公开(公告)号：US10229821B2

公开(公告)日：2019-03-12

申请号：US15542505

申请日：2016-01-04

Applicant: Hitachi High-Technologies Corporation

Inventor： Kiyomi Yoshinari ,  Yasushi Terui

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/42

Abstract: With regard to an object of the invention, in a tandem type mass spectrometry system including three stages of a QMS, sensitivity of a daughter ion decreases due to loss resulting from destabilization of the daughter ion or a decrease in daughter ion generation rate, and an improvement insensitivity of the daughter ion is a significant issue. To solve the above-mentioned problem, the invention provides a mass spectrometry system having means of decreasing a q value of a parent ion and not decreasing a fundamental vibration frequency of the parent ion. According to the means of the invention, the invention may have effects that a mass number range of a daughter ion that may be stably transmitted is expanded, the number of vibrations of a parent ion is substantially the same as that in a first stage of the QMS, and generation efficiency of the daughter ion does not decrease and can be maintained.

公开(公告)号：US10453663B2

公开(公告)日：2019-10-22

申请号：US16069066

申请日：2016-01-21

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shinichi Murakami ,  Yasushi Terui

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/42

Abstract: An object of the invention is to provide a mass spectrometry device and an ion detection method therefor in which an ion amount can be detected with high accuracy.In order to achieve the object described above, a mass spectrometry device is provided which performs a channel scan measurement by changing a voltage to be applied to a mass separation unit to selectively extract a desired ion. The mass spectrometry device includes: an ion detection unit which detects an ion separated by the mass separation unit and outputs an electric signal; an ion amount measuring unit which measures an ion amount from the output of the ion detection unit; and an ion amount correction unit which corrects a detection amount of ion from an output of the ion amount measuring unit. In a process of a channel scan, the ion amount correction unit performs correction of a detection amount of ion detected in a present channel based on a detection amount of ion in a previous channel.

公开(公告)号：US09921195B2

公开(公告)日：2018-03-20

申请号：US15110028

申请日：2014-12-05

Applicant: Hitachi High-Technologies Corporation

Inventor： Mitsuhiro Umeda ,  Shinji Yoshioka ,  Masaki Yoshie ,  Yasushi Terui

IPC: H01J49/00 ,  G01N30/72 ,  H01J49/06 ,  H01J49/16 ,  H01J49/24

CPC classification number: G01N30/7266 ,  H01J49/06 ,  H01J49/061 ,  H01J49/165 ,  H01J49/24

Abstract: This invention improves the sensitivity of a liquid chromatography-mass spectrometry device by reducing the number of neutral particles that are not ionized during ionization and the number of low-molecular ions from a solvent used in the liquid chromatography. Said liquid chromatography-mass spectrometry device is provided with ion sources, a mass spectrometry unit, a detector, and three electrodes laid out so as to be parallel to each other. The first electrode and the second electrode have openings that allow ions to pass therethrough. The trajectories of said ions are deflected between the second electrode and the third electrode, thereby directing ions generated by the ion sources towards the mass spectrometry unit.

公开(公告)号：US09523663B2

公开(公告)日：2016-12-20

申请号：US14908234

申请日：2014-06-27

Applicant: Hitachi High-Technologies Corporation

Inventor： Yasushi Terui ,  Masaki Yoshie

IPC: H01J49/26 ,  G01N30/72 ,  H01J49/06 ,  H01J49/10

CPC classification number: G01N30/7233 ,  H01J49/0404 ,  H01J49/06 ,  H01J49/10

Abstract: The objective of the present invention is to improve the robustness, sensitivity, and maintainability of a mass spectrometer to which a liquid chromatograph can be connected. This mass spectrometer includes: an ion source; a mass spectrometry unit; a plurality of flat plates used as electrodes having openings through which ions can be introduced to the mass spectrometer from an orthogonal direction along an ion introduction axis; a porous member provided between the mass spectrometry unit and the plurality of flat plates; and a mechanism for feeding gas to the plurality of flat plates for the side opposite from the ion introduction direction; the plurality of flat plates being disposed under atmospheric pressure, and the plurality of electrodes being set at a temperature higher than room temperature.

