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公开(公告)号：US09351965B2
公开(公告)日：2016-05-31
申请号：US13994224
申请日：2011-12-16
申请人： Gerald W. Shipps, Jr. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
发明人： Gerald W. Shipps, Jr. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
IPC分类号： C07D231/56 , C07D401/04 , C07D471/04 , C07D401/14 , C07D403/14 , C07D417/04 , A61K31/416 , A61K31/4439 , A61K45/06 , A61K31/437
CPC分类号： A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2，R 3，m如本文所定义。 这些化合物是ERK抑制剂。 还公开了包含上述化合物的药物组合物和使用其的癌症治疗方法。
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公开(公告)号：US20130261125A1
公开(公告)日：2013-10-03
申请号：US13994224
申请日：2011-12-16
申请人： Gerald W. Shipps, JR. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
发明人： Gerald W. Shipps, JR. , Xiaohua Huang , Yongqi Deng , Liang Zhu , Alan B. Cooper , Binyuan Sun , Abdelghani Achab , Sie-Mun Lo
IPC分类号： A61K31/4439 , C07D471/04 , A61K31/437 , C07D401/04
CPC分类号： A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2，R 3，m如本文所定义。 这些化合物是ERK抑制剂。 还公开了包含上述化合物的药物组合物和使用其的癌症治疗方法。
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公开(公告)号：US08999957B2
公开(公告)日：2015-04-07
申请号：US13703250
申请日：2011-06-22
申请人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
发明人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
IPC分类号： C07D401/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D401/14 , C07D405/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07F7/18
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。 这些化合物是ERK抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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公开(公告)号：US20130096084A1
公开(公告)日：2013-04-18
申请号：US13703250
申请日：2011-06-22
申请人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, JR. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
发明人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, JR. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
IPC分类号： C07D401/14 , A61K45/06 , C07D405/14 , A61K31/454 , A61K31/55 , A61K31/551 , C07D401/12 , C07D409/14 , C07D417/14 , A61K31/506 , C07D471/04 , C07F7/18 , A61K31/695 , C07D413/14 , A61K31/5377 , A61K31/4545
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。 这些化合物是ERK抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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公开(公告)号：US20120328691A1
公开(公告)日：2012-12-27
申请号：US12447712
申请日：2007-10-29
申请人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory Poker , Timothy J. Guzi
发明人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory Poker , Timothy J. Guzi
IPC分类号： A61K31/496 , A61K31/55 , C07D417/12 , A61K31/454 , A61K31/427 , A61K31/541 , A61K31/506 , A61K31/497 , C07D471/10 , A61K31/438 , A61K31/4545 , A61K31/5377 , C07D498/10 , A61K31/5386 , A61K31/551 , A61K33/24 , A61K9/127 , A61K39/395 , A61K31/704 , A61K38/19 , A61K31/7068 , A61K38/50 , A61K38/20 , A61K38/21 , A61P35/00 , A61P35/02 , A61N5/10 , C07D417/14
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US08318735B2
公开(公告)日：2012-11-27
申请号：US12447710
申请日：2007-10-29
申请人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
发明人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
IPC分类号： A61K31/5355 , A61K31/496 , C07D401/14 , C07D403/14 , C07D413/14
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性病症，抗增殖病症，炎症，关节炎，中枢神经系统疾病 ，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US09206142B2
公开(公告)日：2015-12-08
申请号：US12447712
申请日：2007-10-29
申请人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory S. Poker , Timothy J. Guzi
发明人： Gerald W. Shipps, Jr. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga Adulla Reddy , Tzu T. Wong , Praveen K. Tadikonda , M. Arshad Siddiqui , Marc A. Labroli , Cory S. Poker , Timothy J. Guzi
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , A61K31/5355 , A61K31/496 , C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US20100130465A1
公开(公告)日：2010-05-27
申请号：US12447710
申请日：2007-10-29
申请人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga A. Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
发明人： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga A. Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi
IPC分类号： A61K31/438 , C07D417/14 , A61K31/497 , C07D471/10 , C07D413/14 , A61K31/5377 , A61K31/551
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性病症，抗增殖病症，炎症，关节炎，中枢神经系统疾病 ，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。
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公开(公告)号：US20130164259A1
公开(公告)日：2013-06-27
申请号：US13518317
申请日：2010-12-20
IPC分类号： A61K31/497 , C07D403/04 , C07D409/14 , C07D471/04 , C07D413/14 , C07D405/14 , C07D403/14 , A61K31/501 , A61K31/506 , A61K31/496 , C07D417/14 , C07D401/12 , C07D495/04 , A61K31/519 , C07D487/04 , A61K31/7088 , A61K39/00 , A61K38/21 , A61K39/395 , A61K39/29 , A61P37/04 , A61P31/12 , A61P31/14 , C07D401/14
CPC分类号： C07D403/12 , C07D239/42 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to 1,4-Substituted Piperazine Derivatives, compositions comprising one or more 1,4-Substituted Piperazine Derivatives, and methods of using the 1,4-Substituted Piperazine Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及1,4-取代的哌嗪衍生物，包含一种或多种1,4-取代的哌嗪衍生物的组合物，以及使用1,4-取代的哌嗪衍生物治疗或预防病毒感染或病毒相关的方法 病人无序。
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公开(公告)号：US20110044940A1
公开(公告)日：2011-02-24
申请号：US12738532
申请日：2008-10-27
IPC分类号： A61K31/454 , C07D417/14 , C07D417/12 , A61K31/4545 , A61K39/395 , A61K38/20 , A61K38/21 , A61K33/24 , A61K31/704 , A61K31/7048 , A61K31/4375 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/7068 , A61K31/568 , A61K38/50 , A61K31/573 , A61K38/14 , A61K31/496 , A61P35/00 , A61K31/5377 , A61K31/52 , A61K31/473
CPC分类号： C07D417/14
摘要： The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译： 本发明涉及新颖的杂环醚或硫醚衍生物，包含杂环醚或硫代醚衍生物的组合物，以及使用杂环醚或硫代醚衍生物治疗或预防增殖性病症，抗增殖性疾病，炎症，关节炎， 中枢神经系统疾病，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒感染，真菌感染或与蛋白激酶活性相关的病症。
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