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1.发明申请ELECTRONIC SENSING OF BIOLOGICAL AND CHEMICAL AGENTS USING FUNCTIONALIZED NANOSTRUCTURES 审中-公开使用功能化纳米结构的生物和化学试剂的电子感测公开(公告)号：US20110154648A1
公开(公告)日：2011-06-30
申请号：US13047593
申请日：2011-03-14
CPC分类号： B82Y30/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582 , Y10T29/49002
摘要： This invention provides for an apparatus and a method for detecting the presence of pathogenic agents with sensors containing functionalized nanostructures integrated into circuits on silicon chips. The nanostructures are functionalized with molecular transducers that recognize and bind targeted analytes which are diagnostic of the pathogenic agent of interest. The molecular transducer includes a receptor portion, which binds the analyte, and an anchor portion that attaches to the nanostructure. Upon binding of the analyte, a change in molecular configuration represented by the newly formed receptor-analyte complex creates a force that is transmitted to the nanostructure via the anchor portion of the transducer. The effect of the force transmitted to the nanostructure is to alter its conductivity. The change in conductivity of the nanotube thus represents a signal that indicates the presence of the pathogenic agent of interest.
摘要翻译： 本发明提供了一种用于检测病原体的存在的装置和方法，所述传感器包含集成在硅芯片上的电路中的功能化纳米结构。 纳米结构用识别和结合目标分析物的分子换能器进行功能化，这些目标分析物是目标病原体的诊断。 分子换能器包括结合分析物的受体部分和附着到纳米结构的锚定部分。 在分析物结合后，由新形成的受体 - 分析物复合物表示的分子构型的变化产生通过换能器的锚定部分传递到纳米结构的力。 传递到纳米结构的力的作用是改变其导电性。 因此，纳米管的电导率的变化表示表示感兴趣的病原体的存在的信号。
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2.发明申请ELECTRONIC SENSING OF BIOLOGICAL AND CHEMICAL AGENTS USING FUNCTIONALIZED NANOSTRUCTURES 审中-公开使用功能化纳米结构的生物和化学试剂的电子感测公开(公告)号：US20100231242A1
公开(公告)日：2010-09-16
申请号：US12634525
申请日：2009-12-09
IPC分类号： G01R27/08
CPC分类号： B82Y30/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582 , Y10T29/49002
摘要： This invention provides for an apparatus and a method for detecting the presence of pathogenic agents with sensors containing functionalized nanostructures integrated into circuits on silicon chips. The nanostructures are functionalized with molecular transducers that recognize and bind targeted analytes which are diagnostic of the pathogenic agent of interest. The molecular transducer includes a receptor portion, which binds the analyte, and an anchor portion that attaches to the nanostructure. Upon binding of the analyte, a change in molecular configuration represented by the newly formed receptor-analyte complex creates a force that is transmitted to the nanostructure via the anchor portion of the transducer. The effect of the force transmitted to the nanostructure is to alter its conductivity. The change in conductivity of the nanotube thus represents a signal that indicates the presence of the pathogenic agent of interest.
摘要翻译： 本发明提供了一种用于检测病原体的存在的装置和方法，所述传感器包含集成在硅芯片上的电路中的功能化纳米结构。 纳米结构用识别和结合目标分析物的分子换能器进行功能化，这些目标分析物是目标病原体的诊断。 分子换能器包括结合分析物的受体部分和附着到纳米结构的锚定部分。 在分析物结合后，由新形成的受体 - 分析物复合物表示的分子构型的变化产生通过换能器的锚定部分传递到纳米结构的力。 传递到纳米结构的力的作用是改变其导电性。 因此，纳米管的电导率的变化表示表示感兴趣的病原体的存在的信号。
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公开(公告)号：US20070114573A1
公开(公告)日：2007-05-24
申请号：US10655529
申请日：2003-09-04
申请人： Tzong-Ru Han , Alexander Star , Philip Collins , Jean-Christophe Gabriel , George Gruner , Keith Bradley
发明人： Tzong-Ru Han , Alexander Star , Philip Collins , Jean-Christophe Gabriel , George Gruner , Keith Bradley
IPC分类号： H01L29/768
CPC分类号： G01N25/20
摘要： A nanostructure sensing device includes a substrate, a nanotube disposed over the substrate, and at least two conductive elements electrically connected to the nanotube. A electric current on the order of about 10 μA, or greater, is passed through the conductive elements and the nanotube. As a result, the nanotube heats up relative to the substrate. In the alternative, some other method may be used to heat the nanotube. When operated as a sensor with a heated nanotube, the sensor's response and/or recovery time may be markedly improved.
