公开(公告)号：US20060241337A1

公开(公告)日：2006-10-26

申请号：US11413260

申请日：2006-04-28

申请人： Michael Jones ,  Jill Uyeno ,  Fred Burbank ,  Greig Altieri

发明人： Michael Jones ,  Jill Uyeno ,  Fred Burbank ,  Greig Altieri

IPC分类号： A61F2/00

CPC分类号： A61B5/14542 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4325

摘要： The invention provides a devices, methods and systems to measure and record uterine tissue environment components such as pH during the course of uterine artery occlusion. The uterus becomes ischemic due to the occlusion thereof, and its pH drops sharply within minutes of uterine artery occlusion and remains relatively low for a period of time. The return of normal pH is an indicator of return of blood to the ischemic tissue. In use, a catheter with a pH measuring tip is advanced through the patient's vaginal canal and into the patient's uterine cavity until the pH measuring active electrode on the distal end of the catheter contacts or penetrates the uterine fundus. The active electrode detects the pH and a signal representing pH is transmitted to a pH recording and monitoring device which preferably displays the pH. The signal may be transmitted through a conductor or by a radio transmitter. Components other than pH may be monitored such a pCO2, and pO2.

摘要翻译： 本发明提供了在子宫动脉闭塞过程中测量和记录子宫组织环境组分如pH的装置，方法和系统。 子宫由于其闭塞而变得缺血，并且其pH在子宫动脉阻塞的几分钟内急剧下降，并且在一段时间内保持相对较低。 正常pH值的返回是血液向缺血组织返回的指标。 在使用中，具有pH测量尖端的导管通过患者的阴道通道进入患者的子宫腔，直到导管远端的pH测量有源电极接触或穿透子宫底。 活性电极检测pH，将表示pH的信号传输到pH记录和监测装置，其优选显示pH值。 信号可以通过导体或无线电发射机传输。 可以监测除pH以外的成分，例如pCO 2和pO 2。

公开(公告)号：US20070049973A1

公开(公告)日：2007-03-01

申请号：US11214606

申请日：2005-08-29

申请人： Fred Burbank ,  Michael Jones ,  R. Serra ,  Greig Altieri ,  Jill Uyeno ,  Yu-Tung Wong ,  Randy Werneth

发明人： Fred Burbank ,  Michael Jones ,  R. Serra ,  Greig Altieri ,  Jill Uyeno ,  Yu-Tung Wong ,  Randy Werneth

IPC分类号： A61N1/00

CPC分类号： A61B17/2812 ,  A61B5/026 ,  A61B8/06 ,  A61B8/12 ,  A61B17/122 ,  A61B17/282 ,  A61B17/2833 ,  A61B17/42 ,  A61B2017/00106 ,  A61B2017/2808 ,  A61B2017/4216

摘要： The invention provides devices, systems and methods for reducing or abolishing blood flow by occluding uterine arteries for treating adenomyosis and endometriosis. A non-invasive uterine artery occlusion device embodying features of the invention includes a pair of pressure-applying members with opposed tissue-contacting surfaces, a supporting shaft configured to adjust the distance between tissue-contacting surfaces, and at least one sensor for locating a uterine artery disposed on at least one pressure-applying member. Uterine arteries are occluded by indirectly compressing the artery by compressing tissue near to an artery. One uterine artery may be occluded or both may be occluded simultaneously. A uterine artery may be accessed via a body cavity, such as a patient's vagina, and may be occluded by compressing a portion of the vaginal wall around a portion of a uterine artery.

摘要翻译： 本发明提供了用于通过闭塞子宫动脉来治疗子宫腺肌症和子宫内膜异位症来减少或消除血流的装置，系统和方法。 体现本发明特征的非侵入性子宫动脉阻塞装置包括一对具有相对的组织接触表面的压力施加构件，配置成调节组织接触表面之间的距离的支撑轴和至少一个用于定位 子宫动脉设置在至少一个压力施加构件上。 通过压迫动脉附近的组织间接压迫动脉来闭塞子宫动脉。 一个子宫动脉可能被闭塞，或两者可能同时闭塞。 子宫动脉可以通过体腔（例如患者的阴道）进入，并且可以通过在子宫动脉的一部分周围压缩阴道壁的一部分来封闭子宫动脉。

