公开(公告)号：US20100300965A1

公开(公告)日：2010-12-02

申请号：US12734866

申请日：2008-12-25

申请人： Itaru Sakai ,  Takeshi Tsuji ,  Masanori Nagafuji ,  Kazutoshi Ohashi ,  Minoru Yamamoto

发明人： Itaru Sakai ,  Takeshi Tsuji ,  Masanori Nagafuji ,  Kazutoshi Ohashi ,  Minoru Yamamoto

IPC分类号： C02F3/20

CPC分类号： C02F3/20 ,  B01F3/04262 ,  B01F3/04269 ,  B01F2003/04177 ,  B01F2003/04297 ,  B01F2003/04361 ,  Y02W10/15

摘要： The present invention provides a diffuser apparatus which has fine pores capable of achieving a high oxygen transfer efficiency and rarely becoming clogged so that the apparatus can be operated stably over a prolonged period. The diffuser apparatus according to the present invention includes: an aeration plate 4 that is disposed in an aeration tank 12 in order to release pressurized air, fed from a diffusing air feed pipe 3, as air bubbles from fine pores formed in an aeration plate surface 4a; blow water feeding means 5 for feeding blow water into the diffusing air feed pipe 3; and an inserted pipe 7 for discharging the blow water, fed into the diffusing air feed pipe 3, from the aeration plate 4.

摘要翻译： 本发明提供一种具有能够实现高氧转移效率并且很少变得堵塞的细孔的扩散器装置，从而可以在长时间内稳定地操作该装置。 根据本发明的扩散装置包括：曝气板4，其设置在曝气池12中，以从扩散空气供给管3释放加压空气，作为形成在曝气板表面中的细孔的气泡 4a; 用于将吹入水供给到扩散空气供给管3中的吹出水供给单元5; 以及从充气板4排出供给到扩散空气供给管3的吹入水的插入管7。

公开(公告)号：US08505882B2

公开(公告)日：2013-08-13

申请号：US12734866

申请日：2008-12-25

申请人： Itaru Sakai ,  Takeshi Tsuji ,  Masanori Nagafuji ,  Kazutoshi Ohashi ,  Minoru Yamamoto

发明人： Itaru Sakai ,  Takeshi Tsuji ,  Masanori Nagafuji ,  Kazutoshi Ohashi ,  Minoru Yamamoto

IPC分类号： B01F3/04

CPC分类号： C02F3/20 ,  B01F3/04262 ,  B01F3/04269 ,  B01F2003/04177 ,  B01F2003/04297 ,  B01F2003/04361 ,  Y02W10/15

摘要： A diffuser apparatus which has fine pores is capable of achieving a high oxygen transfer efficiency and rarely becoming clogged so that the apparatus can be operated stably over a prolonged period. The diffuser apparatus includes: an aeration plate that is disposed in an aeration tank in order to release pressurized air, fed from a diffusing air feed pipe, as air bubbles from fine pores formed in an aeration plate surface; blow water feeder for feeding blow water into the diffusing air feed pipe; and an inserted pipe for discharging the blow water, fed into the diffusing air feed pipe, from the aeration plate.

摘要翻译： 具有细孔的扩散装置能够实现高氧传递效率并且很少变得堵塞，从而能够在长时间内稳定地操作该装置。 扩散装置包括：充气板，其设置在曝气池中，以从扩散空气供给管供给作为气泡从形成在曝气板表面的细孔的气泡释放的增压空气; 用于将吹入水送入扩散空气供给管的吹水给料器; 以及从曝气板排出供给到扩散空气供给管的吹入水的插入管。

公开(公告)号：US08507485B2

公开(公告)日：2013-08-13

申请号：US12931072

申请日：2011-01-24

申请人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

发明人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

IPC分类号： A61K31/5377 ,  A61K31/506

CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/12 ,  C07D409/12

摘要： A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.

摘要翻译： 通过施用治疗有效量的由式（1）表示的化合物或其盐来治疗与血管生成相关的疾病的方法，其中环X表示R 1和R 2独立地表示氢原子，烷基，芳基或 芳香杂环; R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基 芳硫基，烷基亚磺酰基或非芳族杂环; A1表示硫原子，亚磺酰基或磺酰基; A2表示亚烷基。

