公开(公告)号：US20050221422A1

公开(公告)日：2005-10-06

申请号：US10509785

申请日：2003-03-27

申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Hiroko Iwasaki

发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Hiroko Iwasaki

IPC分类号： A61K31/711 ,  A61K38/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12N15/12 ,  C12N15/54 ,  C12Q1/48 ,  C07H21/04 ,  A61K39/395 ,  C12N15/09

CPC分类号： C12N9/1051 ,  A01K2217/05 ,  A61K31/711 ,  A61K38/00 ,  C12Q1/48

摘要： The present inventors succeeded in identifying novel galactosyltransferases, C1Gal-T2 and C1Gal-T3, with a 957-bp ORF and 948-bp ORF, respectively. These enzymes were suggested to be core 1 sugar chain (galactose β1-3 acetylgalactosaminyl α1-R) synthetases. These enzymes and the polynucleotides that encode them are expected to serve as suitable therapeutic agents for diseases caused by abnormal expression or function of these enzymes.

摘要翻译： 本发明人成功地鉴定了新的半乳糖基转移酶，C1Gal-T2和C1Gal-T3，分别具有957bp的ORF和948bp的ORF。 这些酶被认为是核心1糖链（半乳糖β1-3乙酰半乳糖胺基α1-R）合成酶。 预期这些酶和编码它们的多核苷酸可用作由这些酶的异常表达或功能引起的疾病的合适的治疗剂。

公开(公告)号：US20060177822A1

公开(公告)日：2006-08-10

申请号：US10539834

申请日：2003-12-26

申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： C12N9/1051

摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.

公开(公告)号：US20090081668A1

公开(公告)日：2009-03-26

申请号：US12155320

申请日：2008-06-02

申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04 ,  C07K16/18

CPC分类号： C12N9/1051

摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.

摘要翻译： 本发明的肿瘤标志物核酸涉及在严格条件下与SEQ ID NO：1所述核苷酸序列或其互补核苷酸序列杂交的核酸。 测定本发明的癌症的方法是当生物样品中的核酸的转录水平显着超过作为对照的正常生物样品中的生物样品时，将生物样品诊断为癌变的方法。 本发明还涉及具有通过β1,3键将N-乙酰基-D-葡糖胺从供体底物转移到受体底物的活性的β1,3-N-乙酰基-D-葡糖胺基转移酶蛋白。

公开(公告)号：US07262039B1

公开(公告)日：2007-08-28

申请号：US09744748

申请日：1999-07-29

申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Katsutoshi Sasaki

发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Katsutoshi Sasaki

IPC分类号： C12N9/10 ,  C12P21/06 ,  C12P19/18 ,  C07H21/04 ,  C12N9/00

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/26 ,  C12P21/005 ,  C12Q1/6883 ,  C12Q2600/158 ,  Y10T436/143333

摘要： This invention relates to a novel polypeptide having an α1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transformant having the recombinant vector, an antibody recognizing the polypeptide, a method for determining or immunostaining the polypeptide of the present invention using the antibody, a method for producing a fucose-containing sugar chain using the polypeptide or the transformant, a method for screening a substance that changes the expression of a gene encoding the polypeptide, a method for screening a substance that changes the activity of the polypeptide, and a method for diagnosing diseases such as encephalopathy, renal diseases and cancers.

摘要翻译： 本发明涉及一种具有α1,3-岩藻糖基转移酶活性的新型多肽，该多肽的制备方法，该多肽的编码方法，该DNA的制造方法，将DNA插入其中而得到的重组载体， 重组载体，识别多肽的抗体，使用抗体测定或免疫本发明多肽的方法，使用多肽或转化体生产含岩藻糖糖的糖链的方法，用于筛选改变的物质的方法 编码多肽的基因的表达，用于筛选改变多肽的活性的物质的方法，以及诊断疾病如脑病，肾脏疾病和癌症的方法。

公开(公告)号：US07396666B2

公开(公告)日：2008-07-08

申请号：US10539834

申请日：2003-12-26

申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Akira Togayachi ,  Toru Hiruma

IPC分类号： C12N9/10 ,  C12N15/00 ,  C12P21/06 ,  C12P33/20 ,  C12Q1/68 ,  C07H21/04 ,  C07K1/00

CPC分类号： C12N9/1051

摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.

