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公开(公告)号：US20120255373A1
公开(公告)日：2012-10-11
申请号：US13506892
申请日：2012-05-23
申请人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
IPC分类号： G01N1/28
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
摘要： A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
摘要翻译： 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US08993311B2
公开(公告)日：2015-03-31
申请号：US13506892
申请日：2012-05-23
申请人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
摘要： A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
摘要翻译： 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US20120190105A1
公开(公告)日：2012-07-26
申请号：US13374899
申请日：2012-01-23
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
摘要： A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
摘要翻译： 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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公开(公告)号：US08822207B2
公开(公告)日：2014-09-02
申请号：US13374899
申请日：2012-01-23
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
摘要： A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
摘要翻译： 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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公开(公告)号：US08871500B2
公开(公告)日：2014-10-28
申请号：US13374898
申请日：2012-01-23
CPC分类号： G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
摘要： A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
摘要翻译： 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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公开(公告)号：US20120190104A1
公开(公告)日：2012-07-26
申请号：US13374898
申请日：2012-01-23
CPC分类号： G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
摘要： A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
摘要翻译： 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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公开(公告)号：US08736081B2
公开(公告)日：2014-05-27
申请号：US13573201
申请日：2012-08-30
申请人： John S. Foster , Christopher S. Gudeman , Alok Paranjpye , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Christopher S. Gudeman , Alok Paranjpye , Jaquelin K. Spong , Douglas L. Thompson
IPC分类号： H01L23/28
CPC分类号： H01L23/10 , B81C1/00269 , B81C2203/0118 , B81C2203/019 , H01L21/50 , H01L2924/01079 , H01L2924/16235 , H01L2924/163
摘要： Systems and methods for forming an encapsulated device include a hermetic seal which seals an insulating environment between two substrates, one of which supports the device. The hermetic seal is formed by an alloy of two metal layers, one deposited on a first substrate and the other deposited on the second substrate. At least one of the substrates may include a raised feature formed under at least one of the metal layers. The two metals may for an alloy of a predefined stoichiometry in at least two locations on either side of the midpoint of the raised feature. This alloy may have advantageous features in terms of density, mechanical, electrical or physical properties that may improve the hermeticity of the seal, for example.
摘要翻译： 用于形成封装装置的系统和方法包括密封两个基板之间的绝缘环境的气密密封件，其中之一支撑该装置。 气密密封由两个金属层的合金形成，一个沉积在第一基板上，另一个沉积在第二基板上。 衬底中的至少一个可以包括形成在至少一个金属层下面的凸起特征。 两种金属可以在凸起特征的中点的任一侧上的至少两个位置中具有预定化学计量的合金。 例如，该合金在密度，机械，电学或物理性质方面可能具有有利的特征，这可以改善密封的气密性。
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公开(公告)号：US20120319303A1
公开(公告)日：2012-12-20
申请号：US13573201
申请日：2012-08-30
申请人： John S. Foster , Alok Paranjpye , Douglas L. Thompson , Christopher S. Gudeman , Jaquelin K. Spong
发明人： John S. Foster , Alok Paranjpye , Douglas L. Thompson , Christopher S. Gudeman , Jaquelin K. Spong
CPC分类号： H01L23/10 , B81C1/00269 , B81C2203/0118 , B81C2203/019 , H01L21/50 , H01L2924/01079 , H01L2924/16235 , H01L2924/163
摘要： Systems and methods for forming an encapsulated device include a hermetic seal which seals an insulating environment between two substrates, one of which supports the device. The hermetic seal is formed by an alloy of two metal layers, one deposited on a first substrate and the other deposited on the second substrate. At least one of the substrates may include a raised feature formed under at least one of the metal layers. The two metals may for an alloy of a predefined stoichiometry in at least two locations on either side of the midpoint of the raised feature. This alloy may have advantageous features in terms of density, mechanical, electrical or physical properties that may improve the hermeticity of the seal, for example.
