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公开(公告)号：US06217917B1
公开(公告)日：2001-04-17
申请号：US09170918
申请日：1998-10-13
申请人： Janos Bodor , Jan Kuiper , Adrianus Marinus Ledeboer , Marinus Theodorus Pleijsier , Jan Cornelis De Smit , Yvon Maria Ijsseldijk , Robert Vreeker
发明人： Janos Bodor , Jan Kuiper , Adrianus Marinus Ledeboer , Marinus Theodorus Pleijsier , Jan Cornelis De Smit , Yvon Maria Ijsseldijk , Robert Vreeker
IPC分类号： A23C9127
CPC分类号： A23C9/1504 , A23C19/0323 , A23C2220/206 , A23Y2220/39
摘要： Dairy spreads, especially fresh cheese, are sensitive for heat treatments. The heat treated products are often grainy, mealy and chalky. The invention relates to a method of producing a dairy spread wherein a cheese milk or cream or a combination thereof is acid coagulated in the presence of a suitable culture, wherein the culture comprises an exopolysaccharide producing lactic acid bacterium capable of reducing the graininess of the heat treated dairy spread.
摘要翻译： 乳制品传播，特别是新鲜的奶酪，对热处理敏感。 经热处理的产品通常是颗粒状，粉状和白垩。 本发明涉及一种生产乳制品的方法，其中在合适的培养物存在下，将奶酪或奶油或其组合酸化，其中所述培养物包含能够降低热量颗粒度的外多糖产生乳酸菌 经过乳制品传播。
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2.发明授权Lactobacillus sake like strains, production and use of their exopolysaccharides 失效乳酸乳杆菌样菌株，其外多糖的生产和使用
公开(公告)号：US5834043A
公开(公告)日：1998-11-10
申请号：US446831
申请日：1995-09-19
申请人： Dirk Johannes Cornelis Van Den Berg , Adrianus Marinus Ledeboer , Gerard Willem Robijn , Robert Vreeker
发明人： Dirk Johannes Cornelis Van Den Berg , Adrianus Marinus Ledeboer , Gerard Willem Robijn , Robert Vreeker
IPC分类号： A23C19/032 , A21D2/18 , A23C9/123 , A23D7/005 , A23D7/015 , A23L27/60 , A23L29/269 , C08B37/00 , C12N1/20 , C12P19/04 , C12R1/225 , A23C9/12 , A23G3/00
CPC分类号： C12R1/225 , A21D2/181 , A23C9/1234 , A23D7/0056 , A23D7/015 , A23L27/60 , A23L29/269 , C12P19/04 , A23Y2220/77
摘要： New Lactobacillus sake like strains are provided obtainable from meat products, which strains are capable of producing an exopolysaccharide having shear-thinning properties, even at low concentrations, and/or thickening and/or emulsion-stabilizing properties.
摘要翻译： PCT No.PCT / EP93 / 03338 Sec。 371 1995年9月19日第 102（e）1995年9月19日PCT PCT 1993年11月26日PCT公布。 WO94 / 12656 PCT公开号 日期1994年6月9日新鲜的乳酸乳杆菌菌株提供可从肉制品获得，该菌株即使在低浓度下也能够产生具有剪切稀化性质的外多糖，和/或增稠和/或乳化稳定性质。
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公开(公告)号：US20090035288A1
公开(公告)日：2009-02-05
申请号：US11989059
申请日：2006-06-29
IPC分类号： A61K35/74
CPC分类号： A23C9/12 , A23G9/00 , A23G2200/02
摘要： The present invention provides a method of preparing an edible product comprising non-viable bacteria providing a health benefit, the method comprising subjecting viable bacteria to at least two sub-lethal treatments to obtain the non-viable bacteria providing a health benefit, each sub-lethal treatment on its own not being sufficient to render the bacteria non-viable. The method porvides non-viable bacteria providing health benefits but which can conveniently be incorporated into a range of edible products.
