公开(公告)号：US20050176064A1

公开(公告)日：2005-08-11

申请号：US10520039

申请日：2003-06-30

申请人： Holger Klapproth ,  Ulrich Sieben

发明人： Holger Klapproth ,  Ulrich Sieben

IPC分类号： B01J19/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G01N33/542 ,  G01N33/543 ,  G01N33/551 ,  G01N33/566 ,  G01N33/58 ,  G01N33/53

CPC分类号： G01N33/54306 ,  B01J19/0046 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00677 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  B01J2219/00734 ,  B01J2219/0074 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G01N33/542 ,  G01N33/543 ,  G01N33/551 ,  G01N33/566 ,  G01N33/582

摘要： The invention relates to a method for determining the number of receptors on a carrier, in addition to a biosensor, especially a protein sensor, which can be produced using the method.

摘要翻译： 本发明涉及一种用于确定载体上的受体数量的方法，除了可以使用该方法生产的生物传感器，特别是蛋白质传感器。

公开(公告)号：US20050158848A1

公开(公告)日：2005-07-21

申请号：US10511192

申请日：2003-04-10

申请人： Ulrich Sieben ,  Ingo Freund ,  Holger Klapproth

发明人： Ulrich Sieben ,  Ingo Freund ,  Holger Klapproth

IPC分类号： B01J20/32 ,  C09D125/06 ,  C09D179/08 ,  C09D201/00 ,  G01N33/543 ,  G01N37/00 ,  C12M1/34 ,  B05D3/00

CPC分类号： B01J20/3204 ,  B01J20/103 ,  B01J20/28011 ,  B01J20/3257 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3276 ,  B01J20/3289 ,  G01N33/54393

摘要： In a method for immobilizing molecules on a surface, a layer of a hydrophobic, e.g., a non-swelling polymer, may be applied to the surface and molecules are immobilized on a surface of the polymer layer. The hydrophobic polymers may be polyimide or polystyrene, and the surface to which the polymer layer is applied may be made of an inorganic material, e.g., a semiconductor material (silicon), a semiconducting oxide (silicon dioxide), glass, nitride, or ceramic. Hydrophobic polymers such as polyimide or polystyrene can be applied to the surface of an inorganic support with conventional methods. Further, they electrically insulate the support with respect to the molecules applied to the surface of the polymer layer or substances associated with these molecules. Thus, electrical sensors and processor circuits can be integrated into the support without any detrimental effect on their function due to molecules and substances applied to the surface of the polymer layer.

摘要翻译： 在将分子固定在表面上的方法中，可以将一层疏水的，例如不溶胀的聚合物施加到表面上，并将分子固定在聚合物层的表面上。 疏水聚合物可以是聚酰亚胺或聚苯乙烯，并且施加聚合物层的表面可以由无机材料制成，例如半导体材料（硅），半导体氧化物（二氧化硅），玻璃，氮化物或陶瓷 。 疏水性聚合物如聚酰亚胺或聚苯乙烯可以用常规方法施加到无机载体的表面上。 此外，它们相对于施加到聚合物层的表面上的分子或与这些分子相关联的物质将载体电绝缘。 因此，电传感器和处理器电路可以集成到支撑件中，而不会由于施加到聚合物层表面的分子和物质而对它们的功能产生不利影响。

公开(公告)号：US20090017505A1

公开(公告)日：2009-01-15

申请号：US11805242

申请日：2007-05-22

申请人： Ulrich Sieben ,  Holger Klapproth

发明人： Ulrich Sieben ,  Holger Klapproth

IPC分类号： C12P19/34 ,  C12M1/40 ,  C12M1/34

CPC分类号： B01L3/0262 ,  B01F13/0071 ,  B01F13/0084 ,  B01F15/06 ,  B01L3/5085 ,  B01L3/5088 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/143 ,  B01L2300/0819 ,  B01L2300/1822

