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    SYSTEMS AND METHODS FOR GENERATING DATA USING ONE OR MORE ENDOSCOPIC MICROSCOPY TECHNIQUES
    1.
    发明申请
    SYSTEMS AND METHODS FOR GENERATING DATA USING ONE OR MORE ENDOSCOPIC MICROSCOPY TECHNIQUES 审中-公开
    使用一种或多种内窥镜显微技术产生数据的系统和方法

    公开(公告)号：US20070238955A1

    公开(公告)日：2007-10-11

    申请号：US11622854

    申请日：2007-01-12

    申请人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma ,  Wang-Yuhl Oh

    发明人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma ,  Wang-Yuhl Oh

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0066 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/06 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/0205 ,  G01B9/02057 ,  G01B9/02079 ,  G01B9/02091 ,  G01N21/4795 ,  G02B23/2446

    摘要： Exemplary systems and methods for imaging at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to receive at least one first electro-magnetic radiation from the sample and at least one second electro-magnetic radiation from a reference using at least one arrangement. Such arrangement and the reference can be provided in an endoscope enclosure. The image data associated with the portion can be generated as a function of the first and second electro-magnetic radiations. In another exemplary embodiment, an endoscope arrangement can be provided for imaging such portion of the sample. The endoscope arrangement can include at least one interferometric arrangement configured to receive at least one electro-magnetic radiation from the sample, and situated within and at one end of an endoscope enclosure of the endoscope arrangement. According to yet another exemplary embodiment, at least one first Linnik interferometric arrangement at least one second fiber arrangement being in optical communication with the at least one first arrangement can be provided. The second arrangement can be configured to transmit an electro-magnetic radiation to the first arrangement. The first arrangement can be configured to receive an additional electro-magnetic radiation from the sample which can be associated with the first electro-magnetic radiation. The first arrangement can be configured to forward at least one third electro-magnetic radiation which is associated with the at least one second electro-magnetic radiation to the at least one second arrangement.

    摘要翻译： 可以提供用于对样品的至少一部分进行成像的示例性系统和方法。 例如，根据这样的系统和方法的一个示例性实施例，可以使用至少一种布置从样品和来自参考的至少一个第二电磁辐射接收至少一个第一电磁辐射。 这种布置和参考可以设置在内窥镜外壳中。 与该部分相关联的图像数据可以作为第一和第二电磁辐射的函数产生。 在另一个示例性实施例中，可以提供内窥镜装置用于对样品的这样的部分进行成像。 所述内窥镜装置可以包括至少一个干涉装置，其被配置为从所述样品接收至少一个电磁辐射，并且位于所述内窥镜装置的内窥镜罩的内部和一端。 根据另一示例性实施例，可以提供至少一个第一Linnik干涉布置，至少一个第二光纤布置与所述至少一个第一布置光学通信。 第二布置可以被配置为将电磁辐射传输到第一布置。 第一布置可以被配置为从样品接收可以与第一电磁辐射相关联的附加电磁辐射。 第一布置可以被配置为将与至少一个第二电磁辐射相关联的至少一个第三电磁辐射转发到至少一个第二布置。

    Spectrally-encoded endoscopy techniques, apparatus and methods
    2.
    发明授权
    Spectrally-encoded endoscopy techniques, apparatus and methods 有权
    光谱编码的内窥镜检查技术，仪器和方法

    公开(公告)号：US08818149B2

    公开(公告)日：2014-08-26

    申请号：US13427463

    申请日：2012-03-22

    申请人： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

    发明人： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

    IPC分类号： G02B6/32 ,  G02B6/34 ,  G02B6/06

    CPC分类号： G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

    摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can include a ball lens, and be configured to focus and provide there through the first electro-magnetic radiation to generate the focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first electro-magnetic radiation(s) and/or the focused electro-magnetic radiation), and forward a dispersed radiation thereof to at least one section of the structure.