摘要翻译： 本发明提供一种制备包含提供健康益处的非活细菌的食用产品的方法，所述方法包括将活细菌经受至少两次次致死处理以获得提供健康益处的非存活细菌， 致命的治疗本身不足以使细菌不可行。 该方法培养提供健康益处的非活细菌，但可方便地并入一系列可食用产品中。
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公开(公告)号：US20120141503A1
公开(公告)日：2012-06-07
申请号：US13355981
申请日：2012-01-23
CPC分类号： A23L2/39 , A23F3/14 , A23F3/34 , A23G9/363 , A23L2/52 , A23L7/126 , A23L27/60 , A23L33/135 , A23L33/18 , A23L33/195 , A23V2002/00 , A23Y2220/17 , A61K9/0056 , A61K9/1652 , A61K2039/505 , C07K16/10 , C07K2317/22 , C07K2317/569 , C07K2317/622 , A23V2250/5434
摘要： The present invention related to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also related to food products and pharmaceutical preparations comprising the delivery system, and method for the preparation of food products according to the invention.
摘要翻译： 本发明涉及VHH或VNAR类型的重链免疫球蛋白或其片段，或适用于治疗感染，特别是胃肠道的免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）。 本发明还涉及包含VHH或VNAR型的这些重链免疫球蛋白或其功能片段或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）的递送系统，以及包含编码 VHH或VNAR型的这些重链免疫球蛋白或其功能片段，或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）。 本发明还涉及包含递送系统的食品和药物制剂以及用于制备根据本发明的食品的方法。
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公开(公告)号：US07033628B2
公开(公告)日：2006-04-25
申请号：US09929569
申请日：2001-08-14
申请人： David Cooke , Timothy John Foster , Saskia Alexandra Galema , Adrianus Marinus Ledeboer , Jan Willem Sanders
发明人： David Cooke , Timothy John Foster , Saskia Alexandra Galema , Adrianus Marinus Ledeboer , Jan Willem Sanders
IPC分类号： A23C1/12
CPC分类号： A23G9/363 , A23C9/1236 , A23C2220/206 , A23G9/34 , A23G9/52 , A23G2200/02 , A23G2200/06 , A23Y2260/35
摘要： A method for preparing a milk-based composition comprising a homopolysaccharide is provided whereby a mixture comprising milk and fermentable sugar is fermented with a homopolysaccharide-producing microorganism under anaerobic conditions, without regulating the pH, and the fermentation is stopped before the pH of the mixture drops below pH 5.5. Food products comprising such compositions are also provided.
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6.发明授权公开(公告)号：US08309075B2
公开(公告)日：2012-11-13
申请号：US12084854
申请日：2006-10-26
申请人： Ruud Albers , Wilhelmina Martina Blom , Adrianus Marinus Ledeboer , Ingrid Celestina Mohede , Jan Willem Sanders
发明人： Ruud Albers , Wilhelmina Martina Blom , Adrianus Marinus Ledeboer , Ingrid Celestina Mohede , Jan Willem Sanders
IPC分类号： A23B7/148 , A23C17/00 , A21D13/00 , A01N63/00 , A01N65/00 , A61K36/254 , B65D85/00 , C08B37/00
CPC分类号： A23L33/135 , A23L33/105 , A23Y2220/73
摘要： One aspect of the present invention relates to an edible product containing: • probiotic bacteria in an amount of at least 103 bacteria per gram; and • at least 0.5 mg/g of ginseng polysaccharides containing at least 2 monosaccharide units, preferably at least 4 monosaccharide units. Another aspect of the invention relates to the use of the aforementioned product in therapeutic and prophylactic treatments. The present invention further provides a method of producing a packaged liquid edible product containing probiotic bacteria and ginseng polysaccharides in the aforementioned amounts.
摘要翻译： 本发明的一个方面涉及一种食用产品，其含有：•每克至少103个细菌的益生菌; 和至少0.5mg / g的含有至少2个单糖单元，优选至少4个单糖单元的人参多糖。 本发明的另一方面涉及上述产品在治疗和预防治疗中的用途。 本发明还提供一种以上述量生产含有益生菌和人参多糖的包装液体食用产品的方法。
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公开(公告)号：US08105592B2
公开(公告)日：2012-01-31
申请号：US11791456
申请日：2005-11-03
IPC分类号： A61K35/66 , A61K39/395
CPC分类号： A23L2/39 , A23F3/14 , A23F3/34 , A23G9/363 , A23L2/52 , A23L7/126 , A23L27/60 , A23L33/135 , A23L33/18 , A23L33/195 , A23V2002/00 , A23Y2220/17 , A61K9/0056 , A61K9/1652 , A61K2039/505 , C07K16/10 , C07K2317/22 , C07K2317/569 , C07K2317/622 , A23V2250/5434
摘要： The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.
