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    Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties
    2.
    发明授权
    Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties 失效
    咪唑和1,2,4-三唑衍生物与血管紧张素II拮抗剂的性质

    公开(公告)号：US5389661A

    公开(公告)日：1995-02-14

    申请号：US194535

    申请日：1994-02-10

    申请人： Ila Sircar ,  Jagadish C. Sircar

    发明人： Ila Sircar ,  Jagadish C. Sircar

    IPC分类号： C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  A61K31/41 ,  A61K31/415 ,  C07D257/04

    CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D403/14

    摘要： This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of using them are also covered.

    摘要翻译： 本发明涉及拮抗血管紧张素II与其受体的结合的新型取代的咪唑和三唑衍生物。 该化合物可用于治疗高血压，心力衰竭，青光眼和醛固酮增多症。 制备化合物的方法，可用于制备化合物的新中间体，含有该化合物的药物组合物，以及使用它们的方法也被覆盖。

    Imidazole with angiotensin II antagonist properties
    3.
    发明授权
    Imidazole with angiotensin II antagonist properties 失效
    咪唑与血管紧张素II拮抗剂的性质

    公开(公告)号：US5322950A

    公开(公告)日：1994-06-21

    申请号：US985395

    申请日：1992-12-04

    申请人： Ila Sircar ,  Jagadish C. Sircar

    发明人： Ila Sircar ,  Jagadish C. Sircar

    IPC分类号： C07D401/06 ,  C07D403/06 ,  C07D403/14

    CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D403/14

    摘要： This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of using them are also covered.

    摘要翻译： 本发明涉及拮抗血管紧张素II与其受体的结合的新型取代的咪唑和三唑衍生物。 该化合物可用于治疗高血压，心力衰竭，青光眼和醛固酮增多症。 制备化合物的方法，可用于制备化合物的新中间体，含有该化合物的药物组合物，以及使用它们的方法也被覆盖。

    Novel renin inhibiting peptides
    7.
    发明授权
    Novel renin inhibiting peptides 失效
    新型肾素抑制肽

    公开(公告)号：US5071837A

    公开(公告)日：1991-12-10

    申请号：US621138

    申请日：1990-11-28

    申请人： Annette M. Doherty ,  Ila Sircar

    发明人： Annette M. Doherty ,  Ila Sircar

    IPC分类号： A61K38/00 ,  C07K5/02

    CPC分类号： C07K5/0205 ,  A61K38/00

    摘要： The invention concerns certain orally active novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and glaucoma. It is also useful for treating diseases caused by retroviruses including HTLV-I, -II, and -III. Process for preparing the peptides, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和青光眼的某些口服活性的新型肾素抑制肽。 它也可用于治疗由逆转录病毒引起的疾病，包括HTLV-1，-II和-III。 包括肽的制备方法，含有它们的组合物和使用它们的方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。

    Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
    10.
    发明授权
    Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents 失效
    用作强心剂的取代的6-苯基-3（2H） - 哒嗪酮

    公开(公告)号：US4404203A

    公开(公告)日：1983-09-13

    申请号：US263643

    申请日：1981-05-14

    申请人： Ila Sircar

    发明人： Ila Sircar

    IPC分类号： A61K31/50 ,  C07D237/14 ,  C07D237/04 ,  C07D237/24

    CPC分类号： A61K31/50

    摘要： Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents.Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted benzoylpropionic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product.The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.

    摘要翻译： 取代的6-苯基-3（2H） - 哒嗪酮化合物可用作强心剂。 所述化合物引起麻醉狗中心肌收缩力的显着增加。 所述化合物通过使取代的苯甲酰基丙酸与适当取代的肼反应制得，得到6-苯基-4,5-二氢-3（2H） - 哒嗪酮，将其脱氢成所需产物。 中间体6-苯基-4,5-二氢-3（2H） - 哒嗪酮本身可用作强心剂。