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公开(公告)号：US5693623A
公开(公告)日：1997-12-02
申请号：US470046
申请日：1995-06-06
IPC分类号： A61K31/715 , A61K31/737 , A61K45/06 , C07H5/04 , C07H5/06 , C07H23/00
CPC分类号： C08B37/0069 , A61K31/737 , A61K45/06
摘要： Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging from 2000 to 7000, combined with suitable excipients and/or diluents.
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公开(公告)号：US5696099A
公开(公告)日：1997-12-09
申请号：US229025
申请日：1994-04-18
IPC分类号： A61K31/715 , A61K31/737 , A61K45/06 , A61K31/725
CPC分类号： C08B37/0069 , A61K31/737 , A61K45/06
摘要： Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging from 2000 to 7000, combined with suitable excipients and/or diluents.
摘要翻译： 用于治疗痤疮和粉刺性皮炎的局部制剂，其含有作为主要治疗活性成分的N，N'-双（2-羟乙基）壬二酰胺与分子量为2000至7000的皮肤硫酸盐锂盐的治疗活性量的合并赋形剂和/ 或稀释剂。
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公开(公告)号：US5147861A
公开(公告)日：1992-09-15
申请号：US761511
申请日：1991-09-18
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total esters of alginic acid with aliphatic and araliphatic alcohols possess important bioplastic and pharmaceutical qualities and are useful in various fields including the sanitary and surgical fields.
摘要翻译： 藻酸与脂肪族和芳脂肪醇的总酯具有重要的生物塑料和药物特性，可用于包括卫生和外科领域在内的各个领域。
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公开(公告)号：US4897381A
公开(公告)日：1990-01-30
申请号：US209490
申请日：1988-06-21
IPC分类号： A61K31/16 , A61K31/165 , A61K31/195 , A61K31/435 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/48 , A61K31/52 , A61K31/522 , A61K31/66 , A61K31/675 , A61K31/70 , A61K31/7028 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C233/18 , C07C233/71 , C07C235/48 , C07C235/52 , C07C237/08 , C07C237/12 , C07D213/81 , C07D213/82 , C07D457/06 , C07D473/08 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/58 , C07H15/04 , C07H15/10 , C07H15/18 , C07H15/26
CPC分类号： C07D213/81 , C07D213/82 , C07D457/06 , C07D473/08 , C07F9/091 , C07F9/10 , C07F9/113 , C07F9/588 , C07H15/10 , C07H15/18 , C07H15/26
摘要： Organic amide compounds of the formula ##STR1## wherein R.sub.1 --CO is a residue of a carboxylic acid with the proviso that the carboxylic acid is not a natural fatty acid normally bound to nitrogen of nitrogenous lipids, R.sub.2 is a hydrogen atom, a C.sub.1-7 alkyl group, or a C.sub.4-7 cycloalkyl group, and R.sub.3-N is a residue of a nitrogenous lipid. The compounds are useful in increasing or stimulating the in vivo biological activity of in vitro biologically active carboxylic acids.
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5.发明授权Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer 失效香豆素衍生物，含有它们的药物组合物及其在治疗癌症中的用途
公开(公告)号：US4737517A
公开(公告)日：1988-04-12
申请号：US635166
申请日：1984-07-27
IPC分类号： C07D311/00 , A61K31/37 , A61K31/395 , A61K31/40 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61P7/02 , A61P35/00 , C07D311/16 , C07D405/06 , C07D311/06
CPC分类号： C07D311/16
摘要： A compound having the formula: ##STR1## wherein R.sub.1 is halogen or a substituted or unsubstituted hydrocarbon group; R.sub.2 R.sub.6 and R.sub.7, which may be the same or different, each represents hydrogen or a substituted or unsubstituted hydrocarbon group, or R.sub.6 and R.sub.7 taken together may represent a hetero group having one or more hetero atoms; R.sub.3 and R.sub.4 which may be the same or different each represents a substituted or unsubstituted hydrocarbon group; or R.sub.3 and R.sub.4 taken together may represent an alkylene group or a hetero group having one or more hetero atoms and R.sub.5 is hydrogen, a substituted or unsubstituted hydrocarbon group, halogen or a free or protected hydroxy group, or a pharmaceutically acceptable salt thereof. The compounds have antiaggregating properties.
