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    Image sensor structure
    1.
    发明授权
    Image sensor structure 有权

    公开(公告)号：US11610928B2

    公开(公告)日：2023-03-21

    申请号：US17119909

    申请日：2020-12-11

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Ali Agah ,  Tracy H. Fung ,  Dietrich Dehlinger

    IPC: H01L27/146 ,  G01J1/44 ,  G01J1/02 ,  G01N21/64 ,  G01N21/05

    Abstract: An example image sensor structure includes an image layer. The image layer includes an array of light detectors disposed therein. A device stack is disposed over the image layer. An array of light guides is disposed in the device stack. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack. The passivation stack includes a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack. Each nanowell is associated with a light guide of the array of light guides. A crosstalk blocking metal structure is disposed in the passivation stack. The crosstalk blocking metal structure reduces crosstalk within the passivation stack.

    Two-filter light detection devices and methods related to same
    2.
    发明授权
    Two-filter light detection devices and methods related to same 有权

    公开(公告)号：US11256033B2

    公开(公告)日：2022-02-22

    申请号：US15929503

    申请日：2020-05-06

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai

    IPC: G02B6/26 ,  G02B6/293 ,  G01N21/64 ,  G01N33/48 ,  G02B5/20 ,  F21V8/00 ,  G01N21/03

    Abstract: Light detection devices and corresponding methods are provided. The devices include a reaction structure to contain a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The devices also include a plurality of light sensors and device circuitry. The devices further include a plurality of light guides extending toward at least one corresponding light sensor from input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess. The light guides comprise a first filter region that filters the excitation light and permits the light emissions of a first wavelength to pass to the at least one corresponding light sensor, and a second filter region that filters the excitation light and the permits light emissions of a second wavelength to pass to the at least one corresponding light sensor.

    STRUCTURE AND METHOD TO USE ACTIVE SURFACE OF A SENSOR
    3.
    发明申请
    STRUCTURE AND METHOD TO USE ACTIVE SURFACE OF A SENSOR 有权

    公开(公告)号：US20250164386A1

    公开(公告)日：2025-05-22

    申请号：US19028124

    申请日：2025-01-17

    Applicant: Illumina, Inc.

    Inventor： Donglai Lu ,  Xiuyu Cai ,  Wenyi Feng ,  Hai Tran

    IPC: G01N21/05 ,  B01L3/00 ,  H10F39/18

    Abstract: Disclosed is an apparatus and method of forming, including a supporting structure, a sensor on the supporting structure, a pair of columns on the supporting structure at opposite sides of the sensor, the pair of columns having a column height relative to a top surface of the supporting structure, the column height being higher than a height of the active surface of the sensor relative to the top surface of the supporting structure, and a lidding layer on the pair of columns and over the active surface, the lidding layer being supported at opposite ends by the pair of columns. The active surface of the sensor, the lidding layer and the pair of columns form an opening above at least more than about half of the active surface of the sensor, and the supporting structure, the sensor, the lidding layer and the pair of columns together form a flow cell.

    Light detection devices with protective liner and methods related to same
    5.
    发明授权
    Light detection devices with protective liner and methods related to same 有权

    公开(公告)号：US11543352B2

    公开(公告)日：2023-01-03

    申请号：US17190094

    申请日：2021-03-02

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Joseph Francis Pinto ,  Thomas A. Baker ,  Tracy Helen Fung

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/02 ,  H01L31/0216 ,  H01L31/0232 ,  G01N21/05

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

    Light detection devices with protective liner and methods related to same
    6.
    发明授权
    Light detection devices with protective liner and methods related to same 有权

    公开(公告)号：US10955343B2

    公开(公告)日：2021-03-23

    申请号：US16216014

    申请日：2018-12-11

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Joseph Francis Pinto ,  Thomas A. Baker ,  Tracy Helen Fung

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/0216 ,  H01L31/0232 ,  G01N21/05 ,  H01L31/02

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

    SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY
    8.
    发明申请
    SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY 有权

    公开(公告)号：US20250164399A1

    公开(公告)日：2025-05-22

    申请号：US19027132

    申请日：2025-01-17

    Applicant: Illumina, Inc.

    Inventor： Tracy Helen Fung ,  Xiuyu Cai ,  Lisa Kwok ,  Hai Tran ,  Kevan Samiee ,  Liangliang Qiang ,  Boyan Boyanov

    IPC: G01N21/64 ,  B01L3/00 ,  G01N15/1434 ,  G01N21/77

    Abstract: An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

    Light detection devices with protective liner and methods related to same
    9.
    发明授权
    Light detection devices with protective liner and methods related to same 有权

    公开(公告)号：US12188869B2

    公开(公告)日：2025-01-07

    申请号：US18464624

    申请日：2023-09-11

    Applicant: Illumina, Inc.

    Inventor： Xiuyu Cai ,  Joseph Francis Pinto ,  Thomas A. Baker ,  Tracy Helen Fung

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N21/05 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/02 ,  H01L31/0216 ,  H01L31/0232

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

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