公开(公告)号：US20080234567A1

公开(公告)日：2008-09-25

申请号：US12051315

申请日：2008-03-19

申请人： Guillermo J. Tearney ,  George Velmahos ,  Brett E. Bouma ,  Benjamin J. Vakoc

发明人： Guillermo J. Tearney ,  George Velmahos ,  Brett E. Bouma ,  Benjamin J. Vakoc

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0066 ,  A61B5/0095 ,  A61B5/416

摘要： Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.

摘要翻译： 可以提供示例性的装置和过程来确定解剖结构的至少一个特征。 例如，可以使用光声布置在解剖结构中产生声波。然后可以检测声波并确定至少一个血液池是否存在于解剖结构中或解剖结构中，作为 声波的至少一个属性。 此外，可以将至少一个第一电磁辐射转发到解剖结构的至少一个组织，基于在所述至少一个组织的运动或内部检测从所述至少一个组织提供的至少一个第二电磁辐射 至少一个组织以产生检测数据，并且基于检测数据确定至少一个部分的至少一个特性。

公开(公告)号：US20110222563A1

公开(公告)日：2011-09-15

申请号：US13112720

申请日：2011-05-20

申请人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

发明人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

IPC分类号： H01S3/10

CPC分类号： H01S3/08063 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/06 ,  G01J3/10 ,  G02B26/002 ,  G02B26/04 ,  H01S3/08 ,  H01S3/08009 ,  H01S3/0805 ,  H01S3/10046 ,  H01S3/105 ,  H01S3/106

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US20090036782A1

公开(公告)日：2009-02-05

申请号：US12183630

申请日：2008-07-31

申请人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： A61B5/00

CPC分类号： A61B5/0261 ,  A61B5/0066 ,  A61B5/0073

摘要： An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points.

摘要翻译： 可以提供示例性的装置和/或示例性方法，其可以（例如，利用至少一个第一布置）来测量从特定部分提供的至少一个电磁辐射的幅度和/或相位 样品。 此外，可以（例如，使用至少一个第二布置）沿着从样品的第一点到样品的第二点的路径扫描特定部分的位置。 此外，可以控制扫描（例如，利用第二布置），使得扫描可以包括具有正速度的至少一个第一段和至少一个具有负速度的段。 第一段和/或第二段的第一距离可以小于第一和第二点之间的第二距离。

公开(公告)号：US09375158B2

公开(公告)日：2016-06-28

申请号：US12183630

申请日：2008-07-31

申请人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： A61B5/05 ,  A61B5/026 ,  A61B5/00

CPC分类号： A61B5/0261 ,  A61B5/0066 ,  A61B5/0073

摘要： An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points.

摘要翻译： 可以提供示例性的装置和/或示例性方法，其可以（例如，利用至少一个第一布置）来测量从特定部分提供的至少一个电磁辐射的幅度和/或相位 样品。 此外，可以（例如，使用至少一个第二布置）沿着从样品的第一点到样品的第二点的路径扫描特定部分的位置。 此外，可以控制扫描（例如，利用第二布置），使得扫描可以包括具有正速度的至少一个第一段和至少一个具有负速度的段。 第一段和/或第二段的第一距离可以小于第一和第二点之间的第二距离。

公开(公告)号：US08937724B2

公开(公告)日：2015-01-20

申请号：US12635435

申请日：2009-12-10

申请人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： G01B11/02 ,  A61B5/00

CPC分类号： A61B5/6852 ,  A61B5/0066

摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

摘要翻译： 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样品，以便使得至少一个第二辐射从可以基于该样品的样品提供 第一次辐射。 另外，使用至少一个第二布置，可以从样品接收第二辐射，基于第二辐射产生关于样品的至少一部分的多个不同的测量结果， 并且通过与不同测量相关联的多个连续可分辨深度点来表征部分。 此外，可以在多个不同的测量值的多个深度点上解析和明确地表征至少一个部分的表征。

公开(公告)号：US20100254415A1

公开(公告)日：2010-10-07

申请号：US12700552

申请日：2010-02-04

申请人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： H01S3/10 ,  G21G4/00

CPC分类号： H01S3/08009 ,  G01J3/10 ,  H01S3/08013 ,  H01S3/08059 ,  H01S3/0813 ,  H01S3/083 ,  H01S3/105 ,  H01S5/005 ,  H01S5/06216 ,  H01S5/141

