专利检索 ap:("Francois Maltais" OR "Alex Aronov" OR "Michael R. Hale" OR "Young-Choon Moon") AND inv:"Alex Aronov" 第 1 页

1.

发明授权
Compositions useful as protein kinase inhibitors 失效
标题翻译：可用作蛋白激酶抑制剂的组合物

公开(公告)号：US07456190B2

公开(公告)日：2008-11-25

申请号：US10798766

申请日：2004-03-11

申请人： Francois Maltais , Alex Aronov , Michael R. Hale , Young-Choon Moon

发明人： Francois Maltais , Alex Aronov , Michael R. Hale , Young-Choon Moon

IPC分类号： A61K31/506 , A61K31/4439 , A61K31/401 , C07D403/04 , C07D401/14 , C07D207/34

CPC分类号： C07D405/04 , C07D207/34 , C07D403/04

摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

2.

发明授权
Heteroaryl compounds useful as inhibitors or protein kinases 失效
标题翻译：可用作抑制剂或蛋白激酶的杂芳基化合物

公开(公告)号：US07407962B2

公开(公告)日：2008-08-05

申请号：US10771165

申请日：2004-02-03

申请人： Alex Aronov , Michael R. Hale , Francois Maltais , Qing Tang

发明人： Alex Aronov , Michael R. Hale , Francois Maltais , Qing Tang

IPC分类号： C07D487/04 , C07D403/04 , A61K31/4025 , A61K31/517 , A61K31/519 , A61P9/10 , A61P11/06 , A61P25/28 , A61P35/00 , A61K31/506 , A61K31/53

CPC分类号： C07D487/04 , C07D401/14 , C07D403/04

摘要： The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

摘要翻译： 本发明提供了作为蛋白激酶抑制剂的化合物，特别是ERK2，GSK3，PKA，CDK2蛋白激酶的抑制剂，参与增殖性和神经变性疾病的哺乳动物蛋白激酶。本发明还提供包含本发明化合物的药物组合物和利用这些组合物治疗各种疾病的方法。

3.

发明申请
Inhibitors of ERK protein kinase and uses thereof 审中-公开
标题翻译： ERK蛋白激酶的抑制剂及其用途

公开(公告)号：US20060142572A1

公开(公告)日：2006-06-29

申请号：US11302295

申请日：2005-12-13

申请人： Gabriel Martinez-Botella , Alex Aronov , Michael Hale , Francois Maltais , Judith Straub , Qing Tang

发明人： Gabriel Martinez-Botella , Alex Aronov , Michael Hale , Francois Maltais , Judith Straub , Qing Tang

IPC分类号： C07D405/02 , C07D403/02

CPC分类号： C07D239/48

摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.

摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环A，Z 1，Z 2，U，Q， R 1，R 2和L如本文所定义。这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。

4.

发明授权
Heterocyclic inhibitors of ERK2 and uses thereof 有权
标题翻译： ERK2的杂环抑制剂及其用途

公开(公告)号：US07253187B2

公开(公告)日：2007-08-07

申请号：US10770814

申请日：2004-02-03

申请人： Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov

发明人： Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov

IPC分类号： C07D401/04 , A61K31/4427

CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中Z 1和Z 2各自独立地为氮或CH并且环A，T m 第二，第二，第二，第三，第三和第三，第二，如规范。该化合物特别可用作ERK2的抑制剂，并且用于治疗由蛋白激酶抑制剂，特别是癌症，炎性疾病，再狭窄，糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。

5.

发明申请
Heterocyclic inhibitors of ERK2 and uses thereof 审中-公开

公开(公告)号：US20070265263A1

公开(公告)日：2007-11-15

申请号：US11803878

申请日：2007-05-16

申请人： Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Oing Tang , Alex Aronov

发明人： Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Oing Tang , Alex Aronov

IPC分类号： C07D401/02 , A61K31/506 , A61K31/5375 , C07D413/14 , C07D403/02 , A61P35/00

CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

6.

发明申请
Heterocyclic protein kinase inhibitors and uses thereof 有权
标题翻译：杂环蛋白激酶抑制剂及其用途

公开(公告)号：US20050245499A1

公开(公告)日：2005-11-03

申请号：US11001760

申请日：2004-12-02

申请人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis

发明人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis

IPC分类号： A61K31/506 , A61K45/06 , C07D239/48 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K31/4545 , A61K31/53 , C07D43/02

CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00

摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.

摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环B，Z 1，Z 2，U，p， Q，R 1，R 2，R 3，R 3和R 3如本文所定义。这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重性，包括中风，炎性疾病，自身免疫性疾病如SLE狼疮和牛皮癣，增殖性疾病如癌症，以及与器官移植相关的病症。

7.

发明授权
Heterocyclic protein kinase inhibitors and uses thereof 有权
标题翻译：杂环蛋白激酶抑制剂及其用途

公开(公告)号：US07244735B2

公开(公告)日：2007-07-17

申请号：US11001760

申请日：2004-12-02

申请人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis

发明人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis

IPC分类号： A61K31/496 , A61K31/506 , C07D239/48

CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00

摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.

摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环B，Z 1，Z 2，U，p， Q，R 1，R 2，R 3，R 3和R 3如本文所定义。这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重性，包括中风，炎性疾病，自身免疫性疾病如SLE狼疮和牛皮癣，增殖性疾病如癌症，以及与器官移植相关的病症。

8.

发明授权
Heterocyclic inhibitors of ERK2 and uses thereof 有权
标题翻译： ERK2的杂环抑制剂及其用途

公开(公告)号：US06743791B2

公开(公告)日：2004-06-01

申请号：US10071699

申请日：2002-02-08

申请人： Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov

发明人： Jingrong Cao , Jeremy Green , Michael Hale , Francois Maltais , Judy Straub , Qing Tang , Alex Aronov

IPC分类号： C07D40304

CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中Z 1和Z 2各自独立地为氮或CH，环A，TmR 1，Q 2，R un R 3，和Sp如说明书中所述。该化合物特别可用作ERK2的抑制剂，并且用于治疗由蛋白激酶抑制剂，特别是癌症，炎性疾病，再狭窄，糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。