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    Autofocus systems and methods for particle analysis in blood samples
    1.
    发明授权
    Autofocus systems and methods for particle analysis in blood samples 有权

    公开(公告)号：US10705008B2

    公开(公告)日：2020-07-07

    申请号：US14216811

    申请日：2014-03-17

    申请人： IRIS International, Inc.

    发明人： Bart J. Wanders ,  Brett Jordan ,  Gregory A. Farrell ,  Thomas H. Adams ,  Warren Groner

    IPC分类号： G01N15/14 ,  G01N21/00 ,  G01N1/30 ,  G01N15/06 ,  G01N21/53 ,  G01N33/49 ,  G01N33/50 ,  G01N33/80 ,  G01N21/05 ,  G01N15/00 ,  G01N15/10

    摘要： Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

    FLOWCELL, SHEATH FLUID, AND AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN URINE SAMPLES
    7.
    发明申请
    FLOWCELL, SHEATH FLUID, AND AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN URINE SAMPLES 审中-公开

    公开(公告)号：US20180143182A1

    公开(公告)日：2018-05-24

    申请号：US15819298

    申请日：2017-11-21

    申请人： Iris International, Inc.

    发明人： Bart J. Wanders ,  Eric Chapoulaud ,  Brett Jordan

    IPC分类号： G01N33/50 ,  G01N15/14 ,  G01N21/85 ,  G01N15/00

    摘要： The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.