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公开(公告)号：US5750332A
公开(公告)日：1998-05-12
申请号：US375100
申请日：1995-01-19
CPC分类号： C07K14/005 , C07K1/1075 , C07K1/1077 , G01N33/56988 , G01N33/6854 , A61K39/00 , C12N2740/16122 , Y10S435/974
摘要： The present invention relates to synthetic peptide analogues useful as therapeutic agents, immunogens or for the diagnosis of disease. In particular, it relates to peptide multimers which maintain the conformation of the native proteins from which they are derived. Peptomers constructed from peptides derived from gp120 of the human immunodeficiency virus are exemplified.
摘要翻译： 本发明涉及可用作治疗剂，免疫原或疾病诊断的合成肽类似物。 特别地，它涉及保持其衍生的天然蛋白质构象的肽多聚体。 例示了由衍生自人类免疫缺陷病毒的gp120的肽构建的Peptomers。
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2.发明授权Cell line producing human monoclonal antibody which binds to HTLV-I producing cells 失效产生与HTLV-1产生细胞结合的人单克隆抗体的细胞系
公开(公告)号：US4722888A
公开(公告)日：1988-02-02
申请号：US717613
申请日：1985-03-29
IPC分类号： C07K16/10 , C12Q1/70 , A61K39/42 , G01N33/53 , G01N33/577
CPC分类号： C07K16/1036 , C07K2317/734 , Y10S435/974 , Y10S435/975 , Y10S436/811 , Y10S436/813 , Y10S530/826
摘要： The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reagent by binding to the antigen specifically expressed on the surface of HTLV producing cells. Furthermore, this monoclonal antibody is useful as a therapeutic reagent, in combination with complement, for the lysis of HTLV-1 producing cells.
摘要翻译： 本发明是产生与人T细胞白血病病毒1型（HTLV-I）的包膜抗原特异性结合的人单克隆抗体IgG-Kk的永生化B细胞系。 该单克隆抗体通过与在HTLV产生细胞表面特异性表达的抗原结合而用作诊断试剂。 此外，该单克隆抗体可用作治疗试剂，与补体结合用于产生HTLV-1的细胞的裂解。
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公开(公告)号：US20100015211A1
公开(公告)日：2010-01-21
申请号：US11664962
申请日：2005-11-01
IPC分类号： A61K9/127 , A61K39/21 , A61K39/295 , A61K39/116 , A61K39/00 , A61P37/04 , A61P31/12 , A61P31/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N2710/10343 , C12N2740/16122 , C12N2760/16134
摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
摘要翻译： 本发明涉及编码来自HIV亚型和/或不同亚型中的相同或不同菌株的免疫原性相同或类似的HIV多肽的方法，多肽和多核苷酸。 还描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 本文描述的组合方法诱导针对来自给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的免疫应答。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。
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公开(公告)号：US4755457A
公开(公告)日：1988-07-05
申请号：US40748
申请日：1987-04-20
IPC分类号： C07K16/10 , G01N33/569 , C12Q1/70 , G01N33/564
CPC分类号： G01N33/56988 , C07K16/1054 , Y10S435/948 , Y10S435/974
摘要： This invention relates to a method to measure natural human antibodies in sera which will neutralize HTLV-III infection in an in vitro assay. Basically, cell-free virus is incubated with serum and used to infect H9 cells, which are then put in culture for three days, and viral infectivity is assayed using a monoclonal antibody specific for HTLV-III p24 in an immune fluorescent assay.
摘要翻译： 本发明涉及一种测定体外测定中中和HTLV-III感染的血清中天然人抗体的方法。 基本上，将无细胞病毒与血清一起温育并用于感染H9细胞，然后将其置于培养物中3天，并在免疫荧光测定中使用特异于HTLV-III p24的单克隆抗体测定病毒感染性。
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公开(公告)号：US08926987B2
公开(公告)日：2015-01-06
申请号：US11282319
申请日：2005-11-17
IPC分类号： A61K39/12 , A61K39/23 , C12N15/86 , C07K14/005 , A61K39/00
CPC分类号： C12N15/86 , A61K39/21 , A61K2039/5256 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/16143 , C12N2740/15034 , C12N2740/15071 , C12N2740/16034 , C12N2740/16071 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： This invention provides improved replication-competent adenoviral vectors. The improved vectors have both a hybrid regulatory unit that provides for high level transgene expression. The vectors can be use, e.g., for therapeutic or prophylactic purposes.
摘要翻译： 本发明提供了改进的复制能力的腺病毒载体。 改进的载体具有提供高水平转基因表达的杂交调控单位。 可以使用载体，例如用于治疗或预防目的。
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公开(公告)号：US20070166784A1
公开(公告)日：2007-07-19
申请号：US10571882
申请日：2004-09-15
申请人： Susan Barnett , Victor Gomez-Roman , Ying Lian , Bo Peng , Marjorie Robert-Guroff , Indresh Srivastava
发明人： Susan Barnett , Victor Gomez-Roman , Ying Lian , Bo Peng , Marjorie Robert-Guroff , Indresh Srivastava
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K16/1063 , C07K2317/21 , C07K2317/732 , C07K2317/76 , C12N2740/16134
摘要： The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been shown to induce broad and potent neutralizing activity against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
摘要翻译： 本发明涉及编码来自不同亚型的HIV亚型中的不同菌株和/或来自不同亚型的免疫原性HIV多肽的免疫原性HIV多肽的方法，多核苷酸和多肽。 描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 已经显示本文描述的组合方法可以诱导针对给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的中和活性。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。
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公开(公告)号：US20060115456A1
公开(公告)日：2006-06-01
申请号：US11282319
申请日：2005-11-17
IPC分类号： A61K48/00 , C12N15/861 , C12N15/867
CPC分类号： C12N15/86 , A61K39/21 , A61K2039/5256 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/16143 , C12N2740/15034 , C12N2740/15071 , C12N2740/16034 , C12N2740/16071 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： This invention provides improved replication-competent adenoviral vectors. The improved vectors have both a hybrid regulatory unit that provides for high level transgene expression. The vectors can be use, e.g., for therapeutic or prophylactic purposes.
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