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    Electrospray Emitter Assembly
    3.
    发明申请
    Electrospray Emitter Assembly 审中-公开
    电喷发射器组装

    公开(公告)号：US20140047905A1

    公开(公告)日：2014-02-20

    申请号：US14004240

    申请日：2012-03-05

    申请人： Michael J. Tomany ,  Paul Rainville ,  James P. Murphy

    发明人： Michael J. Tomany ,  Paul Rainville ,  James P. Murphy

    IPC分类号： G01N30/72 ,  B05B5/025

    CPC分类号： G01N30/72 ,  B05B5/025 ,  B05B5/0255 ,  H01J49/165 ,  Y10T29/49002

    摘要： An electrospray emitter assembly (4) for an interface device (1) used to connect the output of a liquid chromatograph to the inlet of an electrospray ion source of a mass spectrometer (10). The device (1) incorporates an electrospray emitter assembly (4) that includes an emitter needle (40), a sheath (6) and a housing (5) with an attachment means in the form of a flange (55) for attachment to a mass spectrometer (10). The sheath (6) is arranged to shield the electrospray emitter needle (40) when the assembly is not attached to a mass spectrometer (10). The assembly (4) is operable to move the sheath (6) thereby to reveal, in use, the electrospray emitter needle (40) when the assembly (4) is attached to the mass spectrometer (10).

    摘要翻译： 一种用于将液相色谱仪的输出与质谱仪（10）的电喷雾离子源的入口连接的接口装置（1）的电喷射发射器组件（4）。 装置（1）包括电喷射发射器组件（4），其包括发射针（40），护套（6）和壳体（5），其具有法兰（55）形式的附接装置，用于附接到 质谱仪（10）。 护套（6）布置成当组件未连接到质谱仪（10）时屏蔽电喷射发射器针（40）。 组件（4）可操作以移动护套（6），从而当组件（4）附接到质谱仪（10）时，在使用中显示电喷射发射针（40）。

    Techniques for automated parameter adjustment using ion signal intensity feedback
    4.
    发明授权
    Techniques for automated parameter adjustment using ion signal intensity feedback 有权
    使用离子信号强度反馈进行自动参数调整的技术

    公开(公告)号：US08598522B2

    公开(公告)日：2013-12-03

    申请号：US13698336

    申请日：2011-05-09

    申请人： Michael J. Tomany ,  James P. Murphy ,  Paul Rainville

    发明人： Michael J. Tomany ,  James P. Murphy ,  Paul Rainville

    IPC分类号： G01N30/72

    CPC分类号： H01J49/167 ,  G01N30/7266 ,  H01J49/168

    摘要： Described are techniques for tuning parameters of a system. For one or more values of a distance, mass spectral analysis of a liquid analyte stream is performed. A corresponding ion signal intensity of a selected ion is obtained. The distance is measured from a first end of a first tube to a second end of a second tube which surrounds said first tube. Using a computing device, a current value of the distance is automatically adjusted in accordance with corresponding ion signal intensities obtained for the selected ion. Using a computing device, a desired value for the distance is automatically determined using the corresponding ion signal intensities. The desired value results in an ion signal intensity for the selected ion which is any of more than a threshold intensity and a maximum of ion signal intensities obtained by performing mass spectral analysis using different values for the distance.

    摘要翻译： 描述了用于调整系统参数的技术。 对于一个或多个距离的值，进行液体分析物流的质谱分析。 获得所选离子的对应离子信号强度。 距离是从第一管的第一端到围绕所述第一管的第二管的第二端测量的。 使用计算设备，根据为所选择的离子获得的对应的离子信号强度，自动调整距离的当前值。 使用计算设备，使用相应的离子信号强度自动确定距离的期望值。 期望的值导致所选择的离子的离子信号强度，其通过使用不同的距离值进行质谱分析而获得的超过阈值强度和离子信号强度的最大值中的任何一个。

    TECHNIQUES FOR AUTOMATED PARAMETER ADJUSTMENT USING ION SIGNAL INTENSITY FEEDBACK
    5.
    发明申请
    TECHNIQUES FOR AUTOMATED PARAMETER ADJUSTMENT USING ION SIGNAL INTENSITY FEEDBACK 有权
    使用离子信号强度反馈进行自动参数调整的技术

