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公开(公告)号:US07655010B2
公开(公告)日:2010-02-02
申请号:US10675580
申请日:2003-09-30
申请人: Hassan Serhan , Michael Slivka , Thomas M. DiMauro
发明人: Hassan Serhan , Michael Slivka , Thomas M. DiMauro
IPC分类号: A61B17/60
CPC分类号: A61B17/3468 , A61F2/28 , A61F2/30965 , A61F2/441 , A61F2/4455 , A61F2/447 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30153 , A61F2002/30583 , A61F2002/30772 , A61F2002/4627 , A61F2002/4628 , A61F2210/0004 , A61F2210/0085 , A61F2230/0019 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00353 , A61F2310/00359 , A61F2310/00365
摘要: An intervertebral fusion device includes a body having a proximal portion along a major axis of the body and a distal portion along the major axis, and supporting means at the distal portion. The supporting means supports vertebrae in a distracted position while the vertebrae fuse. At least one of the body and the supporting means has a height distinct from a width, whereby the body or supporting means can distract vertebrae, between which the body or the supporting means has been placed, by rotation of the body or the supporting means about the major axis. A method of fusing vertebrae includes the steps of inserting between two vertebrae an intervertebral fusion device and rotating the body or the supporting means, whereby the vertebrae are supported in a distracted position while the vertebrae fuse.
摘要翻译: 椎间融合装置包括具有沿主体的长轴的近端部分和沿着长轴的远端部分的主体以及远端部分处的支撑装置。 支撑装置支撑脊椎处于分心位置,而椎骨融合。 主体和支撑装置中的至少一个具有与宽度不同的高度,由此主体或支撑装置可以通过主体或支撑装置的旋转来分散已经放置身体或支撑装置的椎骨, 主轴。 融合椎骨的方法包括以下步骤:在两个椎骨之间插入椎间融合装置并旋转身体或支撑装置,由此在椎骨融合的同时椎骨被支撑在分心位置。
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2.Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor 有权
标题翻译: 局部骨内施用骨形成剂和抗吸收剂及其装置公开(公告)号:US08895540B2
公开(公告)日:2014-11-25
申请号:US10723250
申请日:2003-11-26
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas G. Ferro , Vivek N. Shenoy , Alonzo D. Cook , Scott Bruder
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas G. Ferro , Vivek N. Shenoy , Alonzo D. Cook , Scott Bruder
IPC分类号: A01N45/00 , A61K45/06 , A61K33/42 , A61K38/39 , A61K31/565 , A61K39/395 , A61K38/18 , A61K31/566 , A61B17/34 , A61K9/00 , A61M5/145 , A61M5/142 , A61F2/30 , A61F2/28
CPC分类号: A61K33/42 , A61B17/3472 , A61F2002/2817 , A61F2002/30677 , A61K9/0004 , A61K31/565 , A61K31/566 , A61K38/1825 , A61K38/1875 , A61K38/39 , A61K39/395 , A61K45/06 , A61M5/14276 , A61M2005/14513 , A61K2300/00
摘要: This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.
摘要翻译: 本发明涉及局部施用骨形成剂和至少一种抗再吸收剂来治疗骨质疏松症和相关疾病。
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3.Transdiscal administration of anti-TNFα antibodies and growth differentiation factors 有权
标题翻译: 反式TNFα抗体和生长分化因子的经半径给药公开(公告)号:US08877193B2
公开(公告)日:2014-11-04
申请号:US12290998
申请日:2008-11-05
申请人: Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K39/00 , A61K39/395 , A61K38/17
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US08273347B2
公开(公告)日:2012-09-25
申请号:US10714594
申请日:2003-11-14
CPC分类号: A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要: The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译: 本发明涉及将自体未培养的细胞施用于患病的椎间盘。
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5.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US20090175943A1
公开(公告)日:2009-07-09
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K9/10 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US07429378B2
公开(公告)日:2008-09-30
申请号:US10610355
申请日:2003-06-30
申请人: Hassan Serhan , Thomas M. DiMauro , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
发明人: Hassan Serhan , Thomas M. DiMauro , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
IPC分类号: A61K35/00
CPC分类号: A61K38/1841 , A61K35/28 , A61K38/57 , A61K2300/00
摘要: The present invention relates to injecting a high affinity antagonist of MMPs into a diseased intervertebral disc.
摘要翻译: 本发明涉及将MMP的高亲和力拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US20080213261A1
公开(公告)日:2008-09-04
申请号:US11881926
申请日:2007-07-30
申请人: Thomas M. DiMauro , Hassan Serhan , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Thomas M. DiMauro , Hassan Serhan , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K39/395 , A61K35/00 , A61P19/00 , A61K35/12
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
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8.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US08728523B2
公开(公告)日:2014-05-20
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K45/00 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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9.Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权
标题翻译: 将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号:US08361467B2
公开(公告)日:2013-01-29
申请号:US10630227
申请日:2003-07-30
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号: A61K39/395 , A61K39/00 , A61K38/18
CPC分类号: A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译: 本发明涉及向患病关节中透射施用高特异性拮抗剂,所述高特异性拮抗剂选自:i)促炎白细胞介素的抑制剂; ii)TNF-α合成抑制剂; iii)膜结合TNF-α的抑制剂; iv)TNF-α的天然受体的抑制剂; v)NO合酶抑制剂,vi)PLA2酶抑制剂; vii)抗增殖剂; viii)抗氧化剂; ix)选自EPO模拟肽,EPO模拟物,IGF-I,IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂,和x)MMP的抑制剂; 和xi)p38激酶的抑制剂。
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公开(公告)号:US08267883B2
公开(公告)日:2012-09-18
申请号:US12817585
申请日:2010-06-17
申请人: Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
发明人: Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
CPC分类号: A61L31/146 , A61B17/866 , A61F2/30767 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要: An implant comprises a photocatalytic layer on at least one surface and is adapted to act as a sensor. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译: 植入物包括在至少一个表面上的光催化层,并且适于作为传感器。 在一些实施方案中,光催化层是掺杂的半导体氧化物。 根据一些实施例,植入物包括波导。 根据一些实施例,植入物包括光端口。 根据一些实施例,植入物在波导的表面上包括反射材料。 根据一些实施例,植入物包括复合材料,其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。 根据一些实施例,植入物包括适于照射光催化表面的光源。
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