摘要翻译： 纳米结构感测装置包括衬底，设置在衬底上的纳米管以及电连接到纳米管的至少两个导电元件。 大约10μA或更大的电流通过导电元件和纳米管。 结果，纳米管相对于基底加热。 在替代方案中，可以使用一些其它方法来加热纳米管。 当作为具有加热的纳米管的传感器操作时，可以显着改善传感器的响应和/或恢复时间。
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4.发明申请Increasing hydrogen adsorption of nanostructured storage materials by modifying sp2 covalent bonds 审中-公开通过改变sp2共价键来增加纳米结构储存材料的氢吸附公开(公告)号：US20070092437A1
公开(公告)日：2007-04-26
申请号：US10020344
申请日：2001-12-11
申请人： Young-Kyun Kwon , Seung-Hoon Jhi , Keith Bradley , Philip Collins , Jean-Christophe Gabriel , George Gruner
发明人： Young-Kyun Kwon , Seung-Hoon Jhi , Keith Bradley , Philip Collins , Jean-Christophe Gabriel , George Gruner
IPC分类号： C01B3/00
CPC分类号： C01B3/0021 , B82Y30/00 , C01B3/001 , Y02E60/325
摘要： According to the invention, nanostructured storage materials are provided for storing hydrogen. The nanostructured storage materials can include a network of light elements, such as Be, B, C, N, O, F, Mg, P, S, and Cl, coupled with sp2 bonds. The hydrogen adsorption to the nanostructured storage material is improved by modifying the sp2 bonds. The sp2 bonds can be modified by forming the nanostructured storage material from the above light elements, possibly with a shape other than a planar layer, and by introducing defects. A chemical vapor deposition technique can be used for the synthesis, where doping gases are included into the flow. Methods for forming the nanostructured storage material with defects include removing light elements from the nanostructured storage material by irradiation with electrons, neutrons, ions, gamma rays, X-rays, and microwaves.
摘要翻译： 根据本发明，提供用于储存氢的纳米结构储存材料。 纳米结构的储存材料可以包括与Sp 2键结合的诸如Be，B，C，N，O，F，Mg，P，S和Cl的光元件网络。 对纳米结构储存材料的氢吸附通过改变sp 2 O 2键来改善。 可以通过从上述光元件形成纳米结构的储存材料，可能具有不同于平面层的形状，并且通过引入缺陷来修饰sp 2 O 2键。 化学气相沉积技术可以用于合成，其中掺杂气体被包括在流中。 用于形成具有缺陷的纳米结构存储材料的方法包括通过用电子，中子，离子，γ射线，X射线和微波照射从纳米结构的储存材料中去除光元件。
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公开(公告)号：US20060078468A1
公开(公告)日：2006-04-13
申请号：US11139184
申请日：2005-05-27
IPC分类号： G01N33/00
CPC分类号： G01N27/127 , B01J2219/00653 , B01L3/5027 , B82Y15/00 , G01N27/126 , Y10S977/84 , Y10S977/855 , Y10S977/882 , Y10S977/92 , Y10S977/957 , Y10S977/958 , Y10T436/11
摘要： An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifiying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided. The methods involve comparing signals from nanostructure sensing devices that have not been exposed to the chemical species of interest with signals from nanostructure sensing devices that have been exposed to the chemical species of interest. Nanostructure sensing device array structures that can measure and subtract out environmental factors are also disclosed.
