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1.发明授权公开(公告)号：US06218138B1
公开(公告)日：2001-04-17
申请号：US09318732
申请日：1999-05-26
申请人： Ferhat Ilhan , Dieter Kraemer
发明人： Ferhat Ilhan , Dieter Kraemer
IPC分类号： C12P3704
摘要： Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase from E. coli covalently immobilized on support particles. The resulting beta-lactam antibiotic product is solubilized by adding an acid such as sulfuric acid to lower the pH to 1.0 at a temperature in the range of 0° C. to +5° C. The immobilized penicillin amidase is substantially inactivated by the acid. After separating the beta-lactam antibiotic product, the immobilized penicillin amidase is substantially reactivated for reuse in antibiotic synthesis by treatment with a buffer having about a neutral pH. Antibiotics that can be produced include ampicillin, amoxicillin, cephalexin, cefaclor and cefadroxil. Support particles that can be used include particles having a macroporous structure and a particle diameter of 10-1000 &mgr;m, particles having oxirane groups, particles made of a synthetic polymer and inorganic particles such as porous glass particles.
摘要翻译： β-内酰胺抗生素通过氨基-β-内酰胺组分与相应的含氨基酰化侧链组分在共价固定在载体颗粒上的大肠杆菌的青霉素酰胺酶存在下反应而合成。 所得β-内酰胺抗生素产品通过加入酸如硫酸溶解，在0℃至+ 5℃的温度范围内将pH降至1.0。固定的青霉素酰胺酶基本上被酸灭活 。 在分离β-内酰胺抗生素产物之后，通过用具有约中性pH的缓冲液处理，固定化的青霉素酰胺酶基本上被再活化用于抗生素合成中的再利用。 可生产的抗生素包括氨苄青霉素，阿莫西林，头孢氨苄，头孢克洛和头孢羟氨苄。 可以使用的载体颗粒包括具有大孔结构，粒径为10-1000μm的颗粒，具有环氧乙烷基团的颗粒，由合成聚合物制成的颗粒和无机颗粒如多孔玻璃颗粒。
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2.发明授权Gathering configuration settings from a source system to apply to a target system 失效从源系统收集配置设置以应用于目标系统公开(公告)号：US07865707B2
公开(公告)日：2011-01-04
申请号：US11378096
申请日：2006-03-16
申请人： Sven Bittlingmayer , Oliver Goos , Dieter Kraemer , Martin Schwarz , Christopher Seiwert , Axel Westphal , Jens Wissenbach
发明人： Sven Bittlingmayer , Oliver Goos , Dieter Kraemer , Martin Schwarz , Christopher Seiwert , Axel Westphal , Jens Wissenbach
IPC分类号： G06F9/24
CPC分类号： G06F9/44505
摘要： Provided are a method, system and program for gathering configuration settings from a source system to apply to a target system. A source system is queried to determine configuration settings in the source system. A target system is queried to determine configuration settings in the target system. A user is enabled to enter configuration settings. The determined and user entered configuration settings are processed to generate commands to configure the target system to implement the configuration settings in the source system. The generated commands are executed to configure the target system.
摘要翻译： 提供了一种用于从源系统收集配置设置以应用于目标系统的方法，系统和程序。 查询源系统以确定源系统中的配置设置。 查询目标系统以确定目标系统中的配置设置。 启用用户进入配置设置。 处理确定的用户输入的配置设置以生成命令以配置目标系统来实现源系统中的配置设置。 执行生成的命令来配置目标系统。
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公开(公告)号：US4839419A
公开(公告)日：1989-06-13
申请号：US161204
申请日：1988-02-16
IPC分类号： A23C9/12 , B01F17/52 , C07K14/37 , C07K14/41 , C07K14/575 , C07K16/00 , C07K17/00 , C08H1/00 , C09H1/00 , C12N11/00 , C12P13/04 , C12P19/24
CPC分类号： A23C9/1206 , B01J20/3274 , B01J20/3282 , C12N11/00 , C12P13/04 , C12P19/24 , A23C2220/104
摘要： Methods for adsorbing a protein, for example an enzyme, onto an insoluble, solid, macroporous, small-particle support by washing said support with an aqueous solution of the protein containing an electrolyte in an ionic strength of at least 0.15 mole/liter and crosslinking said protein, before, during, or after such adsorption, with a coupling component present in aqueous electrolyte-containing solution.
