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    Process for producing a transglutaminase derived from streptomyces
    1.
    发明授权
    Process for producing a transglutaminase derived from streptomyces 失效
    用于产生源自链霉菌的转谷氨酰胺酶的方法

    公开(公告)号：US5252469A

    公开(公告)日：1993-10-12

    申请号：US750160

    申请日：1991-08-26

    申请人： Hiroyasu Andou ,  Akira Matsuura ,  Susumu Hirose

    发明人： Hiroyasu Andou ,  Akira Matsuura ,  Susumu Hirose

    IPC分类号： C12N9/10 ,  C12P21/04 ,  C12R1/465 ,  C12R1/56 ,  C12N9/78

    CPC分类号： C12N9/1044 ,  C12R1/56

    摘要： A process for producing a transglutaminase which comprises (1) culturing a microorganism having the identifying characteristics of a microorganism selected from the group consisting of Streptomyces sp. No. 83, deposited as FERM BP-3505, Streptomyces lavendulae No. 466, deposited as FERM BP-3506, and mutants thereof, wherein the microorganism is capable of producing a transglutaminase, wherein the transglutaminase is an enzyme which catalyzes an acyl transfer reaction of a .gamma.-carboxyamide group of a glutamine residue in a peptide or protein chain in the presence or absence of Ca.sup.++ and wherein the transglutaminase has an isoelectric point of 10 or 6.8, respectively, and is inhibited by Pb ions, and (2) recovering the transglutaminase from the culture obtained is disclosed.

    摘要翻译： 一种转谷氨酰胺酶的制造方法，其特征在于，（1）培养具有选自由链霉菌属（Streptomyces sp。 以作为FERM BP-3506保藏的FERM BP-3505，粟酒链霉菌466和其突变体保藏的第83号，其中微生物能够产生转谷氨酰胺酶，其中转谷氨酰胺酶是催化酰基转移反应的酶 的存在或不存在Ca ++的肽或蛋白质链中的谷氨酰胺残基的γ-羧酰胺基团，其中转谷氨酰胺酶的等电点分别为10或6.8，并被Pb离子抑制，和（2 ）从所获得的培养物中回收转谷氨酰胺酶。

    Vehicle control system and vehicle control apparatus
    3.
    发明申请
    Vehicle control system and vehicle control apparatus 有权

    公开(公告)号：US20070162191A1

    公开(公告)日：2007-07-12

    申请号：US11600160

    申请日：2006-11-16

    申请人： Manabu Matsubara ,  Hirofumi Takasuka ,  Akira Matsuura

    发明人： Manabu Matsubara ,  Hirofumi Takasuka ,  Akira Matsuura

    IPC分类号： G06F17/00

    CPC分类号： G07C9/00309 ,  G07C2209/63

    摘要： A main control portion of a vehicle has an LF transmission antenna for transmitting a search signal. The LF transmission antenna has five antennas respectively provided on door knobs of the vehicle. A smart key receives the search signals transmitted from respective antennas constituting the LF transmission antenna, and then measures a filed strength of the received search signal. The smart key transmits field strength information representing the measured field strength to the main control portion. The main control portion calculates relative position information of the vehicle to the smart key, based on the field strength information. On the basis of the relative position information, the main control portion controls the door of the vehicle to be locked or unlocked.

    Distortion sensor
    4.
    发明申请
    Distortion sensor 失效
    失真传感器

    公开(公告)号：US20050034528A1

    公开(公告)日：2005-02-17

    申请号：US10489511

    申请日：2002-09-12

    申请人： Akira Matsuura ,  Shinjiro Ueda ,  Toshiro Otobe ,  Yasunobu Kobayashi ,  Katsuhiko Omoto ,  Yasunori Matsukawa ,  Toshiharu Motofusa

    发明人： Akira Matsuura ,  Shinjiro Ueda ,  Toshiro Otobe ,  Yasunobu Kobayashi ,  Katsuhiko Omoto ,  Yasunori Matsukawa ,  Toshiharu Motofusa

    IPC分类号： G01B7/16 ,  G01L1/22 ,  G01L1/00

    CPC分类号： G01L1/2206

    摘要： A strain sensor improved in detection accuracy without variation of bending stresses applied to the strain detecting element. The sensor substrate has a first fixing hole at one end and a second fixing hole at the other end, a detecting hole at the center, and at least one strain detecting element on the upper surface or lower surfce thereof. The first fixing member is press-fitted into the first fixing hole. The second fixing member is press-fitted into the second fixing hole. The detecting member is press-fitted into the detecting hole. Further, when an external force is applied to the detecting member, strain generated due to the positional shift of the detecting member is detected by the strain detecting element with respect to the first fixing member and the second fixing member.