摘要： In a process for mixing microdroplets (2a, 2b, 2c), at least two carriers (3a, 3b) are provided whose surfaces (4a, 4b) are each structured in such a way that at least one hydrophilic surface domain (5a, 5b) is delimited by at least one hydrophobic surface domain (6a, 6b). A first microdroplet (2a, 2b, 2c) is disposed on a hydrophilic surface domain (5a) of a first carrier (3a), and a second microdroplet (2a, 2b, 3c) is disposed on a hydrophilic surface domain (5b) of a second carrier (3b). The carriers (3a, 3b), with their first and second hydrophilic surfaces (4a, 4b) facing each other, are positioned adjacent to each other and sufficiently close to each other by being moved toward each other that the microdroplets (2a, 2b, 2c) come into contact with each other.

摘要翻译： 在混合微滴（2a，2b，2c）的方法中，提供至少两个载体（3a，3b），其表面（4a，4b）各自构造成使得至少一个亲水性表面区域（5a，5b） ）由至少一个疏水性表面结构域（6a，6b）界定。 第一微滴（2a，2b，2c）设置在第一载体（3a）的亲水性表面区域（5a）上，第二微滴（2a，2b，3c）设置在亲水性表面区域 第二载体（3b）。 其第一和第二亲水表面（4a，4b）彼此面对的载体（3a，3b）通过彼此移动彼此相邻并且彼此靠近彼此，使得微滴（2a，2b， 2c）相互接触。

公开(公告)号：US20080286882A1

公开(公告)日：2008-11-20

申请号：US11960090

申请日：2007-12-19

申请人： Ulrich Sieben ,  Holger Klapproth

发明人： Ulrich Sieben ,  Holger Klapproth

IPC分类号： G01N33/543 ,  B01J19/00

CPC分类号： G01N33/54366

摘要： In a method for measuring the concentration of a ligand contained in a sample that is to be tested, at a plurality of test sites that are located on the surface of at least one substrate, in each case at least one receptor that is suitable upon contact with the ligand for specifically binding to said ligand, is immobilized. The sample is brought into contact for a predetermined time with the test sites in such a way that in the sample differently sized diffusion volumes are adjacent to the receptors from which at least one ligand can diffuse to the respective receptor during the predetermined time. After the predetermined time has passed, for each test site a measured signal for the number or density of the binding events at the test site is acquired.

摘要翻译： 在用于测量待测试样品中所含配体浓度的方法中，在位于至少一个底物表面上的多个测试位点，在每种情况下至少一种适合接触的受体 与特异性结合所述配体的配体被固定化。 使样品与测试位置接触预定时间，使得在样品中不同尺寸的扩散体积与受体相邻，在预定时间内至少一种配体可以从该受体扩散到相应的受体。 在预定时间过去之后，对于每个测试站点，获取测试点处的绑定事件的数量或密度的测量信号。

公开(公告)号：US20070107514A1

公开(公告)日：2007-05-17

申请号：US11545778

申请日：2006-10-10

申请人： Ulrich Sieben ,  Holger Klapproth ,  Mirko Lehmann

发明人： Ulrich Sieben ,  Holger Klapproth ,  Mirko Lehmann

IPC分类号： G01F15/14

CPC分类号： G01N21/6454

摘要： An integrated sensor array has a substrates, at least one sensor element, and a signal processing device integrated in the substrate and connected or capable of being connected with the sensor elements. A layer having a measuring surface is capable of being detachably bonded to the substrate so that a signal emitted from the measuring surface is capable of being processed by the signal processing device when the layer is bonded to the substrate. The substrate has at least one feedthrough hole abutting with the layer, which feedthrough hole is connected or capable of being connected to a vacuum generating device in order to bond the layer to the substrate by suction.