摘要： Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

摘要翻译： 可以提供用于例如提供高速波长调谐的装置，源装置和方法的示例性实施例。 根据一个示例性实施例，可以提供至少一种布置，其被配置为发射电磁辐射，其中（i）具有平均频率以大于每毫秒大约6000（或2000）太赫兹的绝对速率变化的频谱， （ii）其平均频率在大于约10太赫兹的范围内变化，和/或（iii）具有小于约15千兆赫兹的瞬时线宽。 根据另一示例性实施例，可以提供至少一种布置，其被配置为周期性地和作为时间的函数，基于所述至少一个第一电磁辐射的平均频率选择至少一个第一电磁辐射， 在第一特征周期执行周期性选择。 平均频率可以随时间线性变化，其中该装置可以发射至少一个第二电磁辐射，其具有在第二特征周期内平均频率作为时间的函数周期性地改变的频谱。 此外，第一特征周期可以大于第二特征周期。

公开(公告)号：US20080175280A1

公开(公告)日：2008-07-24

申请号：US12015642

申请日：2008-01-17

申请人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

发明人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

IPC分类号： H01S3/10

CPC分类号： H01S3/08063 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/06 ,  G01J3/10 ,  G02B26/002 ,  G02B26/04 ,  H01S3/08 ,  H01S3/08009 ,  H01S3/0805 ,  H01S3/10046 ,  H01S3/105 ,  H01S3/106

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US08289522B2

公开(公告)日：2012-10-16

申请号：US12943762

申请日：2010-11-10

申请人： Guillermo J. Tearney ,  Dvir Yelin ,  Benjamin J. Vakoc ,  Wang-Yuhl Oh ,  Brett E. Bouma

发明人： Guillermo J. Tearney ,  Dvir Yelin ,  Benjamin J. Vakoc ,  Wang-Yuhl Oh ,  Brett E. Bouma

IPC分类号： G01B9/02

CPC分类号： G01N33/4833 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6852 ,  G01B9/02 ,  G01B9/02027 ,  G01B9/02049 ,  G01B9/02064 ,  G01B9/02087 ,  G01B9/02091 ,  G01B9/04 ,  G01N21/25 ,  G01N21/27 ,  G01N21/4795 ,  G01N21/6458 ,  G01N21/6486 ,  G01N23/046 ,  G01N2021/1765 ,  G01N2223/419 ,  G02B21/0028 ,  G02B23/2423 ,  G02B23/243 ,  G02B23/2461 ,  G02B23/2476

摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.

摘要翻译： 可以提供根据本发明的示例性实施例的方法和装置。 例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于 第二种模式与第一种模式不同。 可以接收与参考相关联的第三数据。 可以基于第一，第二和第三数据生成进一步的数据。 此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。 第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。 此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

公开(公告)号：US07949019B2

公开(公告)日：2011-05-24

申请号：US12015642

申请日：2008-01-17

申请人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

发明人： Brett E. Bouma ,  Seok-Yun Yun ,  Wang-Yuhl Oh ,  Benjamin J. Vakoc ,  Guillermo J. Tearney

IPC分类号： H01S5/14

CPC分类号： H01S3/08063 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/06 ,  G01J3/10 ,  G02B26/002 ,  G02B26/04 ,  H01S3/08 ,  H01S3/08009 ,  H01S3/0805 ,  H01S3/10046 ,  H01S3/105 ,  H01S3/106

摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

摘要翻译： 可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。 设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。 此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

公开(公告)号：US20100150422A1

公开(公告)日：2010-06-17

申请号：US12635435

申请日：2009-12-10

申请人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

发明人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

IPC分类号： G06K9/00

CPC分类号： A61B5/6852 ,  A61B5/0066

摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

摘要翻译： 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样品，以便使得至少一个第二辐射从可以基于该样品的样品提供 第一次辐射。 另外，使用至少一个第二布置，可以从样品接收第二辐射，基于第二辐射产生关于样品的至少一部分的多个不同的测量结果， 并且通过与不同测量相关联的多个连续可分辨深度点来表征部分。 此外，可以在多个不同的测量值的多个深度点上解析和明确地表征至少一个部分的表征。