公开(公告)号：US20110027898A1

公开(公告)日：2011-02-03

申请号：US12903176

申请日：2010-10-12

Applicant: Guillermo C. BAZAN ,  Bin LIU

Inventor： Guillermo C. BAZAN ,  Bin LIU

IPC: G01N33/50

CPC classification number: C12Q1/6818 ,  C12Q2563/119 ,  C12Q2565/101 ,  C12Q2565/519 ,  C12Q2565/607 ,  C12Q2523/313

Abstract: The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及共轭聚合物，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20100255477A1

公开(公告)日：2010-10-07

申请号：US12711233

申请日：2010-02-23

Applicant: Guillermo C. BAZAN ,  Bin LIU

Inventor： Guillermo C. BAZAN ,  Bin LIU

IPC: C12Q1/68 ,  G01N21/00 ,  G01N33/53 ,  G01N33/68 ,  G01N33/48 ,  C08L81/00

CPC classification number: G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20120214255A1

公开(公告)日：2012-08-23

申请号：US13367358

申请日：2012-02-06

Applicant: Guillermo C. BAZAN ,  Bin LIU

Inventor： Guillermo C. BAZAN ,  Bin LIU

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20090093479A1

公开(公告)日：2009-04-09

申请号：US12336857

申请日：2008-12-17

Applicant: Martha KELLY ,  Younghee LEE ,  Bin LIU ,  Ted FUJIMOTO ,  Joel FREUNDLICH ,  Bruce D. DORSEY ,  Gary A. FLYNN ,  Arifa HUSAIN

Inventor： Martha KELLY ,  Younghee LEE ,  Bin LIU ,  Ted FUJIMOTO ,  Joel FREUNDLICH ,  Bruce D. DORSEY ,  Gary A. FLYNN ,  Arifa HUSAIN

IPC: A61K31/5377 ,  C07D401/02 ,  C07D211/80 ,  C07D409/02 ,  C07D401/14 ,  C07D405/02 ,  A61K31/497 ,  A61K31/506 ,  A61P35/00 ,  A61K31/422 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/44 ,  C07D413/02

CPC classification number: C07D209/08 ,  C07D213/74 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/10

Abstract: The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, non-small cell lung and colon.

Abstract translation: 本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。 化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A1为N或CR1; A3是N或CR3; A5为N或CR5; R1，R3-R6和L在说明书中定义; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环 其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。 它们对广泛的癌症尤其是白血病，非小细胞肺和结肠有效。

公开(公告)号：US20130170073A1

公开(公告)日：2013-07-04

申请号：US13370421

申请日：2012-02-10

Applicant: Da peng ZHAO ,  Xiong Fei WEI ,  Bin LIU ,  Shengxiang CHEN

Inventor： Da peng ZHAO ,  Xiong Fei WEI ,  Bin LIU ,  Shengxiang CHEN

IPC: G11B33/08

CPC classification number: G11B5/5582

Abstract: The present invention directs an anti-shock method for head stack assembly which carries a slider for flying on a disk for operation, and the anti-shock method includes: inputting a constant current to a head disk interface sensor which is deposited in the slider; obtaining a changing voltage of the head disk interface sensor, which is changed with the temperature of the head disk interface sensor as the slider is shocked; outputting the changing voltage to a controller with a threshold set therein; if the changing voltage is bigger than the threshold for a specified number of times, the controller is triggered to control the head stack assembly to stop operating and load on a ramp beside the disk; while if the changing voltage is small than the threshold for said specified number of times, the controller is not be triggered and the head stack assembly still operates.

Abstract translation: 本发明引导了一种用于磁头堆叠组装的抗冲击方法，其具有用于在盘上进行操作的滑块，并且抗冲击方法包括：将恒定电流输入到沉积在滑块中的磁头盘接口传感器; 获得磁头盘接口传感器的变化的电压，随着滑块被震动，头磁盘接口传感器的温度随着磁头盘接口传感器的温度而改变; 将变化的电压输出到其中设置有阈值的控制器; 如果变化的电压大于阈值达指定次数，则控制器被触发以控制磁头堆叠组件停止操作并加载在磁盘旁边的斜坡上; 而如果变化的电压小于所述指定次数的阈值，则控制器不被触发并且磁头堆叠组件仍然运行。

公开(公告)号：US20120330389A1

公开(公告)日：2012-12-27

申请号：US13572200

申请日：2012-08-10

Applicant: Bin LIU ,  Hu LUO

Inventor： Bin LIU ,  Hu LUO

IPC: A61N1/04

CPC classification number: A61N1/046 ,  A61N1/0472 ,  A61N1/0492 ,  A61N1/3925 ,  A61N1/3993

Abstract: A defibrillator includes a defibrillator mainframe and a defibrillating electrode. The defibrillator mainframe includes a main control unit and a master device electrically connected to the main control unit. The defibrillating electrode comprises a slave device supporting a bus protocol, the master device and slave device being interconnected through a bus.

