette to the dispense position above an assay cartridge by a predetermined increment of travel.

    摘要翻译: 描述了分析流体如生物流体的分析方法。 该仪器包括具有移液管的流体分配系统,用于分配流体测试样品和测试试剂以测定药筒。 光学检测系统提供一种在移液管到达分配位置之前拦截移液管的向下行进路径的光束。 结合移液器的位置测量光束的强度使得控制器能够指示移液管尖端的存在或不存在。 此外,通过移液管截取光束,通过预定的行程增加启动移液管到分析盒上方分配位置的最终进场顺序。