公开(公告)号：US5472658A

公开(公告)日：1995-12-05

申请号：US171589

申请日：1993-12-22

申请人： George Collins ,  William M. Pleban ,  Frank Haimbach, IV ,  John A. Flint

发明人： George Collins ,  William M. Pleban ,  Frank Haimbach, IV ,  John A. Flint

IPC分类号： D02J1/20

CPC分类号： D02J1/20

摘要： The tensile modulus of fibers made from liquid crystalline polymers comprising 6-oxy-2-naphthoate and 4-oxybenzoate monomer units that have been heat treated can be increased by applying and then releasing a stress at room temperature in the range of about 25% to about 90% of the tensile strength of the heat treated fiber to yield a "pre-stressed" fiber.

摘要翻译： 包含6-氧基-2-萘甲酸酯和4-羟基苯甲酸酯单体单元的液晶聚合物制成的纤维的拉伸模量可以通过在室温下施加并释放约25％至 约90％的热处理纤维的拉伸强度，以产生“预应力”纤维。

公开(公告)号：US20190134263A1

公开(公告)日：2019-05-09

申请号：US14003062

申请日：2012-03-01

申请人： Cheul H Cho ,  Ali Hussain ,  George Collins ,  Divya Ranendran

发明人： Cheul H Cho ,  Ali Hussain ,  George Collins ,  Divya Ranendran

IPC分类号： A61L27/26

摘要： The present invention relates to a vascularized three dimensional construct for thick tissue, a process for making the construct and to the use of the construct in tissue regeneration and repair and in drug development. The three-dimensional (3-D) tissue technology is used to generate vascularized, biomimetic tissue models in vitro utilizing a biodegradable nanofiber scaffold. The culture system allows the maintenance of long-term survival and function of liver and heart cells. The system utilizes a novel approach to generate structures that mimic in vivo tissue architecture. The system provides a microenvironment for forming 3-D microvascular networks within the nanofiber scaffolds.

公开(公告)号：US09334476B2

公开(公告)日：2016-05-10

申请号：US12661264

申请日：2010-03-12

申请人： Treena Arinzeh ,  George Collins ,  Yee-Shuan Lee

发明人： Treena Arinzeh ,  George Collins ,  Yee-Shuan Lee

IPC分类号： C12N5/079 ,  A61L27/16 ,  A61L27/54 ,  C12N5/00 ,  C12M1/12

CPC分类号： C12N5/0618 ,  A61L27/16 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/12 ,  C12M25/14 ,  C12N5/0068 ,  C12N2533/30 ,  C08L27/16

摘要： Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.

摘要翻译： 提供一种用于生长分离的可分化细胞的电活性结构，其包含由生物相容性合成压电聚合材料形成的纤维的三维矩阵，其中纤维基质用分离的可分化细胞接种，并形成用于生长分离的可分化细胞的支持性支架， 并且其中纤维基质刺激分离的可分化细胞在结构上成熟细胞表型的分化。

公开(公告)号：US09192655B2

公开(公告)日：2015-11-24

申请号：US12661242

申请日：2010-03-12

申请人： Treena Arinzeh ,  George Collins ,  Bruno Mantilla

发明人： Treena Arinzeh ,  George Collins ,  Bruno Mantilla

IPC分类号： A61K38/39 ,  A61F2/00 ,  A01N63/00 ,  A61K35/28 ,  A61L27/26 ,  A61L27/52 ,  C08L1/02 ,  D01D5/00 ,  D01F2/24

CPC分类号： A61K38/39 ,  A61K35/28 ,  A61L27/26 ,  A61L27/52 ,  A61L2430/06 ,  C08L1/02 ,  D01D5/0007 ,  D01F2/24 ,  C08L1/16

摘要： The embodiments and examples provided herein are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the present invention relates to compositions and methods of preparing a hydrogel comprising a water soluble cellulose compound, as well as preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a water soluble cellulose compound. The matrix provides a scaffold supporting and promoting cartilage regeneration and repair.

