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    Systems and devices for high-throughput sequencing with semiconductor-based detection
    1.
    发明授权
    Systems and devices for high-throughput sequencing with semiconductor-based detection 有权

    公开(公告)号：US11561196B2

    公开(公告)日：2023-01-24

    申请号：US16241905

    申请日：2019-01-07

    Applicant: Illumina, Inc.

    Inventor： Dietrich Dehlinger ,  Ali Agah ,  Tracy Helen Fung ,  Emrah Kostem ,  Craig Hetherington

    IPC: G01N27/414 ,  B01L3/00 ,  G06K9/62 ,  G01N21/64 ,  C12Q1/6874 ,  G06V10/75 ,  G01N21/76 ,  B01L7/00 ,  G16B30/00

    Abstract: In one embodiment, a sample surface of a biosensor includes pixel areas and holds a plurality of clusters during a sequence of sampling events such that the clusters are distributed unevenly over the pixel areas. In another embodiment, a biosensor has a sample surface that includes pixel areas and an array of wells overlying the pixel areas, the biosensor including two wells and two clusters per pixel area. The two wells per pixel area include a dominant well and a subordinate well. The dominant well has a larger cross section over the pixel area than the subordinate well. In yet another embodiment, an illumination system is coupled to a biosensor that illuminates the pixel areas with different angles of illumination during a sequence of sampling events, including, for a sampling event, illuminating each of the wells with off-axis illumination to produce asymmetrically illuminated well regions in each of the wells.

    Sensors having integrated protection circuitry
    2.
    发明授权
    Sensors having integrated protection circuitry 有权

    公开(公告)号：US12241835B2

    公开(公告)日：2025-03-04

    申请号：US18313015

    申请日：2023-05-05

    Applicant: ILLUMINA, INC.

    Inventor： Tracy Helen Fung ,  Xiuyu Cai ,  Lisa Kwok ,  Hai Tran ,  Kevan Samiee ,  Liangliang Qiang ,  Boyan Boyanov

    IPC: G01N21/64 ,  B01L3/00 ,  G01N15/1434 ,  G01N21/77

    Abstract: An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

    Sensor system
    3.
    发明授权
    Sensor system 有权

    公开(公告)号：US11784161B2

    公开(公告)日：2023-10-10

    申请号：US16949529

    申请日：2020-11-02

    Applicant: Illumina, Inc.

    Inventor： Tracy Helen Fung ,  Hai Quang Tran

    IPC: H01L25/065 ,  H01L23/31 ,  H01L23/00

    CPC classification number: H01L25/0657 ,  H01L23/3135 ,  H01L24/29 ,  H01L24/45 ,  H01L24/91 ,  H01L2224/02372 ,  H01L2225/06541

    Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.

    Light detection devices with protective liner and methods related to same
    6.
    发明授权
    Light detection devices with protective liner and methods related to same 有权

    公开(公告)号：US11543352B2

    公开(公告)日：2023-01-03

    申请号：US17190094

    申请日：2021-03-02

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Joseph Francis Pinto ,  Thomas A. Baker ,  Tracy Helen Fung

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/02 ,  H01L31/0216 ,  H01L31/0232 ,  G01N21/05

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

    Light detection devices with protective liner and methods related to same
    7.
    发明授权
    Light detection devices with protective liner and methods related to same 有权

    公开(公告)号：US10955343B2

    公开(公告)日：2021-03-23

    申请号：US16216014

    申请日：2018-12-11

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Joseph Francis Pinto ,  Thomas A. Baker ,  Tracy Helen Fung

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/0216 ,  H01L31/0232 ,  G01N21/05 ,  H01L31/02

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

    Sensor system
    8.
    发明授权
    Sensor system 有权

    公开(公告)号：US10861829B2

    公开(公告)日：2020-12-08

    申请号：US16609554

    申请日：2017-12-26

    Applicant: ILLUMINA, INC.

    Inventor： Tracy Helen Fung ,  Hai Quang Tran

    IPC: G01N21/64 ,  H01L25/065 ,  H01L23/31 ,  H01L23/00

    Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.

    SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY
    9.
    发明申请
    SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY 有权

    公开(公告)号：US20250164399A1

    公开(公告)日：2025-05-22

    申请号：US19027132

    申请日：2025-01-17

    Applicant: Illumina, Inc.

    Inventor： Tracy Helen Fung ,  Xiuyu Cai ,  Lisa Kwok ,  Hai Tran ,  Kevan Samiee ,  Liangliang Qiang ,  Boyan Boyanov

    IPC: G01N21/64 ,  B01L3/00 ,  G01N15/1434 ,  G01N21/77

    Abstract: An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

    Light detection devices with protective liner and methods related to same
    10.
    发明授权
    Light detection devices with protective liner and methods related to same 有权

    公开(公告)号：US12188869B2

    公开(公告)日：2025-01-07

    申请号：US18464624

    申请日：2023-09-11

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Joseph Francis Pinto ,  Thomas A. Baker ,  Tracy Helen Fung

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N21/05 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/02 ,  H01L31/0216 ,  H01L31/0232

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

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