Guanidio derivatives of kasugamycin and their production
    8.
    发明授权
    Guanidio derivatives of kasugamycin and their production 失效
    春日霉素的胍基衍生物及其生产

    公开(公告)号:US3968100A

    公开(公告)日:1976-07-06

    申请号:US220374

    申请日:1972-01-24

    IPC分类号: C07H15/207 C07H15/22

    CPC分类号: C07H15/207

    摘要: New guanidino derivatives of kasugamycin in which the oxalamidino group at the 4-position of kasugamycin molecule has been replaced by different guanidino groups are produced and found to show an improved antibacterial activity against Gram negative bacteria and a decreased toxicity to man and animals, as compared to kasugamycin itself. The new guanidino derivatives of kasugamycin may readily be produced by reacting an amine with an isourea derivative of kasugamycin which has been prepared by reacting sodium hypobromite with kasugamycin and then treating the resulting cyanamide derivative with hydrogen chloride in methanol.

    摘要翻译: 产生春日霉素的新胍基衍生物,其中在春日霉素分子的4位上的草酰脒基被不同的胍基取代,发现其显示出对革兰氏阴性细菌的抗菌活性改善和对人和动物的毒性降低, 到春日霉素本身。 春日霉素的新的胍基衍生物可以容易地通过使胺与异硫氰酸钠与春日霉素反应制备的春日霉素的异脲衍生物反应,然后用氯化氢在甲醇中处理所得的氰胺衍生物来制备。