摘要翻译： 本文提供的实施方案和实施例提供给本领域普通技术人员的全面公开和描述如何制备和使用本发明，并不旨在限制本发明涉及组合物和方法 制备包含水溶性纤维素化合物的水凝胶，以及制备微米尺寸电纺纤维的三维基质，其中电纺纤维由包含水溶性纤维素化合物的电纺复合材料形成。 该基质提供支架和促进软骨再生和修复的支架。

公开(公告)号：US20110274742A1

公开(公告)日：2011-11-10

申请号：US13097657

申请日：2011-04-29

申请人： Treena Arinzeh ,  George Collins ,  Piyush Modak ,  Ling-Fang Tseng

发明人： Treena Arinzeh ,  George Collins ,  Piyush Modak ,  Ling-Fang Tseng

IPC分类号： A61K9/70 ,  A61P19/00 ,  A61K31/717 ,  A61P19/02 ,  A61K35/12 ,  C12N5/02

CPC分类号： A61K38/1841 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/28 ,  A61K47/38 ,  A61L27/26 ,  A61L27/3834 ,  A61L27/52 ,  A61L2430/06 ,  C08L1/02 ,  C08L1/16 ,  C08L5/08 ,  C12N5/0655 ,  C12N2533/72 ,  C12N2533/78 ,  D01D5/0007 ,  D01F2/24 ,  D01F9/00 ,  A61K2300/00

摘要： The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and, in certain aspects, a fibrous or filamentous matrix. The hydrogels as described provide a support or scaffold that promotes, facilitates, and/or enhances progenitor or stem cell growth and/or differentiation. In addition, the hydrogel is useful for tissue, e.g., cartilage, regeneration and repair.

摘要翻译： 本发明涉及水凝胶或支架组合物和用于细胞生长和/或再生药物的方法。 水凝胶包含水溶性纤维素化合物，并且在某些方面包括纤维或丝状基质。 如上所述的水凝胶提供促进，促进和/或增强祖细胞或干细胞生长和/或分化的支持物或支架。 此外，水凝胶可用于组织，例如软骨，再生和修复。

公开(公告)号：US4360541A

公开(公告)日：1982-11-23

申请号：US237216

申请日：1981-02-23

申请人： John R. Costanza ,  George Collins

发明人： John R. Costanza ,  George Collins

IPC分类号： C09D4/00 ,  B05D3/06

CPC分类号： C09D4/00

摘要： This invention provides a process for preparing self-pigmented ultraviolet cured coating compositions, which involves preparing a dispersion of water in certain polyunsaturated ultraviolet curable monomers at a solids level of about 35 to about 85 weight percent, applying the dispersion as a coating on a substrate and curing the substrate coating by exposure to ultraviolet light. These cured compositions have utility as self-pigmented protective coatings.

摘要翻译： 本发明提供一种制备自色素的紫外线固化涂料组合物的方法，其包括以大约35至大约85重量％的固体含量制备一些多不饱和紫外线可固化单体中的水分散体，将该分散体作为涂层施涂在基材上 并通过暴露于紫外线固化基底涂层。 这些固化的组合物可用作自色素保护涂层。

公开(公告)号：US07947785B2

公开(公告)日：2011-05-24

申请号：US12470248

申请日：2009-05-21

申请人： Anthony J. East ,  Michael Jaffe ,  Willis B. Hammond ,  George Collins ,  Ronald N. DeMartino ,  Zohar Ophir

发明人： Anthony J. East ,  Michael Jaffe ,  Willis B. Hammond ,  George Collins ,  Ronald N. DeMartino ,  Zohar Ophir

IPC分类号： C08G59/40 ,  C08L63/00

CPC分类号： C08G18/003 ,  C08G18/758

摘要： Disclosed is a method for preparing polyoxazolidones wherein an ether of a bisanhydrohexitol is reacted with a diisocyanate under conditions which form polyoxazolidones. Preferred bisanhydrohexitols include isoidide, isomannide and isosorbide. The polyoxazolidones are highly crosslinked, rigid, and have high solvent resistance.