摘要翻译： 集成传感器阵列具有基板，至少一个传感器元件和集成在基板中并连接或能够与传感器元件连接的信号处理装置。 具有测量表面的层能够可拆卸地结合到基板，使得当该层与基板结合时，从测量表面发射的信号能够被信号处理装置处理。 衬底具有与该层邻接的至少一个馈通孔，所述馈通孔连接或能够连接到真空产生装置，以便通过抽吸将层粘合到衬底。

公开(公告)号：US06754468B1

公开(公告)日：2004-06-22

申请号：US09302391

申请日：1999-04-30

申请人： Ulrich Sieben ,  Miodrag Temerinac

发明人： Ulrich Sieben ,  Miodrag Temerinac

IPC分类号： H04B700

CPC分类号： H04M1/7253

摘要： A Portable communications device (1), particularly as an additional functional unit in a radiotelephone (100), comprising an input, output radio interface (2) for local data exchange between two adjacent communications devices (1; 100) or between a communications device (1; 100) and a data processing device (12) adapted to the,local data exchange, or a data-reproducing device (13), or an adapted data source (50). The range (r) of the input/output radio interface (2) is short compared with the range of a conventional radio interface for data :transfer, and corresponds essentially to a talking distance. The communications device (1, 100) further includes a memory device (6) and a data processing device (5). Different data sequences are identified and selectively retrievable in the memory device (6). The activation of the input/output radio interface (2) can be initiated manually.

摘要翻译： 一种便携式通信设备（1），特别是作为无线电话（100）中的附加功能单元，包括用于两个相邻通信设备（1; 100）之间或通信设备之间的本地数据交换的输入，输出无线电接口（2） （1; 100）和适于本地数据交换的数据处理设备（12）或数据再现设备（13）或适配的数据源（50）。 输入/输出无线电接口（2）的范围（r）与用于数据的传统无线电接口的范围相比较短：传输，并且基本上对应于通话距离。 通信设备（1,100）还包括存储设备（6）和数据处理设备（5）。 在存储器件（6）中识别并选择性地检索不同的数据序列。 可以手动启动输入/输出无线电接口（2）的激活。

公开(公告)号：US06210977B1

公开(公告)日：2001-04-03

申请号：US09468449

申请日：1999-12-21

申请人： Ulrich Sieben ,  Bernhard Wolf ,  Hellmut Haberland ,  Christoph Cremer

发明人： Ulrich Sieben ,  Bernhard Wolf ,  Hellmut Haberland ,  Christoph Cremer

IPC分类号： G01N33543

CPC分类号： G01N27/4145 ,  H01L2924/0002 ,  Y10S436/805 ,  H01L2924/00

摘要： A measuring device for measuring or examining physiological parameters on biocomponents includes an FET sensor 5 whose electrical protective layer 12 is roughened or has a structured coating 15. The structuring of the active sensor contact surface 12 is adapted to the outer contour and topography of the biocomponent in question, so that a better possibility is available for anchoring the biocomponents to the contact surface 24 forming the FET protective layer of the sensor 5.

摘要翻译： 用于测量或检查生物组件上的生理参数的测量装置包括FET传感器5，其电保护层12被粗糙化或具有结构化涂层15.主动传感器接触表面12的结构适用于生物组件的外轮廓和​​形貌 因此有可能将生物组分锚定到形成传感器5的FET保护层的接触表面24上。

公开(公告)号：US5218437A

公开(公告)日：1993-06-08

申请号：US749797

申请日：1991-08-26

申请人： Ulrich Sieben

发明人： Ulrich Sieben

IPC分类号： H04N7/025 ,  H04L7/033 ,  H04N7/03 ,  H04N7/035 ,  H04N7/08 ,  H04N7/088

CPC分类号： H04N7/0882 ,  H04L7/0334 ,  H04N7/035

摘要： A signal separator, particularly a teletext-signal separator, includes an integrating unit which delivers a center-of-bit-indicating (i.e., center-crossing) signal and a residual-value signal. A residual-value-signal-evaluating device evaluates the respective residual value and uses a selection control signal to determine how the value of the current signal bit is to be estimated. This is accomplished by using a selection facility which derives from the current sample value and the preceding and subsequent sample values the respective preaverage value and postaverage value and selects the value best suited for the estimation using the selection control signal. A phase corrector evaluates a signal pattern from an edge logic which indicates whether the current sample value is approaching an edge of the signal, and controls a change of the integration period if the residual-value signal lies within a predetermined residual value signal range.