    公开(公告)号：US20130056631A1

    公开(公告)日：2013-03-07

    申请号：US13698336

    申请日：2011-05-09

    申请人： Michael J. Tomany ,  James P. Murphy ,  Paul Rainville

    发明人： Michael J. Tomany ,  James P. Murphy ,  Paul Rainville

    IPC分类号： H01J49/04 ,  H01J49/26

    CPC分类号： H01J49/167 ,  G01N30/7266 ,  H01J49/168

    摘要： Described are techniques for tuning parameters of a system. For one or more values of a distance, mass spectral analysis of a liquid analyte stream is performed. A corresponding ion signal intensity of a selected ion is obtained. The distance is measured from a first end of a first tube to a second end of a second tube which surrounds said first tube. Using a computing device, a current value of the distance is automatically adjusted in accordance with corresponding ion signal intensities obtained for the selected ion. Using a computing device, a desired value for the distance is automatically determined using the corresponding ion signal intensities. The desired value results in an ion signal intensity for the selected ion which is any of more than a threshold intensity and a maximum of ion signal intensities obtained by performing mass spectral analysis using different values for the distance.

    摘要翻译： 描述了用于调整系统参数的技术。 对于一个或多个距离的值，进行液体分析物流的质谱分析。 获得所选离子的相应离子信号强度。 距离是从第一管的第一端到围绕所述第一管的第二管的第二端测量的。 使用计算设备，根据为所选择的离子获得的对应的离子信号强度，自动调整距离的当前值。 使用计算设备，使用相应的离子信号强度自动确定距离的期望值。 期望的值导致所选择的离子的离子信号强度，其通过使用不同的距离值进行质谱分析而获得的超过阈值强度和离子信号强度的最大值中的任何一个。

    Interface between liquid flow and mass spectrometer
    6.
    发明授权
    Interface between liquid flow and mass spectrometer 失效
    液体流量与质谱仪之间的界面

    公开(公告)号：US5917184A

    公开(公告)日：1999-06-29

    申请号：US797088

    申请日：1997-02-07

    申请人： William W. Carson ,  Stephen C. Gabeler ,  Yin Liang F. Hsieh ,  Stephen A. Martin ,  Michael J. Tomany ,  Anotoli Verentchikov

    发明人： William W. Carson ,  Stephen C. Gabeler ,  Yin Liang F. Hsieh ,  Stephen A. Martin ,  Michael J. Tomany ,  Anotoli Verentchikov

    IPC分类号： H01J49/04 ,  H01J49/10

    CPC分类号： H01J49/044 ,  H01J49/165

    摘要： An interface apparatus for introducing a sample for analysis from a liquid flow into a mass spectrometer as a plurality of charged droplets is disclosed. The interface apparatus includes interface body which defines a spray chamber and an orifice, a spray means defining a liquid-flow inlet channel and an excess-sample-flow exit channel and having an open end disposed inside the spray chamber, and a voltage device for applying a voltage to the sample to form a plurality of charged droplets. The charged droplets pass through the orifice in the interface body and are introduced into a mass spectrometer for analysis. The interface includes a valve for regulating the flow of sample into the sample inlet channel and a device for imposing a pressure gradient on the sample at the open end which induces the sample to flow from the sample inlet channel through the excess sample outlet channel.

    摘要翻译： 公开了一种用于将用于分析的样品从液体流引入质谱仪作为多个带电液滴的界面装置。 接口装置包括限定喷雾室和孔口的界面体，限定液流入口通道的喷射装置和多余样品流出口通道，并且具有设置在喷雾室内部的开口端;以及电压装置， 向样品施加电压以形成多个带电液滴。 带电液滴通过界面体中的孔口，并引入质谱仪进行分析。 该界面包括用于调节样品流入样品入口通道的阀和用于在开口端施加样品上的压力梯度的装置，其引起样品从样品入口通道流过多余的样品出口通道。