公开(公告)号：US20050101974A1

公开(公告)日：2005-05-12

申请号：US10359386

申请日：2003-02-05

申请人： Fred Burbank ,  Michael Jones ,  R. Serra ,  Greig Altieri ,  Jill Uyeno

发明人： Fred Burbank ,  Michael Jones ,  R. Serra ,  Greig Altieri ,  Jill Uyeno

IPC分类号： A61B20060101 ,  A61B17/08

CPC分类号： A61B17/122 ,  A61B5/026 ,  A61B5/489 ,  A61B8/06 ,  A61B8/12 ,  A61B2017/2825 ,  A61B2017/4216 ,  A61B2090/08021

摘要： The invention provides devices, systems and methods for clamping arteries which are useful in reducing or abolishing blood flow in an artery, and may be used to control hemorrhage following a caesarian delivery. A clamping device embodying features of the invention includes a pair of clamping members with opposed pressure-applying members having facing pressure-applying surfaces, at least one of which is a yieldable pressure-applying surface. The yieldable pressure-applying surface is preferably resilient. The clamping members are configured to adjust the distance between pressure-applying surfaces, and a blood flow sensor is disposed on at least one of the pressure-applying members to aid in locating the target artery and also to monitor blood flow through the artery. The clamping device is particularly suitable for occluding uterine arteries by compressing the broad ligament which contains the uterine artery and which is connected to the patient's uterus with the arterial clamp.

摘要翻译： 本发明提供用于夹紧动脉的装置，系统和方法，其可用于减少或消除动脉中的血液流动，并且可用于控制切片输送之后的出血。 体现本发明特征的夹紧装置包括一对夹紧构件，其具有相对的施加压力的构件，其具有面对的压力施加表面，其中至少一个是可屈服的施加压力表面。 可屈服的施加压力的表面优选是弹性的。 夹紧构件被构造成调节压力施加表面之间的距离，并且血压传感器设置在至少一个压力施加构件上，以帮助定位目标动脉并且还监测通过动脉的血流。 夹紧装置特别适用于通过压缩包含子宫动脉的宽韧带并用动脉夹连接到患者的子宫来闭塞子宫动脉。

公开(公告)号：US20060015144A1

公开(公告)日：2006-01-19

申请号：US10894886

申请日：2004-07-19

申请人： Fred Burbank ,  Michael Jones ,  Greig Altieri ,  Jill Uyeno

发明人： Fred Burbank ,  Michael Jones ,  Greig Altieri ,  Jill Uyeno

IPC分类号： A61B17/08

CPC分类号： A61B17/064 ,  A61B17/0643 ,  A61B17/0682 ,  A61B17/076 ,  A61B17/12 ,  A61B17/2812 ,  A61B17/42 ,  A61B2017/00004 ,  A61B2017/0412 ,  A61B2017/0427 ,  A61B2017/0464 ,  A61B2017/2837

摘要： The invention is directed to an intravaginal staple for occluding a female patient's uterine artery in the treatment of a uterine disorder such as fibroids, DUB, PPH, uterine bleeding after caesarian delivery and the like. The intravaginal staple includes an occluding bar having a pressure applying surface and at least one and preferably two tissue penetrating legs which are provided with protuberances which help to retain the staple leg within the penetrated tissue. At least part of the staple is preferably formed of bioabsorbable material so that it will in part self destruct at a preselected time period by separation of staple components caused by the bioabsorption of a bioabsorbable portion of the staple. The staple deployment system may be provided with elongated handles and staple deploying mechanisms on the distal ends of the handles to drive the legs of the staple into the tissue bundle about the uterine artery so that pressure applied by the occlusion bar occludes the uterine artery.

摘要翻译： 本发明涉及用于阻塞女性患者的子宫动脉以治疗子宫疾病如子宫肌瘤，DUB，PPH，在切片分娩后的子宫出血等的阴道内钉。 阴道内钉包括具有压力施加表面的阻塞杆和至少一个并且优选两个组织穿透腿，所述腿部设置有有助于将钉腿保持在穿透组织内的突起。 钉的至少一部分优选地由生物可吸收材料形成，使得其将在预选的时间段内部分地通过由钉的生物可吸收部分的生物吸收引起的缝合组分的分离而自毁。 钉部署系统可以在手柄的远端处设置有细长的手柄和钉展开机构，以将钉的腿部驱动到围绕子宫动脉的组织束中，使得由闭塞杆施加的压力阻塞子宫动脉。

