NEW-TYPE CHITOSAN-BASED HYBRID MACROMOLECULE AND A METHOD FOR PRODUCING OR USING THE MACROMOLECULE
    4.
    发明申请
    NEW-TYPE CHITOSAN-BASED HYBRID MACROMOLECULE AND A METHOD FOR PRODUCING OR USING THE MACROMOLECULE 审中-公开
    新型基于壳聚糖的混合大分子和一种生产或使用大分子的方法

    公开(公告)号:US20120153520A1

    公开(公告)日:2012-06-21

    申请号:US13101676

    申请日:2011-05-05

    IPC分类号: B01J13/02 C08B37/08

    CPC分类号: A61K9/1075 A61K47/36

    摘要: The invention discloses the synthesis of a new-type chitosan-based hybrid macromolecule and a method for producing or using the macromolecule. This macromolecule comprises an amphiphatic chitosan and a silicon-based coupling agent that is anchored by a chemical bonding. The method for producing the hybrid macromolecule can be easily operated under ambient environment. The produced macromolecule can be self-assembled in an aqueous environment to form a nanocarrier, and has the ability to efficiently encapsulate drugs for a subsequent sustained release purpose. This self-assembled hybrid nanocarrier demonstrated features of excellent biocompatibility, drug loading ability and cellular uptake efficiency.

    摘要翻译: 本发明公开了新型壳聚糖类杂合大分子的合成及其制备方法。 该大分子包含通过化学键合锚定的两亲性壳聚糖和硅基偶联剂。 混合高分子的制造方法可以容易地在周围环境下进行。 所制备的大分子可以在水性环境中自组装形成纳米载体,并具有有效地包封药物用于随后的缓释目的的能力。 这种自组装的混合纳米载体表现出优异的生物相容性,药物负载能力和细胞摄取效率的特征。