公开(公告)号：US5494039A

公开(公告)日：1996-02-27

申请号：US93020

申请日：1993-07-16

申请人： Gary Onik ,  George Reyes ,  Larry Pottorff ,  Jeffrey Cohen

发明人： Gary Onik ,  George Reyes ,  Larry Pottorff ,  Jeffrey Cohen

IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/34 ,  A61B18/02 ,  A61B8/00

CPC分类号： A61B17/3403 ,  A61B10/0241 ,  A61B18/02 ,  A61B2017/00274 ,  A61B2018/00547

摘要： A biopsy needle insertion guide and method of use with an ultrasound probe in medical procedures to accurately position biopsy needles in internal tissues. The insertion guide comprises a body which is removably mountable on an ultrasound probe and which comprises a clamp affixable about the probe and an elongated adjustment guide extending from the clamp in a direction perpendicular to the probe. A slide block engages the adjustment guide and is slidably adjustable therealong and a biopsy needle holder and guide assembly is carried by the slide block and is adjustably extendable from the slide block in a direction parallel to the probe. A method of use is described wherein the insertion guide is used to accurately place biopsy needles in a human prostate, the needles being then used to accurately place cryoprobes in the prostate for cryogenic surgery of the gland.

摘要翻译： 活检针插入引导件和在医疗程序中使用超声波探头的方法，以将活检针准确地定位在内部组织中。 插入引导件包括可移除地安装在超声波探头上并且包括可围绕探针固定的夹具的主体和沿着垂直于探针的方向从夹具延伸的细长调节引导件。 滑块与调节引导件接合，并且可滑动地调节，并且活检针保持器和引导组件由滑动块承载，并且可从滑动块沿平行于探针的方向可调节地延伸。 描述了一种使用方法，其中使用插入引导件将活检针精确地放置在人类前列腺中，然后使用针将准确地将冷冻探针放置在前列腺中用于腺体的低温手术。

公开(公告)号：US5437673A

公开(公告)日：1995-08-01

申请号：US13307

申请日：1993-02-04

申请人： John G. Baust ,  Zhao H. Chang ,  Jeffrey Cohen ,  Gary Onik ,  George Reyes

发明人： John G. Baust ,  Zhao H. Chang ,  Jeffrey Cohen ,  Gary Onik ,  George Reyes

IPC分类号： A61B17/00 ,  A61B18/02 ,  A61F7/00 ,  A61F7/12 ,  A61M25/00

CPC分类号： A61F7/12 ,  A61B18/02 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/0212 ,  A61F2007/0054 ,  A61F2007/0086

摘要： The present invention is directed to a closed circulation tissue warming apparatus for use during surgery to maintain the temperature of tissues at a desired level and to a method of using the apparatus in prostate surgery particularly during transperineal cryoablation of the prostate gland in human males to maintain the temperature of the urethral tissues and thereby prevent urethral sloughing. It may also have utility where it is desired to lower the temperature of surrounding tissues, such as during laser ablation. The apparatus includes a multi-lumen catheter inserted into the urethra and connected to a fluid warming and circulation control means whereby warmed water is circulated through the lumens at a controlled flow rate and temperature. The concentric lumen structure of the catheter provides improved flow and even temperature maintenance along the length of the catheter and the urethra.

摘要翻译： 本发明涉及一种封闭循环组织加热装置，用于在外科手术期间将组织的温度维持在期望的水平，以及在前列腺手术中使用该装置的方法，特别是在人类前列腺的经精囊冷冻消融期间维持 尿道组织的温度，从而防止尿道脱落。 在需要降低周围组织的温度的情况下，例如在激光烧蚀期间也可以具有实用性。 该装置包括插入尿道并连接到流体加温和循环控制装置的多腔导管，由此温水以受控的流速和温度循环通过腔。 导管的同心腔结构提供沿着导管和尿道长度的改善的流量和均匀的温度维持。

公开(公告)号：US20120078524A1

公开(公告)日：2012-03-29

申请号：US13136366

申请日：2011-07-29

申请人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

发明人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

IPC分类号： G01N33/48 ,  G01N21/64 ,  G01J3/44

CPC分类号： A61B5/0059 ,  A61B5/417 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/6458 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/16 ,  G02B21/365 ,  G06F19/325 ,  G16H50/70

摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.

