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公开(公告)号:US4993998A
公开(公告)日:1991-02-19
申请号:US296235
申请日:1989-01-12
申请人: Hiroyuki Tanaka , Takaji Nagai , Takahide Mizuno , Yasuhiro Hashimoto , Kazumi Kawai , Hideo Hirai
发明人: Hiroyuki Tanaka , Takaji Nagai , Takahide Mizuno , Yasuhiro Hashimoto , Kazumi Kawai , Hideo Hirai
CPC分类号: F16G1/28
摘要: A toothed belt power transmission system having a belt tooth configuration and pulley groove configuration providing for clearances between the belt tooth root and pulley groove outer surface, and between the belt tooth tip surface and pulley groove inner surface. A power transmitting surface on a midportion of the tooth has facial engagement with a confronting sidewall surface at the midportion of the pulley groove side surface. Locations of the centers of the different arcuate surfaces of the pulley tooth and belt groove for providing the extended life, low noise operation of the drive are disclosed. A number of different constructions embodying the invention are disclosed.
摘要翻译: 带齿带动力传动系统,其具有带齿构造和皮带轮槽结构,其提供带齿根和皮带轮外表面之间以及带齿顶端表面和皮带轮槽内表面之间的间隙。 齿轮中部的动力传递表面在滑轮槽侧表面的中间部分与面对面的侧壁表面接合。 公开了用于提供延长使用寿命,驱动器的低噪声操作的滑轮齿和皮带槽的不同弧形表面的中心的位置。 公开了许多体现本发明的不同结构。
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公开(公告)号:US4915674A
公开(公告)日:1990-04-10
申请号:US222629
申请日:1988-07-21
申请人: Hiroyuki Tanaka , Hideo Hirai , Kazumi Kawai , Tsuneo Shaura
发明人: Hiroyuki Tanaka , Hideo Hirai , Kazumi Kawai , Tsuneo Shaura
摘要: A belt drive having a belt provided with longitudinally spaced teeth arranged to have a preselected clearance between the side flanks thereof and the side flanks of pulley teeth with which the belt teeth are meshed in a driving operation. The clearance is caused to be a maximum at the belt tooth tips and decrease to a minimum or zero at the belt tooth roots. Different belt tooth side flank curvatures are disclosed wherein the curvatures are centered on axes located at different locations relative to the belt body. The locations of the pulley tooth flank curvature axes are related to the positions of the belt tooth flank curvature axes and a number of different relative positions thereof are disclosed.
摘要翻译: 一种皮带传动装置,其带具有纵向间隔开的齿,所述皮带布置成在其侧面和在皮带齿的侧面之间具有预先选定的间隙,皮带齿在驱动操作中啮合。 在皮带齿尖处使间隙达到最大值,并在皮带齿根处减小到最小值或零。 公开了不同的带齿侧面曲面,其中曲率以位于相对于带体的不同位置的轴为中心。 皮带轮齿面曲率轴的位置与带齿曲面曲率轴的位置有关,并且公开了多个不同的相对位置。
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公开(公告)号:US5083983A
公开(公告)日:1992-01-28
申请号:US601313
申请日:1990-10-19
申请人: Hideo Hirai , Yasuhiro Hashimoto , Norikazu Tanaka
发明人: Hideo Hirai , Yasuhiro Hashimoto , Norikazu Tanaka
CPC分类号: F16H7/1218 , F02B2275/06 , F16H2007/081
摘要: An apparatus for tensioning a drive belt and having a tensioner arm with structure thereon for engaging a surface of the drive belt, structure for mounting the tensioner arm to a support for pivoting movement about a first axis in first and second opposite directions relative to the support including a roller bearing for guiding relative movement between the tensioner arm and support, and structure for normally biasing the belt in one of the first and second opposite directions relative to the support.
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公开(公告)号:US4983145A
公开(公告)日:1991-01-08
申请号:US412941
申请日:1989-09-26
申请人: Hideo Hirai , Masakatsu Ando , Yasuhiro Hashimoto , Naoki Fujimoto , Norikazu Tanaka , Susumu Yamakawa
发明人: Hideo Hirai , Masakatsu Ando , Yasuhiro Hashimoto , Naoki Fujimoto , Norikazu Tanaka , Susumu Yamakawa
CPC分类号: F16H7/1218 , F02B2275/06 , F16H2007/081 , F16H2007/084
摘要: An apparatus for tensioning a belt consisting of a tensioner arm having an idler pulley for engagement with a surface of a drive belt, structure for mounting the tensioner arm to a suppport for pivoting movement about a pivot axis in first and second opposite directions, and structure for biasing the tensioner arm in one of the first and second directions. The mounting structure includes first and second members with first and second relatively movable cooperating friction generating surface for damping rotation of the tensioner arm. At least a portion of one of the friction generating surfaces is concave opening towards the tensioner with at least one of the friction generating surfaces having at least a portion defined by other than a radius centered on the pivot axis of the tensioner arm to thereby produce a greater resistance to rotation of the tensioner arm in the other of the first and second directions than in the one of the first and second tensioner arm pivoting directions.