    Device And Method For Analyzing A Sample
    7.
    发明申请
    Device And Method For Analyzing A Sample 有权
    用于分析样品的装置和方法

    公开(公告)号：US20100148057A1

    公开(公告)日：2010-06-17

    申请号：US12524620

    申请日：2008-02-01

    申请人： Joseph A. Jarrell ,  Michael J. Tomany

    发明人： Joseph A. Jarrell ,  Michael J. Tomany

    IPC分类号： H01J49/04 ,  H01J49/26 ,  H01J49/02

    CPC分类号： H01J49/0463

    摘要： Embodiments of the invention relate to a device for analysing a sample surface Comprising an outlet and a frame. The outlet is for forming a jet of gas, the jet forming a sampling region for receiving one or more sample surfaces, and the frame holding the outlet and being adapted to receive a detector means. The detector means has an inlet. In use, the jet produces desorbed sample from sample surfaces received in the sample area. At least a portion of the desorbed sample is ionized to produce one or more sample ions. The frame holds the outlet with respect to the sample ions and produce a signal indicative of the composition of the sample ions.

    摘要翻译： 本发明的实施例涉及一种用于分析包括出口和框架的样品表面的装置。 出口用于形成气体射流，喷射形成用于接收一个或多个样品表面的采样区域，并且保持出口的框架适于接收检测器装置。 检测器装置具有入口。 在使用中，喷射器从样品区域中接收的样品表面产生解吸样品。 解吸的样品的至少一部分被离子化以产生一个或多个样品离子。 框架相对于样品离子保持出口，并产生指示样品离子的组成的信号。

    Ionization electrospray apparatus for mass spectrometry
    10.
    发明授权
    Ionization electrospray apparatus for mass spectrometry 失效
    用于质谱的电离电喷雾装置

    公开(公告)号：US5828062A

    公开(公告)日：1998-10-27

    申请号：US807993

    申请日：1997-03-03

    申请人： Joseph A. Jarrell ,  Michael J. Tomany

    发明人： Joseph A. Jarrell ,  Michael J. Tomany

    IPC分类号： H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC分类号： H01J49/145 ,  H01J49/165

    摘要： An electrospray (ES) apparatus provides efficient reagent addition and improved ionization of an analyte aerosol at high flow rates by combining an ionized reagent aerosol with the analyte aerosol, thereby producing a superior ionized analyte aerosol for mass spectronomy (MS) implementations. The ES apparatus separately receives a reagent and a flow stream comprising analyte. The ES apparatus nebulizes the reagent and flow stream into aerosols, ionizes the reagent aerosol, combines the aerosols into an ionized analyte aerosol, and outputs the ionized analyte aerosol towards a mass spectrometer. The ionized analyte aerosol is formed at high flow rates and with effective reagent mixing, thereby minimizing flow stream aberrations and substantially improving signal sensitivity and selectivity in the mass spectrometer. Contact, mixing, and charge transfer between analyte and reagent particles is positively impacted in an aerosol format, thereby improving reagent mixing efficiency and producing a suitably ionized analyte aerosol at high flow rate. A plurality of nebulizers are used to provide the analyte and ionized reagent aerosols at high flow rate.

    摘要翻译： 电喷雾（ES）装置通过将离子化试剂气溶胶与分析物气溶胶组合而提供高效的试剂加入和改进的高流速下的分析物气溶胶的离子化，由此产生用于质谱分析（MS）实施的优异的电离分析物气溶胶。 ES装置分别接收试剂和包含分析物的流动流。 ES装置将试剂和流动物雾化成气溶胶，将试剂气溶胶离子化，将气溶胶结合成电离的分析物气溶胶，并将离子化的分析物气溶胶输出到质谱仪。 电离的分析物气溶胶以高流速和有效的试剂混合形成，从而最小化流速像差并且在质谱仪中显着提高信号的灵敏度和选择性。 分析物和试剂颗粒之间的接触，混合和电荷转移以气溶胶形式受到积极影响，从而提高试剂混合效率，并以高流速产生合适电离的分析物气溶胶。 使用多个喷雾器以高流速提供分析物和离子化试剂气溶胶。