    摘要翻译： 可以提供用于获得结构信息的示例性装置。 例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。 示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。 第二布置可以包括球形透镜，并且被配置成通过第一电磁辐射聚焦并提供在其上，以产生聚焦的电磁辐射。 此外，示例性装置可以包括至少一个能够接收特定辐射（例如，第一电磁辐射和/或聚焦电磁辐射）的分散第三装置，并且将其分散的辐射 到结构的至少一个部分。

    SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING
    7.
    发明申请
    SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING 有权
    通过路径长度编码角度化合物进行光学相干光谱中的光谱减少

    公开(公告)号：US20100157309A1

    公开(公告)日：2010-06-24

    申请号：US12510047

    申请日：2009-07-27

    申请人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma

    发明人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma

    IPC分类号： G01B9/02 ,  G06K9/00

    CPC分类号： A61B5/0066 ,  A61B5/0059 ,  A61B5/6852 ,  G01B9/02028 ,  G01B9/02082 ,  G01B9/02087 ,  G01B9/02091 ,  G01J9/0215 ,  G01N21/4795 ,  G02B26/105 ,  G02B27/48

    摘要： Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

    摘要翻译： 斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。 本发明的示例性实施例可以有助于通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。 通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。 从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。 因此，可以提供用于照射结构的装置探针导管和方法的示例性实施例。 具体地，干涉仪可以转发电磁辐射。 此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射结构的装置。 这种示例性布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

    Speckle reduction in optical coherence tomography by path length encoded angular compounding
    8.
    发明授权
    Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
    光学相干断层扫描中的斑点减少通过路径长度编码角复合

    公开(公告)号：US07567349B2

    公开(公告)日：2009-07-28

    申请号：US10551735

    申请日：2004-03-31

    申请人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma

    发明人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma

    IPC分类号： G01B9/02

    CPC分类号： A61B5/0066 ,  A61B5/0059 ,  A61B5/6852 ,  G01B9/02028 ,  G01B9/02082 ,  G01B9/02087 ,  G01B9/02091 ,  G01J9/0215 ,  G01N21/4795 ,  G02B26/105 ,  G02B27/48

    摘要： Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

    摘要翻译： 斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。 本发明的示例性实施例可以有助于通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。 通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。 从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。 因此，可以提供用于照射样品的装置探针导管和方法的示例性实施例。 具体地，干涉仪可以转发电磁辐射。 此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射样品的装置。 这种示例性布置可以被配置为相对于至少两个辐射的第二辐射延迟至少两个辐射的第一辐射。

    Method and apparatus for three-dimensional spectrally encoded imaging
    10.
    发明授权
    Method and apparatus for three-dimensional spectrally encoded imaging 有权
    用于三维光谱编码成像的方法和装置

    公开(公告)号：US07551293B2

    公开(公告)日：2009-06-23

    申请号：US10997789

    申请日：2004-11-24

    申请人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

    发明人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

    IPC分类号： G01J3/45 ,  G01B9/02 ,  G01B11/02

    CPC分类号： G01B11/2441 ,  A61B1/042 ,  A61B5/1077 ,  G01B9/02027 ,  G01B9/02044 ,  G01B11/2509

    摘要： A method and apparatus for providing information associated with at least one portion of a sample can be provided. For example, at least one wavelength of electro-magnetic radiation provided on a sample can be encoded to determine at least one transverse location of the portion. A relative phase between at least one first electro-magnetic radiation electro-magnetic radiation being returned from a sample and at least one second electro-magnetic radiation returned from a reference can be obtained to determine at least one relative depth location of the portion. Further, the information of the portion can be provided based on the transverse location and the relative depth location. For example, the information can be depth information and/or three-dimensional information associated with the portion of the sample.

    摘要翻译： 可以提供用于提供与样本的至少一部分相关联的信息的方法和装置。 例如，可以对提供在样品上的至少一个电磁辐射波长进行编码，以确定该部分的至少一个横向位置。 可以获得从样品返回的至少一个第一电磁辐射电磁辐射与从参考物返回的至少一个第二电磁辐射之间的相对相位，以确定该部分的至少一个相对深度位置。 此外，可以基于横向位置和相对深度位置来提供该部分的信息。 例如，信息可以是与样本部分相关联的深度信息和/或三维信息。