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    Process for catalytically preparing aromatic or heteroaromatic nitriles
    8.
    发明授权
    Process for catalytically preparing aromatic or heteroaromatic nitriles 有权
    用于催化制备芳族或杂芳族腈的方法

    公开(公告)号：US08314243B2

    公开(公告)日：2012-11-20

    申请号：US11986398

    申请日：2007-11-21

    申请人： Nikolaus Müller ,  Wolfgang Mägerlein ,  Alain Cotté ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

    发明人： Nikolaus Müller ,  Wolfgang Mägerlein ,  Alain Cotté ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

    IPC分类号： C07D211/78 ,  A01N43/38

    CPC分类号： C07B37/04 ,  C07C1/26 ,  C07C17/10 ,  C07C2529/40 ,  C07D213/61 ,  C07C9/00 ,  C07C19/075

    摘要： A process is described for catalytically preparing optionally substituted aromatic or heteroaromatic nitrites of the general formula (I) Ar—CN  (I) by reacting the corresponding aryl halides of the general formula (II) Ar—X  (II) in which X is chlorine, bromine, iodine, triflate, nonaflate, mesylate or tosylate and Ar is an optionally substituted aromatic or heteroaromatic radical, characterized in that the reaction is performed in the presence of a palladium compound, a phosphine of the general formula (III) or (IV) where R is an alkyl radical and R′, R″ and R′″ are each an alkyl radical or an aryl radical or heteroaryl radical and A is an alkylene or arylene radical, and potassium hexacyanoferrate(II) or potassium hexacyanoferrate(III), optionally in a solvent and optionally with addition of a base.

    摘要翻译： 描述了通过使通式（II）Ar-X（II）的相应芳基卤反应其中X为氯的方法催化制备通式（I）Ar-CN（I）的任选取代的芳族或杂芳族亚硝酸盐的方法 溴，碘，三氟甲磺酸酯，壬酸酯，甲磺酸酯或甲苯磺酸酯，Ar是任选取代的芳族或杂芳族基团，其特征在于反应在钯化合物，通式（III）或（IV） ）其中R是烷基，R'，R“和R”“各自是烷基或芳基或杂芳基，A是亚烷基或亚芳基，六氰基铁酸钾（II）或六氰基铁酸钾（III） ，任选地在溶剂中和任选地加入碱。