摘要翻译： 公开了一种制备聚恶唑烷酮的方法，其中在形成聚恶唑烷酮的条件下，双氢己糖醇的醚与二异氰酸酯反应。 优选的双氢己氮醇包括异氰脲酸酯，异麦芽糖苷和异山梨醇。 聚恶唑烷酮是高度交联的，刚性的，并具有高耐溶剂性。

公开(公告)号：US20100324697A1

公开(公告)日：2010-12-23

申请号：US12661264

申请日：2010-03-12

申请人： Treena Arinzeh ,  George Collins ,  Yee-Shuan Lee

发明人： Treena Arinzeh ,  George Collins ,  Yee-Shuan Lee

IPC分类号： A61F2/02 ,  C12N5/0797 ,  B29C47/30

CPC分类号： C12N5/0618 ,  A61L27/16 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/12 ,  C12M25/14 ,  C12N5/0068 ,  C12N2533/30 ,  C08L27/16

摘要： Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.

摘要翻译： 提供一种用于生长分离的可分化细胞的电活性结构，其包含由生物相容性合成压电聚合材料形成的纤维的三维矩阵，其中纤维基质用分离的可分化细胞接种，并形成用于生长分离的可分化细胞的支持性支架， 并且其中纤维基质刺激分离的可分化细胞在结构上成熟细胞表型的分化。

公开(公告)号：US20100233234A1

公开(公告)日：2010-09-16

申请号：US12661242

申请日：2010-03-12

申请人： Treena Arinzeh ,  George Collins ,  Bruno Mantilla

发明人： Treena Arinzeh ,  George Collins ,  Bruno Mantilla

IPC分类号： A61K35/12 ,  A61K9/00 ,  C08B1/00 ,  A61K38/39 ,  A61K38/18 ,  A61P19/02 ,  A61P19/04

CPC分类号： A61K38/39 ,  A61K35/28 ,  A61L27/26 ,  A61L27/52 ,  A61L2430/06 ,  C08L1/02 ,  D01D5/0007 ,  D01F2/24 ,  C08L1/16

摘要： The embodiments and examples provided herein are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the present invention relates to compositions and methods of preparing a hydrogel comprising a water soluble cellulose compound, as well as preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a water soluble cellulose compound. The matrix provides a scaffold supporting and promoting cartilage regeneration and repair.

摘要翻译： 本文提供的实施方案和实施例提供给本领域普通技术人员的全面公开和描述如何制备和使用本发明，并不旨在限制本发明涉及组合物和方法 制备包含水溶性纤维素化合物的水凝胶，以及制备微米尺寸电纺纤维的三维基质，其中电纺纤维由包含水溶性纤维素化合物的电纺复合材料形成。 该基质提供支架和促进软骨再生和修复的支架。

公开(公告)号：US09504987B2

公开(公告)日：2016-11-29

申请号：US13552550

申请日：2012-07-18

申请人： Bhavita Joshi ,  George Collins ,  Treena Arinzeh

发明人： Bhavita Joshi ,  George Collins ,  Treena Arinzeh

IPC分类号： B01J20/26 ,  B01J20/24 ,  A61L15/60

CPC分类号： B01J20/267 ,  A61L15/60 ,  B01J20/24 ,  B01J20/261 ,  B01J20/265 ,  B01J20/28047 ,  B01J2220/445 ,  B01J2220/68

摘要： A hydrogel matrix and an osmotically active material immobilized in the matrix can be combined into superabsorbent preparations that are capable of adsorbing large amounts of water. The superabsorbent preparations of the invention have advantages in the use of absorbent materials for physiological fluids, such as diapers, incontinence products, wound dressings and the like, as well as agricultural and environmental applications. In addition, biodegradable superabsorbents of the invention can be prepared.

摘要翻译： 固定在基质中的水凝胶基质和渗透活性物质可以组合成能够吸附大量水的超吸收制剂。 本发明的超吸收剂制剂在使用吸收材料用于生理流体，例如尿布，失禁产品，伤口敷料等以及农业和环境应用中具有优点。 此外，可以制备本发明的可生物降解的超吸收剂。