Abstract translation: 本发明的目的是提高可以连接液相色谱仪的质谱仪的鲁棒性，灵敏度和可维护性。 该质谱仪包括：离子源; 质谱分析单元; 多个平板用作具有开口的电极，离子可以沿着离子引入轴从正交方向引入质谱仪; 设置在所述质谱分析单元与所述多个平板之间的多孔构件; 以及用于将气体供给到与离子引入方向相反的一侧的多个平板的机构; 所述多个平板被设置在大气压下，并且所述多个电极被设定在高于室温的温度。

公开(公告)号：US09418825B2

公开(公告)日：2016-08-16

申请号：US14762916

申请日：2014-01-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki Yasuda ,  Shinya Ito ,  Akira Fujii ,  Yasushi Terui

IPC: H01J49/04 ,  H01J49/16 ,  G01N30/72

CPC classification number: H01J49/0445 ,  G01N30/724 ,  H01J49/165

Abstract: A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part. The device is further characterized in that after removing the bubbles, a Taylor cone is formed from the resultant pre-solution, and the specimen is ionized thereafter. Thus, the ionization of an intended specimen is stabilized, and the measurement reproducibility is improved.

Abstract translation: 质谱仪配备有液体试样供给部件，其供给夹在气泡之间的液体试样，离子源部件将样品离子化，以及检测根据质量分离的离子的质谱部分。 特别地，离子源部构成为包括用于从液体试样供给部输送试样的液体供给管，除去气泡的脱气/液体滞留部，使样本电离的喷射部， - 对喷涂部施加高电压的电压电源部。 该装置的特征还在于，在除去气泡之后，由所得预溶液形成泰勒锥体，然后将样品电离。 因此，期望的样品的电离稳定，并且测量再现性提高。

公开(公告)号：US10607825B2

公开(公告)日：2020-03-31

申请号：US16060132

申请日：2016-11-09

Applicant: Hitachi High-Technologies Corporation

Inventor： Kiyomi Yoshinari ,  Yasushi Terui

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42

Abstract: Acceleration of decelerated ions and a reduction in the velocity dispersion width of decelerated ions are both achieved, whereby the sensitivity of detected ion sensitivity is improved and resolution is improved. The distance dx between at least one set of facing rod-shaped electrodes among rod-shaped electrodes (4-2-a) to (4-2-d) differs at the inlet part at which ions enter and the outlet part at which ions exit, and the distance dx between the at least one set of facing rod-shaped electrodes is gradually reduced or increased from the inlet part toward the outlet part.

公开(公告)号：US10068756B2

公开(公告)日：2018-09-04

申请号：US15318858

申请日：2015-05-11

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kiyomi Yoshinari ,  Yasushi Terui

IPC: H01J49/06 ,  H01J49/10 ,  H01J49/42

Abstract: The objective of the presently disclosed subject matter is to provide a mass spectrometer that improves the ionic permeability ratio at the entrance to an ion transport part or the entrance to a mass spectrometry part, and to acquire a high-sensitivity mass spectrum. To reduce the electric-field distortion that is caused by ion loss, electrodes are arranged so that the radius of a circle inscribed within the electrodes of the ion transport part is larger than the radius of a circle inscribed within the electrodes of the mass spectrometry part. The entrance to the electrodes of the mass spectrometry part also can have a tapered, inclined, folded-over, or rounded configuration. Together, these reduce the sharply fluctuating (peak-shaped) distribution of electric potential generated near the entrance to the ion transport part and the entrance to the mass spectrometry part.

公开(公告)号：US20170125230A1

公开(公告)日：2017-05-04

申请号：US15318858

申请日：2015-05-11

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kiyomi Yoshinari ,  Yasushi Terui

IPC: H01J49/06 ,  H01J49/42 ,  H01J49/10

CPC classification number: H01J49/063 ,  H01J49/065 ,  H01J49/10 ,  H01J49/42 ,  H01J49/4215 ,  H01J49/4255

Abstract: The objective of the presently disclosed subject matter is to provide a mass spectrometer that improves the ionic permeability ratio at the entrance to an ion transport part or the entrance to a mass spectrometry part, and to acquire a high-sensitivity mass spectrum. To reduce the electric-field distortion that is caused by ion loss, electrodes are arranged so that the radius of a circle inscribed within the electrodes of the ion transport part is larger than the radius of a circle inscribed within the electrodes of the mass spectrometry part. The entrance to the electrodes of the mass spectrometry part also can have a tapered, inclined, folded-over, or rounded configuration. Together, these reduce the sharply fluctuating (peak-shaped) distribution of electric potential generated near the entrance to the ion transport part and the entrance to the mass spectrometry part.

公开(公告)号：US10332736B2

公开(公告)日：2019-06-25

申请号：US14773902

申请日：2014-01-24

Applicant: Hitachi High-Technologies Corporation

Inventor： Kiyomi Yoshinari ,  Yasushi Terui

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/42

Abstract: An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage U, an amplitude V of a radio-frequency voltage, and a frequency F of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger. By controlling in this manner, the ion frequency when the ion passes through the inside of the mass spectrometry unit 4 is increased as the mass number of an ion becomes higher, and therefore, it is possible to obtain the mass spectrum with higher resolution.