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公开(公告)号：US20120255373A1
公开(公告)日：2012-10-11
申请号：US13506892
申请日：2012-05-23
申请人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
IPC分类号： G01N1/28
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
摘要： A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
摘要翻译： 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US07220594B2
公开(公告)日：2007-05-22
申请号：US11196291
申请日：2005-08-04
申请人： John S. Foster , John C. Harley , Steven H. Hovey , Richard T. Martin , Hung D. Nguyen , Paul J. Rubel
发明人： John S. Foster , John C. Harley , Steven H. Hovey , Richard T. Martin , Hung D. Nguyen , Paul J. Rubel
CPC分类号： C12M47/04 , A61M1/36 , A61M1/3633 , A61M1/3678 , A61M2202/0437 , B01L3/5027 , G01N21/6428 , G01N2015/0288 , G01N2015/149 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A micromechanical particle sorting chip uses laser light directed through at least one of a reflective and refractive surface to come to a focus in an optically transparent layer. The laser light impinges on a particle of interest, causing it to fluoresce. Upon detecting the fluorescence, a micromemchanical actuator is activated, which directs the particle of interest into one of a plurality of possible exit paths.
摘要翻译： 微机械粒子分选芯片使用通过反射和折射表面中的至少一个引导的激光在光学透明层中进行聚焦。 激光照射在感兴趣的颗粒上，使其发出荧光。 在检测到荧光时，微机械致动器被激活，其将感兴趣的颗粒引导到多个可能的出口路径中的一个。
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公开(公告)号：US20150282456A1
公开(公告)日：2015-10-08
申请号：US14246164
申请日：2014-04-07
申请人： John C. HARLEY
发明人： John C. HARLEY
CPC分类号： A01K27/008 , A01K27/006 , A01K27/009 , E01H1/1206 , E01H2001/1273 , E01H2001/128 , E01H2001/1286
摘要： A pet care system is disclosed which may include disposable cartridges for storing and dispensing pet care consumable items. The cartridges may be detachably held in a main structure which may also include a retractable leash, and other pet care related items. The cartridges may have machine-readable indicia affixed thereto, that can point the user to information for ordering cartridges and supplies. The pet care system may have additional features to enhance the safety or convenience of the pet or user, including an RFID tag, a radio transmitter, a radio receiver, a GPS locator, a mechanism for generating audible sounds, a light emitting diode, and a flashlight.
摘要翻译： 公开了一种宠物护理系统，其可以包括用于存储和分发宠物护理消耗品的一次性盒。 盒可以可拆卸地保持在主结构中，该主结构还可以包括可缩回的皮带和其它宠物护理相关物品。 墨盒可能具有附加到其上的机器可读标记，其可以指示用户订购墨盒和耗材的信息。 宠物护理系统可以具有附加特征以增强宠物或用户的安全性或便利性，包括RFID标签，无线电发射器，无线电接收器，GPS定位器，用于产生可听见的声音的机构，发光二极管和 手电筒
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公开(公告)号：US08993311B2
公开(公告)日：2015-03-31
申请号：US13506892
申请日：2012-05-23
申请人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
发明人： John S. Foster , Daryl W. Grummitt , John C. Harley , James P. Linton , Jaquelin K. Spong , Douglas L. Thompson
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , G01N2015/1081 , G01N2015/149
摘要： A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.
摘要翻译： 描述了配备有多个微加工颗粒分选结构的一次性盒。 一次性药筒可以包括将药筒中的流体储存器与颗粒分选结构上的相应的微流体通道连接的通道。 柔性垫片可以防止泄漏并允许流体通过垫圈中的多个孔穿过垫圈屏障，允许流体从储存器转移到微加工颗粒分选结构。 多个颗粒分选结构可以布置在一次性盒中，以便执行多个分离操作，例如顺序或并行排序操作。
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公开(公告)号：US08871500B2
公开(公告)日：2014-10-28
申请号：US13374898
申请日：2012-01-23
CPC分类号： G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
摘要： A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
摘要翻译： 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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公开(公告)号：US08343791B2
公开(公告)日：2013-01-01
申请号：US12923693
申请日：2010-10-05
IPC分类号： H01L21/00
CPC分类号： H01L21/76898 , B32B37/02 , B32B2457/14 , B81B7/0006 , B81B2207/092 , B81B2207/095
摘要： A method for forming through features in a substrate uses a seed layer deposited over a first substrate, and a second substrate bonded to the seed layer. The features may be formed in the first substrate, by plating a conductive filler material onto the seed layer. The first substrate and the second substrate may then be bonded to a third substrate, and the second substrate is removed, leaving through features and first substrate adhered to the third substrate. The through features may provide at least one of electrical access and motion to a plurality of devices formed on the third substrate, or may impart movement to a moveable feature on the first substrate, wherein the third substrate supports the first substrate after removal of the second substrate.