公开(公告)号：US20080097473A1

公开(公告)日：2008-04-24

申请号：US11881981

申请日：2007-07-30

申请人： Fred Burbank ,  Michael Jones ,  Jill Uyeno

发明人： Fred Burbank ,  Michael Jones ,  Jill Uyeno

IPC分类号： A61B17/42

CPC分类号： A61B17/12 ,  A61B17/2812 ,  A61B17/42 ,  A61B2017/00057 ,  A61B2017/2837 ,  A61B2090/064 ,  A61B2090/378

摘要： The invention is directed to instruments and procedures using such instruments for temporarily reducing or terminating blood flow through a female patient's uterine artery to treat post partum hemorrhage (PPH). The uterine artery is occluded by a clamping device which includes a pair of pivotally connected clamping members, with each of the clamping members having a handle and a clamping element at the distal end of the handle. The clamping elements are inclined with respect to the longitudinal axes of the handles at an included obtuse angle between about 120° and about 170°, preferably between about 130° and 160°. An artery locating sensor is provided on the distal end of at least one of the clamping elements. Preferably, the artery locating sensor is a Doppler ultrasound blood flow sensor. After birth, the clamping device is inserted into the female patient's post partum vaginal canal and advanced therein until one of the clamping elements Is in the patient's uterine cervix and the other clamping element is on the exterior of the uterine cervix. The clamping element on the exterior of the patient's uterine cervix is pressed against the patient's vaginal fornix and the clamping device closed so as to occlude the uterine artery disposed within tissue grasped by the clamping device. The clamping device is locked in the closed configuration and maintained in the condition until the patient's uterus is sufficiently clotted up to ensure termination of the hemorrhaging, typically about 5 minutes to about 7 hours.

摘要翻译： 本发明涉及使用这种器械临时减少或终止通过女性患者子宫动脉的血液流动以治疗产后出血（PPH）的仪器和程序。 子宫动脉被包括一对枢转连接的夹紧构件的夹紧装置封闭，其中每个夹紧构件具有手柄和在手柄的远端处的夹紧元件。 夹紧元件相对于把手的纵向轴线以约120°至约170°之间，优选地在约130°至160°之间的包含的钝角倾斜。 动脉定位传感器设置在至少一个夹紧元件的远端上。 优选地，动脉定位传感器是多普勒超声血流传感器。 出生后，将夹紧装置插入雌性患者的产后阴道管中并推进到其中，直到其中一个夹紧元件位于患者的子宫颈中，而另一个夹紧元件位于子宫颈的外部。 患者子宫颈外侧的夹紧元件被压靠在患者的阴道穹窿上，并且夹紧装置关闭，从而封闭设置在由夹紧装置抓握的组织内的子宫动脉。 夹紧装置被锁定在闭合构型中并保持在状态，直到患者的子宫充分凝结，以确保终止出血，通常约5分钟至约7小时。

公开(公告)号：US07229465B2

公开(公告)日：2007-06-12

申请号：US10113096

申请日：2002-03-28

申请人： Fred H. Burbank ,  Michael L. Jones ,  R. J. Serra ,  Greig Altieri ,  Jill Uyeno ,  Yu-Tung Wong ,  Randy Werneth

发明人： Fred H. Burbank ,  Michael L. Jones ,  R. J. Serra ,  Greig Altieri ,  Jill Uyeno ,  Yu-Tung Wong ,  Randy Werneth

IPC分类号： A61B17/00 ,  A61B17/42 ,  A61B17/08 ,  A61B5/02

CPC分类号： A61B17/12 ,  A61B5/026 ,  A61B5/415 ,  A61B5/418 ,  A61B8/06 ,  A61B8/12 ,  A61B17/00234 ,  A61B17/122 ,  A61B17/128 ,  A61B17/1285 ,  A61B17/2812 ,  A61B17/42 ,  A61B2017/0046 ,  A61B2017/4216

摘要： The invention provides devices, systems and methods for occluding arteries without puncturing skin or vessel walls. The devices, systems and methods for occluding arteries are configured to be applied to arteries externally of the arteries. Occlusion may be temporary or permanent, and may be partial or complete. Clamping a device to tissue near to an artery is effective to compress tissue around the artery and to indirectly compress the artery. The methods, devices and systems of the invention find use in, for example, treatment of uterine disorders and conditions which may be treated by occlusion of the uterine arteries. A uterine artery may be accessed via a patient's vagina by compressing a portion of the vaginal wall around a portion of a uterine artery to occlude a uterine artery. Clamping of an artery may also be performed by clamping a device directly onto an artery.