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公开(公告)号：US20050169798A1
公开(公告)日：2005-08-04
申请号：US11090550
申请日：2005-03-25
IPC分类号： G01N27/12 , G01N27/414 , G01N31/22
CPC分类号： B82Y15/00 , G01N27/129 , Y10S977/734
摘要： Nanostructure sensing devices for detecting an analyte are described. The devices include nanostructures connected to conductive elements, all on a substrate. Contact regions adjacent to points of contact between the nanostructures and the conductive elements are given special treatment. The proportion of nanostructure surface area within contact regions can be maximized to effect sensing at very low analyte concentrations. The contact regions can be passivated in an effort to prevent interaction between the environment and the contact regions for sensing at higher analyte concentrations and for reducing cross-sensing. Both contact regions and at least some portion of the nanostructures can be covered with a material that is at least partially permeable to the analyte of interest and impermeable to some other species to tune selectivity and sensitivity of the nanostructure sensing device.
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公开(公告)号：US20070178477A1
公开(公告)日：2007-08-02
申请号：US11212026
申请日：2005-08-24
CPC分类号： C12Q1/6825 , G01N27/4145 , G01N27/4146 , C12Q2565/631 , C12Q2565/107
摘要： A nanotube device is configured as an electronic sensor for a target DNA sequence. A film of nanotubes is deposited over electrodes on a substrate. A solution of single-strand DNA is prepared so as to be complementary to a target DNA sequence. The DNA solution is deposited over the electrodes, dried, and removed from the substrate except in a region between the electrodes. The resulting structure includes strands of the desired DNA sequence in direct contact with nanotubes between opposing electrodes, to form a sensor that is electrically responsive to the presence of target DNA strands. Alternative assay embodiments are described which employ linker groups to attach ssDNA probes to the nanotube sensor device.
摘要翻译： 纳米管装置配置为目标DNA序列的电子传感器。 将纳米管膜沉积在基板上的电极上。 制备单链DNA的溶液以与靶DNA序列互补。 将DNA溶液沉积在电极上，干燥，除去电极之外的区域。 所得结构包括与相对电极之间的纳米管直接接触的所需DNA序列的链，以形成对目标DNA链的存在电响应的传感器。 描述了使用连接体将ssDNA探针连接到纳米管传感器装置的替代试验实施方案。
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公开(公告)号：US06834508B2
公开(公告)日：2004-12-28
申请号：US10285731
申请日：2002-10-31
申请人： Keith Bradley , Jeff Wyatt , Seung-Hoon Jhi , Young-Kyun Kwon , Jean Christophe Gabriel , George Gruner
发明人： Keith Bradley , Jeff Wyatt , Seung-Hoon Jhi , Young-Kyun Kwon , Jean Christophe Gabriel , George Gruner
IPC分类号： F17C1100
CPC分类号： F17C11/005 , G06Q50/06 , Y02E60/321 , Y02P90/45
摘要： This invention provides for an apparatus and a method for operation of a cryogenic hydrogen storage system that contains a porous medium configured to adsorb hydrogen. The hydrogen storage and supply system includes a hydrogen source apparatus and a cryosorptive storage apparatus. Methods and devices that allow for an energy efficient filling of the cryosorptive apparatus from the hydrogen source apparatus are described. The cryosorptive hydrogen storage apparatus is filled with cold, pressurized hydrogen. During the course of filling, heat is generated in the cryosorptive storage device by the process of hydrogen adsorption on to the host medium. Methods and devices are provided for the removal the generated heat and the warm hydrogen. Further provided are devices and methods for the capture and recycle of escaped hydrogen within the hydrogen source apparatus.