    摘要翻译： 应变传感器提高了检测精度，而不会对应变检测元件施加弯曲应力的变化。 传感器基板的一端具有第一固定孔，另一端具有第二固定孔，中心具有检测孔，以及在其上表面或下表面上的至少一个应变检测元件。 第一固定构件压配合到第一固定孔中。 第二固定构件压配合到第二固定孔中。 检测部件压配合到检测孔中。 此外，当对检测部件施加外力时，由应变检测元件相对于第一固定部件和第二固定部件检测由于检测部件的位置偏移而产生的应变。

    Sliding roof device
    5.
    发明授权
    Sliding roof device 有权
    滑动屋顶装置

    公开(公告)号：US06588834B2

    公开(公告)日：2003-07-08

    申请号：US09989190

    申请日：2001-11-21

    申请人： Kenji Maeta ,  Masaji Ishikawa ,  Akira Matsuura ,  Reiki Kawamura ,  Yasuo Oyama

    发明人： Kenji Maeta ,  Masaji Ishikawa ,  Akira Matsuura ,  Reiki Kawamura ,  Yasuo Oyama

    IPC分类号： B60J7053

    CPC分类号： B60J7/0573

    摘要： A sliding roof device includes a housing disposed along at least front edge of an opening formed on a roof of a vehicle, a casing disposed along the housing, a driving force transmitting member slidably mounted and guided in the housing and driven by a driving mechanism and a sliding panel connected to the driving force transmitting member and being movable so as to open and close the opening by the sliding movement of the driving force transmitting member, wherein the casing is formed by a flexible raw material and a plural engaging portions which are displaced at least one of upper and lower and front and rear are formed on the housing, and wherein the casing is securely engaged with the engaging portions so as to be arranged zigzag.

    摘要翻译： 滑动屋顶装置包括沿着车辆顶部形成的开口的至少前边缘设置的壳体，沿着壳体设置的壳体，可滑动地安装和引导在壳体中并由驱动机构驱动的驱动力传递构件， 连接到驱动力传递构件的滑动面板，并且可移动以便通过驱动力传递构件的滑动运动来打开和关闭开口，其中壳体由柔性原料和多个啮合部分形成， 在壳体上形成有上，下和前后两者中的至少一个，并且其中壳体与接合部分牢固地接合以便被锯齿形地布置。

    Sliding roof apparatus
    6.
    发明授权
    Sliding roof apparatus 失效
    滑动屋顶装置

    公开(公告)号：US06196625B1

    公开(公告)日：2001-03-06

    申请号：US09280087

    申请日：1999-03-29

    申请人： Youji Nagashima ,  Kenji Maeta ,  Kenichi Fukura ,  Akira Matsuura ,  Takashi Yoshie ,  Yasuo Oyama ,  Masaji Ishikawa

    发明人： Youji Nagashima ,  Kenji Maeta ,  Kenichi Fukura ,  Akira Matsuura ,  Takashi Yoshie ,  Yasuo Oyama ,  Masaji Ishikawa

    IPC分类号： B60J700

    CPC分类号： B60R13/07 ,  B60J7/022

    摘要： The invention improves a connection portion between a guide rail and a front rail in a sliding roof apparatus and make a mounting operation easy. In the sliding roof apparatus, a gutter is supported to a protruding portion of the guide rail, a side end portion of the front rail is overlapped with a front portion of the gutter from the above, an opening thereof is opposed to a bottom wall of the gutter, and a bracket of the side end portion is fixed to the protruding portion of the guide rail.

    摘要翻译： 本发明改进了滑动车顶装置中的导轨和前导轨之间的连接部分，并且使得安装操作变得容易。 在滑动屋顶装置中，沟槽被支撑在导轨的突出部分上，前导轨的侧端部与上部的沟槽的前部重叠，其开口与 所述沟槽和所述侧端部的支架固定在所述导轨的突出部。

    Charged beam apparatus
    8.
    发明授权
    Charged beam apparatus 失效
    带电束装置

    公开(公告)号：US5591970A

    公开(公告)日：1997-01-07

    申请号：US527583

    申请日：1995-09-13

    申请人： Haruki Komano ,  Akira Matsuura ,  Hiroko Nakamura ,  Kazuyoshi Sugihara

    发明人： Haruki Komano ,  Akira Matsuura ,  Hiroko Nakamura ,  Kazuyoshi Sugihara

    IPC分类号： G01Q30/08 ,  G03F1/30 ,  G03F1/72 ,  G03F1/74 ,  H01J37/305 ,  H01L21/203 ,  H01L21/302 ,  H01L21/31 ,  H01L21/316 ,  H01J37/30

    CPC分类号： H01J37/3056 ,  H01J2237/006 ,  H01J2237/024 ,  H01J2237/31744

    摘要： A charged beam apparatus of this invention comprises a sample table on which a sample is placed, a column for irradiating a charged beam on a surface of the sample, a gas supply mechanism having a gas supply opening for injecting a gas to an irradiated position of the charged beam, and a driving mechanism for moving the gas supply opening parallel to the surface of the sample in order to position the gas supply opening, and moving the gas supply opening perpendicularly to the surface of the sample in order to set a distance from the gas supply opening to a processing position. This allows the gas pressure to be stably held with a high accuracy at the processing position. Accordingly, desired deposition or etching can be performed with a high accuracy, and this further improves the quality of the mask.