摘要翻译： 本发明提供用于闭塞动脉而不刺穿皮肤或血管壁的装置，系统和方法。 用于闭塞动脉的装置，系统和方法被配置为施加到动脉外部的动脉。 闭塞可能是暂时的或永久的，可能是部分或完全的。 将装置夹紧到靠近动脉的组织是有效的压缩动脉周围的组织并间接压缩动脉。 本发明的方法，装置和系统可用于例如治疗可能通过闭塞子宫动脉治疗的子宫疾病和病症。 通过将子宫动脉的一部分周围的一部分阴道壁压缩以阻塞子宫动脉，可以通过患者的阴道进入子宫动脉。 也可以通过将装置直接夹在动脉上来进行动脉的夹紧。

公开(公告)号：US07141057B2

公开(公告)日：2006-11-28

申请号：US10666075

申请日：2003-09-18

申请人： Fred Burbank ,  Michael L. Jones ,  Jill Uyeno ,  Greig E. Altieri ,  R. J. Serra

发明人： Fred Burbank ,  Michael L. Jones ,  Jill Uyeno ,  Greig E. Altieri ,  R. J. Serra

IPC分类号： A61B17/04 ,  A61B8/12

CPC分类号： A61B17/32056 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/12009 ,  A61B18/1477 ,  A61B18/1482 ,  A61B2017/00349 ,  A61B2017/00867 ,  A61B2017/0472 ,  A61B2017/06104 ,  A61B2017/306 ,  A61B2018/00601 ,  A61B2018/0063 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2090/378

摘要： Exemplary embodiments are directed to providing a method of preparing an anatomical vessel contained within a tissue bundle for ligation, including positioning a cannula adjacent to the tissue bundle, wherein the positioning is non-penetrating, the cannula including a first extendable member, a second extendable member, a Doppler wand, and a distal end, transmitting ultrasound signals toward the vessel through the tissue bundle with the Doppler wand, receiving ultrasound signals reflected by the vessel through the tissue bundle with the Doppler wand, invaginating the tissue bundle with the first extendable member on a first side of the tissue bundle, invaginating the tissue bundle with the second extendable member on a second side of the bundle opposite the first side, and interpenetrating a length of ligation material between the first and second extendable members on a side of the vessel opposite the cannula distal end.

公开(公告)号：US06638286B1

公开(公告)日：2003-10-28

申请号：US09713020

申请日：2000-11-16

申请人： Fred Burbank ,  Michael L. Jones ,  Jill Uyeno ,  Greig E. Altieri ,  R. J. Serra

发明人： Fred Burbank ,  Michael L. Jones ,  Jill Uyeno ,  Greig E. Altieri ,  R. J. Serra

IPC分类号： A61B1708

CPC分类号： A61B17/32056 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/12009 ,  A61B18/1477 ,  A61B18/1482 ,  A61B2017/00349 ,  A61B2017/00867 ,  A61B2017/0472 ,  A61B2017/06104 ,  A61B2018/00601 ,  A61B2018/0063 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2090/378

摘要： A ligation device includes a cannula having first and second extendable members and a Doppler wand. The Doppler wand permits an anatomical vessel, such as a blood vessel, to be located in close proximity to the distal end of the cannula. The extendable members are extendable on two opposite sides of the vessel. A length of ligation material, such as suture material, extends through the first extendable member, and is attached to a detachable element mounted to the distalmost end of the extendable member. The second extendable member includes a snare. The first extendable member includes curved portions which, when the member is extended distally, extend the detachable element into position for the snare so that the snare can grab the loop. Once ensnared, the detachable element is released from the first extendable member, which pulls the ligation material around the vessel. The ligation device does not require prior visualization or dissection of the area around the vessel.