摘要翻译： 本发明的肿瘤标志物核酸涉及在严格条件下与SEQ ID NO：1所述核苷酸序列或其互补核苷酸序列杂交的核酸。 测定本发明的癌症的方法是当生物样品中的核酸的转录水平显着超过作为对照的正常生物样品中的生物样品时，将生物样品诊断为癌变的方法。 本发明还涉及具有通过β1,3键将N-乙酰基-D-葡糖胺从供体底物转移到受体底物的活性的β1,3-N-乙酰基-D-葡糖胺基转移酶蛋白。

公开(公告)号：US20080015165A1

公开(公告)日：2008-01-17

申请号：US11836523

申请日：2007-08-09

申请人： Hisashi Narimatsu ,  Takashi Kudo ,  Katsutoshi Sasaki

发明人： Hisashi Narimatsu ,  Takashi Kudo ,  Katsutoshi Sasaki

IPC分类号： A61K31/7088 ,  A01K67/027 ,  A61P35/00 ,  C07H21/00 ,  C07H21/04 ,  C07K16/44 ,  C12P1/00 ,  C12P19/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/26 ,  C12P21/005 ,  C12Q1/6883 ,  C12Q2600/158 ,  Y10T436/143333

摘要： This invention relates to a novel polypeptide having an α1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a recombinant vector obtained by inserting the DNA thereinto, a transformant having the recombinant vector, an antibody recognizing the polypeptide, a method for determining or immunostaining the polypeptide of the present invention using the antibody, a method for producing a fucose-containing sugar chain using the polypeptide or the transformant, a method for screening a substance that changes the expression of a gene encoding the polypeptide, a method for screening a substance that changes the activity of the polypeptide, and a method for diagnosing diseases such as encephalopathy, renal diseases and cancers.

摘要翻译： 本发明涉及一种具有α1,3-岩藻糖基转移酶活性的新型多肽，该多肽的制备方法，该多肽的编码方法，该DNA的制造方法，将DNA插入其中而得到的重组载体， 重组载体，识别多肽的抗体，使用抗体测定或免疫本发明多肽的方法，使用多肽或转化体生产含岩藻糖糖的糖链的方法，用于筛选改变的物质的方法 编码多肽的基因的表达，用于筛选改变多肽的活性的物质的方法，以及诊断疾病如脑病，肾脏疾病和癌症的方法。

公开(公告)号：US08164409B2

公开(公告)日：2012-04-24

申请号：US12801176

申请日：2010-05-26

申请人： Takashi Kudo ,  Masatoshi Shindoh ,  Yuu Okabe ,  Hiroki Kobayashi ,  Takashi Kudo

发明人： Takashi Kudo ,  Masatoshi Shindoh ,  Yuu Okabe ,  Hiroki Kobayashi ,  Takashi Kudo

IPC分类号： H01F27/02 ,  H01F27/24

CPC分类号： H01F17/045 ,  H01F27/263

摘要： A coil component ensuring adhesive bonding between first and second cores. The coil component also includes an inductive component and a pair of terminal electrodes. The first core has a first adhesion surface. The second core is connected to the first core by an adhesive agent and has a second adhesion surface in confrontation with the first adhesion surface. At least one of the first adhesion surface and the second adhesion surface is formed of a glass surface layer to which the adhesive agent is applied. The inductive component is wound over the first core. The pair of terminal electrodes are provided at one of the first core and the second core. The inductive component has one end portion electrically connected to one of the terminal electrodes and has another end portion electrically connected to remaining one of the terminal electrodes.

摘要翻译： 确保第一和第二芯之间的粘合剂的线圈部件。 线圈部件还包括电感部件和一对端子电极。 第一芯具有第一粘附表面。 第二芯通过粘合剂连接到第一芯，并且具有与第一粘合表面相对的第二粘合表面。 第一粘合面和第二粘合面中的至少一个由施加有粘合剂的玻璃表面层形成。 电感元件卷绕在第一芯上。 一对端子电极设置在第一芯和第二芯之一处。 电感元件具有与端子电极中的一个电连接的一个端部，并且具有与剩余的一个端子电极电连接的另一端部。

公开(公告)号：US20110001595A1

公开(公告)日：2011-01-06

申请号：US12801176

申请日：2010-05-26

申请人： Takashi Kudo ,  Masatoshi Shindoh ,  Yuu Okabe ,  Hiroki Kobayashi ,  Takashi Kudo

发明人： Takashi Kudo ,  Masatoshi Shindoh ,  Yuu Okabe ,  Hiroki Kobayashi ,  Takashi Kudo

IPC分类号： H01F27/29

CPC分类号： H01F17/045 ,  H01F27/263

摘要： A coil component ensuring adhesive bonding between first and second cores. The coil component also includes an inductive component and a pair of terminal electrodes. The first core has a first adhesion surface. The second core is connected to the first core by an adhesive agent and has a second adhesion surface in confrontation with the first adhesion surface. At least one of the first adhesion surface and the second adhesion surface is formed of a glass surface layer to which the adhesive agent is applied. The inductive component is wound over the first core. The pair of terminal electrodes are provided at one of the first core and the second core. The inductive component has one end portion electrically connected to one of the terminal electrodes and has another end portion electrically connected to remaining one of the terminal electrodes.

