公开(公告)号：US11835460B2

公开(公告)日：2023-12-05

申请号：US16482638

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: G01N21/64 ,  B01J19/00 ,  C12Q1/6837

CPC classification number: G01N21/6456 ,  B01J19/0046 ,  C12Q1/6837 ,  G01N21/6452 ,  B01J2219/0056 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01L2300/021 ,  G01N2021/6419 ,  G01N2021/6421 ,  H01J2237/24578

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include offset layouts that may be useful in detecting the fiducials in different types and approaches in imaging, and that may help to distinguish regions of the array from one another in image data.

公开(公告)号：US20200248252A1

公开(公告)日：2020-08-06

申请号：US16482613

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: C12Q1/6874 ,  G01N21/64

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include a non-closed shape that may encode information, allow for bubbles to escape during manufacture, and provide additional advantages over closed shape fiducials.

公开(公告)号：US20200064266A1

公开(公告)日：2020-02-27

申请号：US16482653

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: G01N21/64

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include features and materials that are provided on or in the support of the array and that return at least a portion of incident light by reflection. The fiducials may form gratings or other encoding configurations that assist in image processing, alignment, or other aspects of processing of the array.

公开(公告)号：US11886110B2

公开(公告)日：2024-01-30

申请号：US17209814

申请日：2021-03-23

Applicant: ILLUMINA, INC.

Inventor： Timothy J. Merkel ,  Ruibo Wang ,  Daniel Wright ,  Danny Yuan Chan ,  Avishek Aiyar ,  Tanmay Ghonge ,  Neil Brahma ,  Arthur Pitera

IPC: G03F7/00 ,  B29C59/02 ,  C09D183/14 ,  G03F7/16 ,  B29K83/00 ,  B29K105/00

CPC classification number: G03F7/0002 ,  B29C59/022 ,  C09D183/14 ,  G03F7/162 ,  G03F7/168 ,  B29K2083/00 ,  B29K2105/0002

Abstract: An imprinting apparatus includes a silicon master and an anti-stick layer coating the silicon master. The silicon master includes a plurality of features positioned at an average pitch of less than about 425 nm, each of the plurality of features comprises a depression having an opening with its largest opening dimension being less than about 300 nm. The anti-stick layer includes a crosslinked silane polymer network.

公开(公告)号：US11427868B2

公开(公告)日：2022-08-30

申请号：US16482613

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: C12Q1/6874 ,  G01N21/64

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include a non-closed shape that may encode information, allow for bubbles to escape during manufacture, and provide additional advantages over closed shape fiducials.

公开(公告)号：US11262307B2

公开(公告)日：2022-03-01

申请号：US16482653

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: G01N21/64 ,  B01L9/00

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducial markers may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducial markers may include features and materials that are provided on or in the support of a patterned array and that return at least a portion of incident light by reflection. The fiducial markers may form gratings or other encoding configurations that assist in image processing, alignment, or other aspects of processing of the patterned array.

公开(公告)号：US20240102913A1

公开(公告)日：2024-03-28

申请号：US18455467

申请日：2023-08-24

Applicant: ILLUMINA, INC.

Inventor： Casey Scott Irvin ,  Jonathan Ziebarth ,  Michael Rapp ,  Danny Yuan Chan ,  Innsu Daniel Kim ,  Avishek Aiyar

IPC: G01N15/14

CPC classification number: G01N15/1436

Abstract: An example flow cell includes a patterned substrate having an active region and a bonding region that at least partially surrounds the active region. The active region includes first depressions defined in a layer of the patterned substrate, surface chemistry positioned in the first depressions, and first interstitial regions surrounding the first depressions. The bonding region includes second depressions defined in the layer and second interstitial regions surrounding the second depressions. An adhesive is positioned over the second depressions and over the second interstitial regions. A cover is attached to the adhesive such that a flow channel is defined between a portion of the cover and the active region.

公开(公告)号：US11249025B2

公开(公告)日：2022-02-15

申请号：US16482630

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: G01N21/64

Abstract: Fiducial markers are provided on a patterned array of the type that may be used for molecular analysis, such as sequencing. The fiducial markers may have configurations and layouts that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducial markers may include non-rectilinear layouts that may provide for more robust location of both the fiducial markers and sites of the patterned array.

公开(公告)号：US20200009525A1

公开(公告)日：2020-01-09

申请号：US16482592

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: B01J19/00 ,  G06T7/00 ,  C12Q1/6837 ,  G01N21/64

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include an “always on” type that respond to multiple frequencies of radiation used during processing and detection so as to return signals during successive cycles of imaging.

公开(公告)号：US11896944B2

公开(公告)日：2024-02-13

申请号：US16482592

申请日：2018-01-31

Applicant: Illumina, Inc.

Inventor： John S. Vieceli ,  Alex Nemiroski ,  Paul Belitz ,  Robert Langlois ,  M. Shane Bowen ,  Danny Yuan Chan ,  Bala Murali K. Venkatesan ,  Hui Han ,  Kevan Samiee ,  Stephen Tanner

IPC: C12Q1/6837 ,  B01J19/00 ,  G01N21/64 ,  G06T7/00

CPC classification number: B01J19/0046 ,  C12Q1/6837 ,  G01N21/6456 ,  G06T7/0012 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00722

Abstract: Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include an “always on” type that respond to multiple frequencies of radiation used during processing and detection so as to return signals during successive cycles of imaging.