公开(公告)号：US20120323350A1

公开(公告)日：2012-12-20

申请号：US13055334

申请日：2010-06-16

申请人： Minoru Yamamoto ,  Tatsushi Imori ,  Shinobu Hirano

发明人： Minoru Yamamoto ,  Tatsushi Imori ,  Shinobu Hirano

IPC分类号： G05B19/18

CPC分类号： G05B11/42 ,  G05B13/042 ,  G05B17/02

摘要： An object is to provide an equipment parameter setting support system for supporting the setting of parameters in various processing equipment. The equipment parameter setting support system has an execution results acquisition unit for acquiring, from an equipment controller or EES of the equipment design and manufacturing support system, execution results of a real equipment at any two points in time; a parameter calculation unit for calculating PID parameters at each time point on the basis of the acquired execution results; a difference calculation unit for calculating the difference between the calculated PID parameters; and a variation value calculation unit for calculating a variation value for a unit interval in relation to the calculated difference, wherein, in the equipment design and manufacturing support system, the calculated variation value and a PID parameters stored in the equipment simulator are computed to calculate a new PID parameter, and PID control is executed in the equipment simulator using the new PID parameter.

摘要翻译： 目的是提供一种用于支持各种处理设备中参数设置的设备参数设置支持系统。 设备参数设置支持系统具有执行结果获取单元，用于从设备控制器或设备设计制造支持系统的EES获取任意两点的实际设备的执行结果; 参数计算单元，用于基于所获取的执行结果来计算每个时间点的PID参数; 差分计算单元，用于计算所计算的PID参数之间的差; 以及变化值计算单元，用于计算与计算出的差异相关的单位间隔的变化值，其中，在设备设计和制造支持系统中，计算计算的变化值和存储在设备模拟器中的PID参数，以计算 使用新的PID参数在设备模拟器中执行新的PID参数和PID控制。

公开(公告)号：US08288380B2

公开(公告)日：2012-10-16

申请号：US13448674

申请日：2012-04-17

申请人： Hiroyuki Mogi ,  Hisashi Tajima ,  Noriko Mishina ,  Yusuke Yamazaki ,  Shinji Yoneda ,  Katsuhiko Watanabe ,  Junko Fujikawa ,  Minoru Yamamoto

发明人： Hiroyuki Mogi ,  Hisashi Tajima ,  Noriko Mishina ,  Yusuke Yamazaki ,  Shinji Yoneda ,  Katsuhiko Watanabe ,  Junko Fujikawa ,  Minoru Yamamoto

IPC分类号： A61K31/5377 ,  A61K31/4436 ,  A61K31/381 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/444 ,  C07D409/14 ,  C07D409/12 ,  C07D413/12 ,  C07D333/36 ,  C07D417/14 ,  A61P27/02 ,  A61P27/06

CPC分类号： C07D333/36 ,  C07D409/12

摘要： A compound of formula (1): wherein R1 and R2 represent hydrogen, lower alkyl, lower alkenyl, lower alkynyl or R3 represents hydroxyl, lower alkoxy, lower cycloalkyloxy, aryloxy, carboxy, lower alkoxycarbonyl, or NRaRb of the formula R4 and R5 represent halogen, lower alkyl, hydroxyl, or lower alkoxy; R6 represents halogen, lower alkyl, aryl, heterocyclic, hydroxy, lower alkoxy, mercapto, lower alkylthio, lower alkylcarbonyl, amino, nitro or cyano; R7 represents lower alkyl, hydroxyl or lower alkoxy; Ra and Rb represent hydrogen or lower alkyl; ring A represents a cyclic hydrocarbon or a heterocyclic ring; ring B represents a heterocyclic ring; X represents lower alkylene; Z represents a single bond or lower alkylene; Y represents lower alkylene and W1—W2 represents CH—CH, or Y represents a single bond and W1—W2 represents N—CH, CH—N or CH—CH; and 1, m, n and o represent 0, 1, 2, or 3.

摘要翻译： 式（1）的化合物：其中R 1和R 2表示氢，低级烷基，低级烯基，低级炔基或R 3表示羟基，低级烷氧基，低级环烷氧基，芳氧基，羧基，低级烷氧基羰基或NR 4 R b R 5表示 卤素，低级烷基，羟基或低级烷氧基; R6表示卤素，低级烷基，芳基，杂环，羟基，低级烷氧基，巯基，低级烷硫基，低级烷基羰基，氨基，硝基或氰基; R7表示低级烷基，羟基或低级烷氧基; Ra和Rb代表氢或低级烷基; 环A表示环状烃或杂环; 环B表示杂环; X表示低级亚烷基; Z表示单键或低级亚烷基; Y表示低级亚烷基，W1-W2表示CH-CH，或Y表示单键，W1-W2表示N-CH，CH-N或CH-CH; 和1，m，n和o表示0,1,2或3。