摘要翻译： 通过用离子强度至少为0.15摩尔/升的含有电解质的蛋白质的水溶液洗涤所述载体，将蛋白质例如酶吸附到不溶性，固体，大孔的小颗粒载体上的方法和交联 所述蛋白质，在这种吸附之前，期间或之后，存在于含水电解质溶液中的偶联组分。
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公开(公告)号：USD297137S
公开(公告)日：1988-08-09
申请号：US890698
申请日：1986-07-28
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5.发明授权
公开(公告)号：US4829101A
公开(公告)日：1989-05-09
申请号：US75416
申请日：1987-07-20
IPC分类号： C08F2/00 , A61K39/00 , C08F2/22 , C08F291/00 , C08J3/05 , C08L33/00 , C08L33/02 , C08L33/24 , C08L33/26 , C08L51/00 , C08L51/02 , C08L57/00 , C08L101/00 , C12N11/02 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/546 , G01N33/547
CPC分类号： G01N33/54313 , C08F291/00 , C12N11/02 , Y10S525/902
摘要： Polymer particles dispersible to form a latex and latices of such polymer particles, said particles being adaptable to the fixing or bonding thereto of a biologically active substance and having a core-shell construction wherein the polymer material of the core determines the stability of the form of the latex particles and their redispersibility, and the material of the shell(1) is so hydrophilic that it would be completely or largely water soluble if it were not anchored to the core material and/or crosslinked,(2) contains functional groups which are suitable for the covalent fixation or bonding of biological active substances, and(3) in an anhydrous condition has a T.sub..lambda.max from 20.degree.-250.degree. C., depending on its composition, and methods for bonding a biologically active substance to such particles, for example to prepare a diagnostic reagent.
摘要翻译： 可分散以形成胶乳的聚合物颗粒和这种聚合物颗粒的胶乳，所述颗粒适于固定或粘合生物活性物质并具有核 - 壳结构，其中芯的聚合物材料决定了 胶乳颗粒及其再分散性，并且壳（1）的材料是亲水性的，如果它不被锚定到芯材料和/或交联的话，它将完全或大部分是水溶性的，（2）包含官能团 适用于生物活性物质的共价固定或结合，（3）在无水状态下，根据其组成，T值为20〜250℃，以及将生物活性物质与该颗粒结合的方法 ，例如制备诊断试剂。
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公开(公告)号：US4208309A
公开(公告)日：1980-06-17
申请号：US49438
申请日：1979-06-18
IPC分类号： B01J13/18 , C08F220/54 , C12N11/08 , C08J9/00
CPC分类号： C12N11/08 , B01J13/185 , C08F220/54
摘要： What is disclosed is a pearl polymer product, a method of making the same, and the use thereof as a carrier for biologically active materials, said product being composed of hollow pearl particles having a diameter from 5 to 1000 microns and consisting of a cross-linked polymer which is a cross-linked homopolymer or copolymer comprising at least one member selected from the group consisting of acrylamide, methacrylamide, methylene-bis-acrylamide and methylene-bis-methacrylamide, said polymer containing at least 5 percent by weight of a monomer having at least two carbon-carbon double bonds which are activated by a neighboring phenyl group or carbonyl group, said polymer further being of a composition such that x+3y.gtoreq.40, where x is the percent by weight in the polymer of acrylamide and methacrylamide and y is the percent by weight in the polymer of methylene-bis-acrylamide and methylene-bis-methacrylamide.