摘要翻译： 用于在衬底中形成穿透特征的方法使用沉积在第一衬底上的种子层和与种子层结合的第二衬底。 特征可以在第一基板中形成，通过将导电填料材料镀在种子层上。 然后可以将第一衬底和第二衬底接合到第三衬底，并且去除第二衬底，留下通过特征和粘附到第三衬底的第一衬底。 穿透特征可以向形成在第三基底上的多个装置提供电通路和运动中的至少一个，或者可以将运动赋予第一基板上的可移动特征，其中第三基板在移除第二基板之后支撑第一基板 基质。
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公开(公告)号：US20110250092A1
公开(公告)日：2011-10-13
申请号：US12662237
申请日：2010-04-07
CPC分类号： G01N21/645 , G01N15/1459 , G01N15/1484 , G01N21/6428 , G01N2015/149
摘要： An optical material is inlaid into a supporting substrate, with the top surface of the optical material flush with the top surface of the substrate, wherein the optical element is used to shape a beam of light travelling substantially parallel to the top surface of the substrate, but with the central axis of the beam below the top surface of the substrate. The optical elements serve to shape the beam of light for delivery to or from a microfabricated structure within the device.
摘要翻译： 将光学材料嵌入支撑基板中，其中光学材料的顶表面与基板的顶表面齐平，其中光学元件用于成形基本上平行于基板的顶表面行进的光束， 但是梁的中心轴线在基板的顶表面下方。 光学元件用于成形光束，用于传送到或从设备内的微加工结构传输。
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公开(公告)号：US08822207B2
公开(公告)日：2014-09-02
申请号：US13374899
申请日：2012-01-23
CPC分类号： C12M47/04 , B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0439 , B01L2400/0478 , B01L2400/0481 , G01N15/1459 , G01N2015/149
摘要： A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.
摘要翻译： 描述了与MEMS颗粒分选装置兼容的一次性盒。 一次性盒可以包括将盒中的流体储存器与MEMS芯片上的相应微流体通道连接的通道。 柔性垫片可以防止泄漏，并允许流体通过垫圈中的多个孔穿过垫圈屏障。 还可以包括通气孔和隔膜，以允许空气逸出，并由皮下注射针插入液体。 还描述了使用一次性盒的基于MEMS的颗粒分选系统。
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公开(公告)号：US20120190104A1
公开(公告)日：2012-07-26
申请号：US13374898
申请日：2012-01-23
CPC分类号： G01N33/5005 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0633 , C12M47/04
摘要： A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.
摘要翻译： 描述了基于MEMS的系统和方法，用于将目标颗粒与流体流的其余部分分离。 该系统利用形成在基板上的独特的微加工可移动结构，其以旋转方式围绕一个或多个固定点移动，所述固定点都位于运动轴的一侧。 可移动结构由独立的力产生装置致动，该装置与其基板上形成的可移动结构完全分开。 这允许可移动结构完全浸没在样品流体中。
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10.发明授权公开(公告)号：US07229838B2
公开(公告)日：2007-06-12
申请号：US11260367
申请日：2005-10-28
申请人： John S. Foster , John C. Harley , Steven H. Hovey , Richard T. Martin , Hung D. Nguyen , Paul J. Rubel
发明人： John S. Foster , John C. Harley , Steven H. Hovey , Richard T. Martin , Hung D. Nguyen , Paul J. Rubel
CPC分类号： B01L3/502707 , A61M1/3633 , A61M1/3678 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0484 , C12M47/04 , G01N21/6428 , G01N2015/0288 , G01N2015/149 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A micromechanical particle sorting chip uses an actuator divided into two parts to direct a component of interest into one of a plurality of possible exit paths, based on detection of a fluorescent signal emanating from the component of interest. The two-part actuator may include a force-generating portion and a microactuator portion. The microactuator portion may be disposable, whereas the force-generating portion may be reuseable. By bringing the force-generating portion into proximity to the microactuator portion, the microactuator is induced to move, thereby separating the component of interest from the rest of the fluid stream. The force-generating portion and the microactuator portion may be optimized and fabricated separately, thereby leading to faster, more reliable and less expensive particle sorting.
摘要翻译： 微机械粒子分选芯片基于从感兴趣的部件发出的荧光信号的检测，使用分成两部分的致动器将感兴趣的部件引导到多个可能的出口路径中的一个。 两部分致动器可以包括力产生部分和微致动器部分。 微致动器部分可以是一次性的，而力产生部分可以是可再利用的。 通过使力产生部分靠近微致动器部分，微致动器被诱导移动，从而将感兴趣的部件与流体流的其余部分分离。 力产生部分和微致动器部分可以分开优化和制造，从而导致更快，更可靠和更便宜的颗粒分选。
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