摘要翻译： 本发明涉及VHH或VNAR型的重链免疫球蛋白或其片段或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb），其适用于治疗感染，特别是胃肠道 道。 本发明还涉及包含VHH或VNAR型的这些重链免疫球蛋白或其功能片段或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）的递送系统，以及包含编码 VHH或VNAR型的这些重链免疫球蛋白或其功能片段，或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）。 本发明还涉及包含递送系统的食品和药物制剂以及用于制备根据本发明的食品的方法。
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公开(公告)号：US20090226418A1
公开(公告)日：2009-09-10
申请号：US11990214
申请日：2006-05-24
CPC分类号： C07K16/10 , A23G9/363 , A23G9/38 , A23L33/135 , A23L33/18 , A61K35/745 , A61K35/747 , A61K36/06 , A61K39/395 , A61K2039/505 , C07K2317/22 , C07K2317/622 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to food products or pharmaceutical preparations comprising antibodies or antibody fragments which are active in the gut and probiotic micro-organisms independent from the antibodies or antibody fragments. In particular, the invention relates to a method for preparing food products and pharmaceutical preparations comprising the antibodies or antibody fragments and probiotic micro-organisms and the use of these products to deliver health benefits to humans.
摘要翻译： 本发明涉及包含抗体或抗体片段的食品或药物制品，所述抗体或抗体片段与肠道和益生菌微生物在抗体或抗体片段无关。 特别地，本发明涉及制备包含抗体或抗体片段和益生菌微生物的食品和药物制剂的方法，以及这些产品用于向人类提供健康益处的方法。
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公开(公告)号：US06670453B2
公开(公告)日：2003-12-30
申请号：US09530139
申请日：2000-04-27
IPC分类号： C07K1600
CPC分类号： G01N33/531 , A61K38/00 , C07K16/00 , C07K16/1275 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2317/22 , C07K2317/34 , C07K2317/569 , C07K2319/00 , Y10S977/927
摘要： A multivalent antigen binding protein comprises a single polypeptide chain comprising, in series, two or more single domain binding units which are preferably heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains. Methods for their production and uses thereof, in particular for diagnosis, immunoassay and purification methods are disclosed.
摘要翻译： 多价抗原结合蛋白包含单个多肽链，其包含两个或更多个单结构域结合单元，其优选是衍生自天然缺乏轻链的免疫球蛋白的重链可变结构域。 公开了其生产方法及其用途，特别是用于诊断，免疫测定和纯化方法。
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公开(公告)号：US06528056B1
公开(公告)日：2003-03-04
申请号：US09553949
申请日：2000-04-21
申请人： Sandra Bezemer , Leon Gerardus Joseph Frenken , Johannes Joseph Wilhelmus deHaard , Adrianus Marinus Ledeboer , Cornelis Theodorus Verrips
发明人： Sandra Bezemer , Leon Gerardus Joseph Frenken , Johannes Joseph Wilhelmus deHaard , Adrianus Marinus Ledeboer , Cornelis Theodorus Verrips
IPC分类号： A61K39395
CPC分类号： C07K16/08 , A61K2039/505
摘要： A method of inhibiting viral infection using a monovalent antigen binding protein comprising a single domain binding unit capable of binding to a virus is described. Preferably the protein is a heavy chain variable domain derived from an immunoglobulin naturally devoid of light chains. Food, pharmaceutical and cosmetic products comprising such proteins are also described together with a method for selecting inhibiting proteins from a large population of mainly containing non-inhibiting, but infectious agent binding fragments.
摘要翻译： 描述了使用包含能够结合病毒的单结构域结合单元的单价抗原结合蛋白来抑制病毒感染的方法。 优选地，蛋白质是衍生自天然缺乏轻链的免疫球蛋白的重链可变结构域。 还含有这样的蛋白质的食品，药物和化妆品以及从主要含有非抑制性但是感染剂结合片段的大群体中选择抑制蛋白质的方法。
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