摘要翻译： 本发明提供了一种用于操作低温氢存储系统的装置和方法，所述低温储氢系统包含构造成吸附氢气的多孔介质。 氢存储和供给系统包括氢源装置和低温存储装置。 描述允许从氢源装置对冷冻摄影装置进行能量效率充填的方法和装置。 冷藏式氢存储装置充满冷的加压氢气。 在填充过程中，通过氢吸附到主介质上的过程，在冷冻存储装置中产生热量。 提供了用于去除所产生的热量和温氢的方法和装置。 还提供了用于在氢源装置内捕获和再循环逸出的氢的装置和方法。
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公开(公告)号：US20050183424A1
公开(公告)日：2005-08-25
申请号：US11007383
申请日：2004-12-07
申请人： Keith Bradley , Jeff Wyatt , Seung-Hoon Jhi , Young-Kyun Kwon , Jean-Christophe Gabriel , George Gruner
发明人： Keith Bradley , Jeff Wyatt , Seung-Hoon Jhi , Young-Kyun Kwon , Jean-Christophe Gabriel , George Gruner
IPC分类号： B65B1/04 , B65B1/30 , B65B3/04 , B65B3/26 , B67C3/02 , B67D99/00 , F17C11/00 , F17C13/02 , G06F17/00 , B67D5/00
CPC分类号： F17C11/005 , G06Q50/06 , Y02E60/321 , Y02P90/45
摘要： This invention provides for an apparatus and a method for operation of a cryogenic hydrogen storage system that contains a porous medium configured to adsorb hydrogen. The hydrogen storage and supply system includes a hydrogen source apparatus and a cryosorptive storage apparatus. Methods and devices that allow for an energy efficient filling of the cryosorptive apparatus from the hydrogen source apparatus are described. The cryosorptive hydrogen storage apparatus is filled with cold, pressurized hydrogen. During the course of filling, heat is generated in the cryosorptive storage device by the process of hydrogen adsorption on to the host medium. Methods and devices are provided for the removal the generated heat and the warm hydrogen. Further provided are devices and methods for the capture and recycle of escaped hydrogen within the hydrogen source apparatus.
摘要翻译： 本发明提供了一种用于操作低温氢存储系统的装置和方法，该低温储氢系统包含构造成吸附氢气的多孔介质。 氢存储和供给系统包括氢源装置和低温存储装置。 描述允许从氢源装置对冷冻摄影装置进行能量效率充填的方法和装置。 冷藏式氢存储装置充满冷的加压氢气。 在填充过程中，通过氢吸附到主介质上的过程，在冷冻存储装置中产生热量。 提供了用于去除所产生的热量和温氢的方法和装置。 还提供了用于在氢源装置内捕获和再循环逸出的氢的装置和方法。
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公开(公告)号：US20060228723A1
公开(公告)日：2006-10-12
申请号：US11259414
申请日：2005-10-25
申请人： Keith Bradley , Jean-Christophe Gabriel , George Gruner , Alexander Star , Eugene Tu , Christian Valcke
发明人： Keith Bradley , Jean-Christophe Gabriel , George Gruner , Alexander Star , Eugene Tu , Christian Valcke
CPC分类号： B82Y30/00 , B01L3/50857 , B01L2300/0636 , B01L2300/0663 , B01L2300/0819 , B01L2300/0851 , B01L2300/0893 , B01L2300/0896 , B01L2300/16 , B82Y10/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582
摘要： A nanoelectronic device is combined with a cellular membrane component to provide a sensor for biomolecules or to provide information about the structure of the membrane. The nanoelectronic device may comprise a network of randomly-oriented nanotubes, or other nanostructure, arranged on a substrate with adjacent electrodes so as to operate as a field-effect transistor sensor or as a capacitive sensor. A cellular membrane is disposed over the nanostructure element.
摘要翻译： 纳米电子器件与细胞膜组件组合以提供用于生物分子的传感器或提供关于膜结构的信息。 纳米电子器件可以包括布置在具有相邻电极的衬底上的随机取向的纳米管或其他纳米结构的网络，以便作为场效应晶体管传感器或电容式传感器工作。 细胞膜设置在纳米结构元件上。
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