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公开(公告)号:US5195932A
公开(公告)日:1993-03-23
申请号:US421259
申请日:1989-10-12
申请人: Hideo Hirai , Masakatsu Ando , Yasuhiro Hashimoto , Naoki Fujimoto , Norikazu Tanaka , Susumu Yamakawa
发明人: Hideo Hirai , Masakatsu Ando , Yasuhiro Hashimoto , Naoki Fujimoto , Norikazu Tanaka , Susumu Yamakawa
CPC分类号: F16H7/1218 , F02B2275/06 , F16H2007/081 , F16H2007/088
摘要: An apparatus is provided for tensioning a drive belt, which apparatus consists of tensioner arm having an idler pulley thereon for engagement with the surface of a drive belt, structure for mounting the tensioner arm to a support for pivoting movement in first and second opposite directions relative to the support, and a torsion coil spring formed of wire and acting between the mounting structure and tensioner arm for biasing the tensioner arm in one of the first and second directions. The wire has a non-circular cross section.
摘要翻译: 提供一种用于张紧传动带的装置,该装置由张紧器臂组成,其上具有用于与驱动带的表面接合的惰轮,用于将张紧臂安装到支撑件上,用于相对于第一和第二相反方向枢转运动 以及由导线形成并作用在安装结构和张紧器臂之间的扭力螺旋弹簧,用于在第一和第二方向中的一个方向上偏压张紧臂。 电线具有非圆形截面。
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公开(公告)号:US06177458B1
公开(公告)日:2001-01-23
申请号:US09468770
申请日:1999-12-21
申请人: Hideo Hirai , Toshio Ichiba , Hiroko Tonai
发明人: Hideo Hirai , Toshio Ichiba , Hiroko Tonai
IPC分类号: A61K3135
CPC分类号: C12R1/80 , C07D311/76 , C12P17/06
摘要: This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.
摘要翻译: 本发明涉及式(I)的异苯并二氢吡喃化合物及其药学上可接受的盐,其可用作淀粉样聚集抑制剂并用于治疗阿尔茨海默氏病。 本发明还涉及异苯并二氢吡喃化合物的制备方法,该方法包括培养简单微生物FERM BP-6357的青霉菌,然后从发酵液中分离异色素化合物。 本发明还涉及包含异色满化合物的药物组合物。
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公开(公告)号:US5885959A
公开(公告)日:1999-03-23
申请号:US999627
申请日:1997-12-03
IPC分类号: C12P21/04 , A61K38/00 , A61P25/04 , A61P25/30 , A61P39/02 , C07K5/12 , C12P21/02 , C12R1/645 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00
摘要: This invention provides processes for producing novel cyclic peptide compounds, which comprise cultivating Ctenomyces serratus FERM BP-5731 and then isolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I): ##STR1## The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.
摘要翻译: 本发明提供了生产新型环肽化合物的方法,其包括培养C ivating atus ERM FERM BP-5731,然后从发酵液中分离出环状肽化合物。 通过这些方法制备的化合物包括下式(I)的环肽化合物:(I)本发明还涉及包含其的药物组合物,其可用于治疗严重疼痛,解毒 麻醉品依赖或急性毒品中毒等。
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公开(公告)号:US4929639A
公开(公告)日:1990-05-29
申请号:US208665
申请日:1988-06-20
申请人: Hiroyuki Setoi , Akio Kuroda , Hirokazu Tanaka , Hideo Hirai , Hiroshi Marusawa , Masashi Hashimoto
发明人: Hiroyuki Setoi , Akio Kuroda , Hirokazu Tanaka , Hideo Hirai , Hiroshi Marusawa , Masashi Hashimoto
IPC分类号: A61K31/357 , A61P7/02 , C07D309/06 , C07D319/06 , C07D405/12 , C07D409/12
CPC分类号: C07D405/12 , C07D309/06 , C07D319/06 , C07D409/12
摘要: The invention relates to treatment of diseases caused by thromboxane A.sub.2 comprising administering a compound ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl andR.sup.3 is --CH.dbd.N--R.sup.4 in which R.sup.4 is arylureido or arylthioureido andX is --O--,or a pharmaceutically acceptable salt thereof.
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公开(公告)号:US20100177859A1
公开(公告)日:2010-07-15
申请号:US12652976
申请日:2010-01-06
申请人: Shigeki Yokoyama , Makoto Ukai , Munetaka Takahashi , Hideo Hirai , Takuya Miyagawa , Masashi Tanabe
发明人: Shigeki Yokoyama , Makoto Ukai , Munetaka Takahashi , Hideo Hirai , Takuya Miyagawa , Masashi Tanabe
摘要: In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.
摘要翻译: 在钢板混凝土结构的核反应堆建筑物中,其容纳形成有贯穿其外围的压力容器的多个穿透口的压力容器,并且包括设置在压力容器外部的生物屏蔽壁。 压力容器垂直地分成多个块,使得每个块具有设置在同一水平面上的一个或多个压力容器渗透口,并且包括生物屏蔽壁的反应堆建筑物被分成多个模块 由水平面。
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公开(公告)号:US4939241A
公开(公告)日:1990-07-03
申请号:US173294
申请日:1988-03-25
申请人: Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
发明人: Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
IPC分类号: A61K31/22 , A61P35/00 , C07C67/00 , C07C241/00 , C07C245/18 , C12P13/00 , C12R1/465
CPC分类号: C12P13/04 , C07C245/18 , C12P13/00 , Y10S435/886
摘要: The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.
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