摘要翻译： 用于确定测试生物样品的诊断的系统和方法。 一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生 所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。 一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。 可以评估该拉曼数据集以确定样品的诊断。 诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

公开(公告)号：US07956996B2

公开(公告)日：2011-06-07

申请号：US12206500

申请日：2008-09-08

申请人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

发明人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01J3/02 ,  A61B5/0059 ,  A61B5/417 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N33/57415 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  Y02A90/26

摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

摘要翻译： 一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。 提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。 用基本上单色的光照射测试乳样品以产生散射的光子，得到测试拉曼数据集。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。 乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

公开(公告)号：US20090033930A1

公开(公告)日：2009-02-05

申请号：US12248344

申请日：2008-10-09

申请人： John Maier ,  Jeffrey Cohen

发明人： John Maier ,  Jeffrey Cohen

IPC分类号： G01N21/65

CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/129

摘要： A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.

摘要翻译： 鉴定微生物生物膜的光谱方法和系统。 用基本上单色的辐射照射含有样品微生物的样品。 基于从照射样品散射的辐射获得拉曼数据集。 根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。 数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知无形形式相关联。 基于通过搜索识别的已知拉曼数据集来鉴定样品微生物的固定形式。

公开(公告)号：US07477378B2

公开(公告)日：2009-01-13

申请号：US11527839

申请日：2006-09-27

申请人： Jeffrey Cohen ,  John S. Maier

发明人： Jeffrey Cohen ,  John S. Maier

IPC分类号： G01N3/44

CPC分类号： G01J3/02 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/0291 ,  G01N21/6458 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/656

摘要： A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, a database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.

摘要翻译： 将拉曼测量与样本的数字图像相关联的系统和方法，以对样本的疾病状态进行分类。 对于位于分光装置的视野中的样品获得光谱数据集。 从样品中取出样品后，用对比度增强剂处理样品。 经处理的样品在分光装置的视野中重新定位，并获得处理过的样品的数字图像。 通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。 对于样本的光谱数据集，搜索数据库以识别具有良好表征的病理学的已知样品的光谱数据集，其与样品的光谱数据集相匹配。

公开(公告)号：US20070109535A1

公开(公告)日：2007-05-17

申请号：US11598245

申请日：2006-11-09

申请人： John Maier ,  Jeffrey Cohen

发明人： John Maier ,  Jeffrey Cohen

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/129

摘要： A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.

摘要翻译： 鉴定微生物生物膜的光谱方法和系统。 用基本上单色的辐射照射含有样品微生物的样品。 基于从照射样品散射的辐射获得拉曼数据集。 根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。 数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知无形形式相关联。 基于通过搜索识别的已知拉曼数据集来鉴定样品微生物的固定形式。

公开(公告)号：US20060276697A1

公开(公告)日：2006-12-07

申请号：US11146458

申请日：2005-06-07

申请人： Joseph Demuth ,  Patrick Treado ,  John Maier ,  Jeffrey Cohen

发明人： Joseph Demuth ,  Patrick Treado ,  John Maier ,  Jeffrey Cohen

IPC分类号： A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/415 ,  A61B5/418

摘要： The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.

摘要翻译： 本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。 本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估 的血液成分用于表现出血液光学特性的一个或多个区域。

公开(公告)号：US20060253261A1

公开(公告)日：2006-11-09

申请号：US11484040

申请日：2006-07-11

申请人： John Maier ,  Patrick Treado ,  Jeffrey Cohen ,  Jason Neiss

发明人： John Maier ,  Patrick Treado ,  Jeffrey Cohen ,  Jason Neiss

IPC分类号： G06F19/00 ,  A61B5/00

CPC分类号： G01N21/65

摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.

摘要翻译： 用于确定疾病进展的方法和装置。 确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。 用光照射含有至少一个电池的样品。 收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。 每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。 在多个预定向量空间中分析变换点的分布。 根据分析，对样本的疾病状况进行分类。

公开(公告)号：US20050002466A1

公开(公告)日：2005-01-06

申请号：US10600502

申请日：2003-06-20

申请人： Yury Levin ,  Jeffrey Cohen

发明人： Yury Levin ,  Jeffrey Cohen

IPC分类号： H03M13/25 ,  H04L1/00 ,  H04L25/06 ,  H04L27/38 ,  H04L5/12

CPC分类号： H04L1/006 ,  H03M13/256 ,  H04L1/0052 ,  H04L25/067 ,  H04L27/38

摘要： According to some embodiments, distances associated with a Trellis decoder are determined.

摘要翻译： 根据一些实施例，确定与网格解码器相关联的距离。