Process for the preparation of 1-amino-1-methyl-3(4)-aminomethyl
cyclohexane
    5.
    发明授权
    Process for the preparation of 1-amino-1-methyl-3(4)-aminomethyl cyclohexane 失效
    1-氨基-1-甲基-3(4) - 氨基甲基环己烷的制备方法

    公开(公告)号:US5900507A

    公开(公告)日:1999-05-04

    申请号:US38331

    申请日:1998-03-11

    摘要: The present invention relates to a process for the preparation of 1-amino-1-methyl-3(4)-aminomethyl cyclohexane (AMCA) bya) catalytically hydrogenating 1-formamido-1-methyl-3(4)-cyano cyclohexane (FMC) in a first reaction stage to form 1-formamido-1-methyl-3(4)-aminomethyl cyclohexane (FMA), 1-amino-1-methyl-3(4)-formamidomethyl cyclohexane (AMF), 1-formamido-1-methyl-3(4)-formamidomethyl cyclohexane (FMF) and/or AMCA, andb) reacting FMA, AMF and/or FMF in a second reaction stage with an alkaline compound to from AMCA and a formic acid derivative, andc) separating the reaction mixture obtained in step b) into components by fractional distillation and/or by crystallization and filtration.The present invention is also relates to carrying the hydrogenation reaction of step a) in the presence of a formulating agent to form 1-formamido-1-methyl-3(4)-formamidomethyl cyclohexane (FMF).Finally, the present invention relates to the intermediate products 1-formamido-1-methyl-3(4)-aminomethyl cyclohexane (FMA) and 1-formamido-1-methyl-3(4)-formamidomethyl cyclohexane (FMF).

    摘要翻译: 本发明涉及通过以下方法制备1-氨基-1-甲基-3(4) - 氨基甲基环己烷(AMCA)的方法:a)催化氢化1-甲酰氨基-1-甲基-3(4) - 氰基环己烷 FMA),1-氨基-1-甲基-3(4) - 氨基甲基环己烷(FMA),1-氨基-1-甲基-3(4) - 甲酰胺基甲基环己烷(AMF),1-甲酰胺 使甲基-3(4) - 甲酰胺基甲基环己烷(FMF)和/或AMCA,和b)使第二反应阶段中的FMA,AMF和/或FMF与碱性化合物与AMCA和甲酸衍生物反应,以及 c)通过分步和/或通过结晶和过滤将步骤b)中获得的反应混合物分离成组分。 本发明还涉及在配制剂的存在下进行步骤a)的氢化反应以形成1-甲酰氨基-1-甲基-3(4) - 甲酰胺基甲基环己烷(FMF)。 最后,本发明涉及中间产物1-甲酰氨基-1-甲基-3(4) - 氨基甲基环己烷(FMA)和1-甲酰氨基-1-甲基-3(4) - 甲酰胺基甲基环己烷(FMF)。

    Device and method for examining and/or treating and eye
    6.
    发明授权
    Device and method for examining and/or treating and eye 有权
    用于检查和/或治疗和眼睛的装置和方法

    公开(公告)号:US07357504B2

    公开(公告)日:2008-04-15

    申请号:US10416854

    申请日:2001-11-15

    IPC分类号: A61B3/00

    摘要: A device for examining/treating an eye has a base body and an attachment body, which can be combined and applied to the eye. A gel-type liquid is introduced between the two bodies so that the indices can be matched. The interior of the attachment body is provided with a large number of protuberances, ensuring a minimum distance is maintained between the two bodies, allowing air or excess liquid to escape between the two bodies to escape. Only the attachment body, a disposable item producible from cheap materials, needs to be sterilized and a single sterilization is integrated into the production process. The base only needs to be disinfected. This division of the device also allows a large number of base bodies with different configurations to be used with one single attachment body or a large number of attachment bodies with different configurations to be used with one single base body.

    摘要翻译: 用于检查/治疗眼睛的装置具有可以组合并施加到眼睛的基体和附着体。 在两个物体之间引入凝胶型液体,使得指数可以匹配。 连接体的内部设置有大量的突起,确保两个物体之间保持最小的距离,允许空气或多余的液体在两个物体之间逃逸。 只有附属体,即廉价材料可生产的一次性物品需要进行灭菌,并将单次灭菌整合到生产过程中。 基地只需要消毒。 该装置的划分还允许具有不同构造的大量基体与单个附接体或具有不同构造的大量附接体一起用于单个基体。

    Process for the production of
1-amino-1-methyl-3(4)-aminomethylcyclohexane
    7.
    发明授权
    Process for the production of 1-amino-1-methyl-3(4)-aminomethylcyclohexane 失效
    1-氨基-1-甲基-3(4) - 氨基甲基环己烷的制备方法

    公开(公告)号:US5905170A

    公开(公告)日:1999-05-18

    申请号:US38636

    申请日:1998-03-11

    摘要: The present invention relates to a process for the production of 1-amino-1-methyl-3(4)-aminomethylcyclohexane bya) simultaneously reacting 4(5)-aminomethyl-1-methylcyclohexene (CMA), hydrocyanic acid and aqueous sulphuric acid at temperatures of 60.degree. C. to 120.degree. C., preferably 80.degree. C. to 120.degree. C. to form 1-formamido-1-methyl-3(4)-aminomethylcyclohexane (FMA) in a first stage,b) adding water and hydrolyzing 1-formamido-1-methyl-3 (4)-aminomethylcyclohexane (FMA) and unreacted hydrocyanic acid in a second stage andc) adding a base and isolating 1-amino-1-methyl-3 (4)-aminomethylcyclohexane (AMCA) by extraction from the reaction mixture obtained in the second stage of the reaction, optionally after removing of formic acid.

    摘要翻译: 本发明涉及通过以下方法生产1-氨基-1-甲基-3(4) - 氨基甲基环己烷的方法:a)同时使4(5) - 氨基甲基-1-甲基环己烯(CMA),氢氰酸和硫酸水溶液 在60℃至120℃,优选80℃至120℃的温度下,在第一阶段中形成1-甲酰胺基-1-甲基-3(4) - 氨基甲基环己烷(FMA),b)加入 水并在第二阶段水解1-甲酰氨基-1-甲基-3(4) - 氨基甲基环己烷(FMA)和未反应的氢氰酸,和c)加入碱并分离1-氨基-1-甲基-3(4) - 氨基甲基环己烷 (AMCA),通过从反应第二阶段获得的反应混合物中提取,任选地在除去甲酸之后。