Abstract translation: 除颤器包括除颤器主机和去纤颤电极。 除颤器主机包括主控制单元和与主控制单元电连接的主设备。 除颤电极包括支持总线协议的从设备，主设备和从设备通过总线互连。

公开(公告)号：US20090017786A1

公开(公告)日：2009-01-15

申请号：US12234556

申请日：2008-09-19

Applicant: Xiaojun MO ,  Bin LIU ,  Shaoxiong LIAN ,  Kefeng WANG

Inventor： Xiaojun MO ,  Bin LIU ,  Shaoxiong LIAN ,  Kefeng WANG

IPC: H04M11/00

CPC classification number: H04L12/14 ,  H04L41/5029 ,  H04M15/00 ,  H04M15/39 ,  H04M15/43 ,  H04M15/52 ,  H04M15/62

Abstract: A communication system, an intelligent peripheral, a charging method, a service control point, and a service switching point are provided. The communication system includes a service switching point, a service control point and an intelligent peripheral. The service control point is adapted for sending an operation characteristic parameter identifying whether to charge for a service to the intelligent peripheral; the intelligent peripheral is adapted for judging whether to request the service switching point to charge for the service according to the operation characteristic parameter identifying whether to charge for the service, and instructing the intelligent peripheral not to send an answer charging message to the service switching point if a result of the judging is negative. Accurate and efficient charging is achieved in various situations of intelligent peripheral resource utilization in an intelligent network.

Abstract translation: 提供通信系统，智能外设，充电方法，服务控制点和服务切换点。 通信系统包括业务交换点，业务控制点和智能外设。 服务控制点适于发送识别是否向智能外设收取服务的操作特性参数; 所述智能外围设备根据操作特征参数判断是否对服务收费，判断是否请求业务交换点收费，并指示智能外设不向业务交换点发送应答收费消息 如果判断的结果是否定的。 在智能网络智能外设资源利用的各种情况下，可以实现精确高效的收费。

公开(公告)号：US20110029942A1

公开(公告)日：2011-02-03

申请号：US12845204

申请日：2010-07-28

Applicant: Bin LIU ,  Zhiru ZHANG ,  Jason CONG

Inventor： Bin LIU ,  Zhiru ZHANG ,  Jason CONG

IPC: G06F17/50

CPC classification number: G06F17/505

Abstract: A method for implementing soft constraints in scheduling comprises receiving a description of circuit behavior. The description is un-timed. A scheduling solution is generated for use in scheduling the description. The scheduling solution includes scheduling variables and an objective function. The scheduling variables schedule the time of at least one operation. The objective function includes a penalty term and constraints comprising at least one hard constraint and at least one soft constraint. The constraints are created on the scheduling variables. The penalty term comprises a slack variable representing violations of the constraints. The penalty term measures the design cost of violating the soft constraint. Following generation of the scheduling solution, the description is scheduled by applying the scheduling solution to the description. Timing information of the description is provided as an output of the scheduling.

Abstract translation: 用于在调度中实现软约束的方法包括接收电路行为的描述。 描述是不及时的。 生成调度解决方案用于调度描述。 调度解决方案包括调度变量和目标函数。 调度变量调度至少一个操作的时间。 目标函数包括惩罚项和包含至少一个硬约束和至少一个软约束的约束。 在调度变量上创建约束。 惩罚项包括表示违反约束的松弛变量。 罚款条款衡量违反软约束的设计成本。 在生成调度解决方案之后，通过将调度解决方案应用于描述来调度描述。 提供描述的定时信息作为调度的输出。

公开(公告)号：US20190194655A1

公开(公告)日：2019-06-27

申请号：US16060171

申请日：2016-12-08

Applicant: Curt W. Bradshaw ,  Sukumar Sakamuri ,  Bryan R. Meade ,  Laxman Eltepu ,  Giuseppe Dello Iacono ,  Son Lam ,  Joseph Stock ,  Dingguo Liu ,  Bin Liu ,  Solstice Biologics, Ltd.

Inventor： Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Bryan R. MEADE ,  Laxman ELTEPU ,  Giuseppe Dello IACONO ,  Son LAM ,  Joseph STOCK ,  Dingguo LIU ,  Bin LIU

IPC: C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K47/549 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/65616 ,  C12N2310/311 ,  C12N2310/312 ,  C12N2310/315 ,  C12N2310/351

Abstract: The invention features a hybridized polynucleotide construct including a passenger strand, a guide strand loadable into a RISC complex, and one or more auxiliary moieties. At least one of the auxiliary moieties is non-bioreversibly linked to an internucleoside phosphate or phosphorothioate in the passenger strand. The invention further features methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell. The methods typically involve contacting the cell with the hybridized polynucleotide construct.

公开(公告)号：US20170114341A1

公开(公告)日：2017-04-27

申请号：US15315608

申请日：2015-06-08

Applicant: Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Laxman ELTEPU ,  Son LAM ,  Dingguo LIU ,  Bryan MEADE ,  Giuseppe Dello IACONO ,  Joseph STOCK ,  Bin LIU ,  Solstice Biologics, Ltd.

Inventor： Curt W. BRADSHAW ,  Sukumar SAKAMURI ,  Laxman ELTEPU ,  Son LAM ,  Dingguo LIU ,  Bryan MEADE ,  Giuseppe Dello IACONO ,  Joseph STOCK ,  Bin LIU

IPC: C12N15/113 ,  C07H19/20 ,  C07H21/02 ,  C07H19/10 ,  C12N15/85 ,  C07H21/04

CPC classification number: C12N15/113 ,  C07H19/10 ,  C07H19/20 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N2310/14 ,  C12N2310/31 ,  C12N2310/32 ,  C12N2310/346 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2330/30

Abstract: The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.