摘要翻译： 具有下式的化合物：其中R1是卤素或取代或未取代的烃基; 可以相同或不同的R 2 + L，R 6和R 7各自表示氢或取代或未取代的烃基，或者R 6和R 7可以一起表示具有一个或多个杂原子的杂基; 可以相同或不同的R 3和R 4表示取代或未取代的烃基; 或者R 3和R 4一起可以表示亚烷基或具有一个或多个杂原子的杂基，R 5是氢，取代或未取代的烃基，卤素或游离或保护的羟基或其药学上可接受的盐。 该化合物具有抗聚集性质。
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6.发明授权Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions 失效制备神经节苷脂衍生物的方法及其在药物组合物中的应用
公开(公告)号：US4716223A
公开(公告)日：1987-12-29
申请号：US837201
申请日：1986-03-10
CPC分类号： C07H15/10
摘要： The present invention relates to a method for preparing inner ester derivatives of gangliosides and pharmaceutical compositions containing such derivatives to be used in treating disorders of the nervous system. The pharmaceutical compositions of the present invention promote nerve regeneration by stimulating nerve sprouting.
摘要翻译： 本发明涉及一种制备神经节苷脂的内酯衍生物的方法和含有用于治疗神经系统疾病的衍生物的药物组合物。 本发明的药物组合物通过刺激神经发芽来促进神经再生。
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7.发明授权
公开(公告)号：US4349566A
公开(公告)日：1982-09-14
申请号：US185893
申请日：1980-09-10
IPC分类号： A61K31/365 , A61K31/37
CPC分类号： A61K31/365 , Y10S514/821
摘要： A method of treating arrhythmia in mammals which comprises administering 8-chloro- or 8-bromo-3-(.beta.-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycoumarin (or a pharmaceutically acceptable salt thereof) thereto. When formulated in conventional pharmaceutical preparations, the active ingredient may be administered orally or endovenously.
摘要翻译： 一种治疗哺乳动物心律失常的方法，其包括给予8-氯代或8-溴-3-（β-二乙基氨基乙基）-4-甲基-7-乙氧基羰基甲氧基香豆素（或其药学上可接受的盐）。 当配制在常规药物制剂中时，活性成分可以口服或内服给药。
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8.发明授权
公开(公告)号：US5521164A
公开(公告)日：1996-05-28
申请号：US116268
申请日：1993-09-03
IPC分类号： A61K31/70 , A61K31/7028 , A61P25/00 , C07H1/08 , C07H15/04 , C07H15/10 , C07H15/12 , A61K35/30 , A61K31/715
摘要： The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.
摘要翻译： 本发明的方法涉及一种制备神经节苷脂混合物的方法，所述神经节苷脂混合物没有与非传统的危及生命的病毒相关的污染物，而不改变中枢和周围神经系统上混合物的生物学和药理学特性。
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9.发明授权Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions 失效盐和透明质酸与药物活性物质的混合物，含有它们的药物组合物以及用于施用这些组合物的方法
公开(公告)号：US5442053A
公开(公告)日：1995-08-15
申请号：US931949
申请日：1992-08-19
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02 , C07H5/04
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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公开(公告)号：US5336668A
公开(公告)日：1994-08-09
申请号：US722398
申请日：1991-06-20
IPC分类号： A23L29/00 , A61K8/00 , A61K8/30 , A61K8/64 , A61K8/72 , A61K8/73 , A61K9/00 , A61K47/00 , A61K47/36 , A61K47/48 , A61L15/00 , A61L15/16 , A61L15/28 , A61L17/00 , A61L17/10 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/04 , C11D3/48 , A61K9/70 , A61K31/725 , C07H1/00
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L15/28 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total and partial esters of alginic acid which possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
摘要翻译： 藻酸的全部和部分酯具有重要的生物塑料和药物特性，可用于包括医疗，外科，化妆品和食品在内的各个领域。
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