摘要翻译： 连接装置包括具有第一和第二可延伸构件的插管和多普勒棒。 多普勒手柄允许诸如血管的解剖血管位于紧邻套管远端的位置。 可延伸构件可在容器的两个相对侧上延伸。 连接材料（例如缝合材料）的长度延伸穿过第一可延伸构件，并且附接到安装到可延伸构件的最远端的可拆卸元件。 第二可延伸构件包括圈套。 第一可伸展构件包括弯曲部分，当构件向远侧延伸时，将可拆卸元件延伸到圈套的位置，使得圈套可以抓住环路。 一旦被捕获，可拆卸元件从第一可延伸构件释放，其将结扎材料拉向容器周围。 结扎装置不需要先前可视化或解剖血管周围的区域。

公开(公告)号：US06635065B2

公开(公告)日：2003-10-21

申请号：US09909124

申请日：2001-07-17

申请人： Fred Burbank ,  Michael L. Jones ,  Jill Uyeno ,  Greig E. Altieri ,  R. J. Serra

发明人： Fred Burbank ,  Michael L. Jones ,  Jill Uyeno ,  Greig E. Altieri ,  R. J. Serra

IPC分类号： A61B1700

CPC分类号： A61B17/32056 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/12009 ,  A61B18/1477 ,  A61B18/1482 ,  A61B2017/00349 ,  A61B2017/00867 ,  A61B2017/0472 ,  A61B2017/06104 ,  A61B2017/306 ,  A61B2018/00601 ,  A61B2018/0063 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2090/378

摘要： Exemplary embodiments are directed to providing a method of preparing an anatomical vessel contained within a tissue bundle for ligation, including positioning a cannula adjacent to the tissue bundle, wherein the positioning is non-penetrating, the cannula including a first extendable member, a second extendable member, a Doppler wand, and a distal end, transmitting ultrasound signals toward the vessel through the tissue bundle with the Doppler wand, receiving ultrasound signals reflected by the vessel through the tissue bundle with the Doppler wand, invaginating the tissue bundle with the first extendable member on a first side of the tissue bundle, invaginating the tissue bundle with the second extendable member on a second side of the bundle opposite the first side, and interpenetrating a length of ligation material between the first and second extendable members on a side of the vessel opposite the cannula distal end.

公开(公告)号：US06519485B2

公开(公告)日：2003-02-11

申请号：US09736603

申请日：2000-12-13

申请人： William P. Wiesmann ,  Adrian Richard Urias ,  Jill Uyeno ,  Adrian Prokop ,  Jason Milne ,  Kristopher Jarka ,  Farbod Ghassemi

发明人： William P. Wiesmann ,  Adrian Richard Urias ,  Jill Uyeno ,  Adrian Prokop ,  Jason Milne ,  Kristopher Jarka ,  Farbod Ghassemi

IPC分类号： A61B500

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/4244

摘要： A system for assessing organ function couples light emitters into an optical fiber delivery assembly of which the tip extends to or into an internal organ and illuminates tissue; the device senses temperature at the tip, and a collection fiber collects light scattered, reflected or emitted by the surrounding tissue. Control and processing modules drive the laser diodes and process return spectral signals, e.g., to assess metabolic activity and detect onset of shock. A prototype uses four laser diodes with peaks at 735, 760, 805 and 890 nm, with a front end splitter providing a reference beam to a photo detector for normalizing detection output and correcting the signal samples. The device may include a plurality of laser diodes and may select subsets of the sources to tailor spectral illumination to different target enzymes, metabolites or other compounds. The processor may include heuristic correlators for interpreting the physiological state or detecting the onset of shock based on magnitudes of multiple different measured parameters.

摘要翻译： 用于评估器官功能的系统将光发射器耦合到光纤传送组件中，其尖端延伸到内部器官或照射组织; 该装置感测尖端处的温度，并且收集纤维收集由周围组织散射，反射或发射的光。 控制和处理模块驱动激光二极管并处理返回光谱信号，例如评估代谢活动并检测休克的发作。 原型机使用四个具有735,760,805和890nm峰值的激光二极管，前端分离器为光电检测器提供参考光束，用于归一化检测输出和校正信号采样。 该装置可以包括多个激光二极管，并且可以选择源的子集以对不同的靶酶，代谢物或其它化合物定制光谱照明。 处理器可以包括用于解释生理状态的启发式相关器或者基于多个不同测量参数的大小来检测冲击的开始。