公开(公告)号：US4745067A

公开(公告)日：1988-05-17

申请号：US857941

申请日：1986-04-29

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Toshiharu Nagatsu ,  Masa Hamada ,  Shuichi Iwadare ,  Ikuo Matsumoto ,  Hajime Morishima

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Toshiharu Nagatsu ,  Masa Hamada ,  Shuichi Iwadare ,  Ikuo Matsumoto ,  Hajime Morishima

IPC分类号： C12N9/80 ,  C12P13/04 ,  C12P41/00 ,  C12R1/04 ,  C12R1/53 ,  C07B19/02 ,  C12P13/00 ,  C12R1/465 ,  C12R1/52 ,  C12R1/625

CPC分类号： C12N9/80 ,  C12P13/04 ,  C12P41/007 ,  Y10S435/826 ,  Y10S435/886 ,  Y10S435/893 ,  Y10S435/908

摘要： L-aminoacylases S.sub.1 and S.sub.2 derived from actinomycetes and having physicochemical characteristics such that it is a L-aminoacylase which acts on a N-acyl-L-amino acid to give a L-amino acid, its substrate profile is wide, and it acts not only on a N-acyl derivative of a natural L-amino acid, but also on a N-acyl derivative of a synthetic L-amino acid, while it does not act on a N-acyl-D-amino acid, a DL-N-acetyl-.alpha.methylbenzylamine and a N-acetyl-D-glucosamine, etc.

摘要翻译： 来自放线菌的L-氨基酰基酶S1和S2具有物理化学特性，使得它是作用于N-酰基-L-氨基酸产生L-氨基酸的L-氨基酸酰基酶，其底物轮廓宽，并且其作用 不仅在天然L-氨基酸的N-酰基衍生物上，而且在合成的L-氨基酸的N-酰基衍生物上，而不作用于N-酰基-D-氨基酸，DL -N-乙酰基-α甲基苄胺和N-乙酰基-D-葡糖胺等

公开(公告)号：US4699879A

公开(公告)日：1987-10-13

申请号：US668148

申请日：1984-11-05

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Toshiharu Nagatsu ,  Masa Hamada ,  Shuichi Iwadare ,  Ikuo Matsumoto ,  Hajime Morishima

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Toshiharu Nagatsu ,  Masa Hamada ,  Shuichi Iwadare ,  Ikuo Matsumoto ,  Hajime Morishima

IPC分类号： C12P13/04 ,  C12P41/00 ,  C12R1/04 ,  C12R1/465 ,  C12R1/625 ,  C12P13/06

CPC分类号： C12P13/04 ,  C12P41/007 ,  Y10S435/826 ,  Y10S435/886 ,  Y10S435/908

摘要： N-acyl-DL-3-(3,4-dihydroxyphenyl)serine or a catecholic hydroxyl-protected derivative thereof is stereospecifically de-acylated by reaction with a microorganism of the genus Streptomyces or Streptoverticillium having an acylase or with an extract of said microorganism containing said acylase, to produce L-3-(3,4-dihydroxyphenyl)serine or the hydroxyl-protected derivative thereof, with the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound remaining unaltered. The L-3-(3,4-dihydroxyphenyl)serine compound so produced can be separated from the N-acyl-D-3-(3,4-dihydroxyphenyl)serine compound owing to the difference in the properties of them.

摘要翻译： 通过与具有酰基转移酶的链霉菌属或链霉菌属的微生物或与所述微生物的提取物反应，N-酰基-DL-3-（3,4-二羟基苯基）丝氨酸或其儿茶酚羟基保护的衍生物被立体特异性去酰化 含有所述酰基转移酶以产生不改变N-酰基-D-3-（3,4-二羟基苯基）丝氨酸化合物的L-3-（3,4-二羟基苯基）丝氨酸或其羟基保护的衍生物。 由于它们的性质不同，所以可以将如此制备的L-3-（3,4-二羟基苯基）丝氨酸化合物与N-酰基-D-3-（3,4-二羟基苯基）丝氨酸化合物分离。

公开(公告)号：US4049497A

公开(公告)日：1977-09-20

申请号：US747470

申请日：1976-12-06

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Masaaki Ishizuka ,  Hiroshi Naganawa

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Masaaki Ishizuka ,  Hiroshi Naganawa

IPC分类号： C07G11/00

CPC分类号： A61K36/06 ,  C07G11/00 ,  Y10S435/886

摘要： There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).

