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公开(公告)号：US20080045539A1
公开(公告)日：2008-02-21
申请号：US11748527
申请日：2007-05-15
申请人： Jianguo Ji , Tao Li , Christopher Lynch , Murali Gopalakrishnan
发明人： Jianguo Ji , Tao Li , Christopher Lynch , Murali Gopalakrishnan
IPC分类号： A61K31/46 , A61K31/497 , A61K31/501 , A61P25/18 , A61P25/28 , C07D221/22 , C07D401/12
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及稠合的双环杂环取代的氮杂双环烷烃衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20080070929A1
公开(公告)日：2008-03-20
申请号：US11769241
申请日：2007-06-27
申请人： Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid Kouhen , Jinhe Li , Kathy Sarris , Melissa Michmerhuizen , Ying Wang
发明人： Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid Kouhen , Jinhe Li , Kathy Sarris , Melissa Michmerhuizen , Ying Wang
IPC分类号： A61K31/427 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61P25/00 , A61P29/00 , A61P37/00 , C07D417/02 , C07D417/14 , C12Q1/02
CPC分类号： C07D417/04 , C07D413/04 , C07D417/14
摘要： The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要翻译： 本发明涉及一系列噻唑啉和恶唑啉衍生物，其组合物，以及使用这些化合物治疗病症和病症的方法。
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公开(公告)号：US20080064695A1
公开(公告)日：2008-03-13
申请号：US11769395
申请日：2007-06-27
申请人： Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid El Kouhen , Jinhe Li
发明人： Ramin Faghih , Gregory Gfesser , Christopher Lynch , Murali Gopalakrishnan , Sujatha Gopalakrishnan , John Malysz , Earl Gubbins , Rachid El Kouhen , Jinhe Li
IPC分类号： A61K31/4025 , A61K31/40 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P25/00 , A61P29/00 , A61P9/00 , C07D207/00 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02 , C07D413/02 , C12Q1/02 , C12Q1/48
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20070072860A1
公开(公告)日：2007-03-29
申请号：US11600445
申请日：2006-11-16
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： A61K31/53 , A61K31/501 , A61K31/497 , A61K31/444 , A61K31/4439 , C07D413/02 , C07D403/02
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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5.发明申请METHOD AND APPARATUS USEFUL IN THE DIAGNOSIS OF OBSTRUCTIVE SLEEP APNEA OF A PATIENT 审中-公开患者阻塞性睡眠障碍诊断中使用的方法和装置公开(公告)号：US20070051371A1
公开(公告)日：2007-03-08
申请号：US11554378
申请日：2006-10-30
申请人： Colin SULLIVAN , Christopher Lynch
发明人： Colin SULLIVAN , Christopher Lynch
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译： 患者可以运用CPAP系统在家中提供适当的气道压力。 患者的呼吸暂停问题可以在家中进行诊断，而不用CPAP设备进行监督，CPAP设备在大体上整个治疗期间都能持续提供适当的压力。
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6.发明申请3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists 审中-公开3,5-芳基，杂芳基或环烷基取代的-1,2,4-恶二唑作为s1p受体激动剂公开(公告)号：US20070043014A1
公开(公告)日：2007-02-22
申请号：US10571334
申请日：2004-09-27
申请人： George Doherty , Jeffrey Hale , Irene Legiec , Christopher Lynch , Leslie Toth
发明人： George Doherty , Jeffrey Hale , Irene Legiec , Christopher Lynch , Leslie Toth
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4709 , A61K31/4745 , A61K31/4439 , A61K31/4245 , C07D413/04
CPC分类号： C07D413/04 , C07D271/06
摘要： The present invention encompasses compounds of Formula I: (I) as well as the pharmaceutically acceptable salts thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译： 本发明包括式I化合物：（I）及其药学上可接受的盐。 该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。 包括药物组合物和使用方法。
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7.发明授权Method and apparatus useful in the diagnosis of obstructive sleep apnea of a patient 失效用于诊断患者阻塞性睡眠呼吸暂停的方法和装置公开(公告)号：US06770037B2
公开(公告)日：2004-08-03
申请号：US10086444
申请日：2002-03-04
IPC分类号： A21B508
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem ca be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译： 患者可以运用CPAP系统在家中提供适当的气道压力。 患者的呼吸暂停问题可以在家中进行诊断，无需监护，CPAP装置可在整个治疗期间持续提供最低限度的适当压力。
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公开(公告)号：US20060258657A1
公开(公告)日：2006-11-16
申请号：US11202827
申请日：2005-08-12
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： A61K31/53 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4745 , C07D471/02
CPC分类号： C07D207/24 , C07D211/20 , C07D211/26 , C07D211/48 , C07D211/70 , C07D211/72 , C07D213/38 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/12 , C07D257/04 , C07D277/36 , C07D295/155 , C07D295/185 , C07D295/30 , C07D307/22 , C07D309/20 , C07D333/20 , C07D333/34 , C07D401/12 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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9.发明申请3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists 审中-公开3-（2-氨基-1-氮杂环丙基）-5-芳基-1,2,4-恶二唑作为s1p受体激动剂公开(公告)号：US20060252741A1
公开(公告)日：2006-11-09
申请号：US10554665
申请日：2004-05-12
申请人： Vincent Colandrea , George Doherty , Jeffrey Hale , Christopher Lynch , Sander Mills , William Neway III , Leslie Toth
发明人： Vincent Colandrea , George Doherty , Jeffrey Hale , Christopher Lynch , Sander Mills , William Neway III , Leslie Toth
IPC分类号： A61K31/4439 , C07D413/04 , C07D413/14
CPC分类号： C07D413/04 , C07D271/06 , C07D413/14
摘要： The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译： 本发明包括式（I）的化合物及其药学上可接受的盐。 该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。 包括药物组合物和使用方法。
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公开(公告)号：US20060252070A1
公开(公告)日：2006-11-09
申请号：US11380822
申请日：2006-04-28
申请人： Steven Boege , Christopher Lynch , Mark Oldham
发明人： Steven Boege , Christopher Lynch , Mark Oldham
CPC分类号： G06K9/00134 , G06K9/2018
摘要： Methods for biological sample multi-color light detection using color-image detectors with pixel filter arrays or multi-color pixels.
摘要翻译： 使用具有像素滤波器阵列或多色像素的彩色图像检测器进行生物样本多色光检测的方法。
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