摘要翻译： 确保第一和第二芯之间的粘合剂的线圈部件。 线圈部件还包括电感部件和一对端子电极。 第一芯具有第一粘附表面。 第二芯通过粘合剂连接到第一芯，并且具有与第一粘合表面相对的第二粘合表面。 第一粘合面和第二粘合面中的至少一个由施加有粘合剂的玻璃表面层形成。 电感元件卷绕在第一芯上。 一对端子电极设置在第一芯和第二芯之一处。 电感元件具有与端子电极中的一个电连接的一个端部，并且具有与剩余的一个端子电极电连接的另一端部。

公开(公告)号：US07989315B2

公开(公告)日：2011-08-02

申请号：US12624691

申请日：2009-11-24

申请人： Tetsuya Kakehata ,  Takashi Kudo

发明人： Tetsuya Kakehata ,  Takashi Kudo

IPC分类号： H01L21/762

CPC分类号： H01L21/76254 ,  H01L21/02131 ,  H01L21/02238 ,  H01L21/02255 ,  H01L21/0234 ,  H01L21/31662 ,  H01L23/544 ,  H01L2223/54406 ,  H01L2223/54433 ,  H01L2223/5448 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/00

摘要： When printing is performed on a base substrate with a laser after a single crystal silicon layer is transferred to the base substrate, there are problems such as ablation of the single crystal silicon layer in the peripheral portion of a printed dot or attachment of glass chips or the like to the surface of the single crystal silicon layer. After printing is performed on the bonding surface of a silicon wafer with a laser, the surface of the silicon wafer is polished by CMP (chemical mechanical polishing), so that the projection in the peripheral portion of the printed dot is removed. After that, the silicon wafer is bonded to the base substrate. Since the depression of the printed dot remains to some extent by a chemical etching effect even after the polishing by CMP, the single crystal silicon layer is not transferred only at the depression portion at the time of the transfer; accordingly, the information is left on the base substrate.

摘要翻译： 在将单晶硅层转印到基底基板上之后，在具有激光的基底基板上进行印刷的情况下，存在印刷点的周边部分中的单晶硅层的烧蚀或玻璃芯片的附着等问题， 类似于单晶硅层的表面。 在利用激光在硅晶片的接合表面上进行印刷之后，通过CMP（化学机械抛光）对硅晶片的表面进行抛光，从而去除印刷点的周边部分的突起。 之后，将硅晶片接合到基底基板。 由于即使在通过CMP研磨之后，由于印刷点的凹陷在某种程度上仍然通过化学蚀刻效果而保持，所以在转印时单晶硅层不会在凹陷部分传输; 因此，信息留在基底基板上。

公开(公告)号：US07832766B2

公开(公告)日：2010-11-16

申请号：US12378071

申请日：2009-02-11

申请人： Takashi Kudo

发明人： Takashi Kudo

IPC分类号： B62D21/12

CPC分类号： B62K19/24

摘要： A vehicle frame structure for a saddle-type vehicle has a vehicle frame including a subframe portion detachably mounted on a main frame, and a joint between the main frame and the subframe which is disposed in a longitudinally intermediate portion of a continuously extending frame component, wherein the frame component is kept rigid and the joint is maintained in a small size. In the joint, the frame component has a portion divided by a vertical plane into a main-frame-side joint arm and a subframe-side joint arm. The joint arms have distal ends having arcuate outer walls cut off around their fastening positions. The joint arms further have integral upstanding walls disposed on proximal ends thereof, corresponding to the cut-off arcuate outer walls of the joint arms. The joint arms are fastened to each other with the distal ends thereof fitted in cavities surrounded by the upstanding walls.

摘要翻译： 用于鞍式车辆的车架结构具有车架，该车架包括可拆卸地安装在主框架上的副车架部分，以及设置在连续延伸的车架部件的纵向中间部分中的主车架与副车架之间的接头， 其中所述框架部件保持刚性并且所述接头保持在小尺寸。 在接头中，框架部件具有被垂直平面划分成主框架侧连接臂和副车侧侧连接臂的部分。 接合臂具有在其紧固位置周围切断的弓形外壁的远端。 关节臂还具有设置在其近端上的整体直立壁，对应于关节臂的截止弧形外壁。 接合臂彼此紧固，其远端装配在由直立壁包围的空腔中。