摘要翻译： 已经公开了两种以前称为MC916-A和MC916-B的新抗生素，现在称为新西霉素A和新霉素B，其是白血病细胞生长的有效抑制剂，例如。 白血病L-1210细胞在小鼠中。 它们通过Frep-P 2452链霉菌（A.T.C.C. 31123）的对照发酵生产。

公开(公告)号：US3988315A

公开(公告)日：1976-10-26

申请号：US596682

申请日：1975-07-16

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Akira Takamatsu ,  Toshikazu Oki

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Akira Takamatsu ,  Toshikazu Oki

IPC分类号： C07H15/252 ,  C12P1/06 ,  C12P19/56 ,  C07H17/08

CPC分类号： C07H15/252 ,  Y10S435/886

摘要： New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as leukemia L1210 and P388 and lymphoma 6C3HED in mice and hepatomas in rats are produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces galilaeus (MA144-M1 and A.T.C.C. 31133); they are recovered from the broth by conventional methods for recovering antibiotics.

摘要翻译： 新型抗肿瘤剂名为阿沙利霉素A和B，它们是蒽环类苷并抑制各种微生物的生长，例如金黄色葡萄球菌，黄曲霉，牛磺酸棒状杆菌，并抑制小鼠和肝癌中白血病L1210和P388和淋巴瘤6C3HED等动物肿瘤的生长 在大鼠中通过发酵属于链霉菌属（Streptomyces）的微生物来产生，其被命名为马链霉菌（Streptomyces galilaeus）（MA144-M1和ATCC 31133）; 它们通过用于回收抗生素的常规方法从肉汤中回收。

公开(公告)号：US3973608A

公开(公告)日：1976-08-10

申请号：US578709

申请日：1975-05-19

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Hideo Chimura ,  Tsutomu Sawa ,  Masa Hamada

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Hideo Chimura ,  Tsutomu Sawa ,  Masa Hamada

IPC分类号： C07D311/38 ,  C12D9/00

CPC分类号： C07D311/38 ,  Y10S435/803 ,  Y10S435/826

摘要： This invention relates to the novel compounds 3',5,7-trihydroxy-4',6-dimethoxy-isoflavone, 3',5,7-trihydroxy-4',8-dimethoxy-isoflavone and 3',7-dihydroxy-4',6,8-trimethoxy-isoflavone which are powerful inhibitors of catechol-O-methyl transferase (COMT) and to their production by fermentation of Actinomyces roseolus.

摘要翻译： 本发明涉及新化合物3'，5,7-三羟基-4'，6-二甲氧基异黄酮，3'，5,7-三羟基-4'，8-二甲氧基异黄酮和3'，7-二羟基-4' 4'，6,8-三甲氧基异黄酮，它们是儿茶酚-O-甲基转移酶（COMT）的强大抑制剂，以及它们通过玫瑰红放线菌发酵的产生。

公开(公告)号：US4742155A

公开(公告)日：1988-05-03

申请号：US801809

申请日：1985-11-26

申请人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Yasuhiko Muraoka ,  Takaaki Nishikiori

发明人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Yasuhiko Muraoka ,  Takaaki Nishikiori

IPC分类号： C12P21/04 ,  A61K35/74 ,  A61K38/00 ,  A61P37/06 ,  A61P37/08 ,  C07K7/06 ,  C07K7/64 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12N9/99 ,  C12P21/02 ,  C12R1/085 ,  C07K5/12

CPC分类号： C07K7/06 ,  C12R1/085 ,  A61K38/00 ,  Y10S930/27

摘要： Plipastatin represented by the general formula ##STR1## wherein R.sub.1 is --C.sub.13 H.sub.27 or --C.sub.14 H.sub.29 ; and R.sub.2 is Ala or Val, or salts thereof, which is prepared by culturing a Plipastatin-producing strain belonging to the genus Bacillus to produce and accumulate Plipastatin in a cultured broth and then isolating Plipastatin from the cultured broth. Plipastatin exhibits an enzyme inhibiting activity against phospholipase A.sub.2, C and D and which will be useful as an immunosuppressive agent or as a type I anti-allergic agent.