摘要翻译： 信号分离器，特别是图文电视信号分离器，包括递送位中指示（即中心交叉）信号和残余值信号的积分单元。 剩余值信号评估装置评估相应的残差值，并使用选择控制信号来确定如何估计当前信号比特的值。 这是通过使用从当前采样值和先前和后续采样值得出各自预平均值和平均后值的选择设施来实现的，并且使用选择控制信号选择最适合于估计的值。 相位校正器评估来自边缘逻辑的信号模式，其指示当前采样值是否接近信号的边沿，并且如果剩余值信号位于预定的剩余值信号范围内，则控制积分周期的变化。

公开(公告)号：US07606869B2

公开(公告)日：2009-10-20

申请号：US10499774

申请日：2002-12-17

申请人： Ulrich Sieben ,  Miodrag Temerimac ,  Burkhard Swirski

发明人： Ulrich Sieben ,  Miodrag Temerimac ,  Burkhard Swirski

IPC分类号： G06F15/167 ,  G05B11/01 ,  B60Q1/00 ,  G08G1/123

CPC分类号： H04L29/06 ,  H04L67/18 ,  H04L67/306 ,  H04L69/329

摘要： A system for exchanging data includes at least two memory units, each unit functioning as both a transmitter and a receiver of data. The exchange of data occurs whenever at least two memory units are within a certain distance of each other. The user is thus capable of simultaneously being both a transmitter and a receiver of data, such that the transmitter can send data continuously but can receive data transmitted from other memory units only when the receiver is within a certain distance from a transmitter. As a result, data are received only by those memory units that are located in the immediate environment of the transmitter. Since the data transmitted can be selected personally by the user, the data thus reflects the preferences of the user acting as the transmitter.

摘要翻译： 用于交换数据的系统包括至少两个存储器单元，每个单元用作数据的发送器和接收器。 只要至少两个存储器单元在彼此的一定距离内，就发生数据交换。 因此，用户能够同时成为数据的发送器和接收器，使得发送器可以连续地发送数据，但是只有当接收器距离发送器在一定距离内时才可以接收从其他存储器单元发送的数据。 因此，数据仅由位于发射机的直接环境中的那些存储器单元接收。 由于发送的数据可以由用户个人选择，因此数据反映了用作发送器的用户的偏好。

公开(公告)号：US20080028477A1

公开(公告)日：2008-01-31

申请号：US11579213

申请日：2005-02-02

申请人： Mirko Lehmann ,  Ulrich Sieben

发明人： Mirko Lehmann ,  Ulrich Sieben

IPC分类号： G06F1/26 ,  G08B29/16

CPC分类号： H01M8/02 ,  G06K19/0702 ,  G06K19/073 ,  G06K19/07381 ,  H01L23/576 ,  H01L2924/0002 ,  H01M8/04559 ,  H01M8/04917 ,  H01M8/04947 ,  H01M8/2475 ,  H01M2250/00 ,  H01M2250/30 ,  Y02B90/18 ,  H01L2924/00

摘要： A chip includes a memory that stores confidential data, a power supply device to apply a voltage and/or or a current, and an interface to transfer the data from and/or to another device. To secure the data in the memory, the power supply device is an integrated component of the chip. The power supply device is equipped with a limited, non-replenishable fuel reservoir so that data can be maintained in the memory over a limited service life. In other embodiments, voltage provided by the power supply device can also be employed actively to delete data in the memory in the event of unauthorized access to the chip.

摘要翻译： 芯片包括存储秘密数据的存储器，用于施加电压和/或电流的电源装置，以及将数据从和/或传送到另一装置的接口。 为了保护存储器中的数据，电源设备是芯片的集成组件。 电源设备配备有限的，不可补充的燃料储存器，以便数据可在有限的使用寿命内保持在存储器中。 在其他实施例中，在未经授权的访问芯片的情况下，还可以主动地采用由电源装置提供的电压来删除存储器中的数据。