    摘要翻译： 本发明的充电光束装置包括：样品台，放置样品的样品台;用于在样品表面照射带电束的色谱柱;气体供给机构，具有用于将气体注入照射位置的气体供给口 带电束，以及用于使气体供给开口平行于样品表面移动以便定位气体供应开口的驱动机构，并且使气体供给开口垂直于样品的表面移动，以设定距离 气体供应开口到处理位置。 这样可以在加工位置高精度地稳定地保持气体压力。 因此，可以高精度地进行期望的沉积或蚀刻，这进一步提高了掩模的质量。

    Thrombolytic agent
    9.
    发明授权
    Thrombolytic agent 失效
    溶血剂

    公开(公告)号：US4568545A

    公开(公告)日：1986-02-04

    申请号：US508163

    申请日：1983-06-27

    申请人： Hisashi Mihara ,  Hiroyuki Sumi ,  Akira Matsuura ,  Tadahiko Inukai

    发明人： Hisashi Mihara ,  Hiroyuki Sumi ,  Akira Matsuura ,  Tadahiko Inukai

    IPC分类号： A61K38/00 ,  C12N9/64 ,  A61K37/54 ,  C12N9/48

    CPC分类号： C12N9/6402 ,  A61K38/00 ,  Y10S514/822

    摘要： The invention discloses that the tissues of earthworms contain fibrinolytically or thrombolytically active ingredients which can be extracted and purified by a suitable sequence of extraction and purification procedures into the individual active ingredients including six novel proteases named F-O-HM-45, F-I-1-HM-54, F-I-2-HM-15, F-II-HM-64, F-III-1-HM-27 and F-III-2-HM-89. The chromatographic fractionation of the earthworm extract with an aqueous extractant gives five active fractions, the first four of which contain each one of the first mentioned four proteases and the last of which contains the last mentioned two proteases. The disclosure includes description of the suitable purification methods for the proteases as well as the physico-chemical identification data thereof. Various thrombolytic medicament forms prepared with the novel proteases as the effective ingredient are described together with the results of the clinical tests carried out by the oral administration of the novel proteases.

    摘要翻译： 本发明公开了蚯蚓的组织含有纤维蛋白溶解或血栓溶解活性成分，其可以通过适当的提取和纯化程序提取和纯化到各个活性成分中，包括六种新的命名为FO-HM-45，FI-1-HM -54，FI-2-HM-15，F-II-HM-64，F-III-1-HM-27和F-III-2-HM-89。 用含水萃取剂的蚯蚓提取物的色谱分离提供了五种活性级分，其中前四种含有前述四种蛋白酶中的每一种，最后含有最后提到的两种蛋白酶。 本公开包括对蛋白酶的合适的纯化方法的描述以及其物理化学鉴定数据。 用新型蛋白酶作为有效成分制备的各种血栓溶解药物形式与通过口服施用新型蛋白酶进行的临床试验的结果一并描述。

    Vehicle control system and vehicle control apparatus
    10.
    发明授权
    Vehicle control system and vehicle control apparatus 有权
    车辆控制系统和车辆控制装置

    公开(公告)号：US07915998B2

    公开(公告)日：2011-03-29

    申请号：US11600160

    申请日：2006-11-16

    申请人： Manabu Matsubara ,  Hirofumi Takasuka ,  Akira Matsuura

    发明人： Manabu Matsubara ,  Hirofumi Takasuka ,  Akira Matsuura

    IPC分类号： B60R25/00

    CPC分类号： G07C9/00309 ,  G07C2209/63

    摘要： A main control portion of a vehicle has an LF transmission antenna for transmitting a search signal. The LF transmission antenna has five antennas respectively provided on door knobs of the vehicle. A smart key receives the search signals transmitted from respective antennas constituting the LF transmission antenna, and then measures a filed strength of the received search signal. The smart key transmits field strength information representing the measured field strength to the main control portion. The main control portion calculates relative position information of the vehicle to the smart key, based on the field strength information. On the basis of the relative position information, the main control portion controls the door of the vehicle to be locked or unlocked.

    摘要翻译： 车辆的主控制部分具有用于发送搜索信号的LF发送天线。 LF发射天线具有分别设置在车辆的门把手上的五个天线。 智能钥匙接收从构成LF发送天线的各个天线发送的搜索信号，然后测量接收到的搜索信号的归档强度。 智能钥匙将表示测得的场强的场强信息发送到主控制部分。 主控制部根据场强信息，计算车辆对智能钥匙的相对位置信息。 基于相对位置信息，主控制部分控制车辆的门被锁定或解锁。