摘要翻译： 用于形成封装装置的系统和方法包括密封两个基板之间的绝缘环境的气密密封件，其中之一支撑该装置。 气密密封由两个金属层的合金形成，一个沉积在第一基板上，另一个沉积在第二基板上。 衬底中的至少一个可以包括形成在至少一个金属层下面的凸起特征。 两种金属可以在凸起特征的中点的任一侧上的至少两个位置中具有预定化学计量的合金。 例如，该合金在密度，机械，电学或物理性质方面可能具有有利的特征，这可以改善密封的气密性。
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9.发明授权Disk drive with controlled actuator oscillation for release of head carriers 失效磁盘驱动器具有控制执行器振荡以释放磁头载体
公开(公告)号：US5384675A
公开(公告)日：1995-01-24
申请号：US118537
申请日：1993-09-08
摘要： A magnetic recording disk drive has a startup routine that frees the recording head carriers and moves them to a parking location, such as load/unload ramp or a disk landing zone, if they are stuck to the disks when the drive motor is attempted to be started. If the drive motor does not achieve its operating speed at normal startup of the disk drive, thus indicating that static friction or other "stiction" forces are adhering the carriers to the disks, a series of alternating current pulses is applied to the actuator to dither the carriers at an initial frequency that is generally equal to or above the resonant frequency of the actuator system with stuck carriers. The frequency and amplitude of the pulses is swept downward from the initial frequency and amplitude and repeated until the drive motor rotates at its operating speed. The alternating current pulses that perform the dithering of the carriers have different amplitudes or durations so that a net force is applied to the actuator to move the carriers to the parking location.
摘要翻译： 磁记录磁盘驱动器具有启动程序，如果驱动电机试图成为磁盘时，它们会释放记录磁头托架并将其移动到停放位置，如加载/卸载斜坡或磁盘着陆区域 开始了 如果驱动电机在磁盘驱动器的正常启动时没有达到其运行速度，因此表明静摩擦或其他“静止”力将载体粘附到磁盘上，则一系列交流电脉冲施加到致动器以进行抖动 载波的初始频率通常等于或高于具有卡住的载波的致动器系统的谐振频率。 脉冲的频率和振幅从初始频率和振幅向下扫描，并重复，直到驱动电机以其运行速度旋转。 执行载波抖动的交流脉冲具有不同的振幅或持续时间，从而将净力施加到致动器以将载体移动到停车位置。
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公开(公告)号：US5196701A
公开(公告)日：1993-03-23
申请号：US739011
申请日：1991-07-31
申请人： John S. Foster , Kurt A. Rubin , Jaquelin K. Spong
发明人： John S. Foster , Kurt A. Rubin , Jaquelin K. Spong
CPC分类号： G11B9/1409 , B82Y10/00 , B82Y35/00 , G01Q10/065 , G11B11/007 , G11B9/149 , G01Q80/00 , G11B2005/0021 , Y10S977/861 , Y10S977/863 , Y10S977/871 , Y10S977/947
摘要： The method to detect and determine the profile of the material property or the structure changes not only on surface but also at the subsurface, of a storage medium or a scanned sample. This method comprises the following steps: (a), a nondestructive periodic or modulated perturbation is applied to the sample to be scanned. (b) the perturbed sample is then scanned using a microprobe, e.g., scanning tunneling microscopy (STM) or atomic force microscopy (AFM), which is responsive to the applied periodic or modulated perturbations and (c) the modulated output signals from the microprobe, in combination with the input perturbation signals, are processed and demodulated to automatically control the motion of the probe, and to determine the profiles of the material properties or the structure changes of the scanned sample.
摘要翻译： 检测和确定材料特性或结构的轮廓的方法不仅在表面上而且在地下，存储介质或扫描样品上变化。 该方法包括以下步骤：（a）将非破坏性周期性或调制扰动施加到要扫描的样品。 （b）然后使用微探针扫描扰动的样品，例如扫描隧道显微镜（STM）或原子力显微镜（AFM），其响应于施加的周期性或调制扰动，以及（c）来自微探针的调制输出信号 与输入扰动信号组合，被处理和解调以自动控制探针的运动，并确定扫描样本的材料性质或结构变化的轮廓。
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