公开(公告)号：US08258242B2

公开(公告)日：2012-09-04

申请号：US12310314

申请日：2007-08-16

申请人： Ryoichi Hiroi ,  Minoru Yamamoto

发明人： Ryoichi Hiroi ,  Minoru Yamamoto

IPC分类号： C08G65/321

CPC分类号： C08L77/00 ,  C08J3/226 ,  C08K3/22 ,  C08K7/00 ,  C08L23/06 ,  C08L23/083 ,  C08L23/30 ,  C08L67/07 ,  C08L69/00 ,  C08L71/12 ,  C08L81/02 ,  C08L101/00 ,  C08L81/00 ,  C08L2666/02

摘要： Disclosed are: a compatibilizing agent for a polymer alloy, which can increase the compatibility with a variety of polymers; a polymer alloy using the compatibilizing agent; and master batch for a polymer alloy. Specifically disclosed is a compatibilizing agent which is used for the preparation of a polymer alloy by blending at least one polymer (A) selected from the group consisting of a polyphenylene sulfide, a polyphenylene ether and a polyamide with a polymer (B) of a different type from the polymer (A) at such a ratio that the amount of the polymer (A) blended is the same as or more than that of the polymer (B). The compatibilizing agent comprises a nanosheet-shaped layered titanic acid which is produced by intercalate an organic basic compound between the layers of a layered titanic acid.

摘要翻译： 公开了一种用于聚合物合金的相容剂，其可以增加与各种聚合物的相容性; 使用相容剂的聚合物合金; 和聚合物合金的母料。 具体公开了一种相容剂，其通过将选自聚苯硫醚，聚苯醚和聚酰胺的至少一种聚合物（A）与不同的聚合物（B）共混而用于制备聚合物合金 以聚合物（A）的配合量与聚合物（B）相同或更多的比例从聚合物（A）中加入。 相容剂包括通过在层状钛酸的层之间插入有机碱性化合物而制备的纳米片状层状钛酸。

公开(公告)号：US08017775B2

公开(公告)日：2011-09-13

申请号：US11992088

申请日：2006-09-14

申请人： Mamoru Matsuda ,  Toshiyuki Mori ,  Kenji Kawashima ,  Masato Nagatsuka ,  Sachiko Kobayashi ,  Minoru Yamamoto ,  Masatomo Kato ,  Miwa Takai ,  Tomoko Oda

发明人： Mamoru Matsuda ,  Toshiyuki Mori ,  Kenji Kawashima ,  Masato Nagatsuka ,  Sachiko Kobayashi ,  Minoru Yamamoto ,  Masatomo Kato ,  Miwa Takai ,  Tomoko Oda

IPC分类号： C07D215/38

CPC分类号： C07D215/14 ,  C07D215/20 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S(O)R8 or S(O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.

摘要翻译： 本发明的目的是研究新型1,2-二氢喹啉衍生物的合成，并找到衍生物的药理作用。 由通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面是有效的。 在该式中，环X表示苯环或吡啶环; R1表示卤素原子，烷基，羟基，烷氧基，氨基等; p表示0〜5的整数， R2表示卤素原子，烷基，羟基等; q表示0〜2的整数， R3表示氢原子，烷基，烯基等; R4和R5表示氢原子等; R6表示氢原子等; A表示亚烷基等; 并且R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8或S（O）2 R 8，其中R 8表示芳基，杂环基等，R 9表示氢原子等。

公开(公告)号：US20110124668A1

公开(公告)日：2011-05-26

申请号：US13054041

申请日：2009-07-14

申请人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

发明人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

IPC分类号： A61K31/404 ,  C07D209/42 ,  C07D403/12 ,  A61K31/506 ,  C07D401/12 ,  A61K31/4439 ,  C07D405/10 ,  A61P29/00 ,  A61P27/06 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  A61P3/00 ,  A61P25/00 ,  A61P37/06 ,  A61P31/00 ,  A61P37/08

CPC分类号： C07D209/42 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

摘要： The present invention relates to synthetic studies on novel indole derivatives having a carbamoyl group, a ureido group and a substituted oxy group or a salt thereof, and pharmaceutical actions of the derivatives. The compound and a salt thereof represented by the general formula (1) has an IKKβ inhibitory activity and is useful as a preventive and/or therapeutic agent for diseases considered to be associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group which may have a substituent, a hydroxy group, or a lower alkoxy group which may have a substituent, or the like; R2 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, or a heterocyclic group which may have a substituent, or the like; R3 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or the like; m represents 0, 1, 2, or the like.

