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公开(公告)号：US20060264404A1
公开(公告)日：2006-11-23
申请号：US11258621
申请日：2005-10-25
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Alan Huang , Haolun Jin , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , William Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号： A61K31/675 , C07F9/6512
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译： 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。
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公开(公告)号：US20060079478A1
公开(公告)日：2006-04-13
申请号：US10833293
申请日：2004-04-26
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Alan Huang , Choung Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher Lee , Kuei-Ying Lin , Richard Mackman , David Markevitch , Peter Nelson , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang , Lijun Zhang
IPC分类号： A61K31/7076 , A61K31/7072 , C07H19/04 , A61K31/675
CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20050227947A1
公开(公告)日：2005-10-13
申请号：US10832817
申请日：2004-04-26
申请人： James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William Watkins
发明人： James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William Watkins
IPC分类号： A61K31/66 , A61K31/675
CPC分类号： A61K31/66 , A61K31/675 , A61K47/548
摘要： The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有用于治疗代谢性疾病和/或病症（例如糖尿病和高胆固醇血症）的活性的磷取代的化合物，以及含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于 制备此类化合物。
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公开(公告)号：US20050256078A1
公开(公告)日：2005-11-17
申请号：US10832829
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Thorsten Kirschberg , Hyung-Jung Pyun , William Watkins , Jennifer Zhang
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Thorsten Kirschberg , Hyung-Jung Pyun , William Watkins , Jennifer Zhang
IPC分类号： A61K31/662 , A61K31/675 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/40 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6503 , C07F9/6509 , C07F9/653 , C07F9/6539 , C07F9/655 , C07F9/6553 , C07F9/6561
CPC分类号： C07F9/4075 , A61K31/662 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561
摘要： The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的IMPDH抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20050215513A1
公开(公告)日：2005-09-29
申请号：US10832815
申请日：2004-04-26
申请人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , William Lee , Richard MacKman , David Markevitch , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
发明人： Constantine Boojamra , Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan Huang , Choung Kim , Thorsten Kirschberg , Christopher Lee , William Lee , Richard MacKman , David Markevitch , David Oare , Vidya Prasad , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
IPC分类号： A61K31/662 , A61K31/675 , A61K31/7072 , A61K31/7076 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/40 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6503 , C07F9/6509 , C07F9/653 , C07F9/6539 , C07F9/655 , C07F9/6553 , C07F9/6561
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20060199788A1
公开(公告)日：2006-09-07
申请号：US10833294
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Thorsten Kirschberg , Christopher Lee , Kuei-Ying Lin , Richard Mackman , Peter Nelson , David Oare , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph Hirschmann , Thorsten Kirschberg , Christopher Lee , Kuei-Ying Lin , Richard Mackman , Peter Nelson , David Oare , Hyung-Jung Pyun , Adrian Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William Watkins , Jennifer Zhang
CPC分类号： C07F9/65583 , A61K31/60 , A61K47/548 , C07F9/4006 , C07F9/4021 , C07F9/46 , C07F9/572 , C07F9/5728 , C07F9/65031 , C07F9/65038 , C07F9/650905 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561 , C07F9/65616
摘要： The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20060035866A1
公开(公告)日：2006-02-16
申请号：US10833295
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Alan Huang , Thorsten Kirschberg , Christopher Lee , Richard Mackman , Peter Nelson , Hyung-Jung Pyun , Adrian Ray , William Watkins , Jennifer Zhang , Sundaramoorthi Swaminathan
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Alan Huang , Thorsten Kirschberg , Christopher Lee , Richard Mackman , Peter Nelson , Hyung-Jung Pyun , Adrian Ray , William Watkins , Jennifer Zhang , Sundaramoorthi Swaminathan
IPC分类号： A61K31/66
CPC分类号： A61K47/548 , A61K47/542
摘要： The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20090247488A1
公开(公告)日：2009-10-01
申请号：US12145611
申请日：2008-06-25
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralp F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralp F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/675 , C07F9/28 , A61P29/00
CPC分类号： C07F9/65616 , A61K31/675 , A61K47/54 , C07D237/14 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/65038 , C07F9/6512 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07432261B2
公开(公告)日：2008-10-07
申请号：US10833294
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/60 , C07D237/00
CPC分类号： C07F9/65583 , A61K31/60 , A61K47/548 , C07F9/4006 , C07F9/4021 , C07F9/46 , C07F9/572 , C07F9/5728 , C07F9/65031 , C07F9/65038 , C07F9/650905 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561 , C07F9/65616
摘要： The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20090131372A1
公开(公告)日：2009-05-21
申请号：US12145329
申请日：2008-06-24
申请人： James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins
发明人： James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins
IPC分类号： A61K31/675 , C07F9/38 , A61P3/00
CPC分类号： A61K31/66 , A61K31/675 , A61K47/548
摘要： The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及具有用于治疗代谢性疾病和/或病症（例如糖尿病和高胆固醇血症）的活性的磷取代的化合物，以及含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于 制备此类化合物。
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