摘要翻译： 由通式 + TR 表示的普伐他汀，其中R1为-C13H27或-C14H29; R2是Ala或Val或其盐，其通过培养属于芽孢杆菌属的Plipastatin产生菌株在培养的肉汤中产生并积累Plipastatin，然后从培养的肉汤中分离Plipastatin来制备。 Plipastatin对磷脂酶A2，C和D具有酶抑制活性，可用作免疫抑制剂或I型抗过敏剂。

公开(公告)号：US4052449A

公开(公告)日：1977-10-04

申请号：US690457

申请日：1976-05-27

申请人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Yoshiro Okami

发明人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Yoshiro Okami

IPC分类号： C12P13/04 ,  C12P21/02 ,  C07C101/72

CPC分类号： C12P13/04 ,  C12P21/02

摘要： This invention provides a new chemical named bestatin which inhibits aminopeptidase B, leucine aminopeptidase and bleomycin hydrolase, enhances the antitumor effect of bleomycin, has the chemical name [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine and has the following structure: ##STR1## and also provides a process for the production thereof which comprises cultivating a strain of streptomyces which produces bestatin in a nutrient medium under aerobic conditions until substantial activity inhibitory to aminopeptidase B is imparted to said cultured medium and then recovering said bestatin from said cultured medium. A preferred strain is Streptomyces olivoreticuli FERM-P No. 2590 (A.T.C.C. 31159).

公开(公告)号：US4550159A

公开(公告)日：1985-10-29

申请号：US545137

申请日：1983-10-25

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Takeshi Uchida ,  Masaya Imoto

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Takeshi Uchida ,  Masaya Imoto

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  A61K31/71 ,  C07H15/24

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465

摘要： An anthracycline compound, ditrisarubicin, of the formula: ##STR1## wherein R represents one of the following substituents (A), (B), and (C): ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, ditrisarubicin, and then recovering the anthracycline compound, ditrisarubicin, from the cultured medium. This ditrisarubicin, or an acid addition salt of the ditrisarubicin, can be contained as the active ingredient in antitumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.

摘要翻译： 其中R代表以下取代基之一（A），（B）和（C）的蒽环类化合物，二硝基菌素：其中R代表下列取代基之一：（A） C）是通过包括在有氧条件下在合适的培养基中培养链霉菌菌株的方法生产的，所述菌株具有生产蒽环类化合物，二硝酸菌素的能力，然后从培养基中回收蒽环类化合物二硝酸菌素。 这种二硝维菌素或二硝基阿霉素的酸加成盐可以作为活性成分包含在抗肿瘤剂和用于治疗由革兰氏阳性微生物诱导的感染的药物组合物中，从而获得良好的结果。

公开(公告)号：US4495347A

公开(公告)日：1985-01-22

申请号：US439446

申请日：1982-11-05

申请人： Hamao Umezawa ,  Nobuyoshi Shimada ,  Hiroshi Naganawa ,  Tomohisa Takita ,  Masa Hamada ,  Tomio Takeuchi

发明人： Hamao Umezawa ,  Nobuyoshi Shimada ,  Hiroshi Naganawa ,  Tomohisa Takita ,  Masa Hamada ,  Tomio Takeuchi

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07H19/24 ,  C12P19/28 ,  C12P19/40 ,  C12R1/465 ,  C07H17/00

CPC分类号： C12R1/465 ,  C07H19/24 ,  C12P19/28 ,  Y10S435/886 ,  Y10S514/908

摘要： The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.

公开(公告)号：US4420473A

公开(公告)日：1983-12-13

申请号：US296923

申请日：1981-08-27

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Kiyoto Ishii

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Kiyoto Ishii

IPC分类号： C07H17/04 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07G11/00 ,  C12P1/06 ,  C12P19/00 ,  C12P19/60 ,  C12R1/465 ,  A61K35/00

CPC分类号： C12R1/465 ,  C12P1/06

摘要： New antibiotic designated MF266 substance is now obtained from fermentaton of a new microorganism Streptomyces MF266-g4 (desposited under FERM-P 5401 or ATCC 31910). This new substance is useful as antibacterial agent and/or an antitumor agent for the inhibition of experimental animal tumors.

摘要翻译： 现在从新发微生物链霉菌MF266-g4的发酵得到新的指定为MF266物质的抗生素（在FERM-P 5401或ATCC 31910下进行）。 这种新物质可用作抑制实验动物肿瘤的抗菌剂和/或抗肿瘤剂。