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    Non-compliant balloon with compliant top-layer to protect coated stents during expansion
    4.
    发明申请
    Non-compliant balloon with compliant top-layer to protect coated stents during expansion 审中-公开

    公开(公告)号：US20060206191A1

    公开(公告)日：2006-09-14

    申请号：US11431826

    申请日：2006-05-11

    Applicant: Jan Weber ,  Tim O'Connor

    Inventor： Jan Weber ,  Tim O'Connor

    IPC: A61F2/84

    CPC classification number: A61M25/104 ,  A61F2/958 ,  A61F2002/9583 ,  A61M25/1027 ,  A61M2025/1081

    Abstract: In order to minimize the potential for damage to bio-compatible and/or therapeutic-containing stent coatings, there is provided a compliant elastic sheath over layer between a non-compliant stent expansion balloon and an unexpanded stent, which is secured over the balloon with a securing crimp. This stent deployment assembly, which is mounted on a catheter, is maneuvered through a patient's body to a desired deployment site and then inflated to expand the stent to the desired diameter. During expansion, the compliant elastic material between the stent and the non-compliant balloon prevents non-compliant balloon-induced damage to the stent's coating, as well as preventing degradation of the non-compliant balloon by, for example, stent-caused punctures. The deflated non-compliant stent expansion balloon and compliant elastic sheath are then withdrawn from the patient's body, leaving the deployed stent at the desired implantation site with its coating substantially intact.

    Nerve modulation system having helical guide
    5.
    发明授权
    Nerve modulation system having helical guide 有权
    神经调制系统具有螺旋引导

    公开(公告)号：US09186209B2

    公开(公告)日：2015-11-17

    申请号：US13554459

    申请日：2012-07-20

    Applicant: Jan Weber ,  Aiden Flanagan ,  Tim O'Connor

    Inventor： Jan Weber ,  Aiden Flanagan ,  Tim O'Connor

    IPC: A61B18/14 ,  A61N1/05 ,  A61B18/00

    CPC classification number: A61N1/0551 ,  A61B2018/00511 ,  A61B2018/00577 ,  F04C2270/0421

    Abstract: Systems for nerve modulation and methods for making and using the same are disclosed. An example system for nerve modulation may include a first elongate element having a distal end and a proximal end and having a helical guide having a proximal end and a distal end. The system may also include a second elongate element having a distal end and a proximal end and having a nerve modulation element proximate the distal end. A sheath may be disposed about both the first and second elongate elements. Pulling proximally on the proximal end of the first elongate element may cause simultaneous radial and longitudinal displacement of the nerve modulation element.

    Abstract translation: 公开了神经调制系统及其制造和使用方法。 用于神经调节的示例性系统可以包括具有远端和近端的具有近端和远端的螺旋引导件的第一细长元件。 该系统还可以包括具有远端和近端并且具有靠近远端的神经调制元件的第二细长元件。 鞘可围绕第一和第二细长元件设置。 在第一细长元件的近端上向近侧拉动可引起神经调制元件的同时径向和纵向位移。

    Medical devices having a coating of inorganic material
    10.
    发明授权
    Medical devices having a coating of inorganic material 有权
    具有无机材料涂层的医疗器械

    公开(公告)号：US08920491B2

    公开(公告)日：2014-12-30

    申请号：US12425791

    申请日：2009-04-17

    Applicant: Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    Inventor： Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    IPC: A61F2/06 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

    CPC classification number: A61L29/10 ,  A61L29/16 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/61

    Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.

    Abstract translation: 在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。 在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中 可膨胀材料是暴露于含水环境时膨胀的材料。 在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。 在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中， 阻挡层具有多个不连续性。 还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

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