摘要翻译： 本发明涉及具有氨基甲酰基，脲基和取代的氧基或其盐的新型吲哚衍生物的合成研究以及衍生物的药物作用。 由通式（1）表示的化合物及其盐具有IKK＆bgr; 抑制活性，并且可用作被认为与IKK＆bgr相关的疾病的预防和/或治疗剂。 式中，R 1表示氢原子，可以具有取代基的低级烷基，羟基或可具有取代基的低级烷氧基等。 R2表示氢原子，可以具有取代基的低级烷基，可以具有取代基的低级环烷基，可以具有取代基的芳基或可以具有取代基的杂环基等。 R3表示卤原子，可以具有取代基的低级烷基，可以具有取代基的低级烯基，可以具有取代基的低级炔基，可以具有取代基的低级环烷基，可以具有取代基的低级环烷基， 可以具有取代基，可以具有取代基的杂环基等; m表示0,1,2等。

公开(公告)号：US20100292843A1

公开(公告)日：2010-11-18

申请号：US12793646

申请日：2010-06-03

申请人： Hirokazu Kariyazaki ,  Shinichi Maehara ,  Minoru Yamamoto ,  Michiharu Tanaka

发明人： Hirokazu Kariyazaki ,  Shinichi Maehara ,  Minoru Yamamoto ,  Michiharu Tanaka

IPC分类号： B25J9/00 ,  G06F19/00 ,  G05B19/04 ,  G05B15/02

CPC分类号： B25J9/1676 ,  A61B34/30 ,  G05B2219/39098 ,  G05B2219/40203

摘要： A robot system includes a robot and a robot controller including a drive unit, a memory that stores an arm-occupied region and a movement-forbidden region, a target position calculation unit that outputs a target position of a tool or a workpiece, a movement-forbidden region entry monitoring unit that checks whether the arm-occupied region based on the target position enters the movement-forbidden region and outputs a stop request if it is checked that the arm-occupied region enters the movement-forbidden region, and a predicted-coasting-position calculating unit that calculates a predicted coasting position of each axis and a coasting position of the tool or the workpiece in the case that the robot is urgently stopped. The movement-forbidden region entry monitoring unit checks whether the arm-occupied region at the coasting position enters the movement-forbidden region and outputs another stop request if it is checked that the arm-occupied region enters the movement-forbidden region.

摘要翻译： 机器人系统包括机器人和机器人控制器，其包括驱动单元，存储臂占用区域和禁止移动区域的存储器，输出工具或工件的目标位置的目标位置计算单元，移动 - 禁止区域进入监视单元，其检查基于目标位置的手臂占用区域是否进入禁止移动区域，并且如果检查到所述臂占用区域进入禁止运动区域则输出停止请求，并且预测 - 加工位置计算单元，其在机器人紧急停止的情况下，计算各轴的预测的滑行位置和工具或工件的滑行位置。 移动禁止区域进入监视单元检查在滑行位置的手臂占用区域是否进入禁止运动区域，如果检查到手臂占用区域进入禁止移动区域，则输出另一个停止请求。

公开(公告)号：US20090272348A1

公开(公告)日：2009-11-05

申请号：US11721895

申请日：2005-12-07

申请人： Minoru Yamamoto ,  Toshimasa Morita

发明人： Minoru Yamamoto ,  Toshimasa Morita

IPC分类号： F01L1/34

CPC分类号： F01L1/022 ,  F01L1/08 ,  F01L1/181 ,  F01L1/344 ,  F01L2001/0535 ,  F01L2101/00 ,  F01L2105/00 ,  F01L2820/01 ,  F01L2820/035

摘要： When an engine speed of an engine is low, a force by a spring to bias a low speed lock pin in the direction in which the pin is to be inserted into a low speed pin introduction hole is greater than a centrifugal force acting on a weight. This causes the low speed lock pin to be inserted into the low speed pin introduction hole, so that the phase of an intake camshaft relative to an exhaust camshaft is fixed. When the engine speed of the engine is high, a force to bias a high speed lock pin in the direction in which the pin is to be inserted in a high speed pin introduction hole by a centrifugal force acting on a weight is greater than a force by a spring to bias the high speed lock pin in the direction in which the pin is pulled out from the high speed lock pin introduction hole. This causes the high speed lock pin to be inserted into the high speed pin introduction hole, so that the phase of the intake camshaft relative to the exhaust camshaft is fixed.

摘要翻译： 当发动机的发动机转速低时，通过弹簧将低速锁定销偏压到插入低速销引入孔的方向上的力大于作用在重量上的离心力 。 这导致低速锁定销插入到低速销引入孔中，使得进气凸轮轴相对于排气凸轮轴的相位是固定的。 当发动机的发动机转速高时，通过作用在重量上的离心力将高速锁定销偏置在销插入高速销引入孔的方向上的力大于力 通过弹簧将高速锁定销沿从高速锁定销引入孔拉出的方向偏置。 这使得高速锁定销插入到高速销引入孔中，使得进气凸轮轴相对于排气凸轮轴的相位是固定的。