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公开(公告)号：US4070348A
公开(公告)日：1978-01-24
申请号：US544830
申请日：1975-01-28
CPC分类号： C08F2/14 , C12N11/08 , Y10S435/897 , Y10S526/909 , Y10S526/91
摘要： Water-swellable, cross-linked, bead copolymers of (A) an ethylenically unsaturated monomer having a carboxylic acid anhydride, glycidyl or succinimide group, (B) a comonomer having at least two radical-polymerizable carbon double bonds, and (C) a radical-polymerizable water-soluble comonomer are disclosed to be excellent carriers capable of bonding with biologically active substances such as enzymes, enzyme substrates, inhibitors, hormones, antibiotics, antigens, and peptides.
摘要翻译： （A）具有羧酸酐的烯键式不饱和单体，缩水甘油基或琥珀酰亚胺基，（B）具有至少两个可自由基聚合的碳双键的共聚单体的水溶胀性，交联的珠粒共聚物，（C） 可自由基聚合的水溶性共聚单体被公开为能够与酶，酶底物，抑制剂，激素，抗生素，抗原和肽等生物活性物质结合的优异载体。
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公开(公告)号：US5342646A
公开(公告)日：1994-08-30
申请号：US979425
申请日：1992-11-19
CPC分类号： G01N33/545 , C07K17/08 , C12N11/08
摘要： What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.
摘要翻译： 公开的是一种制备载体系统的方法，其适用于生物活性材料的共价键合，其由已知的固体支持材料组成，所述固体支持材料具有涂覆有包含适于共价键合的官能团的聚合物的表面，通过用 一种成膜聚合物分散体和一种非成膜聚合物分散体，适当地混合两种聚合物分散体中的至少一种，其含有具有适于与生物活性材料共价键合的官能团的聚合物。
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公开(公告)号：US4388271A
公开(公告)日：1983-06-14
申请号：US300899
申请日：1981-09-10
申请人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
发明人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
CPC分类号： G01N33/725 , C12Q1/28 , Y10S436/904
摘要： The invention relates to diagnostic agents for the rapid diagnostic detection of blood in excretions and body fluids, consisting essentially of a solid support which is charged with a chromogenic substance as indicator and impregnated with an acrylic and/or methacrylic resin.
摘要翻译： 本发明涉及用于快速诊断检测排泄物和体液中的血液的诊断剂，其基本上由固体支持物组成，所述固体支持物装载有显色物质作为指示剂并用丙烯酸和/或甲基丙烯酸树脂浸渍。
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公开(公告)号：US4190713A
公开(公告)日：1980-02-26
申请号：US905892
申请日：1978-05-15
CPC分类号： C08F220/54
摘要： What is disclosed is a pearl polymer product, a method of making the same, and the use thereof as a carrier for biologically active materials, said product being composed of hollow pearl particles having a diameter from 5 to 1000 microns and consisting of a cross-linked polymer which is a cross-linked homopolymer or copolymer comprising at least one member selected from the group consisting of acrylamide, methacrylamide, methylene-bis-acrylamide and methylene-bis-methacrylamide, said polymer containing at least 5 percent by weight of a monomer having at least two carbon-carbon double bonds which are activated by a neighboring phenyl group or carbonyl group, said polymer further being of a composition such that x+3y.gtoreq.40, where x is the percent by weight in the polymer of acrylamide and methacrylamide and y is the percent by weight in the polymer of methylene-bis-acrylamide and methylene-bis-methacrylamide.
摘要翻译： 所公开的是珍珠聚合物产品，其制备方法及其作为生物活性材料载体的用途，所述产品由直径为5至1000微米的中空珍珠颗粒组成， 连接的聚合物，其是包含选自丙烯酰胺，甲基丙烯酰胺，亚甲基双丙烯酰胺和亚甲基双 - 甲基丙烯酰胺的至少一种的交联的均聚物或共聚物，所述聚合物含有至少5重量％的单体 具有至少两个被相邻苯基或羰基活化的碳 - 碳双键，所述聚合物还具有使得x + 3y> = 40的组成，其中x是丙烯酰胺聚合物中的重量百分数 和甲基丙烯酰胺，y是亚甲基双丙烯酰胺和亚甲基双 - 甲基丙烯酰胺的聚合物中的重量百分比。
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